Natural Product: NPC266383

Natural Product ID:  NPC266383
Common Name:   Matrine
IUPAC Name:  
Synonyms:   Matrine
Molecular Formula:   C15H24N2O
Standard InCHIKey:  ZSBXGIUJOOQZMP-JLNYLFASSA-N
Standard InCHI:  InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
Canonical SMILES:  O=C1CCC[C@H]2N1C[C@@H]1CCCN3[C@@H]1[C@@H]2CCC3
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO7715 Sophora tonkinensis Species Fabaceae Eukaryota Rhizomes Nanning, Guangxi Province, China 2012-DEC PMID[26132528]
NPO18668 Asimina parviflora Species Annonaceae Eukaryota UNPD*
NPO27514 Glyphotaelius pellucidus Species Limnephilidae Eukaryota UNPD*
NPO17258 Rhinella marina Species Bufonidae Eukaryota UNPD*
NPO1059 Sphaeranthus bullatus Species Asteraceae Eukaryota UNPD*
NPO20624 Simarouba glauca Species Simaroubaceae Eukaryota UNPD*
NPO28202 Helichrysum tenuifolium Species Asteraceae Eukaryota UNPD*
NPO20879 Clerodendrum bungei Species Lamiaceae Eukaryota UNPD*
NPO22937 Vernonia fagifolia Species Asteraceae Eukaryota UNPD*
NPO19231 Sophora flavescens Species Fabaceae Eukaryota TCM_Taiwan*
NPO20471 Sophora alopecuroides Species Fabaceae Eukaryota TCM_Taiwan*
NPO27572 Sophora subprostrata Species Fabaceae Eukaryota TCM_Taiwan*
NPO3886 Leontice alberti Species Berberidaceae Eukaryota UNPD*
NPO27666 Sophora tetraptera Species Fabaceae Eukaryota TCM_Taiwan*
NPO19995 Baccharis neglecta Species Asteraceae Eukaryota UNPD*
NPO30647 Sophora vicllfolia Species Fabaceae Eukaryota TCM_Taiwan*
NPO3152 Morella rubra Species Myricaceae Eukaryota UNPD*
NPO7715 Sophora tonkinensis Species Fabaceae Eukaryota TCM_Taiwan*
NPO21495 Abelia chinensis Species Caprifoliaceae Eukaryota UNPD*
NPO9683 Sophora chrysophylla Species Fabaceae Eukaryota TCM_Taiwan*
NPO9968 Shigella dysenteriae Species Enterobacteriaceae Bacteria UNPD*
NPO17560 Pancratium sickenbergeri Species Amaryllidaceae Eukaryota UNPD*
NPO13449 Syzygium polycephaloides Species Myrtaceae Eukaryota UNPD*
NPO27367 Latrunculia magnifica Species Latrunculiidae Eukaryota UNPD*
NPO20598 Lythrum salicaria Species Lythraceae Eukaryota UNPD*
NPO19667 Hypericum styphelioides Species Hypericaceae Eukaryota UNPD*
NPO19036 Esenbeckia leiocarpa Species Rutaceae Eukaryota UNPD*
NPO21562 Diospyros assimilis Species Ebenaceae Eukaryota UNPD*
NPO18866 Pteridium esculentum Species Dennstaedtiaceae Eukaryota UNPD*
NPO28169 Aleurites cordata Species Euphorbiaceae Eukaryota UNPD*
NPO12313 Haplophyllum obtusifolium Species Rutaceae Eukaryota UNPD*
NPO4051 Tricholoma columbetta Species Tricholomataceae Eukaryota UNPD*
NPO121 Fraxinus malacophylla Species Oleaceae Eukaryota UNPD*
NPO21170 Embelia parviflora Species Primulaceae Eukaryota UNPD*
NPO20421 Aplophyllum alberti-regelii NA NA NA UNPD*
NPO21631 Faramea salicifolia Species Rubiaceae Eukaryota UNPD*
NPO21108 Eria anomala Species Orchidaceae Eukaryota UNPD*
NPO20680 Erythrina melanacantha Species Fabaceae Eukaryota UNPD*
NPO19912 Vellozia nanuzae Species Velloziaceae Eukaryota UNPD*
NPO18286 Lycogala epidendrum Species Enteridiidae Eukaryota UNPD*
NPO16141 Piper regnellii Species Piperaceae Eukaryota UNPD*
NPO19511 Dolabella californica Species Aplysiidae Eukaryota UNPD*
NPO18143 Dendronephthya griffini Species Nephtheidae Eukaryota UNPD*
NPO17849 Centaurea maculosa Species Asteraceae Eukaryota UNPD*
NPO16569 Gymnocalycium schickendantzii Species Cactaceae Eukaryota UNPD*
NPO20843 Monsonia senegalensis Species Geraniaceae Eukaryota UNPD*
NPO17334 Onopordum acanthium Species Asteraceae Eukaryota UNPD*
NPO28367 Talauma arcabucoana Species Magnoliaceae Eukaryota UNPD*
NPO12056 Chondrodendron tomentosum Species Menispermaceae Eukaryota UNPD*
NPO21375 Euphorbia nematocypha Species Euphorbiaceae Eukaryota UNPD*
NPO15557 Menispermi rhizoma NA NA NA TCMSP*
NPO21243 Siphonaria capensis Species Siphonariidae Eukaryota UNPD*
NPO22961 Cordia leucocephala Species Cordiaceae Eukaryota UNPD*
NPO29721 Cuscutae semen NA NA NA TCMSP*
NPO28072 Theonella conica Species Theonellidae Eukaryota UNPD*
NPO17736 Fructussophorae NA NA NA TCMSP*
NPO19930 [clostridium] symbiosum Species Lachnospiraceae Bacteria UNPD*
NPO19231 Sophora flavescens Species Fabaceae Eukaryota UNPD*
NPO5900 Sophorae tonkinensis radix et rhizome NA NA NA TCMSP*
NPO18473 Plathymenia reticulata Species Fabaceae Eukaryota UNPD*
NPO21038 Lemaireocereus longispinus Species Cactaceae Eukaryota UNPD*
NPO3430 Sophorae flavescentis radix NA NA NA TCMSP*
NPO28857 Ixanthus viscosus Species Gentianaceae Eukaryota UNPD*
NPO20489 Epilobium hirsutum Species Onagraceae Eukaryota UNPD*
NPO19231 Sophora flavescens Species Fabaceae Eukaryota TM-MC*
NPO20142 Embelia schimperi Species Primulaceae Eukaryota UNPD*
NPO20084 Atraphaxis spinosa Species Polygonaceae Eukaryota UNPD*
NPO7715 Sophora tonkinensis Species Fabaceae Eukaryota TM-MC*
NPO5903 Conus mus Species Conidae Eukaryota UNPD*
NPO14241 Planchonia grandis Species Asterolecaniidae Eukaryota UNPD*
NPO19810 Myxococcus stipitatus Species Myxococcaceae Bacteria UNPD*
NPO18176 Ephedra sinica Species Ephedraceae Eukaryota UNPD*
NPO11523 Erysimum leptophyllum Species Brassicaceae Eukaryota UNPD*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT963 Organism Hepatitis B virus Hepatitis B virus Activity = 30.9 % 16364643
NPT963 Organism Hepatitis B virus Hepatitis B virus Activity = 8.9 % 16364643
NPT963 Organism Hepatitis B virus Hepatitis B virus Activity = 2.7 % 16364643
NPT963 Organism Hepatitis B virus Hepatitis B virus Activity = 0 % 16364643
NPT65 Cell Line HepG2 Homo sapiens Activity >= 25 % 16364643
NPT2 Others Unspecified FC = 5.11 21036613
NPT113 Cell Line RAW264.7 Mus musculus IC50 > 200000 nM 21036613
NPT2 Others Unspecified Inhibition = 52.4 % 21218816
NPT2 Others Unspecified Inhibition = 52.4 % 21757347
NPT2 Others Unspecified IC50 = 15.3 ug/ml 22578453
NPT169 Cell Line B16-F10 Mus musculus IC50 = 17 ug/ml 22578453
NPT81 Cell Line A549 Homo sapiens IC50 = 9.7 ug/ml 22578453
NPT2 Others Unspecified IC50 = 16.3 ug/ml 22578453
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus Inhibition = -1.14 % 23062825
NPT67 Individual Protein Cholinesterase Equus caballus Inhibition = 22.38 % 23062825
NPT616 Cell Line MDCK Canis lupus familiaris CC50 > 80000 nM 25147619
NPT1453 Organism Influenza A virus (A/PR/8/34(H1N1)) Influenza A virus (A/Puerto Rico/8/1934(H1N1)) EC50 > 80000 nM 25147619
NPT81 Cell Line A549 Homo sapiens IC50 > 50000 nM 25959813
NPT2 Others Unspecified IC50 > 50000 nM 25959813
NPT165 Cell Line HeLa Homo sapiens IC50 > 50000 nM 25959813
NPT83 Cell Line MCF7 Homo sapiens IC50 > 50000 nM 25959813
NPT81 Cell Line A549 Homo sapiens Activity = 28.4 % 25959813
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 > 40000 nM 26865176
NPT2 Others Unspecified IC50 > 40000 nM 26865176
NPT91 Cell Line KB Homo sapiens IC50 > 40000 nM 26865176
NPT81 Cell Line A549 Homo sapiens IC50 > 40000 nM 26865176

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC266383 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC68043
1.0 High Similarity NPC271803
1.0 High Similarity NPC180401
1.0 High Similarity NPC206241
1.0 High Similarity NPC48448
1.0 High Similarity NPC290231
0.9275 High Similarity NPC80447
0.8312 Intermediate Similarity NPC124359
0.7901 Intermediate Similarity NPC168017
0.7711 Intermediate Similarity NPC178632
0.7564 Intermediate Similarity NPC268580
0.75 Intermediate Similarity NPC151004
0.75 Intermediate Similarity NPC228980
0.75 Intermediate Similarity NPC243635
0.7089 Intermediate Similarity NPC308050
0.6867 Remote Similarity NPC255430
0.6707 Remote Similarity NPC127430
0.6707 Remote Similarity NPC120699
0.6324 Remote Similarity NPC248956
0.6322 Remote Similarity NPC61321
0.6322 Remote Similarity NPC78058
0.6322 Remote Similarity NPC207048
0.6322 Remote Similarity NPC135639
0.6322 Remote Similarity NPC234822
0.6322 Remote Similarity NPC143344
0.6222 Remote Similarity NPC237535
0.6136 Remote Similarity NPC57163
0.6136 Remote Similarity NPC116881
0.6 Remote Similarity NPC39308
0.5926 Remote Similarity NPC255050
0.5926 Remote Similarity NPC127553
0.5851 Remote Similarity NPC145707
0.5732 Remote Similarity NPC473442
0.5732 Remote Similarity NPC120167
0.5714 Remote Similarity NPC17770
0.5714 Remote Similarity NPC34811
0.5692 Remote Similarity NPC141914

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC266383 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.75 Intermediate Similarity NPD1821 Approved
0.75 Intermediate Similarity NPD1822 Approved
0.75 Intermediate Similarity NPD1823 Approved
0.6707 Remote Similarity NPD7155 Clinical (unspecified phase)
0.6364 Remote Similarity NPD3176 Clinical (unspecified phase)
0.6087 Remote Similarity NPD6934 Discontinued
0.6056 Remote Similarity NPD3727 Discontinued
0.5862 Remote Similarity NPD3155 Clinical (unspecified phase)
0.5811 Remote Similarity NPD605 Clinical (unspecified phase)

Structure

External Identifiers

PubChem CID   91466
ChEMBL   CHEMBL204860
ZINC  

Physicochemical Properties

Molecular Weight:  248.19
ALogP:  -1.9058
MLogP:  2.78
XLogP:  1.381
# Rotatable Bonds:  0
Polar Surface Area:  23.55
# H-Bond Aceptor:  3
# H-Bond Donor:  0
# Rings:  4
# Heavy Atoms:  18

Download Data

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