Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT414 | Individual Protein | Neuronal acetylcholine receptor protein alpha-7 subunit | Rattus norvegicus | IC50 | = | 1800 | nM | 8941400 |
NPT2 | Others | Unspecified | EC50 | = | 85113.8 | nM | 20594622 | |
NPT66 | Individual Protein | Acetylcholinesterase | Electrophorus electricus | Inhibition | = | 19.97 | % | 23062825 |
NPT67 | Individual Protein | Cholinesterase | Equus caballus | Inhibition | = | -5.97 | % | 23062825 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC267217 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
1.0 | High Similarity | NPC8009 |
1.0 | High Similarity | NPC83047 |
1.0 | High Similarity | NPC48127 |
0.9703 | High Similarity | NPC139778 |
0.8909 | High Similarity | NPC208118 |
0.8909 | High Similarity | NPC96080 |
0.8909 | High Similarity | NPC99905 |
0.8899 | High Similarity | NPC475887 |
0.8376 | Intermediate Similarity | NPC476497 |
0.8305 | Intermediate Similarity | NPC476967 |
0.8291 | Intermediate Similarity | NPC476501 |
0.8214 | Intermediate Similarity | NPC476502 |
0.7769 | Intermediate Similarity | NPC212106 |
0.776 | Intermediate Similarity | NPC474210 |
0.7611 | Intermediate Similarity | NPC287764 |
0.7417 | Intermediate Similarity | NPC476504 |
0.7377 | Intermediate Similarity | NPC476503 |
0.735 | Intermediate Similarity | NPC476499 |
0.7273 | Intermediate Similarity | NPC201712 |
0.7222 | Intermediate Similarity | NPC155985 |
0.719 | Intermediate Similarity | NPC470594 |
0.719 | Intermediate Similarity | NPC470593 |
0.7182 | Intermediate Similarity | NPC475249 |
0.7179 | Intermediate Similarity | NPC476498 |
0.7143 | Intermediate Similarity | NPC309249 |
0.7129 | Intermediate Similarity | NPC109533 |
0.7091 | Intermediate Similarity | NPC473537 |
0.7054 | Intermediate Similarity | NPC475518 |
0.7043 | Intermediate Similarity | NPC46981 |
0.7027 | Intermediate Similarity | NPC252564 |
0.7009 | Intermediate Similarity | NPC312637 |
0.7 | Intermediate Similarity | NPC476955 |
0.6887 | Remote Similarity | NPC21035 |
0.6855 | Remote Similarity | NPC238323 |
0.6768 | Remote Similarity | NPC304499 |
0.6726 | Remote Similarity | NPC220111 |
0.6724 | Remote Similarity | NPC212874 |
0.6696 | Remote Similarity | NPC289140 |
0.6694 | Remote Similarity | NPC28224 |
0.6607 | Remote Similarity | NPC174117 |
0.66 | Remote Similarity | NPC475458 |
0.6585 | Remote Similarity | NPC165396 |
0.6579 | Remote Similarity | NPC91604 |
0.6571 | Remote Similarity | NPC296734 |
0.6569 | Remote Similarity | NPC302578 |
0.6569 | Remote Similarity | NPC128951 |
0.6569 | Remote Similarity | NPC476233 |
0.6569 | Remote Similarity | NPC192046 |
0.6569 | Remote Similarity | NPC477227 |
0.6569 | Remote Similarity | NPC185915 |
0.6569 | Remote Similarity | NPC105208 |
0.6566 | Remote Similarity | NPC252182 |
0.6566 | Remote Similarity | NPC470071 |
0.6566 | Remote Similarity | NPC187471 |
0.6566 | Remote Similarity | NPC1340 |
0.6535 | Remote Similarity | NPC317242 |
0.6505 | Remote Similarity | NPC18857 |
0.6505 | Remote Similarity | NPC67657 |
0.65 | Remote Similarity | NPC473994 |
0.65 | Remote Similarity | NPC153719 |
0.6496 | Remote Similarity | NPC241879 |
0.6491 | Remote Similarity | NPC292819 |
0.6471 | Remote Similarity | NPC163597 |
0.6466 | Remote Similarity | NPC262050 |
0.6465 | Remote Similarity | NPC192192 |
0.6465 | Remote Similarity | NPC232925 |
0.6465 | Remote Similarity | NPC63588 |
0.6465 | Remote Similarity | NPC251201 |
0.6455 | Remote Similarity | NPC228059 |
0.6442 | Remote Similarity | NPC477282 |
0.6442 | Remote Similarity | NPC269333 |
0.6442 | Remote Similarity | NPC81074 |
0.6442 | Remote Similarity | NPC287452 |
0.6436 | Remote Similarity | NPC477508 |
0.6429 | Remote Similarity | NPC167644 |
0.6429 | Remote Similarity | NPC474756 |
0.6429 | Remote Similarity | NPC311246 |
0.6423 | Remote Similarity | NPC478137 |
0.6417 | Remote Similarity | NPC470595 |
0.6415 | Remote Similarity | NPC475388 |
0.641 | Remote Similarity | NPC470592 |
0.6408 | Remote Similarity | NPC133596 |
0.6408 | Remote Similarity | NPC11907 |
0.64 | Remote Similarity | NPC100586 |
0.64 | Remote Similarity | NPC157422 |
0.64 | Remote Similarity | NPC221196 |
0.64 | Remote Similarity | NPC39485 |
0.64 | Remote Similarity | NPC109457 |
0.64 | Remote Similarity | NPC127094 |
0.6396 | Remote Similarity | NPC279329 |
0.6389 | Remote Similarity | NPC232044 |
0.6389 | Remote Similarity | NPC273290 |
0.6389 | Remote Similarity | NPC266651 |
0.6381 | Remote Similarity | NPC7479 |
0.6381 | Remote Similarity | NPC257296 |
0.6381 | Remote Similarity | NPC248944 |
0.6373 | Remote Similarity | NPC243027 |
0.6373 | Remote Similarity | NPC196136 |
0.6373 | Remote Similarity | NPC158208 |
0.6372 | Remote Similarity | NPC113500 |
0.6372 | Remote Similarity | NPC477224 |
0.6372 | Remote Similarity | NPC3538 |
0.6364 | Remote Similarity | NPC254037 |
0.6364 | Remote Similarity | NPC477820 |
0.6364 | Remote Similarity | NPC66407 |
0.6364 | Remote Similarity | NPC129829 |
0.6346 | Remote Similarity | NPC471769 |
0.6339 | Remote Similarity | NPC59006 |
0.6339 | Remote Similarity | NPC293609 |
0.6339 | Remote Similarity | NPC36372 |
0.6337 | Remote Similarity | NPC470610 |
0.6333 | Remote Similarity | NPC317534 |
0.633 | Remote Similarity | NPC471240 |
0.6321 | Remote Similarity | NPC192456 |
0.6311 | Remote Similarity | NPC472359 |
0.6306 | Remote Similarity | NPC323156 |
0.63 | Remote Similarity | NPC282454 |
0.6296 | Remote Similarity | NPC320824 |
0.6296 | Remote Similarity | NPC227260 |
0.6286 | Remote Similarity | NPC476176 |
0.6283 | Remote Similarity | NPC277774 |
0.6275 | Remote Similarity | NPC10476 |
0.6275 | Remote Similarity | NPC48795 |
0.6275 | Remote Similarity | NPC192501 |
0.6275 | Remote Similarity | NPC228994 |
0.6273 | Remote Similarity | NPC210658 |
0.6273 | Remote Similarity | NPC5943 |
0.6273 | Remote Similarity | NPC472396 |
0.6273 | Remote Similarity | NPC161928 |
0.6271 | Remote Similarity | NPC176012 |
0.6262 | Remote Similarity | NPC470611 |
0.626 | Remote Similarity | NPC265275 |
0.626 | Remote Similarity | NPC246399 |
0.626 | Remote Similarity | NPC48886 |
0.626 | Remote Similarity | NPC94881 |
0.626 | Remote Similarity | NPC34977 |
0.625 | Remote Similarity | NPC473542 |
0.625 | Remote Similarity | NPC474574 |
0.625 | Remote Similarity | NPC64081 |
0.6239 | Remote Similarity | NPC290612 |
0.6238 | Remote Similarity | NPC473279 |
0.623 | Remote Similarity | NPC147835 |
0.623 | Remote Similarity | NPC253645 |
0.623 | Remote Similarity | NPC85001 |
0.623 | Remote Similarity | NPC95920 |
0.6228 | Remote Similarity | NPC473774 |
0.6228 | Remote Similarity | NPC45959 |
0.6228 | Remote Similarity | NPC473503 |
0.6228 | Remote Similarity | NPC175 |
0.6228 | Remote Similarity | NPC30687 |
0.6228 | Remote Similarity | NPC252253 |
0.6228 | Remote Similarity | NPC309866 |
0.6228 | Remote Similarity | NPC24960 |
0.6226 | Remote Similarity | NPC16449 |
0.6226 | Remote Similarity | NPC474714 |
0.6216 | Remote Similarity | NPC281004 |
0.6216 | Remote Similarity | NPC128475 |
0.6214 | Remote Similarity | NPC231680 |
0.6214 | Remote Similarity | NPC91387 |
0.6214 | Remote Similarity | NPC270306 |
0.6212 | Remote Similarity | NPC470537 |
0.621 | Remote Similarity | NPC124358 |
0.6207 | Remote Similarity | NPC477223 |
0.6207 | Remote Similarity | NPC477222 |
0.6204 | Remote Similarity | NPC232023 |
0.6204 | Remote Similarity | NPC478054 |
0.6202 | Remote Similarity | NPC242692 |
0.62 | Remote Similarity | NPC107919 |
0.6198 | Remote Similarity | NPC478053 |
0.6195 | Remote Similarity | NPC473830 |
0.6195 | Remote Similarity | NPC149966 |
0.6195 | Remote Similarity | NPC5632 |
0.6195 | Remote Similarity | NPC204881 |
0.6194 | Remote Similarity | NPC478139 |
0.619 | Remote Similarity | NPC147993 |
0.619 | Remote Similarity | NPC471045 |
0.6182 | Remote Similarity | NPC131365 |
0.6182 | Remote Similarity | NPC321340 |
0.6182 | Remote Similarity | NPC215968 |
0.6182 | Remote Similarity | NPC119633 |
0.6182 | Remote Similarity | NPC270957 |
0.6182 | Remote Similarity | NPC155531 |
0.6182 | Remote Similarity | NPC171698 |
0.6174 | Remote Similarity | NPC469710 |
0.6174 | Remote Similarity | NPC473065 |
0.6174 | Remote Similarity | NPC473067 |
0.6174 | Remote Similarity | NPC473064 |
0.6174 | Remote Similarity | NPC92196 |
0.6168 | Remote Similarity | NPC73515 |
0.6167 | Remote Similarity | NPC470596 |
0.6167 | Remote Similarity | NPC475239 |
0.6162 | Remote Similarity | NPC48079 |
0.6161 | Remote Similarity | NPC473472 |
0.6161 | Remote Similarity | NPC82955 |
0.6161 | Remote Similarity | NPC102725 |
0.6161 | Remote Similarity | NPC74258 |
0.6154 | Remote Similarity | NPC473638 |
0.6154 | Remote Similarity | NPC470145 |
0.614 | Remote Similarity | NPC144790 |
0.614 | Remote Similarity | NPC149400 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC267217 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
0.7345 | Intermediate Similarity | NPD7646 | Clinical (unspecified phase) |
0.7222 | Intermediate Similarity | NPD7991 | Discontinued |
0.7091 | Intermediate Similarity | NPD7919 | Phase 3 |
0.7091 | Intermediate Similarity | NPD7920 | Phase 3 |
0.7027 | Intermediate Similarity | NPD8088 | Phase 1 |
0.7 | Intermediate Similarity | NPD7755 | Approved |
0.7 | Intermediate Similarity | NPD7754 | Approved |
0.6957 | Remote Similarity | NPD6920 | Discontinued |
0.693 | Remote Similarity | NPD7911 | Approved |
0.693 | Remote Similarity | NPD7987 | Approved |
0.693 | Remote Similarity | NPD7912 | Approved |
0.693 | Remote Similarity | NPD7986 | Approved |
0.681 | Remote Similarity | NPD8040 | Discontinued |
0.6752 | Remote Similarity | NPD7989 | Approved |
0.6752 | Remote Similarity | NPD7990 | Approved |
0.6667 | Remote Similarity | NPD8418 | Phase 2 |
0.6636 | Remote Similarity | NPD8308 | Discontinued |
0.6555 | Remote Similarity | NPD8174 | Phase 2 |
0.6555 | Remote Similarity | NPD6415 | Discontinued |
0.6475 | Remote Similarity | NPD8077 | Approved |
0.6475 | Remote Similarity | NPD8078 | Approved |
0.6381 | Remote Similarity | NPD6928 | Phase 2 |
0.62 | Remote Similarity | NPD4267 | Clinical (unspecified phase) |
0.619 | Remote Similarity | NPD6940 | Discontinued |
0.616 | Remote Similarity | NPD8298 | Phase 2 |
0.6 | Remote Similarity | NPD8171 | Discontinued |
0.598 | Remote Similarity | NPD4787 | Phase 1 |
0.5965 | Remote Similarity | NPD6700 | Approved |
0.5965 | Remote Similarity | NPD6701 | Clinical (unspecified phase) |
0.5913 | Remote Similarity | NPD6703 | Approved |
0.5913 | Remote Similarity | NPD6702 | Approved |
0.587 | Remote Similarity | NPD8449 | Approved |
0.5827 | Remote Similarity | NPD8450 | Suspended |
0.5741 | Remote Similarity | NPD6115 | Approved |
0.5741 | Remote Similarity | NPD6118 | Approved |
0.5741 | Remote Similarity | NPD6114 | Approved |
0.5741 | Remote Similarity | NPD6697 | Approved |
0.5664 | Remote Similarity | NPD394 | Phase 3 |
PubChem CID   | 5281278 |
ChEMBL   | CHEMBL1242438 |
ZINC   |
Molecular Weight:   | 377.26 |
ALogP:   | -2.568 |
MLogP:   | 3.33 |
XLogP:   | 0.869 |
# Rotatable Bonds:   | 8 |
Polar Surface Area:   | 73.16 |
# H-Bond Aceptor:   | 5 |
# H-Bond Donor:   | 3 |
# Rings:   | 6 |
# Heavy Atoms:   | 27 |