Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT443 | Individual Protein | Histone acetyltransferase GCN5 | Homo sapiens | Potency | 25118.9 | nM | PubChem BioAssay data set | |
NPT199 | Individual Protein | DNA polymerase kappa | Homo sapiens | Potency | 29934.9 | nM | PubChem BioAssay data set |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC16561 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
0.8214 | Intermediate Similarity | NPC38513 |
0.7931 | Intermediate Similarity | NPC266539 |
0.7931 | Intermediate Similarity | NPC31891 |
0.7931 | Intermediate Similarity | NPC287191 |
0.7931 | Intermediate Similarity | NPC266144 |
0.7586 | Intermediate Similarity | NPC88325 |
0.7419 | Intermediate Similarity | NPC76765 |
0.7419 | Intermediate Similarity | NPC179103 |
0.6765 | Remote Similarity | NPC151719 |
0.6552 | Remote Similarity | NPC127355 |
0.6389 | Remote Similarity | NPC62779 |
0.6341 | Remote Similarity | NPC160588 |
0.6216 | Remote Similarity | NPC182392 |
0.6207 | Remote Similarity | NPC178306 |
0.6176 | Remote Similarity | NPC34671 |
0.6098 | Remote Similarity | NPC469969 |
0.6071 | Remote Similarity | NPC33192 |
0.5897 | Remote Similarity | NPC216416 |
0.5882 | Remote Similarity | NPC138325 |
0.587 | Remote Similarity | NPC475153 |
0.5862 | Remote Similarity | NPC225855 |
0.5833 | Remote Similarity | NPC471327 |
0.5833 | Remote Similarity | NPC196831 |
0.5833 | Remote Similarity | NPC3649 |
0.5833 | Remote Similarity | NPC100879 |
0.5814 | Remote Similarity | NPC99746 |
0.5745 | Remote Similarity | NPC475071 |
0.5714 | Remote Similarity | NPC138113 |
0.5641 | Remote Similarity | NPC213767 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC16561 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
NPD |
PubChem CID   | 284148 |
ChEMBL   | CHEMBL1702186 |
ZINC   |
Molecular Weight:   | 232.08 |
ALogP:   | -0.1525 |
MLogP:   | 2.56 |
XLogP:   | 6.28 |
# Rotatable Bonds:   | 10 |
Polar Surface Area:   | 0 |
# H-Bond Aceptor:   | 0 |
# H-Bond Donor:   | 0 |
# Rings:   | 0 |
# Heavy Atoms:   | 12 |