Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT1287 | Individual Protein | Cannabinoid CB2 receptor | Homo sapiens | Ki | = | 860 | nM | 26149623 |
NPT232 | Individual Protein | Cannabinoid CB1 receptor | Homo sapiens | Ki | = | 410 | nM | 26149623 |
NPT2 | Others | Unspecified | Ratio Ki | = | 2 | 26149623 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC477524 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
0.9867 | High Similarity | NPC477523 |
0.7722 | Intermediate Similarity | NPC97614 |
0.6809 | Remote Similarity | NPC81195 |
0.6737 | Remote Similarity | NPC53240 |
0.6535 | Remote Similarity | NPC233932 |
0.6437 | Remote Similarity | NPC470994 |
0.6222 | Remote Similarity | NPC325936 |
0.6154 | Remote Similarity | NPC188785 |
0.5978 | Remote Similarity | NPC474833 |
0.5833 | Remote Similarity | NPC178758 |
0.5833 | Remote Similarity | NPC196102 |
0.5824 | Remote Similarity | NPC281154 |
0.5795 | Remote Similarity | NPC45060 |
0.5795 | Remote Similarity | NPC280065 |
0.5765 | Remote Similarity | NPC206660 |
0.5758 | Remote Similarity | NPC324506 |
0.5729 | Remote Similarity | NPC474312 |
0.5714 | Remote Similarity | NPC252684 |
0.5682 | Remote Similarity | NPC249713 |
0.5682 | Remote Similarity | NPC474812 |
0.5664 | Remote Similarity | NPC476875 |
0.5649 | Remote Similarity | NPC469426 |
0.5649 | Remote Similarity | NPC469427 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC477524 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
0.6 | Remote Similarity | NPD1452 | Discontinued |
PubChem CID   | |
ChEMBL   | CHEMBL3597331 |
ZINC   |
Molecular Weight:   | 499.20 |
ALogP:   | -0.0894 |
MLogP:   | 3.11 |
XLogP:   | 6.217 |
# Rotatable Bonds:   | 27 |
Polar Surface Area:   | 55.84 |
# H-Bond Aceptor:   | 5 |
# H-Bond Donor:   | 0 |
# Rings:   | 0 |
# Heavy Atoms:   | 31 |