Natural Product: NPC45256

Natural Product ID:  NPC45256
Common Name:   n.a.
IUPAC Name:  
Synonyms:   GNF-Pf-5671
Molecular Formula:   C15H22O5
Standard InCHIKey:  BLUAFEHZUWYNDE-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3
Canonical SMILES:  O=C1OC2OC3(C)CCC4C2(C(C1C)CCC4C)OO3
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO26589 Artemisia annua Species Asteraceae Eukaryota TM-MC*
NPO10506 Artemisia apiacea Species Asteraceae Eukaryota TM-MC*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT6 Organism Plasmodium falciparum Plasmodium falciparum EC50 = 4.58 nM 18579783
NPT6 Organism Plasmodium falciparum Plasmodium falciparum EC50 = 11.98 nM 18579783
NPT1229 Cell Line Huh-7 Homo sapiens CC50 > 100000 nM 18579783
NPT149 Individual Protein Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Homo sapiens Potency = 39810.7 nM PubChem BioAssay data set
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 35481.3 nM PubChem BioAssay data set
NPT53 Individual Protein 4'-phosphopantetheinyl transferase ffp Bacillus subtilis Potency = 89125.1 nM PubChem BioAssay data set
NPT54 Individual Protein Nonstructural protein 1 Influenza A virus Potency = 6309.6 nM PubChem BioAssay data set
NPT151 Individual Protein 15-hydroxyprostaglandin dehydrogenase [NAD+] Homo sapiens Potency = 39810.7 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 14125.4 nM PubChem BioAssay data set
NPT135 Individual Protein Chromobox protein homolog 1 Homo sapiens Potency 100000 nM PubChem BioAssay data set
NPT8 Individual Protein DNA polymerase iota Homo sapiens Potency 89125.1 nM PubChem BioAssay data set
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency 3.3 nM PubChem BioAssay data set
NPT367 Cell Line MDA-N Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT368 Cell Line SN12C Homo sapiens GI50 92257.14 nM PubChem BioAssay data set
NPT370 Cell Line NCI-H23 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT369 Cell Line ACHN Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT371 Cell Line UO-31 Homo sapiens GI50 82224.26 nM PubChem BioAssay data set
NPT372 Cell Line HOP-92 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT116 Cell Line HL-60 Homo sapiens GI50 37411.06 nM PubChem BioAssay data set
NPT374 Cell Line SF-539 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT373 Cell Line SK-MEL-5 Homo sapiens GI50 96161.23 nM PubChem BioAssay data set
NPT375 Cell Line Malme-3M Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT376 Cell Line A498 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT111 Cell Line K562 Homo sapiens GI50 33113.11 nM PubChem BioAssay data set
NPT377 Cell Line OVCAR-3 Homo sapiens GI50 67297.67 nM PubChem BioAssay data set
NPT112 Cell Line MOLT-4 Homo sapiens GI50 66069.34 nM PubChem BioAssay data set
NPT379 Cell Line HOP-62 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT380 Cell Line U-251 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT381 Cell Line OVCAR-8 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT382 Cell Line OVCAR-5 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT383 Cell Line SNB-19 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT572 Cell Line DMS-273 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT82 Cell Line MDA-MB-231 Homo sapiens GI50 62373.48 nM PubChem BioAssay data set
NPT385 Cell Line SR Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT573 Cell Line M19-MEL Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT384 Cell Line TK-10 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT323 Cell Line SW-620 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT455 Cell Line NCI-H522 Homo sapiens GI50 45081.67 nM PubChem BioAssay data set
NPT386 Cell Line KM12 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT574 Cell Line XF498 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT387 Cell Line M14 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT389 Cell Line RPMI-8226 Homo sapiens GI50 53210.83 nM PubChem BioAssay data set
NPT388 Cell Line NCI-H322M Homo sapiens GI50 75335.56 nM PubChem BioAssay data set
NPT390 Cell Line LOX IMVI Homo sapiens GI50 97949 nM PubChem BioAssay data set
NPT456 Cell Line OVCAR-4 Homo sapiens GI50 72777.98 nM PubChem BioAssay data set
NPT457 Cell Line BT-549 Homo sapiens GI50 86496.79 nM PubChem BioAssay data set
NPT147 Cell Line SK-MEL-2 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT575 Cell Line KM-20L2 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT81 Cell Line A549 Homo sapiens GI50 89125.09 nM PubChem BioAssay data set
NPT392 Cell Line SNB-75 Homo sapiens GI50 61659.5 nM PubChem BioAssay data set
NPT391 Cell Line HCC 2998 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT393 Cell Line HCT-116 Homo sapiens GI50 81658.24 nM PubChem BioAssay data set
NPT148 Cell Line HCT-15 Homo sapiens GI50 98401.11 nM PubChem BioAssay data set
NPT395 Cell Line SF-268 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT394 Cell Line EKVX Homo sapiens GI50 97051 nM PubChem BioAssay data set
NPT83 Cell Line MCF7 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT306 Cell Line PC-3 Homo sapiens GI50 66834.39 nM PubChem BioAssay data set
NPT731 Cell Line LXFL 529 Homo sapiens GI50 65463.62 nM PubChem BioAssay data set
NPT576 Cell Line DMS-114 Homo sapiens GI50 80352.61 nM PubChem BioAssay data set
NPT146 Cell Line SK-OV-3 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT398 Cell Line UACC-62 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT397 Cell Line NCI-H460 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT308 Cell Line CAKI-1 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT458 Cell Line IGROV-1 Homo sapiens GI50 88920.11 nM PubChem BioAssay data set
NPT399 Cell Line SF-295 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT577 Cell Line RXF 631 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT402 Cell Line Hs-578T Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT401 Cell Line 786-0 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT578 Cell Line SNB-78 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT403 Cell Line UACC-257 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT404 Cell Line CCRF-CEM Homo sapiens GI50 82985.08 nM PubChem BioAssay data set
NPT579 Cell Line DLD-1 Homo sapiens GI50 82794.22 nM PubChem BioAssay data set
NPT405 Cell Line NCI-H226 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT139 Cell Line HT-29 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT170 Cell Line SK-MEL-28 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT407 Cell Line COLO 205 Homo sapiens GI50 100000 nM PubChem BioAssay data set
NPT406 Cell Line RXF 393 Homo sapiens GI50 72945.75 nM PubChem BioAssay data set
NPT732 Cell Line HOP-18 Homo sapiens GI50 61801.64 nM PubChem BioAssay data set
NPT11 Individual Protein Guanine nucleotide-binding protein G(s), subunit alpha Homo sapiens Potency 11220.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 819.9 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 841.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 18837.5 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 11582.1 nM PubChem BioAssay data set
NPT160 Individual Protein TAR DNA-binding protein 43 Homo sapiens Potency 4466.8 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 2818.4 nM PubChem BioAssay data set

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC45256 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC285480
1.0 High Similarity NPC30443
1.0 High Similarity NPC260977
0.9351 High Similarity NPC60568
0.8765 High Similarity NPC30102
0.8765 High Similarity NPC128816
0.8765 High Similarity NPC67158
0.8427 Intermediate Similarity NPC148872
0.8421 Intermediate Similarity NPC29005
0.8421 Intermediate Similarity NPC51956
0.8421 Intermediate Similarity NPC5209
0.8101 Intermediate Similarity NPC200167
0.8101 Intermediate Similarity NPC31046
0.8101 Intermediate Similarity NPC209666
0.8101 Intermediate Similarity NPC53868
0.764 Intermediate Similarity NPC221993
0.7553 Intermediate Similarity NPC266417
0.7529 Intermediate Similarity NPC125366
0.7442 Intermediate Similarity NPC329490
0.7442 Intermediate Similarity NPC328639
0.7317 Intermediate Similarity NPC123122
0.7273 Intermediate Similarity NPC476721
0.7263 Intermediate Similarity NPC475785
0.7263 Intermediate Similarity NPC475765
0.7229 Intermediate Similarity NPC55508
0.7222 Intermediate Similarity NPC476717
0.7204 Intermediate Similarity NPC475878
0.7191 Intermediate Similarity NPC51135
0.7191 Intermediate Similarity NPC82492
0.7191 Intermediate Similarity NPC25802
0.7191 Intermediate Similarity NPC101138
0.7191 Intermediate Similarity NPC79308
0.7188 Intermediate Similarity NPC472273
0.7129 Intermediate Similarity NPC203974
0.7126 Intermediate Similarity NPC471216
0.7126 Intermediate Similarity NPC471217
0.7126 Intermediate Similarity NPC134227
0.7111 Intermediate Similarity NPC476715
0.7045 Intermediate Similarity NPC71541
0.7033 Intermediate Similarity NPC471410
0.7033 Intermediate Similarity NPC471411
0.7033 Intermediate Similarity NPC474008
0.7033 Intermediate Similarity NPC470657
0.7024 Intermediate Similarity NPC96759
0.7011 Intermediate Similarity NPC474754
0.7 Intermediate Similarity NPC65133
0.699 Remote Similarity NPC228190
0.699 Remote Similarity NPC236753
0.6979 Remote Similarity NPC215570
0.6977 Remote Similarity NPC143250
0.6977 Remote Similarity NPC70996
0.6961 Remote Similarity NPC126753
0.6957 Remote Similarity NPC31349
0.6923 Remote Similarity NPC470622
0.6923 Remote Similarity NPC477205
0.6907 Remote Similarity NPC193785
0.6905 Remote Similarity NPC109510
0.6905 Remote Similarity NPC476718
0.69 Remote Similarity NPC471254
0.69 Remote Similarity NPC80640
0.6897 Remote Similarity NPC177343
0.6893 Remote Similarity NPC469826
0.6893 Remote Similarity NPC207693
0.6857 Remote Similarity NPC469824
0.6854 Remote Similarity NPC476494
0.6848 Remote Similarity NPC244174
0.6842 Remote Similarity NPC474631
0.6837 Remote Similarity NPC74466
0.6837 Remote Similarity NPC471241
0.6832 Remote Similarity NPC34562
0.6832 Remote Similarity NPC107385
0.6832 Remote Similarity NPC471253
0.6827 Remote Similarity NPC22709
0.6792 Remote Similarity NPC157571
0.6792 Remote Similarity NPC477489
0.6786 Remote Similarity NPC478227
0.6782 Remote Similarity NPC474003
0.6778 Remote Similarity NPC248415
0.6774 Remote Similarity NPC470920
0.6774 Remote Similarity NPC239938
0.6771 Remote Similarity NPC474379
0.6765 Remote Similarity NPC470167
0.6765 Remote Similarity NPC267637
0.6765 Remote Similarity NPC469827
0.6762 Remote Similarity NPC471431
0.6762 Remote Similarity NPC475501
0.6742 Remote Similarity NPC475456
0.6742 Remote Similarity NPC1882
0.6739 Remote Similarity NPC478111
0.6737 Remote Similarity NPC18536
0.6737 Remote Similarity NPC50443
0.6733 Remote Similarity NPC213528
0.6733 Remote Similarity NPC244969
0.6733 Remote Similarity NPC470172
0.6706 Remote Similarity NPC474755
0.6703 Remote Similarity NPC15091
0.6702 Remote Similarity NPC471221
0.6702 Remote Similarity NPC236459
0.6702 Remote Similarity NPC476379
0.6701 Remote Similarity NPC476722
0.6701 Remote Similarity NPC477495
0.67 Remote Similarity NPC80417
0.67 Remote Similarity NPC20028
0.6699 Remote Similarity NPC158051
0.6699 Remote Similarity NPC158367
0.6699 Remote Similarity NPC119628
0.6699 Remote Similarity NPC184805
0.6699 Remote Similarity NPC273189
0.6699 Remote Similarity NPC41681
0.6667 Remote Similarity NPC475743
0.6667 Remote Similarity NPC216137
0.6667 Remote Similarity NPC473406
0.6667 Remote Similarity NPC474020
0.6667 Remote Similarity NPC470632
0.6667 Remote Similarity NPC471046
0.6667 Remote Similarity NPC79193
0.6667 Remote Similarity NPC248216
0.6667 Remote Similarity NPC87393
0.6667 Remote Similarity NPC469825
0.6636 Remote Similarity NPC470543
0.6635 Remote Similarity NPC40716
0.6635 Remote Similarity NPC475234
0.6635 Remote Similarity NPC475630
0.6635 Remote Similarity NPC138219
0.6635 Remote Similarity NPC293512
0.6635 Remote Similarity NPC471430
0.6634 Remote Similarity NPC478181
0.6634 Remote Similarity NPC477172
0.6633 Remote Similarity NPC57964
0.6633 Remote Similarity NPC94582
0.6632 Remote Similarity NPC200580
0.663 Remote Similarity NPC9060
0.663 Remote Similarity NPC181871
0.663 Remote Similarity NPC473299
0.663 Remote Similarity NPC18953
0.6628 Remote Similarity NPC166250
0.6604 Remote Similarity NPC66513
0.6602 Remote Similarity NPC100078
0.6602 Remote Similarity NPC88469
0.66 Remote Similarity NPC472144
0.6598 Remote Similarity NPC475307
0.6593 Remote Similarity NPC148740
0.6593 Remote Similarity NPC102156
0.6591 Remote Similarity NPC476719
0.6591 Remote Similarity NPC307865
0.6588 Remote Similarity NPC96322
0.6585 Remote Similarity NPC84562
0.6582 Remote Similarity NPC478126
0.6574 Remote Similarity NPC189884
0.6574 Remote Similarity NPC47063
0.6574 Remote Similarity NPC204458
0.6574 Remote Similarity NPC138334
0.6571 Remote Similarity NPC473688
0.6571 Remote Similarity NPC472079
0.6571 Remote Similarity NPC471626
0.6571 Remote Similarity NPC231566
0.6571 Remote Similarity NPC94942
0.6571 Remote Similarity NPC262567
0.6569 Remote Similarity NPC310031
0.6569 Remote Similarity NPC80191
0.6566 Remote Similarity NPC238796
0.6566 Remote Similarity NPC237071
0.6566 Remote Similarity NPC476728
0.6566 Remote Similarity NPC203434
0.6566 Remote Similarity NPC235109
0.6562 Remote Similarity NPC472146
0.6562 Remote Similarity NPC470114
0.6562 Remote Similarity NPC327183
0.6562 Remote Similarity NPC328935
0.6562 Remote Similarity NPC185529
0.6559 Remote Similarity NPC474572
0.6548 Remote Similarity NPC178541
0.6545 Remote Similarity NPC179429
0.6542 Remote Similarity NPC477073
0.6538 Remote Similarity NPC103172
0.6538 Remote Similarity NPC166079
0.6538 Remote Similarity NPC215408
0.6538 Remote Similarity NPC56656
0.6538 Remote Similarity NPC306776
0.6538 Remote Similarity NPC164600
0.6535 Remote Similarity NPC41843
0.6531 Remote Similarity NPC476716
0.6531 Remote Similarity NPC41649
0.6531 Remote Similarity NPC96736
0.6531 Remote Similarity NPC178949
0.6531 Remote Similarity NPC151214
0.6531 Remote Similarity NPC191915
0.6531 Remote Similarity NPC470424
0.6526 Remote Similarity NPC191221
0.6526 Remote Similarity NPC476435
0.6526 Remote Similarity NPC33398
0.6526 Remote Similarity NPC470872
0.6526 Remote Similarity NPC470009
0.6522 Remote Similarity NPC241959
0.6522 Remote Similarity NPC474346
0.6522 Remote Similarity NPC474253
0.6522 Remote Similarity NPC474284
0.6522 Remote Similarity NPC475820
0.6522 Remote Similarity NPC213737
0.6522 Remote Similarity NPC269684

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC45256 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
1.0 High Similarity NPD1780 Approved
1.0 High Similarity NPD1779 Approved
0.8765 High Similarity NPD3669 Approved
0.8765 High Similarity NPD3670 Clinical (unspecified phase)
0.8421 Intermediate Similarity NPD2687 Approved
0.8421 Intermediate Similarity NPD2686 Approved
0.8421 Intermediate Similarity NPD2254 Approved
0.8101 Intermediate Similarity NPD1810 Approved
0.8101 Intermediate Similarity NPD1811 Approved
0.6509 Remote Similarity NPD8132 Clinical (unspecified phase)
0.6442 Remote Similarity NPD8170 Clinical (unspecified phase)
0.6396 Remote Similarity NPD8295 Clinical (unspecified phase)
0.6364 Remote Similarity NPD3702 Approved
0.6273 Remote Similarity NPD8133 Approved
0.6154 Remote Similarity NPD6115 Approved
0.6154 Remote Similarity NPD6697 Approved
0.6154 Remote Similarity NPD6114 Approved
0.6154 Remote Similarity NPD6118 Approved
0.6111 Remote Similarity NPD5345 Clinical (unspecified phase)
0.6095 Remote Similarity NPD8085 Approved
0.6095 Remote Similarity NPD8086 Approved
0.6095 Remote Similarity NPD8138 Approved
0.6095 Remote Similarity NPD8139 Approved
0.6095 Remote Similarity NPD8083 Approved
0.6095 Remote Similarity NPD8084 Approved
0.6095 Remote Similarity NPD8082 Approved
0.6068 Remote Similarity NPD8328 Phase 3
0.6044 Remote Similarity NPD6116 Phase 1
0.6038 Remote Similarity NPD8276 Approved
0.6038 Remote Similarity NPD8275 Approved
0.6023 Remote Similarity NPD5777 Approved
0.6 Remote Similarity NPD1700 Approved
0.5981 Remote Similarity NPD8081 Approved
0.5981 Remote Similarity NPD3710 Phase 2
0.5963 Remote Similarity NPD6686 Approved
0.5943 Remote Similarity NPD8300 Approved
0.5943 Remote Similarity NPD8301 Approved
0.5934 Remote Similarity NPD6117 Approved
0.5926 Remote Similarity NPD8393 Approved
0.5877 Remote Similarity NPD6940 Discontinued
0.5872 Remote Similarity NPD6412 Phase 2
0.5872 Remote Similarity NPD5954 Clinical (unspecified phase)
0.5833 Remote Similarity NPD7507 Approved
0.5824 Remote Similarity NPD3703 Phase 2
0.5806 Remote Similarity NPD4802 Phase 2
0.5806 Remote Similarity NPD4238 Approved
0.5784 Remote Similarity NPD8171 Discontinued
0.578 Remote Similarity NPD6008 Approved
0.5765 Remote Similarity NPD371 Approved
0.5763 Remote Similarity NPD8517 Approved
0.5763 Remote Similarity NPD8515 Approved
0.5763 Remote Similarity NPD8516 Approved
0.5763 Remote Similarity NPD8513 Phase 3
0.573 Remote Similarity NPD7532 Clinical (unspecified phase)
0.5727 Remote Similarity NPD8140 Approved
0.5727 Remote Similarity NPD8307 Discontinued
0.5714 Remote Similarity NPD5955 Clinical (unspecified phase)
0.5714 Remote Similarity NPD6113 Clinical (unspecified phase)
0.5698 Remote Similarity NPD9496 Clinical (unspecified phase)
0.5691 Remote Similarity NPD7319 Approved
0.569 Remote Similarity NPD6009 Approved
0.5686 Remote Similarity NPD8035 Phase 2
0.5686 Remote Similarity NPD8034 Phase 2
0.5682 Remote Similarity NPD229 Approved
0.5656 Remote Similarity NPD8293 Discontinued
0.5632 Remote Similarity NPD4224 Phase 2
0.5625 Remote Similarity NPD615 Clinical (unspecified phase)
0.5625 Remote Similarity NPD8305 Approved
0.5625 Remote Similarity NPD4061 Clinical (unspecified phase)
0.5625 Remote Similarity NPD8306 Approved
0.561 Remote Similarity NPD7736 Approved
0.56 Remote Similarity NPD3573 Approved

Structure

External Identifiers

PubChem CID   2240
ChEMBL   CHEMBL345083
ZINC  

Physicochemical Properties

Molecular Weight:  282.15
ALogP:  0.8012
MLogP:  2.56
XLogP:  3.039
# Rotatable Bonds:  3
Polar Surface Area:  53.99
# H-Bond Aceptor:  5
# H-Bond Donor:  0
# Rings:  3
# Heavy Atoms:  20

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs