Similar Natural Products in NPASS
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient 
● The left chart: Distribution of similarity level between NPC61558 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).
| range |
Tanimoto Coefficient |
| 0-0.1 | 14868 |
| 0.1-0.2 | 14390 |
| 0.2-0.3 | 1265 |
| 0.3-0.4 | 294 |
| 0.4-0.5 | 52 |
| 0.5-0.6 | 16 |
| 0.6-0.7 | 3 |
| 0.7-0.8 | 1 |
| 0.8-0.85 | 0 |
| 0.85-0.9 | 0 |
| 0.9-0.95 | 0 |
| 0.95-1 | 0 |
Similar Clinical/Approved Drugs
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
● The left chart: Distribution of similarity level between NPC61558 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
| range |
Tanimoto Coefficient |
| 0-0.1 | 2649 |
| 0.1-0.2 | 5567 |
| 0.2-0.3 | 691 |
| 0.3-0.4 | 221 |
| 0.4-0.5 | 24 |
| 0.5-0.6 | 7 |
| 0.6-0.7 | 1 |
| 0.7-0.8 | 1 |
| 0.8-0.85 | 0 |
| 0.85-0.9 | 0 |
| 0.9-0.95 | 0 |
| 0.95-1 | 0 |
| Similarity Score |
Similarity Level |
Drug ID |
Developmental Stage |
| 0.7 |
Intermediate Similarity |
NPD8622 |
Discontinued |
| 0.6562
|
Remote Similarity |
NPD8794 |
Clinical (unspecified phase) |
