Natural Product: NPC28280

Natural Product ID:  NPC28280
Common Name:   Cyclopamine
IUPAC Name:   (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
Synonyms:   Cyclopamine; [3H]-Cyclopamine
Molecular Formula:   C27H41NO2
Standard InCHIKey:  QASFUMOKHFSJGL-LAFRSMQTSA-N
Standard InCHI:  InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
Canonical SMILES:  O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC2=C(C)[C@]4(CC[C@@H]32)O[C@H]2[C@H]([C@H]4C)NC[C@H](C2)C)C1)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO4250 Gloriosa superba Species Colchicaceae Eukaryota UNPD*
NPO1073 Phlomis samia Species Lamiaceae Eukaryota UNPD*
NPO9596 Baeria coronaria NA NA NA UNPD*
NPO12742 Botryotrichum peruvianum Species Chaetomiaceae Eukaryota UNPD*
NPO14649 Thais orbita Species Muricidae Eukaryota UNPD*
NPO29691 Fritillariae pallidiflorae bulbus NA NA NA TCMSP*
NPO17922 Fritiliariae irrhosae bulbus NA NA NA TCMSP*
NPO29635 Eucommiae cortex NA NA NA TCMSP*
NPO12144 Fontanesia phillyreoides Species Oleaceae Eukaryota UNPD*
NPO5237 Stevia isomeca Species Asteraceae Eukaryota UNPD*
NPO12181 Albizia julibrissin Species Fabaceae Eukaryota UNPD*
NPO2906 Leptactina senegambica Species Rubiaceae Eukaryota UNPD*
NPO4897 Veratrum grandiflorum Species Melanthiaceae Eukaryota UNPD*
NPO9996 Garcinia quaesita Species Clusiaceae Eukaryota UNPD*
NPO11380 Neurolaena macrocephala Species Asteraceae Eukaryota UNPD*
NPO13582 Leucopaxillus giganteus Species Tricholomataceae Eukaryota UNPD*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT81 Cell Line A549 Homo sapiens IC50 = 49000 nM 18221872
NPT1892 Cell Line H4 Rattus norvegicus Activity = 108.75 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 75.21 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 96.38 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 511.72 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 110.76 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 313.88 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 1564.12 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 91.74 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 111.02 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 109.69 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 103.97 % 18024584
NPT2 Others Unspecified Activity = 40 % 17494766
NPT2 Others Unspecified EC50 = 170 nM 18842035
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus EC50 = 500 nM 19309080
NPT2 Others Unspecified IC50 = 46 nM 19091559
NPT1895 Individual Protein Smoothened homolog Mus musculus IC50 = 1200 nM 19091559
NPT1099 Individual Protein Smoothened homolog Homo sapiens IC50 = 280 nM 19091559
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus Ratio IC50 = 11 19541490
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus IC50 = 1312 nM 19541490
NPT2 Others Unspecified IC50 = 15500 nM 20116904
NPT2 Others Unspecified EC50 = 300 nM 20708941
NPT2 Others Unspecified EC50 = 13440 nM 17417631
NPT2 Others Unspecified EC50 = 1000 nM 17417631
NPT533 Protein-Protein Interaction Runt-related transcription factor 1/Core-binding factor subunit beta Homo sapiens Potency 6309.6 nM PubChem BioAssay data set
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus IC50 = 300 nM 21592788
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus IC50 = 600 nM 21592788
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus Inhibition = 71 % 21592788
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus Inhibition = 105 % 21592788
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus Inhibition = 58 % 21592788
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus Inhibition = 96 % 21592788
NPT1894 Individual Protein Sonic hedgehog protein Mus musculus Inhibition = 98 % 21592788
NPT2 Others Unspecified Inhibition = 6.93 % 22226657
NPT2 Others Unspecified IC50 = 22500 nM 22226657
NPT198 Individual Protein Vitamin D receptor Homo sapiens FC = 1.6 22226657
NPT198 Individual Protein Vitamin D receptor Homo sapiens FC = 0.9 22226657
NPT1875 Individual Protein Vitamin D receptor Mus musculus FC = 0.99 22226657
NPT1099 Individual Protein Smoothened homolog Homo sapiens IC50 = 300 nM 22268551
NPT1099 Individual Protein Smoothened homolog Homo sapiens Inhibition = 92 % 22268551
NPT2 Others Unspecified IC50 = 620 nM 22268551
NPT2 Others Unspecified Inhibition = 98 % 22268551
NPT1099 Individual Protein Smoothened homolog Homo sapiens Inhibition = 57 % 22268551
NPT2 Others Unspecified IC50 = 100 nM 22268551
NPT1099 Individual Protein Smoothened homolog Homo sapiens IC50 = 64 nM 22268551
NPT1895 Individual Protein Smoothened homolog Mus musculus IC50 = 1500 nM 23074541
NPT1895 Individual Protein Smoothened homolog Mus musculus IC50 = 1900 nM 23074541
NPT1898 Individual Protein Sonic hedgehog protein Homo sapiens IC50 = 600 nM 23074541
NPT2 Others Unspecified Kd = 116 nM 23063522
NPT1099 Individual Protein Smoothened homolog Homo sapiens Kd = 12.4 nM 23063522
NPT2 Others Unspecified FC = 19 23063522
NPT2 Others Unspecified IC50 = 414 nM 23063522
NPT1895 Individual Protein Smoothened homolog Mus musculus IC50 = 484 nM 23063522
NPT2 Others Unspecified Ki = 232 nM 23063522
NPT1099 Individual Protein Smoothened homolog Homo sapiens Ki = 12.7 nM 23063522
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus Inhibition = -3.81 % 23062825
NPT67 Individual Protein Cholinesterase Equus caballus Inhibition = 5.84 % 23062825
NPT1899 Cell Line DSH1 Homo sapiens IC50 = 1625661.36 nM 10.6019/CHEMBL1201861
NPT464 Cell Line Daudi Homo sapiens IC50 = 191128.31 nM 10.6019/CHEMBL1201861
NPT1900 Cell Line DU-4475 Homo sapiens IC50 = 3403453.74 nM 10.6019/CHEMBL1201861
NPT394 Cell Line EKVX Homo sapiens IC50 = 814978.72 nM 10.6019/CHEMBL1201861
NPT1901 Cell Line EM-2 Homo sapiens IC50 = 1644975.88 nM 10.6019/CHEMBL1201861
NPT1902 Cell Line ES1 Homo sapiens IC50 = 452753.13 nM 10.6019/CHEMBL1201861
NPT1903 Cell Line ES5 Homo sapiens IC50 = 2701706.8 nM 10.6019/CHEMBL1201861
NPT1904 Cell Line ES3 Homo sapiens IC50 = 524727.98 nM 10.6019/CHEMBL1201861
NPT1905 Cell Line ES4 Homo sapiens IC50 = 223783.49 nM 10.6019/CHEMBL1201861
NPT1906 Cell Line EB-3 Homo sapiens IC50 = 123093.72 nM 10.6019/CHEMBL1201861
NPT1907 Cell Line EB2 Homo sapiens IC50 = 1570741.37 nM 10.6019/CHEMBL1201861
NPT1908 Cell Line EC-GI-10 Homo sapiens IC50 = 3213355.51 nM 10.6019/CHEMBL1201861
NPT1909 Cell Line ECC12 Homo sapiens IC50 = 753333.48 nM 10.6019/CHEMBL1201861
NPT1910 Cell Line ECC4 Homo sapiens IC50 = 1145895.84 nM 10.6019/CHEMBL1201861
NPT1911 Cell Line C2BBe1 Homo sapiens IC50 = 791158.24 nM 10.6019/CHEMBL1201861
NPT1912 Cell Line COLO-800 Homo sapiens IC50 = 1824512.3 nM 10.6019/CHEMBL1201861
NPT1189 Cell Line DG-75 Homo sapiens IC50 = 415697.99 nM 10.6019/CHEMBL1201861
NPT1913 Cell Line DJM-1 Homo sapiens IC50 = 56339.11 nM 10.6019/CHEMBL1201861
NPT1914 Cell Line COLO-824 Homo sapiens IC50 = 1750486.45 nM 10.6019/CHEMBL1201861
NPT1915 Cell Line COLO-829 Homo sapiens IC50 = 26848.31 nM 10.6019/CHEMBL1201861
NPT576 Cell Line DMS-114 Homo sapiens IC50 = 1056144.19 nM 10.6019/CHEMBL1201861
NPT1916 Cell Line ACN Homo sapiens IC50 = 493598.78 nM 10.6019/CHEMBL1201861
NPT1452 Cell Line C8166 Homo sapiens IC50 = 1801837.04 nM 10.6019/CHEMBL1201861
NPT1917 Cell Line CA46 Homo sapiens IC50 = 899709.56 nM 10.6019/CHEMBL1201861
NPT1918 Cell Line DMS-79 Homo sapiens IC50 = 666993.3 nM 10.6019/CHEMBL1201861
NPT1919 Cell Line DOHH-2 Homo sapiens IC50 = 9356.89 nM 10.6019/CHEMBL1201861
NPT1920 Cell Line ALL-PO Homo sapiens IC50 = 11773.43 nM 10.6019/CHEMBL1201861
NPT1921 Cell Line COR-L279 Homo sapiens IC50 = 291584.25 nM 10.6019/CHEMBL1201861
NPT1922 Cell Line COR-L88 Homo sapiens IC50 = 564885.47 nM 10.6019/CHEMBL1201861
NPT1923 Cell Line DMS-153 Homo sapiens IC50 = 2225760.65 nM 10.6019/CHEMBL1201861
NPT1924 Cell Line AM-38 Homo sapiens IC50 = 2452276.36 nM 10.6019/CHEMBL1201861
NPT1925 Cell Line CAL-148 Homo sapiens IC50 = 1121755.33 nM 10.6019/CHEMBL1201861
NPT1926 Cell Line CP66-MEL Homo sapiens IC50 = 1098903.34 nM 10.6019/CHEMBL1201861
NPT1927 Cell Line ARH-77 Homo sapiens IC50 = 394007.52 nM 10.6019/CHEMBL1201861
NPT1928 Cell Line ATN-1 Homo sapiens IC50 = 31232.87 nM 10.6019/CHEMBL1201861
NPT1929 Cell Line CPC-N Homo sapiens IC50 = 788319.92 nM 10.6019/CHEMBL1201861
NPT1930 Cell Line CTB-1 Homo sapiens IC50 = 269972.74 nM 10.6019/CHEMBL1201861
NPT1931 Cell Line BB30-HNC Homo sapiens IC50 = 34330.56 nM 10.6019/CHEMBL1201861
NPT1932 Cell Line CTV-1 Homo sapiens IC50 = 51074.02 nM 10.6019/CHEMBL1201861
NPT1933 Cell Line CW-2 Homo sapiens IC50 = 1089655.64 nM 10.6019/CHEMBL1201861
NPT1094 Cell Line 697 Homo sapiens IC50 = 26615.51 nM 10.6019/CHEMBL1201861
NPT1934 Cell Line BB49-HNC Homo sapiens IC50 = 1119486.08 nM 10.6019/CHEMBL1201861
NPT1935 Cell Line BB65-RCC Homo sapiens IC50 = 376245.18 nM 10.6019/CHEMBL1201861
NPT929 Cell Line BC1 cell line IC50 = 37974.62 nM 10.6019/CHEMBL1201861
NPT1936 Cell Line BC-3 Homo sapiens IC50 = 265177.92 nM 10.6019/CHEMBL1201861
NPT1937 Cell Line CAS-1 Homo sapiens IC50 = 472072.7 nM 10.6019/CHEMBL1201861
NPT1938 Cell Line Calu-6 Homo sapiens IC50 = 475265.22 nM 10.6019/CHEMBL1201861
NPT1939 Cell Line 8-MG-BA Homo sapiens IC50 = 13112.29 nM 10.6019/CHEMBL1201861
NPT1940 Cell Line BE-13 Homo sapiens IC50 = 99047.74 nM 10.6019/CHEMBL1201861
NPT404 Cell Line CCRF-CEM Homo sapiens IC50 = 1187628.81 nM 10.6019/CHEMBL1201861
NPT1941 Cell Line A101D Homo sapiens IC50 = 1991676.45 nM 10.6019/CHEMBL1201861
NPT1942 Cell Line CESS Homo sapiens IC50 = 44223.22 nM 10.6019/CHEMBL1201861
NPT1943 Cell Line CGTH-W-1 Homo sapiens IC50 = 1290703.89 nM 10.6019/CHEMBL1201861
NPT1944 Cell Line D-247MG Homo sapiens IC50 = 73544.16 nM 10.6019/CHEMBL1201861
NPT1945 Cell Line CHP-126 Homo sapiens IC50 = 1590964.95 nM 10.6019/CHEMBL1201861
NPT1946 Cell Line D-263MG Homo sapiens IC50 = 1301475.63 nM 10.6019/CHEMBL1201861
NPT1947 Cell Line D283 Med IC50 = 3457537.81 nM 10.6019/CHEMBL1201861
NPT1948 Cell Line A253 cell line IC50 = 1222835.96 nM 10.6019/CHEMBL1201861
NPT1949 Cell Line BL-41 Homo sapiens IC50 = 637392.1 nM 10.6019/CHEMBL1201861
NPT1950 Cell Line BL-70 Homo sapiens IC50 = 123126.96 nM 10.6019/CHEMBL1201861
NPT1951 Cell Line CMK Homo sapiens IC50 = 149515.04 nM 10.6019/CHEMBL1201861
NPT1952 Cell Line COLO-320-HSR Homo sapiens IC50 = 522594.07 nM 10.6019/CHEMBL1201861
NPT1953 Cell Line D-336MG Homo sapiens IC50 = 260697.83 nM 10.6019/CHEMBL1201861
NPT1954 Cell Line D-392MG Homo sapiens IC50 = 40221.47 nM 10.6019/CHEMBL1201861
NPT1955 Cell Line A3-KAW Homo sapiens IC50 = 947757.81 nM 10.6019/CHEMBL1201861
NPT1956 Cell Line COLO-668 Homo sapiens IC50 = 1139590.2 nM 10.6019/CHEMBL1201861
NPT1957 Cell Line D-502MG Homo sapiens IC50 = 51627.11 nM 10.6019/CHEMBL1201861
NPT1958 Cell Line A388 Homo sapiens IC50 = 42584.83 nM 10.6019/CHEMBL1201861
NPT1959 Cell Line A4-Fuk Homo sapiens IC50 = 3130321.52 nM 10.6019/CHEMBL1201861
NPT845 Cell Line BT-474 Homo sapiens IC50 = 1491197.85 nM 10.6019/CHEMBL1201861
NPT1960 Cell Line BV-173 Homo sapiens IC50 = 100324.91 nM 10.6019/CHEMBL1201861
NPT1961 Cell Line D-542MG Homo sapiens IC50 = 68413.49 nM 10.6019/CHEMBL1201861
NPT1962 Cell Line DB Homo sapiens IC50 = 1402980.25 nM 10.6019/CHEMBL1201861
NPT376 Cell Line A498 Homo sapiens IC50 = 1359063.31 nM 10.6019/CHEMBL1201861
NPT1963 Cell Line Becker Homo sapiens IC50 = 174180.13 nM 10.6019/CHEMBL1201861
NPT1964 Cell Line COLO-684 Homo sapiens IC50 = 575658.15 nM 10.6019/CHEMBL1201861
NPT1965 Cell Line DEL Homo sapiens IC50 = 20147.13 nM 10.6019/CHEMBL1201861
NPT1966 Cell Line NCI-H1838 Homo sapiens IC50 = 1289397.07 nM 10.6019/CHEMBL1201861
NPT639 Cell Line NCI-H187 Homo sapiens IC50 = 2541132.18 nM 10.6019/CHEMBL1201861
NPT1967 Cell Line NCI-H526 Homo sapiens IC50 = 2690278.5 nM 10.6019/CHEMBL1201861
NPT1968 Cell Line OMC-1 Homo sapiens IC50 = 2011662.96 nM 10.6019/CHEMBL1201861
NPT389 Cell Line RPMI-8226 Homo sapiens IC50 = 135045.13 nM 10.6019/CHEMBL1201861
NPT926 Cell Line SK-MEL-1 Homo sapiens IC50 = 147130.36 nM 10.6019/CHEMBL1201861
NPT147 Cell Line SK-MEL-2 Homo sapiens IC50 = 2454238.97 nM 10.6019/CHEMBL1201861
NPT1969 Cell Line TGW Homo sapiens IC50 = 679378.9 nM 10.6019/CHEMBL1201861
NPT1970 Cell Line THP-1 Homo sapiens IC50 = 1471830.29 nM 10.6019/CHEMBL1201861
NPT1971 Cell Line GI-1 Homo sapiens IC50 = 56614.95 nM 10.6019/CHEMBL1201861
NPT1972 Cell Line GI-ME-N Homo sapiens IC50 = 187968.8 nM 10.6019/CHEMBL1201861
NPT116 Cell Line HL-60 Homo sapiens IC50 = 4041681.11 nM 10.6019/CHEMBL1201861
NPT1973 Cell Line IST-SL1 Homo sapiens IC50 = 690277.02 nM 10.6019/CHEMBL1201861
NPT1974 Cell Line IST-SL2 Homo sapiens IC50 = 38223.98 nM 10.6019/CHEMBL1201861
NPT1975 Cell Line KS-1 Homo sapiens IC50 = 101639.17 nM 10.6019/CHEMBL1201861
NPT1976 Cell Line LNCaP-Clone-FGC Homo sapiens IC50 = 1129081.78 nM 10.6019/CHEMBL1201861
NPT1977 Cell Line LOUCY Homo sapiens IC50 = 1635073.44 nM 10.6019/CHEMBL1201861
NPT1978 Cell Line MFM-223 Homo sapiens IC50 = 3462201.72 nM 10.6019/CHEMBL1201861
NPT1979 Cell Line NB13 Homo sapiens IC50 = 2338310.64 nM 10.6019/CHEMBL1201861
NPT1980 Cell Line NB14 Homo sapiens IC50 = 1464827.84 nM 10.6019/CHEMBL1201861
NPT1981 Cell Line NCI-H1882 Homo sapiens IC50 = 2637999.12 nM 10.6019/CHEMBL1201861
NPT1982 Cell Line NCI-H1963 Homo sapiens IC50 = 1958372.4 nM 10.6019/CHEMBL1201861
NPT1983 Cell Line NCI-H64 Homo sapiens IC50 = 653545.4 nM 10.6019/CHEMBL1201861
NPT1984 Cell Line ONS-76 Homo sapiens IC50 = 1336302.83 nM 10.6019/CHEMBL1201861
NPT1985 Cell Line OPM-2 Homo sapiens IC50 = 1062631.86 nM 10.6019/CHEMBL1201861
NPT1986 Cell Line RPMI 8402 Homo sapiens IC50 = 15853.7 nM 10.6019/CHEMBL1201861
NPT1987 Cell Line RPMI-8866 Homo sapiens IC50 = 3101614.31 nM 10.6019/CHEMBL1201861
NPT1988 Cell Line SW684 Homo sapiens IC50 = 2434225.71 nM 10.6019/CHEMBL1201861
NPT384 Cell Line TK-10 Homo sapiens IC50 = 1253277 nM 10.6019/CHEMBL1201861
NPT1989 Cell Line GOTO Homo sapiens IC50 = 1314889.62 nM 10.6019/CHEMBL1201861
NPT1990 Cell Line J-RT3-T3-5 Homo sapiens IC50 = 1595065.37 nM 10.6019/CHEMBL1201861
NPT1991 Cell Line KU812 cell line IC50 = 161901.64 nM 10.6019/CHEMBL1201861
NPT1992 Cell Line KURAMOCHI Homo sapiens IC50 = 2620574.9 nM 10.6019/CHEMBL1201861
NPT390 Cell Line LOX IMVI Homo sapiens IC50 = 53588.37 nM 10.6019/CHEMBL1201861
NPT1993 Cell Line LP-1 Homo sapiens IC50 = 82873.14 nM 10.6019/CHEMBL1201861
NPT1994 Cell Line MHH-CALL-2 Homo sapiens IC50 = 1133572.01 nM 10.6019/CHEMBL1201861
NPT1995 Cell Line NB17 Homo sapiens IC50 = 851976.55 nM 10.6019/CHEMBL1201861
NPT1996 Cell Line NB5 Homo sapiens IC50 = 3832060.78 nM 10.6019/CHEMBL1201861
NPT1396 Cell Line NCI-H69 Homo sapiens IC50 = 142932.43 nM 10.6019/CHEMBL1201861
NPT1997 Cell Line OS-RC-2 Homo sapiens IC50 = 5866.6 nM 10.6019/CHEMBL1201861
NPT1998 Cell Line RS4-11 Homo sapiens IC50 = 49093.81 nM 10.6019/CHEMBL1201861
NPT1999 Cell Line TUR Homo sapiens IC50 = 1966024.97 nM 10.6019/CHEMBL1201861
NPT2000 Cell Line GR-ST Homo sapiens IC50 = 527231.64 nM 10.6019/CHEMBL1201861
NPT379 Cell Line HOP-62 Homo sapiens IC50 = 1603509.59 nM 10.6019/CHEMBL1201861
NPT2001 Cell Line JAR Homo sapiens IC50 = 256225.27 nM 10.6019/CHEMBL1201861
NPT2002 Cell Line KY821 Homo sapiens IC50 = 336594.52 nM 10.6019/CHEMBL1201861
NPT2003 Cell Line LS-1034 Homo sapiens IC50 = 501429.99 nM 10.6019/CHEMBL1201861
NPT2004 Cell Line LS-123 Homo sapiens IC50 = 1129321.17 nM 10.6019/CHEMBL1201861
NPT2005 Cell Line MHH-NB-11 Homo sapiens IC50 = 1194716.26 nM 10.6019/CHEMBL1201861
NPT2006 Cell Line MHH-PREB-1 Homo sapiens IC50 = 72844.13 nM 10.6019/CHEMBL1201861
NPT2007 Cell Line NB6 Homo sapiens IC50 = 1484604.97 nM 10.6019/CHEMBL1201861
NPT2008 Cell Line NB69 Homo sapiens IC50 = 2112249.98 nM 10.6019/CHEMBL1201861
NPT2009 Cell Line NCI-H2081 Homo sapiens IC50 = 2009839.2 nM 10.6019/CHEMBL1201861
NPT2010 Cell Line NCI-H716 Homo sapiens IC50 = 3589154.72 nM 10.6019/CHEMBL1201861
NPT2011 Cell Line NCI-H719 Homo sapiens IC50 = 1669636.14 nM 10.6019/CHEMBL1201861
NPT2012 Cell Line NCI-H720 Homo sapiens IC50 = 714877.36 nM 10.6019/CHEMBL1201861
NPT456 Cell Line OVCAR-4 Homo sapiens IC50 = 63565.7 nM 10.6019/CHEMBL1201861
NPT406 Cell Line RXF 393 Homo sapiens IC50 = 1457957.85 nM 10.6019/CHEMBL1201861
NPT2013 Cell Line SK-MM-2 Homo sapiens IC50 = 1207534.55 nM 10.6019/CHEMBL1201861
NPT2014 Cell Line SW872 Homo sapiens IC50 = 863124.55 nM 10.6019/CHEMBL1201861
NPT2015 Cell Line U-266 Homo sapiens IC50 = 3129204.19 nM 10.6019/CHEMBL1201861
NPT2016 Cell Line ES6 Homo sapiens IC50 = 239429.5 nM 10.6019/CHEMBL1201861
NPT2017 Cell Line ES7 Homo sapiens IC50 = 1634159.69 nM 10.6019/CHEMBL1201861
NPT2018 Cell Line GT3TKB Homo sapiens IC50 = 1972261.24 nM 10.6019/CHEMBL1201861
NPT2019 Cell Line JVM-2 Homo sapiens IC50 = 1024344.32 nM 10.6019/CHEMBL1201861
NPT2020 Cell Line JVM-3 Homo sapiens IC50 = 2790095.21 nM 10.6019/CHEMBL1201861
NPT2021 Cell Line LS-411N Homo sapiens IC50 = 354660.5 nM 10.6019/CHEMBL1201861
NPT2022 Cell Line LS-513 Homo sapiens IC50 = 11354.73 nM 10.6019/CHEMBL1201861
NPT2023 Cell Line NB7 Homo sapiens IC50 = 270999.51 nM 10.6019/CHEMBL1201861
NPT2024 Cell Line NCI-H209 Homo sapiens IC50 = 1285035.98 nM 10.6019/CHEMBL1201861
NPT2025 Cell Line NCI-H747 Homo sapiens IC50 = 1047988.61 nM 10.6019/CHEMBL1201861
NPT80 Cell Line Raji Homo sapiens IC50 = 468143.09 nM 10.6019/CHEMBL1201861
NPT2026 Cell Line Ramos-2G6-4C10 Homo sapiens IC50 = 169914.78 nM 10.6019/CHEMBL1201861
NPT2027 Cell Line SK-N-DZ Homo sapiens IC50 = 1902840.41 nM 10.6019/CHEMBL1201861
NPT2028 Cell Line SK-N-FI Homo sapiens IC50 = 3394385.42 nM 10.6019/CHEMBL1201861
NPT2029 Cell Line SW 954 Homo sapiens IC50 = 1578157.02 nM 10.6019/CHEMBL1201861
NPT2030 Cell Line U-698-M Homo sapiens IC50 = 298243.42 nM 10.6019/CHEMBL1201861
NPT1535 Cell Line U-87 MG Homo sapiens IC50 = 2582078.57 nM 10.6019/CHEMBL1201861
NPT2031 Cell Line ES8 Homo sapiens IC50 = 294181.52 nM 10.6019/CHEMBL1201861
NPT2032 Cell Line HAL-01 Homo sapiens IC50 = 379838.06 nM 10.6019/CHEMBL1201861
NPT2033 Cell Line JIYOYE Homo sapiens IC50 = 828781.04 nM 10.6019/CHEMBL1201861
NPT111 Cell Line K562 Homo sapiens IC50 = 126244.69 nM 10.6019/CHEMBL1201861
NPT2034 Cell Line LU-134-A Homo sapiens IC50 = 3816320.43 nM 10.6019/CHEMBL1201861
NPT2035 Cell Line NCCIT Homo sapiens IC50 = 112529.45 nM 10.6019/CHEMBL1201861
NPT2036 Cell Line NCI-H1092 Homo sapiens IC50 = 3164195.13 nM 10.6019/CHEMBL1201861
NPT2037 Cell Line NCI-H2107 Homo sapiens IC50 = 193739.41 nM 10.6019/CHEMBL1201861
NPT1082 Cell Line NCI-H2126 Homo sapiens IC50 = 2042202.17 nM 10.6019/CHEMBL1201861
NPT2038 Cell Line NCI-H748 Homo sapiens IC50 = 1363911.56 nM 10.6019/CHEMBL1201861
NPT2039 Cell Line NCI-H82 Homo sapiens IC50 = 110975.78 nM 10.6019/CHEMBL1201861
NPT2040 Cell Line P30-OHK Homo sapiens IC50 = 1362549.7 nM 10.6019/CHEMBL1201861
NPT2041 Cell Line P31-FUJ Homo sapiens IC50 = 2376901.43 nM 10.6019/CHEMBL1201861
NPT2042 Cell Line SBC-1 Homo sapiens IC50 = 2656931.06 nM 10.6019/CHEMBL1201861
NPT2043 Cell Line SK-NEP-1 Homo sapiens IC50 = 53392.32 nM 10.6019/CHEMBL1201861
NPT2044 Cell Line SW 962 Homo sapiens IC50 = 917654.54 nM 10.6019/CHEMBL1201861
NPT403 Cell Line UACC-257 Homo sapiens IC50 = 1027137.41 nM 10.6019/CHEMBL1201861
NPT2045 Cell Line ETK-1 Homo sapiens IC50 = 1259839.99 nM 10.6019/CHEMBL1201861
NPT2046 Cell Line EVSA-T Homo sapiens IC50 = 27556.1 nM 10.6019/CHEMBL1201861
NPT2047 Cell Line HC-1 Homo sapiens IC50 = 367787.38 nM 10.6019/CHEMBL1201861
NPT2048 Cell Line HCC1187 Homo sapiens IC50 = 282811.33 nM 10.6019/CHEMBL1201861
NPT2049 Cell Line HT Homo sapiens IC50 = 367711.26 nM 10.6019/CHEMBL1201861
NPT2050 Cell Line K052 Homo sapiens IC50 = 2463077.84 nM 10.6019/CHEMBL1201861
NPT2051 Cell Line K5 Homo sapiens IC50 = 2214847.87 nM 10.6019/CHEMBL1201861
NPT2052 Cell Line KALS-1 Homo sapiens IC50 = 115941.3 nM 10.6019/CHEMBL1201861
NPT2053 Cell Line LU-139 Homo sapiens IC50 = 178019.31 nM 10.6019/CHEMBL1201861
NPT2054 Cell Line LU-165 Homo sapiens IC50 = 1328375.44 nM 10.6019/CHEMBL1201861
NPT2055 Cell Line ML-2 Homo sapiens IC50 = 52919.51 nM 10.6019/CHEMBL1201861
NPT2056 Cell Line MLMA Homo sapiens IC50 = 1822162.02 nM 10.6019/CHEMBL1201861
NPT2057 Cell Line NCI-H1155 Homo sapiens IC50 = 3698050.25 nM 10.6019/CHEMBL1201861
NPT2058 Cell Line NCI-H128 Homo sapiens IC50 = 1418884.1 nM 10.6019/CHEMBL1201861
NPT2059 Cell Line NCI-H2141 Homo sapiens IC50 = 2711133.25 nM 10.6019/CHEMBL1201861
NPT2060 Cell Line NCI-H2171 Homo sapiens IC50 = 2724180.7 nM 10.6019/CHEMBL1201861
NPT2061 Cell Line NCI-H889 Homo sapiens IC50 = 1274583.83 nM 10.6019/CHEMBL1201861
NPT2062 Cell Line SCC-15 Homo sapiens IC50 = 4766687.99 nM 10.6019/CHEMBL1201861
NPT2063 Cell Line SK-PN-DW Homo sapiens IC50 = 194718.9 nM 10.6019/CHEMBL1201861
NPT2064 Cell Line UACC-812 Homo sapiens IC50 = 4012448.77 nM 10.6019/CHEMBL1201861
NPT2065 Cell Line EW-1 Homo sapiens IC50 = 1082140.17 nM 10.6019/CHEMBL1201861
NPT2066 Cell Line EW-11 Homo sapiens IC50 = 936303.8 nM 10.6019/CHEMBL1201861
NPT2067 Cell Line KARPAS-299 Homo sapiens IC50 = 149120.25 nM 10.6019/CHEMBL1201861
NPT2068 Cell Line L-363 Homo sapiens IC50 = 31746.1 nM 10.6019/CHEMBL1201861
NPT2069 Cell Line Lu-65 Homo sapiens IC50 = 1476786.91 nM 10.6019/CHEMBL1201861
NPT2070 Cell Line LXF-289 cell line IC50 = 139781.15 nM 10.6019/CHEMBL1201861
NPT2071 Cell Line MMAC-SF Homo sapiens IC50 = 2050438.6 nM 10.6019/CHEMBL1201861
NPT2072 Cell Line MN-60 Homo sapiens IC50 = 3058007.99 nM 10.6019/CHEMBL1201861
NPT2073 Cell Line NCI-H1304 Homo sapiens IC50 = 2122835.56 nM 10.6019/CHEMBL1201861
NPT2074 Cell Line NCI-H1355 Homo sapiens IC50 = 135587.07 nM 10.6019/CHEMBL1201861
NPT2075 Cell Line NCI-H2196 Homo sapiens IC50 = 973559.56 nM 10.6019/CHEMBL1201861
NPT2076 Cell Line NCI-H2227 Homo sapiens IC50 = 974825.03 nM 10.6019/CHEMBL1201861
NPT788 Cell Line SNU1 Homo sapiens IC50 = 1221073.9 nM 10.6019/CHEMBL1201861
NPT2077 Cell Line SCC-3 Homo sapiens IC50 = 810062.98 nM 10.6019/CHEMBL1201861
NPT2078 Cell Line SK-UT-1 Homo sapiens IC50 = 824491.64 nM 10.6019/CHEMBL1201861
NPT2079 Cell Line EW-12 Homo sapiens IC50 = 2569339.14 nM 10.6019/CHEMBL1201861
NPT2080 Cell Line EW-13 Homo sapiens IC50 = 2053943.74 nM 10.6019/CHEMBL1201861
NPT2081 Cell Line HCC1599 Homo sapiens IC50 = 84283.74 nM 10.6019/CHEMBL1201861
NPT2082 Cell Line HT-144 Homo sapiens IC50 = 133163.54 nM 10.6019/CHEMBL1201861
NPT2083 Cell Line KARPAS-422 Homo sapiens IC50 = 228351.7 nM 10.6019/CHEMBL1201861
NPT2084 Cell Line KARPAS-45 Homo sapiens IC50 = 84699.19 nM 10.6019/CHEMBL1201861
NPT2085 Cell Line Kasumi 1 IC50 = 2280652.81 nM 10.6019/CHEMBL1201861
NPT2086 Cell Line L-428 Homo sapiens IC50 = 842063.14 nM 10.6019/CHEMBL1201861
NPT2087 Cell Line L-540 Homo sapiens IC50 = 431030.99 nM 10.6019/CHEMBL1201861
NPT1358 Cell Line LAMA-84 Homo sapiens IC50 = 32521.1 nM 10.6019/CHEMBL1201861
NPT2088 Cell Line MOLT-16 Homo sapiens IC50 = 104986.1 nM 10.6019/CHEMBL1201861
NPT2089 Cell Line NCI-H1395 Homo sapiens IC50 = 179995.89 nM 10.6019/CHEMBL1201861
NPT405 Cell Line NCI-H226 Homo sapiens IC50 = 1858412.67 nM 10.6019/CHEMBL1201861
NPT2090 Cell Line SNU-16 Homo sapiens IC50 = 284247.69 nM 10.6019/CHEMBL1201861
NPT2091 Cell Line SNU-5 Homo sapiens IC50 = 3015038.87 nM 10.6019/CHEMBL1201861
NPT2092 Cell Line NEC8 Homo sapiens IC50 = 165025.66 nM 10.6019/CHEMBL1201861
NPT2093 Cell Line PF-382 Homo sapiens IC50 = 134361.38 nM 10.6019/CHEMBL1201861
NPT2094 Cell Line SKM-1 Homo sapiens IC50 = 2726821.71 nM 10.6019/CHEMBL1201861
NPT392 Cell Line SNB-75 Homo sapiens IC50 = 221939.98 nM 10.6019/CHEMBL1201861
NPT2095 Cell Line TALL-1 Homo sapiens IC50 = 1625745.89 nM 10.6019/CHEMBL1201861
NPT2096 Cell Line VA-ES-BJ Homo sapiens IC50 = 937165.6 nM 10.6019/CHEMBL1201861
NPT2097 Cell Line EW-16 Homo sapiens IC50 = 1882597.97 nM 10.6019/CHEMBL1201861
NPT2098 Cell Line EW-18 Homo sapiens IC50 = 557314.1 nM 10.6019/CHEMBL1201861
NPT2099 Cell Line KE-37 Homo sapiens IC50 = 66266.8 nM 10.6019/CHEMBL1201861
NPT2100 Cell Line KG-1 IC50 = 478440.09 nM 10.6019/CHEMBL1201861
NPT2101 Cell Line LAN-6 Homo sapiens IC50 = 2771256.21 nM 10.6019/CHEMBL1201861
NPT2102 Cell Line MC-CAR Homo sapiens IC50 = 202252.52 nM 10.6019/CHEMBL1201861
NPT112 Cell Line MOLT-4 Homo sapiens IC50 = 2457316.06 nM 10.6019/CHEMBL1201861
NPT2103 Cell Line MONO-MAC-6 Homo sapiens IC50 = 960154.3 nM 10.6019/CHEMBL1201861
NPT2104 Cell Line NCI-H1417 Homo sapiens IC50 = 3574669.49 nM 10.6019/CHEMBL1201861
NPT2105 Cell Line NCI-H1436 Homo sapiens IC50 = 1150314.89 nM 10.6019/CHEMBL1201861
NPT370 Cell Line NCI-H23 Homo sapiens IC50 = 2816606.3 nM 10.6019/CHEMBL1201861
NPT2106 Cell Line NH-12 Homo sapiens IC50 = 1868148.29 nM 10.6019/CHEMBL1201861
NPT2107 Cell Line PSN1 Homo sapiens IC50 = 1393175.57 nM 10.6019/CHEMBL1201861
NPT2108 Cell Line QIMR-WIL Homo sapiens IC50 = 179646.31 nM 10.6019/CHEMBL1201861
NPT2109 Cell Line SCH Homo sapiens IC50 = 3559651.76 nM 10.6019/CHEMBL1201861
NPT2110 Cell Line SCLC-21H Homo sapiens IC50 = 2851820.95 nM 10.6019/CHEMBL1201861
NPT2111 Cell Line SF-126 Homo sapiens IC50 = 1750551.22 nM 10.6019/CHEMBL1201861
NPT2112 Cell Line TE-1 Homo sapiens IC50 = 595674.28 nM 10.6019/CHEMBL1201861
NPT2113 Cell Line EW-24 Homo sapiens IC50 = 1521331.17 nM 10.6019/CHEMBL1201861
NPT2114 Cell Line EW-3 Homo sapiens IC50 = 507383.94 nM 10.6019/CHEMBL1201861
NPT2115 Cell Line HCC2157 Homo sapiens IC50 = 657652.06 nM 10.6019/CHEMBL1201861
NPT2116 Cell Line HCC2218 Homo sapiens IC50 = 266415.47 nM 10.6019/CHEMBL1201861
NPT2117 Cell Line HuTu80 Homo sapiens IC50 = 419185.27 nM 10.6019/CHEMBL1201861
NPT2118 Cell Line KGN Homo sapiens IC50 = 1893177.66 nM 10.6019/CHEMBL1201861
NPT2119 Cell Line KINGS-1 Homo sapiens IC50 = 310674.27 nM 10.6019/CHEMBL1201861
NPT2120 Cell Line LB1047-RCC Homo sapiens IC50 = 266752.96 nM 10.6019/CHEMBL1201861
NPT2121 Cell Line LB2241-RCC Homo sapiens IC50 = 116679.4 nM 10.6019/CHEMBL1201861
NPT2122 Cell Line MC116 Homo sapiens IC50 = 458116.26 nM 10.6019/CHEMBL1201861
NPT2123 Cell Line MPP-89 Homo sapiens IC50 = 156034.95 nM 10.6019/CHEMBL1201861
NPT2124 Cell Line MRK-nu-1 Homo sapiens IC50 = 73470.5 nM 10.6019/CHEMBL1201861
NPT2125 Cell Line NCI-H1522 Homo sapiens IC50 = 2470510.28 nM 10.6019/CHEMBL1201861
NPT2126 Cell Line NKM-1 Homo sapiens IC50 = 2669202.45 nM 10.6019/CHEMBL1201861
NPT2127 Cell Line NMC-G1 Homo sapiens IC50 = 1458926.25 nM 10.6019/CHEMBL1201861
NPT2128 Cell Line RCC10RGB Homo sapiens IC50 = 460005.29 nM 10.6019/CHEMBL1201861
NPT395 Cell Line SF-268 Homo sapiens IC50 = 508152.7 nM 10.6019/CHEMBL1201861
NPT2129 Cell Line SNU-C1 Homo sapiens IC50 = 1405001.99 nM 10.6019/CHEMBL1201861
NPT2130 Cell Line TE-10 Homo sapiens IC50 = 1087941.87 nM 10.6019/CHEMBL1201861
NPT2131 Cell Line WSU-NHL Homo sapiens IC50 = 3158833.21 nM 10.6019/CHEMBL1201861
NPT2132 Cell Line EOL1 Homo sapiens IC50 = 18594.8 nM 10.6019/CHEMBL1201861
NPT391 Cell Line HCC 2998 Homo sapiens IC50 = 1361732.41 nM 10.6019/CHEMBL1201861
NPT2133 Cell Line KM-H2 Homo sapiens IC50 = 1287965.34 nM 10.6019/CHEMBL1201861
NPT2134 Cell Line LB2518-MEL Homo sapiens IC50 = 100789.18 nM 10.6019/CHEMBL1201861
NPT2135 Cell Line LB373-MEL-D Homo sapiens IC50 = 577685.73 nM 10.6019/CHEMBL1201861
NPT2136 Cell Line MDA-MB-134-VI Homo sapiens IC50 = 3308198.3 nM 10.6019/CHEMBL1201861
NPT2137 Cell Line MS-1 Homo sapiens IC50 = 50935.09 nM 10.6019/CHEMBL1201861
NPT2138 Cell Line MSTO-211H Homo sapiens IC50 = 1387541.84 nM 10.6019/CHEMBL1201861
NPT2139 Cell Line NCI-H1581 Homo sapiens IC50 = 538392.58 nM 10.6019/CHEMBL1201861
NPT2140 Cell Line NOMO-1 Homo sapiens IC50 = 182850.34 nM 10.6019/CHEMBL1201861
NPT2141 Cell Line NOS-1 Homo sapiens IC50 = 34295.6 nM 10.6019/CHEMBL1201861
NPT2142 Cell Line REH Homo sapiens IC50 = 162125.22 nM 10.6019/CHEMBL1201861
NPT374 Cell Line SF-539 Homo sapiens IC50 = 574622.33 nM 10.6019/CHEMBL1201861
NPT385 Cell Line SR Homo sapiens IC50 = 23671.53 nM 10.6019/CHEMBL1201861
NPT2143 Cell Line ST486 Homo sapiens IC50 = 277412.06 nM 10.6019/CHEMBL1201861
NPT2144 Cell Line TE-12 Homo sapiens IC50 = 546240.31 nM 10.6019/CHEMBL1201861
NPT2145 Cell Line TE-15 Homo sapiens IC50 = 1531711.47 nM 10.6019/CHEMBL1201861
NPT2146 Cell Line YT Homo sapiens IC50 = 4288618.79 nM 10.6019/CHEMBL1201861
NPT386 Cell Line KM12 Homo sapiens IC50 = 496589.14 nM 10.6019/CHEMBL1201861
NPT2147 Cell Line LB647-SCLC Homo sapiens IC50 = 175845.36 nM 10.6019/CHEMBL1201861
NPT2148 Cell Line LB771-HNC Homo sapiens IC50 = 482231.84 nM 10.6019/CHEMBL1201861
NPT1649 Cell Line MV4-11 Homo sapiens IC50 = 60653.78 nM 10.6019/CHEMBL1201861
NPT2149 Cell Line MZ1-PC Homo sapiens IC50 = 345617.96 nM 10.6019/CHEMBL1201861
NPT2150 Cell Line NCI-H1648 Homo sapiens IC50 = 229489.21 nM 10.6019/CHEMBL1201861
NPT388 Cell Line NCI-H322M Homo sapiens IC50 = 1409788.54 nM 10.6019/CHEMBL1201861
NPT2151 Cell Line NCI-H345 Homo sapiens IC50 = 2131499.5 nM 10.6019/CHEMBL1201861
NPT2152 Cell Line NTERA-2-cl-D1 Homo sapiens IC50 = 42707.43 nM 10.6019/CHEMBL1201861
NPT2153 Cell Line RH-1 Homo sapiens IC50 = 2612505.5 nM 10.6019/CHEMBL1201861
NPT2154 Cell Line SH-4 Homo sapiens IC50 = 427564.86 nM 10.6019/CHEMBL1201861
NPT2155 Cell Line SHP77 Homo sapiens IC50 = 1307146.77 nM 10.6019/CHEMBL1201861
NPT2156 Cell Line SU-DHL-1 Homo sapiens IC50 = 560174.31 nM 10.6019/CHEMBL1201861
NPT2157 Cell Line SUP-T1 Homo sapiens IC50 = 1320878.07 nM 10.6019/CHEMBL1201861
NPT2158 Cell Line TE-441-T Homo sapiens IC50 = 1132605.49 nM 10.6019/CHEMBL1201861
NPT2159 Cell Line TE-5 Homo sapiens IC50 = 1522667.48 nM 10.6019/CHEMBL1201861
NPT2160 Cell Line no-10 Homo sapiens IC50 = 9903.9 nM 10.6019/CHEMBL1201861
NPT2161 Cell Line no-11 Homo sapiens IC50 = 40552.08 nM 10.6019/CHEMBL1201861
NPT2162 Cell Line HCE-T Homo sapiens IC50 = 502130.48 nM 10.6019/CHEMBL1201861
NPT2163 Cell Line KMOE-2 Homo sapiens IC50 = 456710.63 nM 10.6019/CHEMBL1201861
NPT2164 Cell Line KMS-12-PE Homo sapiens IC50 = 189273.3 nM 10.6019/CHEMBL1201861
NPT2165 Cell Line KNS-42 Homo sapiens IC50 = 425814.58 nM 10.6019/CHEMBL1201861
NPT2166 Cell Line LB831-BLC Homo sapiens IC50 = 977549.57 nM 10.6019/CHEMBL1201861
NPT2167 Cell Line LB996-RCC Homo sapiens IC50 = 191698.53 nM 10.6019/CHEMBL1201861
NPT2168 Cell Line MZ2-MEL Homo sapiens IC50 = 858326.87 nM 10.6019/CHEMBL1201861
NPT2169 Cell Line MZ7-mel Homo sapiens IC50 = 397233 nM 10.6019/CHEMBL1201861
NPT1820 Cell Line NCI-H1650 Homo sapiens IC50 = 2990769.53 nM 10.6019/CHEMBL1201861
NPT937 Cell Line NCI-H446 Homo sapiens IC50 = 957784.69 nM 10.6019/CHEMBL1201861
NPT2170 Cell Line RKO Homo sapiens IC50 = 541621.82 nM 10.6019/CHEMBL1201861
NPT2171 Cell Line SIG-M5 Homo sapiens IC50 = 359781.53 nM 10.6019/CHEMBL1201861
NPT2172 Cell Line SIMA Homo sapiens IC50 = 403933.39 nM 10.6019/CHEMBL1201861
NPT2173 Cell Line TE-6 Homo sapiens IC50 = 1231297.78 nM 10.6019/CHEMBL1201861
NPT2174 Cell Line TE-8 Homo sapiens IC50 = 2027172.01 nM 10.6019/CHEMBL1201861
NPT2175 Cell Line GAK Homo sapiens IC50 = 2369020.84 nM 10.6019/CHEMBL1201861
NPT2176 Cell Line HD-MY-Z Homo sapiens IC50 = 118487.92 nM 10.6019/CHEMBL1201861
NPT2177 Cell Line HDLM-2 Homo sapiens IC50 = 1129362.96 nM 10.6019/CHEMBL1201861
NPT2178 Cell Line KNS-81-FD Homo sapiens IC50 = 241197.23 nM 10.6019/CHEMBL1201861
NPT2179 Cell Line LC-1F Homo sapiens IC50 = 1748549.73 nM 10.6019/CHEMBL1201861
NPT2180 Cell Line LC-2-ad Homo sapiens IC50 = 900893.46 nM 10.6019/CHEMBL1201861
NPT2181 Cell Line MEG-01 Homo sapiens IC50 = 657713.88 nM 10.6019/CHEMBL1201861
NPT2182 Cell Line Mo Homo sapiens IC50 = 3383594.89 nM 10.6019/CHEMBL1201861
NPT2183 Cell Line NCI-H1694 Homo sapiens IC50 = 372934.2 nM 10.6019/CHEMBL1201861
NPT2184 Cell Line NCI-H510A Homo sapiens IC50 = 1896599.83 nM 10.6019/CHEMBL1201861
NPT2185 Cell Line OCI-AML2 Homo sapiens IC50 = 76936.85 nM 10.6019/CHEMBL1201861
NPT2186 Cell Line RL Homo sapiens IC50 = 1515886.96 nM 10.6019/CHEMBL1201861
NPT2187 Cell Line RL95-2 Homo sapiens IC50 = 460236.74 nM 10.6019/CHEMBL1201861
NPT2188 Cell Line SJSA-1 Homo sapiens IC50 = 510336.85 nM 10.6019/CHEMBL1201861
NPT2189 Cell Line TE-9 Homo sapiens IC50 = 266626.55 nM 10.6019/CHEMBL1201861
NPT2190 Cell Line GB-1 Homo sapiens IC50 = 149321.99 nM 10.6019/CHEMBL1201861
NPT2191 Cell Line GCIY Homo sapiens IC50 = 99095.4 nM 10.6019/CHEMBL1201861
NPT2192 Cell Line HEL Homo sapiens IC50 = 309148.89 nM 10.6019/CHEMBL1201861
NPT2193 Cell Line IM-9 Homo sapiens IC50 = 1851888.11 nM 10.6019/CHEMBL1201861
NPT2194 Cell Line IMR-5 Homo sapiens IC50 = 1235385.07 nM 10.6019/CHEMBL1201861
NPT2195 Cell Line LC4-1 Homo sapiens IC50 = 40871.62 nM 10.6019/CHEMBL1201861
NPT623 Cell Line NALM-6 Homo sapiens IC50 = 19016.69 nM 10.6019/CHEMBL1201861
NPT2196 Cell Line NB1 Homo sapiens IC50 = 260515.93 nM 10.6019/CHEMBL1201861
NPT2197 Cell Line NCI-H1770 Homo sapiens IC50 = 108784.19 nM 10.6019/CHEMBL1201861
NPT2198 Cell Line NCI-H524 Homo sapiens IC50 = 2676381.57 nM 10.6019/CHEMBL1201861
NPT2199 Cell Line OCUB-M Homo sapiens IC50 = 1379674.66 nM 10.6019/CHEMBL1201861
NPT2200 Cell Line RPMI-6666 Homo sapiens IC50 = 2000131.09 nM 10.6019/CHEMBL1201861
NPT2201 Cell Line SK-LMS-1 Homo sapiens IC50 = 815035.77 nM 10.6019/CHEMBL1201861
NPT2202 Cell Line TGBC1TKB Homo sapiens IC50 = 753022.42 nM 10.6019/CHEMBL1201861
NPT2203 Cell Line GDM-1 Homo sapiens IC50 = 2758661.84 nM 10.6019/CHEMBL1201861
NPT2204 Cell Line HH Homo sapiens IC50 = 117394.61 nM 10.6019/CHEMBL1201861
NPT2205 Cell Line IST-MEL1 Homo sapiens IC50 = 513725.97 nM 10.6019/CHEMBL1201861
NPT2206 Cell Line IST-MES1 Homo sapiens IC50 = 60549.31 nM 10.6019/CHEMBL1201861
NPT2207 Cell Line KP-N-YN Homo sapiens IC50 = 3187553.58 nM 10.6019/CHEMBL1201861
NPT2208 Cell Line KP-N-YS Homo sapiens IC50 = 168395.27 nM 10.6019/CHEMBL1201861
NPT2209 Cell Line MFH-ino Homo sapiens IC50 = 634688.93 nM 10.6019/CHEMBL1201861
NPT2210 Cell Line NB10 Homo sapiens IC50 = 441233.85 nM 10.6019/CHEMBL1201861
NPT2211 Cell Line NB12 Homo sapiens IC50 = 513476.88 nM 10.6019/CHEMBL1201861
NPT198 Individual Protein Vitamin D receptor Homo sapiens FC = 1 24900716
NPT2 Others Unspecified IC50 = 160 nM 24900716
NPT1875 Individual Protein Vitamin D receptor Mus musculus FC = 0.8 24900716
NPT2 Others Unspecified IC50 = 660 nM 24900716
NPT1875 Individual Protein Vitamin D receptor Mus musculus FC = 1.5 24900716
NPT2 Others Unspecified IC50 = 430 nM 24900716
NPT2 Others Unspecified IC50 = 800 nM 24900716
NPT2 Others Unspecified Potency 5353.8 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 11883.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 6007 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 10682.2 nM PubChem BioAssay data set
NPT152 Individual Protein Nuclear factor erythroid 2-related factor 2 Homo sapiens Potency 13333.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 8485.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 13333.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 8412.7 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 29849.3 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 35481.3 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 26603.2 nM PubChem BioAssay data set
NPT49 Individual Protein DNA-(apurinic or apyrimidinic site) lyase Homo sapiens Potency 12589.3 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 2131.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 3010.7 nM PubChem BioAssay data set

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC28280 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC304646
0.9138 High Similarity NPC96010
0.9138 High Similarity NPC317654
0.8793 High Similarity NPC478138
0.8548 High Similarity NPC297058
0.843 Intermediate Similarity NPC478136
0.8393 Intermediate Similarity NPC253645
0.8393 Intermediate Similarity NPC85001
0.8393 Intermediate Similarity NPC95920
0.8393 Intermediate Similarity NPC147835
0.8349 Intermediate Similarity NPC176012
0.8318 Intermediate Similarity NPC474164
0.8145 Intermediate Similarity NPC478139
0.7876 Intermediate Similarity NPC212874
0.7748 Intermediate Similarity NPC91604
0.7739 Intermediate Similarity NPC46981
0.7727 Intermediate Similarity NPC289140
0.7647 Intermediate Similarity NPC478137
0.7627 Intermediate Similarity NPC79238
0.7479 Intermediate Similarity NPC474459
0.7431 Intermediate Similarity NPC84171
0.7417 Intermediate Similarity NPC474452
0.7395 Intermediate Similarity NPC472313
0.7323 Intermediate Similarity NPC296686
0.7265 Intermediate Similarity NPC477000
0.7265 Intermediate Similarity NPC477001
0.7241 Intermediate Similarity NPC50815
0.7227 Intermediate Similarity NPC159367
0.7217 Intermediate Similarity NPC135799
0.7203 Intermediate Similarity NPC86906
0.72 Intermediate Similarity NPC35037
0.7155 Intermediate Similarity NPC118275
0.713 Intermediate Similarity NPC75810
0.7121 Intermediate Similarity NPC25455
0.7121 Intermediate Similarity NPC15249
0.7119 Intermediate Similarity NPC475239
0.7105 Intermediate Similarity NPC476903
0.7094 Intermediate Similarity NPC247060
0.7068 Intermediate Similarity NPC122819
0.7059 Intermediate Similarity NPC195841
0.7059 Intermediate Similarity NPC233256
0.7043 Intermediate Similarity NPC240650
0.7043 Intermediate Similarity NPC140300
0.7018 Intermediate Similarity NPC155985
0.7015 Intermediate Similarity NPC147753
0.7015 Intermediate Similarity NPC150057
0.6992 Remote Similarity NPC40488
0.6972 Remote Similarity NPC157257
0.6972 Remote Similarity NPC274448
0.6949 Remote Similarity NPC471083
0.6916 Remote Similarity NPC474759
0.6916 Remote Similarity NPC82986
0.6916 Remote Similarity NPC474683
0.6916 Remote Similarity NPC7505
0.6916 Remote Similarity NPC474752
0.6916 Remote Similarity NPC474731
0.6903 Remote Similarity NPC471453
0.6891 Remote Similarity NPC241879
0.6884 Remote Similarity NPC478140
0.6881 Remote Similarity NPC470077
0.687 Remote Similarity NPC470382
0.687 Remote Similarity NPC25033
0.687 Remote Similarity NPC476261
0.687 Remote Similarity NPC119225
0.687 Remote Similarity NPC471635
0.6852 Remote Similarity NPC470049
0.6847 Remote Similarity NPC149224
0.6829 Remote Similarity NPC287764
0.6822 Remote Similarity NPC476504
0.6818 Remote Similarity NPC266511
0.6812 Remote Similarity NPC287885
0.6794 Remote Similarity NPC476503
0.6783 Remote Similarity NPC144202
0.6783 Remote Similarity NPC280710
0.6783 Remote Similarity NPC243985
0.6774 Remote Similarity NPC66862
0.6769 Remote Similarity NPC469943
0.675 Remote Similarity NPC45365
0.675 Remote Similarity NPC293299
0.6742 Remote Similarity NPC237286
0.6742 Remote Similarity NPC265275
0.6742 Remote Similarity NPC94881
0.6742 Remote Similarity NPC48886
0.6724 Remote Similarity NPC272732
0.6724 Remote Similarity NPC311164
0.6721 Remote Similarity NPC25340
0.672 Remote Similarity NPC476498
0.6697 Remote Similarity NPC49964
0.6697 Remote Similarity NPC87489
0.6696 Remote Similarity NPC27531
0.6696 Remote Similarity NPC93027
0.6696 Remote Similarity NPC307776
0.6694 Remote Similarity NPC72753
0.6667 Remote Similarity NPC201359
0.6667 Remote Similarity NPC245410
0.6667 Remote Similarity NPC295668
0.6667 Remote Similarity NPC470390
0.6667 Remote Similarity NPC192437
0.6667 Remote Similarity NPC270511
0.6639 Remote Similarity NPC239768
0.6639 Remote Similarity NPC55462
0.6639 Remote Similarity NPC477292
0.6639 Remote Similarity NPC128698
0.6637 Remote Similarity NPC471952
0.6636 Remote Similarity NPC475789
0.6636 Remote Similarity NPC275910
0.6636 Remote Similarity NPC470558
0.6614 Remote Similarity NPC476499
0.6612 Remote Similarity NPC474583
0.6612 Remote Similarity NPC98765
0.6612 Remote Similarity NPC90538
0.6606 Remote Similarity NPC47761
0.6606 Remote Similarity NPC264245
0.6587 Remote Similarity NPC56796
0.6583 Remote Similarity NPC176406
0.6581 Remote Similarity NPC8774
0.6577 Remote Similarity NPC205845
0.6577 Remote Similarity NPC238485
0.6577 Remote Similarity NPC474047
0.6577 Remote Similarity NPC231310
0.6574 Remote Similarity NPC84694
0.6574 Remote Similarity NPC47982
0.6574 Remote Similarity NPC143182
0.6574 Remote Similarity NPC109546
0.6574 Remote Similarity NPC28862
0.6574 Remote Similarity NPC81306
0.656 Remote Similarity NPC472359
0.6545 Remote Similarity NPC202389
0.6545 Remote Similarity NPC101462
0.6545 Remote Similarity NPC5985
0.6545 Remote Similarity NPC155521
0.6542 Remote Similarity NPC214570
0.6542 Remote Similarity NPC155986
0.6542 Remote Similarity NPC198968
0.6542 Remote Similarity NPC318495
0.6529 Remote Similarity NPC473289
0.6529 Remote Similarity NPC185530
0.6525 Remote Similarity NPC98457
0.6525 Remote Similarity NPC227583
0.6525 Remote Similarity NPC12103
0.6522 Remote Similarity NPC14380
0.6518 Remote Similarity NPC477578
0.6514 Remote Similarity NPC12035
0.6514 Remote Similarity NPC241290
0.6514 Remote Similarity NPC209944
0.6514 Remote Similarity NPC164840
0.6514 Remote Similarity NPC234193
0.65 Remote Similarity NPC275686
0.6496 Remote Similarity NPC127718
0.6496 Remote Similarity NPC65402
0.6486 Remote Similarity NPC474634
0.6486 Remote Similarity NPC132635
0.6481 Remote Similarity NPC473943
0.6481 Remote Similarity NPC474216
0.6475 Remote Similarity NPC26478
0.6475 Remote Similarity NPC36688
0.6466 Remote Similarity NPC234335
0.6466 Remote Similarity NPC177641
0.646 Remote Similarity NPC6391
0.646 Remote Similarity NPC261266
0.6457 Remote Similarity NPC477291
0.6457 Remote Similarity NPC80834
0.6457 Remote Similarity NPC124358
0.6457 Remote Similarity NPC469968
0.6455 Remote Similarity NPC209620
0.6455 Remote Similarity NPC23852
0.6449 Remote Similarity NPC321381
0.6449 Remote Similarity NPC240604
0.6449 Remote Similarity NPC300324
0.6449 Remote Similarity NPC202642
0.6449 Remote Similarity NPC321016
0.6449 Remote Similarity NPC46160
0.6449 Remote Similarity NPC107059
0.6449 Remote Similarity NPC73875
0.6441 Remote Similarity NPC174117
0.6439 Remote Similarity NPC242692
0.6435 Remote Similarity NPC323156
0.6429 Remote Similarity NPC185568
0.6429 Remote Similarity NPC63511
0.6423 Remote Similarity NPC119329
0.6422 Remote Similarity NPC328714
0.6422 Remote Similarity NPC30986
0.6422 Remote Similarity NPC209430
0.6417 Remote Similarity NPC92275
0.641 Remote Similarity NPC235126
0.641 Remote Similarity NPC242419
0.6396 Remote Similarity NPC218616
0.6396 Remote Similarity NPC189972
0.6396 Remote Similarity NPC201852
0.6396 Remote Similarity NPC296701
0.6396 Remote Similarity NPC304285
0.6396 Remote Similarity NPC50964
0.6393 Remote Similarity NPC471889
0.6387 Remote Similarity NPC288970
0.6387 Remote Similarity NPC72204
0.6379 Remote Similarity NPC476226
0.6379 Remote Similarity NPC77796
0.6379 Remote Similarity NPC92885
0.6372 Remote Similarity NPC474349
0.6372 Remote Similarity NPC474189

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC28280 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7563 Intermediate Similarity NPD7335 Phase 2
0.7563 Intermediate Similarity NPD7336 Phase 2
0.7563 Intermediate Similarity NPD7337 Clinical (unspecified phase)
0.7068 Intermediate Similarity NPD8449 Approved
0.7015 Intermediate Similarity NPD8450 Suspended
0.6355 Remote Similarity NPD7339 Approved
0.6355 Remote Similarity NPD6942 Approved
0.6328 Remote Similarity NPD6430 Approved
0.6328 Remote Similarity NPD6429 Approved
0.6308 Remote Similarity NPD7754 Approved
0.6308 Remote Similarity NPD7755 Approved
0.6216 Remote Similarity NPD7525 Registered
0.6194 Remote Similarity NPD6909 Approved
0.6194 Remote Similarity NPD6908 Approved
0.6174 Remote Similarity NPD8308 Discontinued
0.6147 Remote Similarity NPD3701 Clinical (unspecified phase)
0.6121 Remote Similarity NPD4751 Clinical (unspecified phase)
0.6116 Remote Similarity NPD5349 Clinical (unspecified phase)
0.6111 Remote Similarity NPD7333 Discontinued
0.6111 Remote Similarity NPD6920 Discontinued
0.6066 Remote Similarity NPD7919 Phase 3
0.6066 Remote Similarity NPD7920 Phase 3
0.6048 Remote Similarity NPD4159 Approved
0.6016 Remote Similarity NPD8088 Phase 1
0.6 Remote Similarity NPD4786 Approved
0.5985 Remote Similarity NPD7122 Discontinued
0.5982 Remote Similarity NPD7645 Phase 2
0.5963 Remote Similarity NPD6924 Approved
0.5963 Remote Similarity NPD6926 Approved
0.5957 Remote Similarity NPD6914 Discontinued
0.5929 Remote Similarity NPD4748 Discontinued
0.5913 Remote Similarity NPD6695 Phase 3
0.5902 Remote Similarity NPD7991 Discontinued
0.5891 Remote Similarity NPD6415 Discontinued
0.5887 Remote Similarity NPD7638 Approved
0.5882 Remote Similarity NPD6051 Approved
0.5874 Remote Similarity NPD6845 Suspended
0.5862 Remote Similarity NPD7338 Clinical (unspecified phase)
0.5856 Remote Similarity NPD6933 Approved
0.584 Remote Similarity NPD7640 Approved
0.584 Remote Similarity NPD7639 Approved
0.5826 Remote Similarity NPD3667 Approved
0.582 Remote Similarity NPD5771 Approved
0.5818 Remote Similarity NPD4785 Approved
0.5818 Remote Similarity NPD4784 Approved
0.5814 Remote Similarity NPD7646 Clinical (unspecified phase)
0.5809 Remote Similarity NPD7518 Approved
0.5809 Remote Similarity NPD7519 Approved
0.5809 Remote Similarity NPD7517 Approved
0.5789 Remote Similarity NPD6930 Phase 2
0.5789 Remote Similarity NPD6931 Approved
0.578 Remote Similarity NPD4243 Approved
0.5778 Remote Similarity NPD7115 Discovery
0.5766 Remote Similarity NPD2227 Clinical (unspecified phase)
0.5752 Remote Similarity NPD8131 Suspended
0.575 Remote Similarity NPD5328 Approved
0.5745 Remote Similarity NPD6025 Phase 1
0.5738 Remote Similarity NPD6399 Phase 3
0.5736 Remote Similarity NPD6640 Phase 3
0.5735 Remote Similarity NPD7327 Approved
0.5735 Remote Similarity NPD7328 Approved
0.5725 Remote Similarity NPD8033 Approved
0.5724 Remote Similarity NPD3638 Discontinued
0.5714 Remote Similarity NPD7750 Discontinued
0.5714 Remote Similarity NPD7524 Approved
0.5714 Remote Similarity NPD8077 Approved
0.5714 Remote Similarity NPD8078 Approved
0.5702 Remote Similarity NPD6929 Approved
0.5694 Remote Similarity NPD7260 Phase 2
0.5693 Remote Similarity NPD7516 Approved
0.5686 Remote Similarity NPD7625 Phase 1
0.5683 Remote Similarity NPD7725 Approved
0.5682 Remote Similarity NPD6420 Discontinued
0.5674 Remote Similarity NPD7249 Approved
0.5674 Remote Similarity NPD7250 Approved
0.5656 Remote Similarity NPD6079 Approved
0.5652 Remote Similarity NPD7514 Phase 3
0.5652 Remote Similarity NPD2106 Clinical (unspecified phase)
0.5652 Remote Similarity NPD8377 Approved
0.5652 Remote Similarity NPD8294 Approved
0.5636 Remote Similarity NPD7152 Approved
0.5636 Remote Similarity NPD7150 Approved
0.5636 Remote Similarity NPD7151 Approved
0.563 Remote Similarity NPD3618 Phase 1
0.5625 Remote Similarity NPD7751 Phase 1
0.5625 Remote Similarity NPD8264 Approved
0.562 Remote Similarity NPD4230 Clinical (unspecified phase)
0.5614 Remote Similarity NPD7322 Clinical (unspecified phase)
0.5612 Remote Similarity NPD8378 Approved
0.5612 Remote Similarity NPD8380 Approved
0.5612 Remote Similarity NPD8296 Approved
0.5612 Remote Similarity NPD8379 Approved
0.5612 Remote Similarity NPD8335 Approved
0.5612 Remote Similarity NPD1710 Approved
0.561 Remote Similarity NPD4202 Approved
0.5607 Remote Similarity NPD616 Clinical (unspecified phase)

Structure

External Identifiers

PubChem CID   442972
ChEMBL   CHEMBL254129
ZINC  

Physicochemical Properties

Molecular Weight:  411.31
ALogP:  0.683
MLogP:  4.1
XLogP:  3.646
# Rotatable Bonds:  5
Polar Surface Area:  41.49
# H-Bond Aceptor:  3
# H-Bond Donor:  2
# Rings:  6
# Heavy Atoms:  30

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs