Natural Product: NPC280807

Natural Product ID:  NPC280807
Common Name:   Trichostatin
IUPAC Name:   (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
Synonyms:   GNF-Pf-1011
Molecular Formula:   C17H22N2O3
Standard InCHIKey:  RTKIYFITIVXBLE-QEQCGCAPSA-N
Standard InCHI:  InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
Canonical SMILES:  C[C@@H](C(=O)c1ccc(cc1)N(C)C)/C=C(/C=C/C(=NO)O)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO32587 streptomyces sp. cpcc 203909 Species Streptomycetaceae Bacteria PMID[25556102]
NPO33673 Streptomyces sp. RM72 Species Streptomycetaceae Bacteria PMID[22276693]
NPO13391 Streptomyces hygroscopicus Species Streptomycetaceae Bacteria PMID[21504214]
NPO22810 Streptomyces Species Streptomycetaceae Bacteria StreptomeDB*
NPO13391 Streptomyces hygroscopicus Species Streptomycetaceae Bacteria StreptomeDB*
NPO28993 Streptomyces venezuelae Species Streptomycetaceae Bacteria StreptomeDB*
NPO32077 Streptomyces rm72 Species Streptomycetaceae Bacteria StreptomeDB*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2 Others Unspecified IC50 = 3.3 nM 11992774
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 12 nM 14613312
NPT5657 Protein Family Histone deacetylase_UNCURATED Mus musculus IC50 = 1.44 nM 14613312
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 3 nM 14613312
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 12 nM 14613312
NPT2813 Cell Line Friend leukemia cell line IC50 = 40 nM 14613312
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 26 nM 14613312
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 5 nM 14613312
NPT393 Cell Line HCT-116 Homo sapiens EC50 = 1000 nM 14613312
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens EC50 = 1000 nM 14613312
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens EC50 = 4000 nM 14613312
NPT2 Others Unspecified Ratio = 1.4 14613312
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 3.3 nM 14613312
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 7.2 nM 14613312
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 7 nM 11960489
NPT5660 Individual Protein Histone deacetylase 1 Mus musculus IC50 = 2 nM 11960489
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays Ki = 4.365 nM 11960489
NPT5660 Individual Protein Histone deacetylase 1 Mus musculus Ki = 1.072 nM 11960489
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 3 nM 10579829
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 5 nM 11597413
NPT393 Cell Line HCT-116 Homo sapiens EC50 = 1000 nM 11597413
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens EC50 = 1000 nM 11597413
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 > 25000 nM 12593661
NPT550 Cell Line T-24 Homo sapiens IC50 = 4000 nM 12593661
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 900 nM 12593661
NPT2338 Cell Line SW48 Homo sapiens IC50 = 5000 nM 12593661
NPT81 Cell Line A549 Homo sapiens IC50 = 4500 nM 12593661
NPT937 Cell Line NCI-H446 Homo sapiens IC50 = 1500 nM 12593661
NPT90 Cell Line DU-145 Homo sapiens IC50 = 3500 nM 12593661
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 3500 nM 12593661
NPT83 Cell Line MCF7 Homo sapiens IC50 = 10000 nM 12593661
NPT5661 Cell Line Fibroblast MRHFcell line IC50 = 36000 nM 12593661
NPT1059 Cell Line HMEC Homo sapiens IC50 = 32000 nM 12593661
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 4.6 nM 10425110
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens EC50 = 6000 nM 14584932
NPT2 Others Unspecified IC50 = 38 nM 14584932
NPT2 Others Unspecified EC50 = 8600 nM 14584932
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 7.2 nM 14584932
NPT2 Others Unspecified IC50 = 0.4 nM 14584932
NPT2 Others Unspecified IC50 = 0.8 nM 14584932
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 3 nM 12109913
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 12 nM 12109913
NPT2813 Cell Line Friend leukemia cell line IC50 = 40 nM 12109913
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 7.2 nM 14998325
NPT5660 Individual Protein Histone deacetylase 1 Mus musculus IC50 2 nM 14998325
NPT5660 Individual Protein Histone deacetylase 1 Mus musculus IC50 = 1.995 nM 14998325
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 7.079 nM 14998325
NPT81 Cell Line A549 Homo sapiens IC50 = 80 nM 14667227
NPT134 Cell Line SK-BR-3 Homo sapiens IC50 = 20 nM 14667227
NPT1097 Cell Line MKN-45 Homo sapiens IC50 = 100 nM 14667227
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 53.29 nM 14667227
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 3.4 nM 14592473
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 5 nM 12061890
NPT550 Cell Line T-24 Homo sapiens IC50 = 150 nM 12061890
NPT393 Cell Line HCT-116 Homo sapiens IC50 < 50 nM 12061890
NPT2338 Cell Line SW48 Homo sapiens IC50 = 100 nM 12061890
NPT81 Cell Line A549 Homo sapiens IC50 = 160 nM 12061890
NPT937 Cell Line NCI-H446 Homo sapiens IC50 = 80 nM 12061890
NPT90 Cell Line DU-145 Homo sapiens IC50 = 200 nM 12061890
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 90 nM 12061890
NPT83 Cell Line MCF7 Homo sapiens IC50 = 100 nM 12061890
NPT1059 Cell Line HMEC Homo sapiens IC50 = 1600 nM 12061890
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC90 = 100 nM 10.1016/S0960-894X(97)00284-9
NPT1523 Cell Line NFF Homo sapiens IC50 = 200 nM 15163181
NPT1524 Cell Line MM96L Homo sapiens IC50 = 30 nM 15163181
NPT170 Cell Line SK-MEL-28 Homo sapiens IC50 = 280 nM 15163181
NPT5662 Cell Line DO4 Homo sapiens IC50 = 90 nM 15163181
NPT90 Cell Line DU-145 Homo sapiens IC50 = 60 nM 15163181
NPT83 Cell Line MCF7 Homo sapiens IC50 = 20 nM 15163181
NPT5663 Cell Line JAM cell line IC50 = 80 nM 15163181
NPT5664 Cell Line C180-13S Homo sapiens IC50 = 60 nM 15163181
NPT306 Cell Line PC-3 Homo sapiens IC50 = 4999999.95 nM 14741273
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 7.2 nM 14971890
NPT5660 Individual Protein Histone deacetylase 1 Mus musculus IC50 = 19 nM 15109626
NPT5665 Individual Protein Histone deacetylase 5 Mus musculus IC50 = 20 nM 15109626
NPT5666 Individual Protein Histone deacetylase 6 Mus musculus IC50 = 28 nM 15109626
NPT5667 Individual Protein Histone deacetylase 8 Mus musculus IC50 = 40 nM 15109626
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 12 nM 12749885
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 5 nM 15109636
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays Ki = 4.365 nM 11405644
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 7.2 nM 11405644
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 26 nM 11831887
NPT664 Protein Family Histone deacetylase Homo sapiens AC50 = 400 nM 11831887
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 100 nM 11831887
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 13 nM 11831887
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 26 nM 14521422
NPT2410 Cell Line NCI-H1299 Homo sapiens IC50 = 100 nM 14521422
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 13 nM 14521422
NPT664 Protein Family Histone deacetylase Homo sapiens Inhibition = 0.0035 nM 15713393
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 12 nM 15456267
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 13.3 nM 15456267
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 26.3 nM 15456267
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 54.5 nM 15456267
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 20.7 nM 15456267
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 1526 nM 15456267
NPT5659 Protein Family Histone deacetylase Rattus norvegicus IC50 = 20.4 nM 15456267
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 20 nM 15454224
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 20 nM 15454224
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 20 nM 15454224
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 40 nM 15454224
NPT317 Uncleic Acid Nucleic Acid EC50 = 770 nM 15454224
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 7 nM 15857140
NPT2 Others Unspecified IC50 = 0.4 nM 15857140
NPT2 Others Unspecified IC50 = 0.8 nM 15857140
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 20 nM 16137884
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 39 nM 16137884
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 91 nM 16137884
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 81 nM 16884291
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 34 nM 16884291
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 21 nM 16884291
NPT5658 Individual Protein Histone deacetylase HD2 Zea mays IC50 = 7 nM 17004718
NPT2 Others Unspecified IC50 = 0.8 nM 17004718
NPT5668 Individual Protein Histone deacetylase HD1B Zea mays IC50 = 0.4 nM 17004718
NPT5660 Individual Protein Histone deacetylase 1 Mus musculus IC50 = 1.8 nM 17004718
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 26 nM 17257837
NPT2 Others Unspecified IC50 < 300 nM 16904890
NPT2 Others Unspecified IC50 = 100 nM 16904890
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 1.3 nM 16904890
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 41 nM 17419603
NPT2 Others Unspecified IC50 = 85 nM 17624773
NPT2 Others Unspecified IC50 = 85 nM 17897824
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 21 nM 17929798
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 34 nM 17929798
NPT5666 Individual Protein Histone deacetylase 6 Mus musculus IC50 = 81 nM 17929798
NPT2 Others Unspecified Ratio IC50 = 0.26 17929798
NPT2 Others Unspecified Ratio IC50 = 0.42 17929798
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 16 nM 17588744
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 29 nM 17588744
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 53 nM 17588744
NPT2 Others Unspecified Ratio IC50 = 1 17881232
NPT5666 Individual Protein Histone deacetylase 6 Mus musculus IC50 = 2.8 nM 17881232
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 1.9 nM 17881232
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 2 nM 17881232
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 190 nM 17900911
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 200 nM 17900911
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 280 nM 17900911
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 300 nM 18247554
NPT5669 Cell Line SQ20B Homo sapiens IC50 = 200 nM 18247554
NPT5660 Individual Protein Histone deacetylase 1 Mus musculus IC50 = 1.8 nM 18247554
NPT1524 Cell Line MM96L Homo sapiens IC50 = 30 nM 18247554
NPT2 Others Unspecified IC50 = 200 nM 18247554
NPT1523 Cell Line NFF Homo sapiens IC50 = 6700 nM 18247554
NPT81 Cell Line A549 Homo sapiens IC50 = 80 nM 18247554
NPT134 Cell Line SK-BR-3 Homo sapiens IC50 = 20 nM 18247554
NPT1097 Cell Line MKN-45 Homo sapiens IC50 = 100 nM 18247554
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 53 nM 18247554
NPT2 Others Unspecified IC50 = 3.5 nM 18247554
NPT1892 Cell Line H4 Rattus norvegicus Activity = 40.15 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 636.52 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 864.85 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 1649.69 % 18024584
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 36.6 nM 18397826
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 62.9 nM 18397826
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 83.3 nM 18397826
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 1.5 nM 18430569
NPT4345 Protein Complex Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Homo sapiens IC50 = 9 nM 18430569
NPT4345 Protein Complex Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Homo sapiens Ki = 0.26 nM 18430569
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 16.8 nM 18430569
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens Ki = 0.13 nM 18430569
NPT677 Individual Protein Coagulation factor III Homo sapiens IC50 = 20 nM 17675290
NPT677 Individual Protein Coagulation factor III Homo sapiens IC50 = 30 nM 17675290
NPT677 Individual Protein Coagulation factor III Homo sapiens Inhibition = 95 % 17675290
NPT677 Individual Protein Coagulation factor III Homo sapiens Inhibition = 91 % 17675290
NPT677 Individual Protein Coagulation factor III Homo sapiens IC50 = 50 nM 17675290
NPT5670 Individual Protein Tissue factor Mus musculus Inhibition = 60 % 17675290
NPT32 Organism Mus musculus Mus musculus Activity = 50 % 17675290
NPT2 Others Unspecified FC = 2 17675290
NPT2 Others Unspecified Activity = 75 % 17675290
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 15.6 nM 18362073
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 15.49 nM 18362073
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 10 nM 18362073
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 9.772 nM 18362073
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 5 nM 18397827
NPT5668 Individual Protein Histone deacetylase HD1B Zea mays IC50 = 0.4 nM 17698257
NPT2 Others Unspecified IC50 = 0.8 nM 17698257
NPT2 Others Unspecified Ratio IC50 = 2 17698257
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 4 nM 18494463
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 14 nM 18494463
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 2 nM 18494463
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 1380 nM 18494463
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 5 nM 18494463
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 1 nM 18494463
NPT2 Others Unspecified Ratio IC50 = 4 18494463
NPT2 Others Unspecified Ratio IC50 = 0.8 18494463
NPT2 Others Unspecified IC50 = 28000 nM 18942826
NPT4346 Individual Protein Histone deacetylase Plasmodium falciparum IC50 = 0.6 nM 19317450
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 16 nM 19317450
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 7 nM 19285395
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 23 nM 19285395
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 10 nM 19285395
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 12 nM 19285395
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens IC50 = 16 nM 19285395
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 0.4 nM 19285395
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens IC50 = 22 nM 19285395
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 90 nM 19285395
NPT691 Individual Protein Histone deacetylase 9 Homo sapiens IC50 = 38 nM 19285395
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 20 nM 19285395
NPT5648 Individual Protein Histone deacetylase 11 Homo sapiens IC50 = 15 nM 19285395
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 10 nM 19111466
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 20 nM 19111466
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 770 nM 19111466
NPT2 Others Unspecified Ratio IC50 = 1 19111466
NPT2 Others Unspecified Ratio IC50 = 39 19111466
NPT550 Cell Line T-24 Homo sapiens EC50 = 10 nM 19111466
NPT2356 Cell Line NCI-H661 Homo sapiens IC50 = 100 nM 19385600
NPT2356 Cell Line NCI-H661 Homo sapiens FC = 50 19385600
NPT2356 Cell Line NCI-H661 Homo sapiens FC = 4 19385600
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 4 nM 18642892
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 14 nM 18642892
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 2 nM 18642892
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 1.38 nM 18642892
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 1 nM 18642892
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 5 nM 18642892
NPT4347 Individual Protein Histone deacetylase-like amidohydrolase Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) Ki = 700 nM 19457659
NPT4347 Individual Protein Histone deacetylase-like amidohydrolase Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) IC50 = 1200 nM 19457659
NPT2 Others Unspecified IC50 = 17 nM 19457659
NPT2 Others Unspecified IC50 = 1 nM 19457659
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 6 nM 19457659
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 300 nM 19457659
NPT2 Others Unspecified IC50 = 250 nM 19534534
NPT664 Protein Family Histone deacetylase Homo sapiens Ki = 504 nM 19520580
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 3 nM 19705846
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 3.3 nM 19705846
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 11 nM 19705846
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 25 nM 19705846
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 6 nM 19705846
NPT6 Organism Plasmodium falciparum Plasmodium falciparum EC50 = 200.2 nM 18579783
NPT1229 Cell Line Huh-7 Homo sapiens CC50 = 1587 nM 18579783
NPT6 Organism Plasmodium falciparum Plasmodium falciparum EC50 = 170.8 nM 18579783
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 23 nM 20045316
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 44 nM 20045316
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 65 nM 20045316
NPT2 Others Unspecified Ratio IC50 = 2.6 19914074
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 0.095 ug/ml 19914074
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 0.0495 ug/ml 19914074
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 0.0412 ug/ml 19914074
NPT633 Organism Leishmania donovani Leishmania donovani IC50 = 1.37 ug/ml 19914074
NPT2 Others Unspecified Ratio IC50 = 2.2 19914074
NPT633 Organism Leishmania donovani Leishmania donovani IC90 = 20.5 ug/ml 19914074
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 5 nM 19914074
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 28.9 nM 20167479
NPT664 Protein Family Histone deacetylase Homo sapiens Inhibition = 90 % 20167479
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 1 nM 20055418
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 2 nM 20055418
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 4 nM 20055418
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 5 nM 20055418
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 14 nM 20055418
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 1380 nM 20055418
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 20 nM 20381359
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens Ki = 130 nM 20223566
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens Ki = 7 nM 20223566
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens Ki = 0.58 nM 20223566
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens Ki = 0.23 nM 20223566
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens Ki = 0.76 nM 20223566
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens Ki = 0.99 nM 20223566
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 0.15 nM 20472442
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 1 nM 20472442
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 0.6 nM 20472442
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 13 nM 20472442
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 300 nM 20472442
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 800 nM 20452226
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 9.9 nM 20452226
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens Ki = 0.2 nM 20139990
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens Ki = 0.65 nM 20139990
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens Ki = 0.5 nM 20139990
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens Ki = 400 nM 20139990
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens Ki = 260 nM 20139990
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens Ki = 1 nM 20139990
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens Ki = 195 nM 20139990
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens Ki = 45 nM 20139990
NPT691 Individual Protein Histone deacetylase 9 Homo sapiens Ki = 800 nM 20139990
NPT306 Cell Line PC-3 Homo sapiens FC = 0.268 16680159
NPT4169 Individual Protein Splicing factor 3B subunit 3 Homo sapiens IC50 = 611.2 nM 17643112
NPT4169 Individual Protein Splicing factor 3B subunit 3 Homo sapiens IC50 = 577.6 nM 17643112
NPT4169 Individual Protein Splicing factor 3B subunit 3 Homo sapiens Activity = 82.4 % 17643112
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens FC = 2.5 19966789
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 3 nM 19966789
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 10 nM 19966789
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 5 nM 19966789
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 8 nM 19966789
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens IC50 = 6 nM 19966789
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 0.8 nM 19966789
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens IC50 = 200 nM 19966789
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 100 nM 19966789
NPT691 Individual Protein Histone deacetylase 9 Homo sapiens IC50 = 20 nM 19966789
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 8 nM 19966789
NPT2 Others Unspecified IC50 = 100 nM 19966789
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 8 nM 18212103
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 11 nM 18212103
NPT2 Others Unspecified Ratio IC50 = 25 18212103
NPT2 Others Unspecified Ratio IC50 = 18 18212103
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 10 nM 20947351
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 56 nM 20947351
NPT2 Others Unspecified Ratio IC50 = 0.2 20947351
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 15 nM 21067930
NPT3877 Cell Line NSCLC Homo sapiens Potency = 40 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 200 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 141.3 nM PubChem BioAssay data set
NPT93 Individual Protein Survival motor neuron protein Homo sapiens Potency = 1412.5 nM PubChem BioAssay data set
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 35481.3 nM PubChem BioAssay data set
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 28183.8 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 1120 nM PubChem BioAssay data set
NPT442 Individual Protein Ferritin light chain Equus caballus Potency = 35481.3 nM PubChem BioAssay data set
NPT2466 Cell Line NCI-H358 Homo sapiens Potency = 40 nM PubChem BioAssay data set
NPT93 Individual Protein Survival motor neuron protein Homo sapiens Potency = 1122 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 794.3 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 35.5 nM PubChem BioAssay data set
NPT3877 Cell Line NSCLC Homo sapiens Potency = 100 nM PubChem BioAssay data set
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 7.12 nM 21073160
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 22.95 nM 21073160
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 10.32 nM 21073160
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 89.53 nM 21073160
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 12.07 nM 21073160
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens IC50 = 16.48 nM 21073160
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens IC50 = 22.46 nM 21073160
NPT691 Individual Protein Histone deacetylase 9 Homo sapiens IC50 = 38.12 nM 21073160
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 0.42 nM 21073160
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 20.1 nM 21073160
NPT5648 Individual Protein Histone deacetylase 11 Homo sapiens IC50 = 15.15 nM 21073160
NPT397 Cell Line NCI-H460 Homo sapiens IC50 = 100 nM 21073160
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 43 nM 21073160
NPT2 Others Unspecified IC50 = 3000000 nM 21109435
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 3900 nM 21256006
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 7600 nM 21256006
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 5200 nM 21256006
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 7690 nM 21256006
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 600 nM 21256006
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 73100 nM 21256006
NPT61 Individual Protein Beta-glucocerebrosidase Homo sapiens Potency 17782.8 nM PubChem BioAssay data set
NPT5672 Individual Protein Ribosome maturation protein SDO1 Saccharomyces cerevisiae S288c AC50 < 0.75 nM PubChem BioAssay data set
NPT5 Individual Protein Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Homo sapiens Potency 15848.9 nM PubChem BioAssay data set
NPT312 Organism Saccharomyces cerevisiae Saccharomyces cerevisiae MIC = 50 ug/ml 21504214
NPT4604 Cell Line DMS-53 Homo sapiens IC50 = 25 nM 21504214
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 3 nM 21621883
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 3 nM 21723733
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 4 nM 21723733
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 51 nM 21723733
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 960 nM 21723733
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 16 nM 21875796
NPT198 Individual Protein Vitamin D receptor Homo sapiens Potency 89125.1 nM PubChem BioAssay data set
NPT698 Individual Protein Regulator of G-protein signaling 4 Homo sapiens Potency 37685.8 nM PubChem BioAssay data set
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 8.22 nM 21548582
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 68 nM 21548582
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 122 nM 21548582
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens IC50 = 8.08 nM 21548582
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 2.31 nM 21548582
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens IC50 = 139 nM 21548582
NPT691 Individual Protein Histone deacetylase 9 Homo sapiens IC50 = 20.1 nM 21548582
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 11.3 nM 21548582
NPT5648 Individual Protein Histone deacetylase 11 Homo sapiens IC50 = 13.9 nM 21548582
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 6 nM 22321215
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 18 nM 22321215
NPT888 Individual Protein 78 kDa glucose-regulated protein Homo sapiens Potency 1258.9 nM PubChem BioAssay data set
NPT888 Individual Protein 78 kDa glucose-regulated protein Homo sapiens Potency 12589.3 nM PubChem BioAssay data set
NPT2 Others Unspecified FC > 15 21984958
NPT2 Others Unspecified FC = 25 21984958
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 12 nM 22276693
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 2.3 nM 22465091
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 1.1 nM 22465091
NPT83 Cell Line MCF7 Homo sapiens IC50 = 1700 nM 22465091
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 12 nM 22932316
NPT2 Others Unspecified IC50 = 50 nM 22932316
NPT64 Individual Protein ATPase family AAA domain-containing protein 5 Homo sapiens Potency 11186.8 nM PubChem BioAssay data set
NPT64 Individual Protein ATPase family AAA domain-containing protein 5 Homo sapiens Potency 20596.8 nM PubChem BioAssay data set
NPT64 Individual Protein ATPase family AAA domain-containing protein 5 Homo sapiens Potency 14083.4 nM PubChem BioAssay data set
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 65 nM 23021104
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 34 nM 23021104
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 23 nM 23021104
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 390 nM 23010266
NPT2 Others Unspecified Ratio IC50 = 4 23009203
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 1.2 nM 23009203
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 5 nM 23009203
NPT5648 Individual Protein Histone deacetylase 11 Homo sapiens IC50 = 31 nM 23252603
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 196 nM 23252603
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 1.5 nM 23252603
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens IC50 = 6155 nM 23252603
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 8439 nM 23252603
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 32.1 nM 23252603
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 10.9 nM 23252603
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 250 nM 23252603
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 430 nM 23252603
NPT179 Cell Line A2780 Homo sapiens IC50 = 220 nM 23252603
NPT179 Cell Line A2780 Homo sapiens IC50 = 290 nM 23252603
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens Activity = 59.23 % 23693069
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens Activity = 35.37 % 23693069
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens Activity = 5.72 % 23693069
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens Activity = 5.12 % 23693069
NPT4345 Protein Complex Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Homo sapiens Activity = 0.95 % 23693069
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens Activity = 0.07 % 23693069
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens Activity = 0.02 % 23693069
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 1360 nM 23719282
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 14 nM 23719282
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 4.3 nM 23719282
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens Ki = 14547 nM 24900743
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens Ki = 4120 nM 24900743
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens Ki = 69.65 nM 24900743
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens Ki = 3.02 nM 24900743
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens Ki = 1.06 nM 24900743
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens Ki = 0.87 nM 24900743
NPT2 Others Unspecified Ratio IC50 = 53.12 23820574
NPT2 Others Unspecified Ratio IC50 = 3.06 23820574
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 1.6 nM 23820574
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 85 nM 23820574
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 4.9 nM 23820574
NPT2 Others Unspecified Ratio IC50 = 143 23905680
NPT2 Others Unspecified Ratio IC50 = 6 23905680
NPT5648 Individual Protein Histone deacetylase 11 Homo sapiens IC50 = 17.3 nM 23905680
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 9 nM 23905680
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 0.9 nM 23905680
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 129 nM 23905680
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 5 nM 23905680
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 5 nM 23905680
NPT2 Others Unspecified Potency 35481.3 nM PubChem BioAssay data set
NPT64 Individual Protein ATPase family AAA domain-containing protein 5 Homo sapiens Potency 629.1 nM PubChem BioAssay data set
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 10.3 nM 24742384
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 12.1 nM 24742384
NPT5648 Individual Protein Histone deacetylase 11 Homo sapiens IC50 = 15.2 nM 24742384
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens IC50 = 16.5 nM 24742384
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 20.1 nM 24742384
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens IC50 = 22.5 nM 24742384
NPT691 Individual Protein Histone deacetylase 9 Homo sapiens IC50 = 38.1 nM 24742384
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 0.419 nM 24742384
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 7.12 nM 24742384
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 89.5 nM 24742384
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 8 nM 24904967
NPT2 Others Unspecified IC50 = 200 nM 24904967
NPT2 Others Unspecified Ratio IC50 = 18 24904967
NPT2 Others Unspecified Inhibition = 78.1 % 24904967
NPT2 Others Unspecified Inhibition = 93.3 % 24904967
NPT2 Others Unspecified IC50 = 80 nM 24960627
NPT165 Cell Line HeLa Homo sapiens IC50 = 110 nM 24960627
NPT2 Others Unspecified IC50 = 100 nM 24960627
NPT83 Cell Line MCF7 Homo sapiens IC50 = 60 nM 24960627
NPT2341 Cell Line NCI-H1975 Homo sapiens IC50 = 210 nM 24960627
NPT81 Cell Line A549 Homo sapiens IC50 = 50 nM 24960627
NPT116 Cell Line HL-60 Homo sapiens IC50 = 80 nM 24960627
NPT111 Cell Line K562 Homo sapiens IC50 = 410 nM 24960627
NPT112 Cell Line MOLT-4 Homo sapiens IC50 = 30 nM 24960627
NPT466 Cell Line U-937 Homo sapiens IC50 = 100 nM 24960627
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 7.4 nM 25455492
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 28.2 nM 25455492
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 8.2 nM 25455492
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 7.5 nM 25455492
NPT2 Others Unspecified EC50 = 380 nM 25556102
NPT1045 Cell Line U2OS Homo sapiens IC50 = 14930 nM 25556102
NPT65 Cell Line HepG2 Homo sapiens IC50 = 960 nM 25556102
NPT165 Cell Line HeLa Homo sapiens IC50 = 850 nM 25556102
NPT2 Others Unspecified IC50 = 210 nM 25556102
NPT71 Cell Line HEK293 Homo sapiens IC50 = 160 nM 25556102
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 23 nM 24997578
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 34 nM 24997578
NPT5666 Individual Protein Histone deacetylase 6 Mus musculus IC50 = 65 nM 24997578
NPT2 Others Unspecified Ratio IC50 = 3 24997578
NPT165 Cell Line HeLa Homo sapiens FC < 5 20870783
NPT165 Cell Line HeLa Homo sapiens FC = 45 20870783
NPT165 Cell Line HeLa Homo sapiens FC = 18 20870783
NPT165 Cell Line HeLa Homo sapiens Activity = -0.46 /hr 20870783
NPT165 Cell Line HeLa Homo sapiens FC = 25 20870783
NPT5673 Individual Protein Arylamine N-acetyltransferase 1 Homo sapiens FC < 1.5 20870783
NPT5673 Individual Protein Arylamine N-acetyltransferase 1 Homo sapiens FC = 4.1 20870783
NPT5673 Individual Protein Arylamine N-acetyltransferase 1 Homo sapiens FC = 3.2 20870783
NPT2 Others Unspecified IC50 = 8 nM 10.1039/C3MD00371J
NPT5674 Organism Enterovirus Enterovirus IC50 = 600 nM 10.1039/C3MD00371J
NPT2 Others Unspecified IC50 = 90 nM 10.1039/C3MD00371J
NPT116 Cell Line HL-60 Homo sapiens IC50 = 30 nM 10.1039/C3MD00371J
NPT165 Cell Line HeLa Homo sapiens IC50 = 100 nM 10.1039/C3MD00371J
NPT81 Cell Line A549 Homo sapiens IC50 = 50 nM 10.1039/C3MD00371J
NPT83 Cell Line MCF7 Homo sapiens IC50 = 60 nM 10.1039/C3MD00371J
NPT112 Cell Line MOLT-4 Homo sapiens IC50 = 30 nM 10.1039/C3MD00371J
NPT2 Others Unspecified IC50 = 80 nM 10.1039/C3MD00371J
NPT111 Cell Line K562 Homo sapiens IC50 = 160 nM 10.1039/C3MD00371J
NPT466 Cell Line U-937 Homo sapiens IC50 = 50 nM 10.1039/C3MD00371J
NPT2341 Cell Line NCI-H1975 Homo sapiens IC50 = 90 nM 10.1039/C3MD00371J
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens Ki = 0.5 nM 25637120
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens Ki = 0.7 nM 25637120
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens Ki = 0.2 nM 25637120
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 = 5000 nM 25637120
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens Ki = 45 nM 25637120
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens Ki = 1400 nM 25637120
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens Ki = 260 nM 25637120
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens Ki = 195 nM 25637120
NPT691 Individual Protein Histone deacetylase 9 Homo sapiens Ki = 800 nM 25637120
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens Ki = 1 nM 25637120
NPT5648 Individual Protein Histone deacetylase 11 Homo sapiens IC50 = 25 nM 26264503
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 31 nM 26264503
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 1.1 nM 26264503
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 170 nM 26264503
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 21 nM 26264503
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 25 nM 26264503
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 9.2 nM 26264503
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens IC50 = 9100 nM 26264503
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens IC50 = 1400 nM 26264503
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens IC50 = 2300 nM 26264503
NPT691 Individual Protein Histone deacetylase 9 Homo sapiens IC50 = 5000 nM 26264503
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 12 nM 10.1039/C4MD00211C
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 2 nM 26481659
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 65 nM 26481659
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 160 nM 26481659
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens Inhibition = 100 % 26005563
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens Inhibition = 99.2 % 26005563
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens Inhibition = 99.8 % 26005563
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens Inhibition = 2.4 % 26005563
NPT689 Individual Protein Histone deacetylase 5 Homo sapiens Inhibition = 10.8 % 26005563
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens Inhibition = 100 % 26005563
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens Inhibition = 6.3 % 26005563
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens Inhibition = 17.9 % 26005563
NPT691 Individual Protein Histone deacetylase 9 Homo sapiens Inhibition = 14.4 % 26005563
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens Inhibition = 100 % 26005563
NPT5648 Individual Protein Histone deacetylase 11 Homo sapiens Inhibition = 32.8 % 26005563
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens EC50 = 5.2 nM 26611919
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 1.42 nM 26588603
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 8.5 nM 26705137
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 52 nM 26705137
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 9 nM 26705137
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 360 nM 26705137
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 4550 nM 26681404
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 38 nM 26681404
NPT686 Individual Protein Histone deacetylase 3 Homo sapiens IC50 = 20 nM 26681404
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 15 nM 26681404
NPT684 Individual Protein Histone deacetylase 1 Homo sapiens IC50 = 6.574 nM 27060764
NPT5648 Individual Protein Histone deacetylase 11 Homo sapiens IC50 = 11.37 nM 27060764
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens IC50 = 307.4 nM 27060764
NPT692 Individual Protein Histone deacetylase 6 Homo sapiens IC50 = 1.716 nM 27060764
NPT685 Individual Protein Histone deacetylase 2 Homo sapiens IC50 = 10.51 nM 27060764
NPT4345 Protein Complex Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Homo sapiens IC50 = 11.07 nM 27060764
NPT5649 Individual Protein Histone deacetylase 10 Homo sapiens IC50 = 34.81 nM 27060764
NPT5675 Protein Complex Histone deacetylase 3/NCoR1 Homo sapiens Ki = 0.54 nM 10.1039/C5MD00451A
NPT687 Individual Protein Histone deacetylase 8 Homo sapiens Ki = 200 nM 10.1039/C5MD00451A
NPT688 Individual Protein Histone deacetylase 4 Homo sapiens Ki = 980 nM 10.1039/C5MD00451A
NPT690 Individual Protein Histone deacetylase 7 Homo sapiens Ki = 300 nM 10.1039/C5MD00451A

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC280807 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9754 High Similarity NPC150863
0.9675 High Similarity NPC472245
0.936 High Similarity NPC314431
0.9194 High Similarity NPC470343
0.9194 High Similarity NPC472244
0.8872 High Similarity NPC472243
0.8815 High Similarity NPC478040
0.875 High Similarity NPC314186
0.871 High Similarity NPC226143
0.8686 High Similarity NPC472242
0.8623 High Similarity NPC478039
0.8603 High Similarity NPC472241
0.8176 Intermediate Similarity NPC253667
0.8176 Intermediate Similarity NPC35510
0.808 Intermediate Similarity NPC57051
0.7868 Intermediate Similarity NPC314098
0.7846 Intermediate Similarity NPC291962
0.7846 Intermediate Similarity NPC177684
0.7803 Intermediate Similarity NPC39818
0.7786 Intermediate Similarity NPC161956
0.7786 Intermediate Similarity NPC112373
0.7786 Intermediate Similarity NPC258531
0.7594 Intermediate Similarity NPC257490
0.75 Intermediate Similarity NPC205946
0.7388 Intermediate Similarity NPC179605
0.7388 Intermediate Similarity NPC279385
0.7333 Intermediate Similarity NPC103292
0.7194 Intermediate Similarity NPC322433
0.7174 Intermediate Similarity NPC192533
0.7163 Intermediate Similarity NPC194562
0.7153 Intermediate Similarity NPC300299
0.7143 Intermediate Similarity NPC471574
0.7123 Intermediate Similarity NPC83214
0.7083 Intermediate Similarity NPC253476
0.7075 Intermediate Similarity NPC242933
0.707 Intermediate Similarity NPC27904
0.7059 Intermediate Similarity NPC314223
0.7054 Intermediate Similarity NPC172170
0.7039 Intermediate Similarity NPC300596
0.7039 Intermediate Similarity NPC237649
0.7029 Intermediate Similarity NPC268534
0.7 Intermediate Similarity NPC136002
0.6993 Remote Similarity NPC316746
0.6993 Remote Similarity NPC144691
0.6972 Remote Similarity NPC209389
0.6959 Remote Similarity NPC315051
0.6953 Remote Similarity NPC38262
0.6944 Remote Similarity NPC53044
0.6918 Remote Similarity NPC476231
0.6913 Remote Similarity NPC471164
0.6913 Remote Similarity NPC316202
0.6884 Remote Similarity NPC150323
0.6871 Remote Similarity NPC318183
0.6857 Remote Similarity NPC254698
0.6848 Remote Similarity NPC471743
0.6831 Remote Similarity NPC314278
0.6824 Remote Similarity NPC287358
0.6821 Remote Similarity NPC314287
0.6807 Remote Similarity NPC474081
0.6806 Remote Similarity NPC187231
0.68 Remote Similarity NPC2823
0.6792 Remote Similarity NPC36495
0.6783 Remote Similarity NPC476950
0.6779 Remote Similarity NPC319645
0.6779 Remote Similarity NPC469560
0.6776 Remote Similarity NPC470822
0.6761 Remote Similarity NPC474926
0.6747 Remote Similarity NPC475607
0.6746 Remote Similarity NPC470317
0.6735 Remote Similarity NPC162417
0.6735 Remote Similarity NPC316104
0.6733 Remote Similarity NPC207554
0.6711 Remote Similarity NPC122553
0.6707 Remote Similarity NPC14849
0.6689 Remote Similarity NPC173295
0.6689 Remote Similarity NPC43477
0.6687 Remote Similarity NPC248862
0.6687 Remote Similarity NPC475594
0.6667 Remote Similarity NPC475761
0.6667 Remote Similarity NPC6982
0.6646 Remote Similarity NPC474058
0.6645 Remote Similarity NPC315829
0.6644 Remote Similarity NPC471123
0.6643 Remote Similarity NPC27833
0.6641 Remote Similarity NPC167336
0.6626 Remote Similarity NPC471130
0.6615 Remote Similarity NPC202613
0.6608 Remote Similarity NPC471742
0.6605 Remote Similarity NPC88970
0.6603 Remote Similarity NPC242000
0.6599 Remote Similarity NPC40364
0.6599 Remote Similarity NPC207428
0.6591 Remote Similarity NPC45033
0.6587 Remote Similarity NPC328611
0.6582 Remote Similarity NPC117032
0.6568 Remote Similarity NPC182057
0.6568 Remote Similarity NPC147298
0.6568 Remote Similarity NPC131450
0.6568 Remote Similarity NPC474041
0.6566 Remote Similarity NPC292265
0.6564 Remote Similarity NPC189116
0.6564 Remote Similarity NPC204867
0.6562 Remote Similarity NPC84317
0.6561 Remote Similarity NPC473329
0.6558 Remote Similarity NPC130797
0.6554 Remote Similarity NPC130655
0.6552 Remote Similarity NPC72473
0.6552 Remote Similarity NPC58827
0.6552 Remote Similarity NPC307437
0.6547 Remote Similarity NPC192209
0.6532 Remote Similarity NPC78154
0.6522 Remote Similarity NPC104345
0.6519 Remote Similarity NPC154602
0.6514 Remote Similarity NPC313293
0.6512 Remote Similarity NPC75496
0.6506 Remote Similarity NPC472118
0.6503 Remote Similarity NPC293458
0.65 Remote Similarity NPC220698
0.65 Remote Similarity NPC229353
0.6494 Remote Similarity NPC308197
0.6489 Remote Similarity NPC471317
0.6488 Remote Similarity NPC470548
0.6481 Remote Similarity NPC154478
0.6481 Remote Similarity NPC193410
0.6481 Remote Similarity NPC471122
0.6478 Remote Similarity NPC285381
0.6474 Remote Similarity NPC324445
0.6467 Remote Similarity NPC355
0.6458 Remote Similarity NPC317758
0.6457 Remote Similarity NPC316405
0.6453 Remote Similarity NPC159125
0.6447 Remote Similarity NPC315224
0.6447 Remote Similarity NPC181527
0.6446 Remote Similarity NPC70949
0.6446 Remote Similarity NPC224970
0.6446 Remote Similarity NPC167724
0.6446 Remote Similarity NPC470971
0.6446 Remote Similarity NPC223595
0.6442 Remote Similarity NPC248117
0.6442 Remote Similarity NPC315368
0.6438 Remote Similarity NPC295021
0.6424 Remote Similarity NPC115232
0.6423 Remote Similarity NPC473031
0.642 Remote Similarity NPC123241
0.642 Remote Similarity NPC211525
0.642 Remote Similarity NPC153694
0.642 Remote Similarity NPC61013
0.6412 Remote Similarity NPC291610
0.6412 Remote Similarity NPC157583
0.6408 Remote Similarity NPC130931
0.6405 Remote Similarity NPC130251
0.6402 Remote Similarity NPC242116
0.6402 Remote Similarity NPC199737
0.64 Remote Similarity NPC184437
0.6398 Remote Similarity NPC114808
0.6395 Remote Similarity NPC122235
0.6391 Remote Similarity NPC469529
0.6386 Remote Similarity NPC472115
0.6386 Remote Similarity NPC472114
0.638 Remote Similarity NPC80681
0.6377 Remote Similarity NPC187036
0.6369 Remote Similarity NPC259678
0.6369 Remote Similarity NPC470579
0.6364 Remote Similarity NPC271797
0.6364 Remote Similarity NPC470301
0.6364 Remote Similarity NPC21174
0.6364 Remote Similarity NPC313757
0.6364 Remote Similarity NPC265100
0.6364 Remote Similarity NPC22082
0.6364 Remote Similarity NPC186284
0.6364 Remote Similarity NPC301760
0.6351 Remote Similarity NPC477432
0.635 Remote Similarity NPC275410
0.6346 Remote Similarity NPC323798
0.6345 Remote Similarity NPC285394
0.6343 Remote Similarity NPC471447
0.6341 Remote Similarity NPC93653
0.634 Remote Similarity NPC153007
0.6335 Remote Similarity NPC251391
0.6329 Remote Similarity NPC254798
0.6325 Remote Similarity NPC71132
0.6325 Remote Similarity NPC471124
0.6325 Remote Similarity NPC470069
0.6325 Remote Similarity NPC52059
0.6322 Remote Similarity NPC285923
0.6319 Remote Similarity NPC113946
0.6319 Remote Similarity NPC76982
0.6316 Remote Similarity NPC83774
0.6312 Remote Similarity NPC313889
0.6312 Remote Similarity NPC313449
0.6303 Remote Similarity NPC214106
0.6303 Remote Similarity NPC472117
0.6301 Remote Similarity NPC288305
0.6301 Remote Similarity NPC79698
0.6301 Remote Similarity NPC113626
0.6296 Remote Similarity NPC55529
0.6294 Remote Similarity NPC469726
0.6294 Remote Similarity NPC329338
0.6287 Remote Similarity NPC279527
0.6287 Remote Similarity NPC214960

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC280807 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8529 High Similarity NPD3434 Clinical (unspecified phase)
0.8273 Intermediate Similarity NPD4464 Clinical (unspecified phase)
0.806 Intermediate Similarity NPD2918 Clinical (unspecified phase)
0.806 Intermediate Similarity NPD2919 Clinical (unspecified phase)
0.7863 Intermediate Similarity NPD1079 Discontinued
0.7852 Intermediate Similarity NPD1781 Discontinued
0.7778 Intermediate Similarity NPD6017 Discontinued
0.7609 Intermediate Similarity NPD1619 Phase 3
0.7535 Intermediate Similarity NPD2670 Approved
0.7518 Intermediate Similarity NPD2331 Discontinued
0.7483 Intermediate Similarity NPD6655 Clinical (unspecified phase)
0.7465 Intermediate Similarity NPD5227 Clinical (unspecified phase)
0.7463 Intermediate Similarity NPD1124 Approved
0.7463 Intermediate Similarity NPD1123 Approved
0.7426 Intermediate Similarity NPD1640 Clinical (unspecified phase)
0.7347 Intermediate Similarity NPD5918 Discontinued
0.7329 Intermediate Similarity NPD6566 Discontinued
0.7279 Intermediate Similarity NPD2820 Phase 3
0.7273 Intermediate Similarity NPD2470 Clinical (unspecified phase)
0.7273 Intermediate Similarity NPD1410 Phase 1
0.726 Intermediate Similarity NPD4461 Discontinued
0.7254 Intermediate Similarity NPD1527 Phase 2
0.7254 Intermediate Similarity NPD1541 Approved
0.7254 Intermediate Similarity NPD6740 Clinical (unspecified phase)
0.7234 Intermediate Similarity NPD486 Clinical (unspecified phase)
0.7219 Intermediate Similarity NPD5748 Phase 2
0.7215 Intermediate Similarity NPD4643 Clinical (unspecified phase)
0.7214 Intermediate Similarity NPD4549 Discontinued
0.7211 Intermediate Similarity NPD2365 Approved
0.7211 Intermediate Similarity NPD6768 Approved
0.7194 Intermediate Similarity NPD9540 Approved
0.719 Intermediate Similarity NPD2360 Approved
0.7188 Intermediate Similarity NPD6299 Approved
0.7188 Intermediate Similarity NPD6300 Approved
0.7172 Intermediate Similarity NPD6342 Discontinued
0.7153 Intermediate Similarity NPD4775 Clinical (unspecified phase)
0.7123 Intermediate Similarity NPD7142 Discontinued
0.7111 Intermediate Similarity NPD1668 Clinical (unspecified phase)
0.7068 Intermediate Similarity NPD5631 Phase 3
0.705 Intermediate Similarity NPD9539 Approved
0.705 Intermediate Similarity NPD9541 Approved
0.7047 Intermediate Similarity NPD7082 Approved
0.7045 Intermediate Similarity NPD181 Approved
0.7014 Intermediate Similarity NPD441 Approved
0.7014 Intermediate Similarity NPD1874 Clinical (unspecified phase)
0.7007 Intermediate Similarity NPD3170 Approved
0.7 Intermediate Similarity NPD7259 Approved
0.6992 Remote Similarity NPD1175 Approved
0.698 Remote Similarity NPD6513 Approved
0.698 Remote Similarity NPD6512 Approved
0.6978 Remote Similarity NPD1360 Approved
0.6977 Remote Similarity NPD1065 Approved
0.6977 Remote Similarity NPD1064 Approved
0.6974 Remote Similarity NPD1802 Approved
0.6974 Remote Similarity NPD1801 Approved
0.6962 Remote Similarity NPD2506 Approved
0.6954 Remote Similarity NPD5932 Phase 3
0.6954 Remote Similarity NPD5931 Phase 3
0.6954 Remote Similarity NPD7295 Approved
0.6954 Remote Similarity NPD5933 Phase 3
0.6944 Remote Similarity NPD1920 Approved
0.6944 Remote Similarity NPD1919 Approved
0.6939 Remote Similarity NPD4077 Clinical (unspecified phase)
0.6929 Remote Similarity NPD4735 Approved
0.6929 Remote Similarity NPD4734 Approved
0.6928 Remote Similarity NPD4161 Discontinued
0.6913 Remote Similarity NPD1222 Discontinued
0.6913 Remote Similarity NPD2010 Phase 3
0.6903 Remote Similarity NPD5965 Clinical (unspecified phase)
0.6897 Remote Similarity NPD2949 Approved
0.6897 Remote Similarity NPD2950 Approved
0.6884 Remote Similarity NPD9272 Approved
0.6879 Remote Similarity NPD6320 Approved
0.6867 Remote Similarity NPD3482 Approved
0.6863 Remote Similarity NPD7088 Discontinued
0.6835 Remote Similarity NPD212 Discontinued
0.6831 Remote Similarity NPD797 Clinical (unspecified phase)
0.6821 Remote Similarity NPD5020 Approved
0.6818 Remote Similarity NPD4888 Discontinued
0.6818 Remote Similarity NPD7528 Approved
0.6818 Remote Similarity NPD4942 Approved
0.6797 Remote Similarity NPD1956 Clinical (unspecified phase)
0.6792 Remote Similarity NPD2427 Approved
0.6788 Remote Similarity NPD5919 Clinical (unspecified phase)
0.6788 Remote Similarity NPD5466 Approved
0.6788 Remote Similarity NPD4736 Clinical (unspecified phase)
0.6779 Remote Similarity NPD1110 Approved
0.6779 Remote Similarity NPD1109 Approved
0.6776 Remote Similarity NPD4046 Approved
0.6776 Remote Similarity NPD7487 Discontinued
0.6776 Remote Similarity NPD3481 Approved
0.6776 Remote Similarity NPD4043 Approved
0.6772 Remote Similarity NPD6855 Clinical (unspecified phase)
0.6772 Remote Similarity NPD2351 Discontinued
0.677 Remote Similarity NPD1631 Approved
0.6761 Remote Similarity NPD1036 Approved
0.6759 Remote Similarity NPD1070 Approved
0.6759 Remote Similarity NPD1069 Approved
0.6753 Remote Similarity NPD7794 Clinical (unspecified phase)
0.6752 Remote Similarity NPD7612 Clinical (unspecified phase)
0.6752 Remote Similarity NPD5086 Approved
0.6752 Remote Similarity NPD2790 Discontinued
0.6748 Remote Similarity NPD2037 Approved
0.6746 Remote Similarity NPD1099 Approved
0.6746 Remote Similarity NPD1100 Approved
0.6741 Remote Similarity NPD5180 Approved
0.6741 Remote Similarity NPD5179 Approved
0.6741 Remote Similarity NPD5181 Approved
0.6739 Remote Similarity NPD922 Approved
0.6736 Remote Similarity NPD766 Clinical (unspecified phase)
0.6713 Remote Similarity NPD1593 Approved
0.6709 Remote Similarity NPD4045 Phase 2
0.6709 Remote Similarity NPD4042 Phase 2
0.6709 Remote Similarity NPD7072 Phase 2
0.6707 Remote Similarity NPD4092 Approved
0.6707 Remote Similarity NPD3376 Clinical (unspecified phase)
0.6689 Remote Similarity NPD2791 Discontinued
0.6687 Remote Similarity NPD6629 Discontinued
0.6687 Remote Similarity NPD7449 Clinical (unspecified phase)
0.6687 Remote Similarity NPD1630 Approved
0.6667 Remote Similarity NPD7091 Discontinued
0.6667 Remote Similarity NPD2193 Phase 2
0.6667 Remote Similarity NPD3782 Discontinued
0.6667 Remote Similarity NPD2648 Phase 3
0.6667 Remote Similarity NPD1560 Clinical (unspecified phase)
0.6667 Remote Similarity NPD813 Approved
0.6667 Remote Similarity NPD2196 Discontinued
0.6647 Remote Similarity NPD4091 Approved
0.6646 Remote Similarity NPD4311 Approved
0.6646 Remote Similarity NPD5992 Approved
0.6646 Remote Similarity NPD737 Phase 2
0.6645 Remote Similarity NPD7478 Approved
0.6644 Remote Similarity NPD1190 Approved
0.6643 Remote Similarity NPD6330 Clinical (unspecified phase)
0.6641 Remote Similarity NPD2197 Approved
0.6641 Remote Similarity NPD2192 Approved
0.6627 Remote Similarity NPD4330 Approved
0.6627 Remote Similarity NPD4329 Approved
0.6627 Remote Similarity NPD5997 Discontinued
0.6627 Remote Similarity NPD5445 Approved
0.6626 Remote Similarity NPD5430 Discontinued
0.6625 Remote Similarity NPD5659 Approved
0.6625 Remote Similarity NPD5660 Approved
0.6625 Remote Similarity NPD6019 Approved
0.6625 Remote Similarity NPD6018 Approved
0.6623 Remote Similarity NPD989 Approved
0.6622 Remote Similarity NPD1627 Clinical (unspecified phase)
0.6618 Remote Similarity NPD23 Approved
0.6617 Remote Similarity NPD1342 Approved
0.6615 Remote Similarity NPD2244 Clinical (unspecified phase)
0.6607 Remote Similarity NPD3792 Approved
0.6606 Remote Similarity NPD1573 Approved
0.6606 Remote Similarity NPD2369 Discontinued
0.6606 Remote Similarity NPD1575 Approved
0.6603 Remote Similarity NPD4939 Clinical (unspecified phase)
0.6601 Remote Similarity NPD1625 Approved
0.6601 Remote Similarity NPD5526 Phase 2
0.6601 Remote Similarity NPD5527 Clinical (unspecified phase)
0.6599 Remote Similarity NPD2846 Clinical (unspecified phase)
0.6597 Remote Similarity NPD9567 Approved
0.6597 Remote Similarity NPD553 Approved
0.6597 Remote Similarity NPD552 Approved
0.6596 Remote Similarity NPD1517 Clinical (unspecified phase)
0.6594 Remote Similarity NPD1344 Phase 2
0.6587 Remote Similarity NPD7662 Clinical (unspecified phase)
0.6587 Remote Similarity NPD3522 Approved
0.6585 Remote Similarity NPD4645 Clinical (unspecified phase)
0.6582 Remote Similarity NPD3248 Phase 1
0.6582 Remote Similarity NPD2501 Discontinued
0.6579 Remote Similarity NPD3625 Discontinued
0.6577 Remote Similarity NPD1071 Clinical (unspecified phase)
0.6575 Remote Similarity NPD5131 Approved
0.657 Remote Similarity NPD6163 Clinical (unspecified phase)
0.6568 Remote Similarity NPD3997 Approved
0.6568 Remote Similarity NPD3998 Approved
0.6568 Remote Similarity NPD3999 Approved
0.6567 Remote Similarity NPD7633 Discontinued
0.6566 Remote Similarity NPD2432 Approved
0.6566 Remote Similarity NPD1165 Clinical (unspecified phase)
0.6566 Remote Similarity NPD3776 Discontinued
0.6566 Remote Similarity NPD2431 Approved
0.6566 Remote Similarity NPD5727 Clinical (unspecified phase)
0.6565 Remote Similarity NPD2577 Clinical (unspecified phase)
0.6562 Remote Similarity NPD7105 Phase 1
0.6556 Remote Similarity NPD7254 Discontinued
0.6548 Remote Similarity NPD2083 Clinical (unspecified phase)
0.6548 Remote Similarity NPD3004 Clinical (unspecified phase)
0.6545 Remote Similarity NPD2454 Approved
0.6545 Remote Similarity NPD2455 Approved
0.6541 Remote Similarity NPD4115 Approved
0.6541 Remote Similarity NPD4114 Approved
0.6538 Remote Similarity NPD2171 Approved
0.6538 Remote Similarity NPD1419 Approved
0.6538 Remote Similarity NPD1417 Approved
0.6532 Remote Similarity NPD3315 Phase 3
0.6528 Remote Similarity NPD2634 Clinical (unspecified phase)
0.6527 Remote Similarity NPD3377 Discontinued
0.6519 Remote Similarity NPD7606 Phase 3
0.6519 Remote Similarity NPD5982 Phase 2
0.6512 Remote Similarity NPD4412 Phase 2

Structure

External Identifiers

PubChem CID   444732
ChEMBL   CHEMBL99
ZINC  

Physicochemical Properties

Molecular Weight:  302.16
ALogP:  1.3262
MLogP:  2.78
XLogP:  3.035
# Rotatable Bonds:  12
Polar Surface Area:  73.13
# H-Bond Aceptor:  3
# H-Bond Donor:  2
# Rings:  1
# Heavy Atoms:  22

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Biological Activities  
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