NPASS Natural Product

Natural Product: NPC146422

Natural Product ID:	NPC146422
Common Name:	Dopamine
IUPAC Name:	4-(2-aminoethyl)benzene-1,2-diol
Synonyms:	Carbilev; Dopamine; Intropin; Parcopa; Sinemet
Molecular Formula:	C8H11NO2
Standard InCHIKey:	VYFYYTLLBUKUHU-UHFFFAOYSA-N
Standard InCHI:	InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
Canonical SMILES:	NCCc1ccc(c(c1)O)O
First Find Year:
Max Developmental Stage:
Synthetic Gene Cluster:	;

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Reference
NPO11363	Piper argyrophyllum	Species	Piperaceae	Eukaryota		UNPD*
NPO15165	Magnolia borealis	Species	Magnoliaceae	Eukaryota		UNPD*
NPO27952	Rhizoma dioscoreae	NA	NA	NA		TCMSP*
NPO29621	Portulacae herba	NA	NA	NA		TCMSP*
NPO4640	Portulaca oleracea	Species	Portulacaceae	Eukaryota		TM-MC*
NPO1797	Homo sapiens	Species	Hominidae	Eukaryota	cerebrospinal fluid	PMID[12834252]
NPO1797	Homo sapiens	Species	Hominidae	Eukaryota	Faeces	PMID[20669995]
NPO1797	Homo sapiens	Species	Hominidae	Eukaryota	blood	PMID[17031479]
NPO1797	Homo sapiens	Species	Hominidae	Eukaryota	urine	PMID[15080725]
NPO20338	Mus musculus	Species	Muridae	Eukaryota		PMID[19425150]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria		PMID[21988831]

Biological Activity

Activity Type	# Activity
AC50	3
EC50	73
ED50	4
IC50	52
Kd	8
Ki	115
Others	89
Potency	89

Activity Type	# Activity
Cell Line	3
Individual Protein	287
Organism	33
Others	92
Protein Family	18

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	210	%	7069700
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	167	%	7069700
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Ki	=	192	nM	1973733
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	32	%	7252978
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	IC50	=	29	nM	7252978
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	1860	nM	3172140
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	1700	nM	3172140
NPT288	Individual Protein	Serotonin 1a (5-HT1a) receptor	Rattus norvegicus	Ki	>	10000	nM	8230102
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Kd	=	6200	nM	10956209
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Kd	=	267000	nM	10956209
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Kd	=	37000	nM	10956209
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Kd	=	49000	nM	10956209
NPT4222	Cell Line	YT-NU	Homo sapiens	Inhibition	=	40	%	6788955
NPT4223	Cell Line	Don	Cricetulus griseus	Inhibition	=	30	%	6788955
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	ED20	=	11	nM kg-1	10.1016/S0960-894X(96)00518-5
NPT4657	Individual Protein	Dopamine D1 receptor	Bos taurus	Ki	=	4300	nM	11206464
NPT2	Others	Unspecified		Ki	=	130	nM	11206464
NPT2	Others	Unspecified		Ki	=	15	nM	11206464
NPT4411	Others	Dopamine receptors; D2 & D4	Homo sapiens	Ratio	=	9		11206464
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	1.89	nM	10465538
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	759	nM	10465538
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ratio	=	400		10465538
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Inhibition	=	16	%	10465538
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	ED50	=	3.5	nM	2875183
NPT419	Organism	Oryctolagus cuniculus	Oryctolagus cuniculus	ED50	=	0.037	nM	2875183
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	3045	nM	2888899
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Ki	=	416.87	nM	10691686
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Ki	=	724.44	nM	10691686
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	EC50	=	3.5		4068005
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Kb	=	2350	nM	4068005
NPT419	Organism	Oryctolagus cuniculus	Oryctolagus cuniculus	ED50	=	37	nM	4068005
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	1.89	nM	8893836
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	572	nM	8893836
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	13.2	nM	8893836
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Activity	=	18.8	%	8893836
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Activity	=	19.8	%	8893836
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	1200	nM	3950903
NPT968	Protein Family	Adrenergic receptor alpha-1	Rattus norvegicus	IC50	=	90000	nM	3950903
NPT246	Individual Protein	Dopamine transporter	Homo sapiens	Ki	=	6400	nM	14592523
NPT246	Individual Protein	Dopamine transporter	Homo sapiens	IC50	=	460	nM	14592523
NPT295	Individual Protein	Serotonin transporter	Homo sapiens	Ki	>	1100000	nM	14592523
NPT295	Individual Protein	Serotonin transporter	Homo sapiens	IC50	>	30000	nM	14592523
NPT228	Individual Protein	Norepinephrine transporter	Homo sapiens	Ki	>	28000	nM	14592523
NPT228	Individual Protein	Norepinephrine transporter	Homo sapiens	IC50	=	6.63	nM	14592523
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Ki	=	18200	nM	9784114
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	7940	nM	9784114
NPT938	Organism	Cavia porcellus	Cavia porcellus	EC50	=	1500	nM	7277389
NPT938	Organism	Cavia porcellus	Cavia porcellus	EC50	=	1700	nM	7277389
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	Potency	=	58.1	nM kg-1	7277389
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	Potency	=	125	nM kg-1	7277389
NPT4659	Protein Family	Dopamine receptor	Bos taurus	IC50	=	64	nM	6106063
NPT4659	Protein Family	Dopamine receptor	Bos taurus	IC50	=	1700	nM	6106063
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EC50	=	3500	nM	7069713
NPT2	Others	Unspecified		Ratio	=	56		7069713
NPT2	Others	Unspecified		Ratio	=	113		7069713
NPT2	Others	Unspecified		Ratio	=	141		7069713
NPT4657	Individual Protein	Dopamine D1 receptor	Bos taurus	IC50	=	200	nM	10.1016/S0960-894X(00)80265-6
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	IC50	=	8000	nM	10.1016/S0960-894X(00)80265-6
NPT3052	Protein Family	Dopamine receptor	Rattus norvegicus	IC50	=	2	nM	7200145
NPT3052	Protein Family	Dopamine receptor	Rattus norvegicus	IC50	=	2.1	nM	7200145
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Ki	=	309.03	nM	10.1016/0960-894X(95)00413-N
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Ki	=	104.71	nM	10.1016/0960-894X(95)00413-N
NPT970	Protein Family	Adrenergic receptor alpha-1	Homo sapiens	Ki	=	2511.89	nM	10.1016/0960-894X(95)00413-N
NPT3054	Individual Protein	Adenosine A2b receptor	Rattus norvegicus	Ki	=	977.24	nM	10.1016/0960-894X(95)00413-N
NPT419	Organism	Oryctolagus cuniculus	Oryctolagus cuniculus	EC50	=	38	nM	2871192
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	20	nM	10691700
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	17	nM	10691700
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	50	nM	10691700
NPT245	Individual Protein	Dopamine D4 receptor	Homo sapiens	Ki	=	1.2	nM	10691700
NPT4657	Individual Protein	Dopamine D1 receptor	Bos taurus	Ki	=	7	nM	10691700
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	11	nM	10691700
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	1.8	nM	10691700
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	1900	nM	10691700
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	1100	nM	10691700
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	1600	nM	10691700
NPT245	Individual Protein	Dopamine D4 receptor	Homo sapiens	Ki	=	62	nM	10691700
NPT4657	Individual Protein	Dopamine D1 receptor	Bos taurus	Ki	=	650	nM	10691700
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	1600	nM	10691700
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	42	nM	10691700
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	34	nM	10691700
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	52	nM	10691700
NPT245	Individual Protein	Dopamine D4 receptor	Homo sapiens	Ki	=	57	nM	10691700
NPT4657	Individual Protein	Dopamine D1 receptor	Bos taurus	Ki	=	36	nM	10691700
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	51	nM	10691700
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	15000	nM	10691700
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	290	nM	10691700
NPT245	Individual Protein	Dopamine D4 receptor	Homo sapiens	Ki	=	97	nM	10691700
NPT4657	Individual Protein	Dopamine D1 receptor	Bos taurus	Ki	=	1600	nM	10691700
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	12000000	nM	10691700
NPT1786	Protein Family	Dopamine receptor	Homo sapiens	IC50	=	15	nM	6737423
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Ki	=	15	nM	3761308
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Ki	=	4400	nM	3761308
NPT4660	Individual Protein	cyclic AMP phosphoprotein	Rattus norvegicus	EC50	=	3500	nM	6317860
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	5340	nM	6317860
NPT2	Others	Unspecified		IC50	=	61	nM	6317860
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Ki	=	130	nM	7658429
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	EC50	=	100	nM	7658429
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	260	nM	7658429
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	170	nM	7658429
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Kd	=	2500	nM	8632409
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Kd	=	17000	nM	8632409
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Ki	>	3000	nM	1825848
NPT3056	Individual Protein	Dopamine D3 receptor	Rattus norvegicus	Ki	=	11	nM	9748351
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	10000	nM	6143827
NPT4046	Individual Protein	Melatonin receptor 1A	Homo sapiens	Ki	=	7100	nM	10.1016/S0960-894X(97)00444-7
NPT4047	Individual Protein	Melatonin receptor 1B	Homo sapiens	Ki	=	9100	nM	10.1016/S0960-894X(97)00444-7
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	IC50	=	8.00E-06	nM	3156993
NPT419	Organism	Oryctolagus cuniculus	Oryctolagus cuniculus	EC50	=	73	nM	3712384
NPT419	Organism	Oryctolagus cuniculus	Oryctolagus cuniculus	EC50	=	76	nM	2955118
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	IC50	=	4700	nM	2955118
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	EC50	=	3500	nM	2955118
NPT245	Individual Protein	Dopamine D4 receptor	Homo sapiens	EC50	=	2.2	nM	15239663
NPT4661	Individual Protein	Dopamine D4 receptor	Rattus norvegicus	EC50	=	2.7	nM	15239663
NPT4661	Individual Protein	Dopamine D4 receptor	Rattus norvegicus	EC50	=	2.4	nM	15239663
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	18	nM	15239663
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	EC50	=	8	nM	15239663
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	EC50	=	1.1	nM	15239663
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	IC50	=	3000	nM	1975274
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	2200	nM	1975274
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Ki	=	843	nM	2136916
NPT968	Protein Family	Adrenergic receptor alpha-1	Rattus norvegicus	Ki	=	14000	nM	10780918
NPT969	Protein Family	Adrenergic receptor alpha-2	Rattus norvegicus	Ki	=	58	nM	10780918
NPT4558	Individual Protein	Beta-1 adrenergic receptor	Rattus norvegicus	Ki	=	10000	nM	10780918
NPT4663	Individual Protein	Beta-2 adrenergic receptor	Canis lupus familiaris	Ki	=	50000	nM	10780918
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	IC50	=	800	nM	1971308
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	1500	nM	1971308
NPT2	Others	Unspecified		IC50	=	5000	nM	1971308
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Ki	=	1437	nM	8093734
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Ki	=	5268	nM	8093734
NPT4659	Protein Family	Dopamine receptor	Bos taurus	IC50	=	4.5	nM	7120288
NPT4659	Protein Family	Dopamine receptor	Bos taurus	IC50	=	3.7	nM	7120288
NPT4659	Protein Family	Dopamine receptor	Bos taurus	IC50	>	10000	nM	7120288
NPT4657	Individual Protein	Dopamine D1 receptor	Bos taurus	Ki	=	4300	nM	9836610
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	14.9	nM	9836610
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	1520	nM	9836610
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	617	nM	9836610
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	3045	nM	1671414
NPT4664	Protein Family	Adenylate cyclase	Rattus norvegicus	EC50	=	3500	nM	6980283
NPT3052	Protein Family	Dopamine receptor	Rattus norvegicus	IC50	=	5340	nM	6980283
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	ED15	=	2.7	ug kg-1	6980283
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Ki	=	150	nM	3761310
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	2350	nM	3761310
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	ED30	=	5.5	nM	3528490
NPT3056	Individual Protein	Dopamine D3 receptor	Rattus norvegicus	Ki	=	49.3	nM	8098771
NPT1073	Individual Protein	Dopamine transporter	Rattus norvegicus	Ki	>	5000	nM	8182712
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	ED15	=	3.5	ug kg-1	2878077
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	ED30	=	151	ug kg-1	2878077
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	ED20	=	378	ug kg-1	2878077
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EC50	=	3500	nM	2878077
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	EC50	=	5000	nM	8568818
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	34	nM	2565402
NPT3471	Individual Protein	Dopamine D2 receptor	Bos taurus	Ki	=	3380	nM	2565402
NPT14	Individual Protein	Tyrosine-protein kinase FYN	Homo sapiens	IC50	>	100000	nM	10.1016/S0960-894X(96)00589-6
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Ki	>	1000	nM	8863801
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Ki	>	1000	nM	8863801
NPT2	Others	Unspecified		ED50	=	3.5	nM	2886663
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	ED15	=	2.7	ug kg-1	7411552
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EC50	=	3500	nM	7411552
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	IC50	=	3700	nM	1360027
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	3500	nM	1360027
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Ratio	=	1.06		1360027
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Inhibition	=	95	%	1360027
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Inhibition	=	92	%	1360027
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Inhibition	=	87	%	1360027
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Inhibition	=	83	%	1360027
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Inhibition	=	104	%	1360027
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Inhibition	=	113	%	1360027
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Inhibition	=	110	%	1360027
NPT1857	Individual Protein	Dopamine D1 receptor	Rattus norvegicus	Inhibition	=	151	%	1360027
NPT4659	Protein Family	Dopamine receptor	Bos taurus	IC50	=	150000	nM	7154005
NPT4659	Protein Family	Dopamine receptor	Bos taurus	IC50	=	510	nM	7154005
NPT1403	Organism	Felis catus	Felis catus	ID50	=	0.105	umol/kg	7154005
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Ki	=	296	nM	2966245
NPT1811	Individual Protein	Dopamine D5 receptor	Homo sapiens	Ki	=	2440	nM	15801855
NPT2	Others	Unspecified		Ki	=	3310	nM	15801855
NPT741	Individual Protein	Tyrosinase	Homo sapiens	Inhibition	=	10	%	16442796
NPT4106	Individual Protein	Amine oxidase, copper containing	Homo sapiens	Activity	=	0	%	17034126
NPT4369	Individual Protein	Amine oxidase, copper containing	Mus musculus	Activity	=	0	%	17034126
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	EC50	=	120	nM	17154515
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	EC50	=	5	nM	17154515
NPT245	Individual Protein	Dopamine D4 receptor	Homo sapiens	EC50	=	10	nM	17154515
NPT245	Individual Protein	Dopamine D4 receptor	Homo sapiens	EC50	=	2.2	nM	17149874
NPT2	Others	Unspecified		EC50	=	2.7	nM	17149874
NPT4661	Individual Protein	Dopamine D4 receptor	Rattus norvegicus	EC50	=	2.4	nM	17149874
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	18	nM	17149874
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	8	nM	17149874
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	EC50	=	1.1	nM	17149874
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	209	nM	18072730
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	8.53	nM	18072730
NPT2	Others	Unspecified		Ratio EC50	=	24.5		18072730
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	EC50	=	35	nM	18313303
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	43	nM	18313303
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	209	nM	18410082
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	8.53	nM	18410082
NPT2	Others	Unspecified		Ratio EC50	=	24.5		18410082
NPT613	Individual Protein	Solute carrier family 22 member 1	Homo sapiens	Inhibition	=	11.8	%	18788725
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	450	nM	18834111
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	360	nM	18834111
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	240	nM	18834111
NPT245	Individual Protein	Dopamine D4 receptor	Homo sapiens	Ki	=	6.2	nM	18834111
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	72	nM	18834111
NPT2	Others	Unspecified		Ki	=	1100	nM	18834111
NPT2	Others	Unspecified		Ratio Ki	=	15		18834111
NPT2	Others	Unspecified		Ki	>	80000	nM	18834111
NPT2	Others	Unspecified		Ratio Ki	>	1100		18834111
NPT1073	Individual Protein	Dopamine transporter	Rattus norvegicus	IC50	=	200	nM	8676127
NPT2	Others	Unspecified		Ratio IC50	=	4.8		8676127
NPT2	Others	Unspecified		Ratio IC50	=	4		8676127
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	209	nM	19427222
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	8.53	nM	19427222
NPT2	Others	Unspecified		Ratio EC50	=	24.5		19427222
NPT226	Individual Protein	Beta-2 adrenergic receptor	Homo sapiens	Kd	=	64560	nM	19168263
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Ki	=	197	nM	19454369
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	EC50	=	1425	nM	19454369
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Ki	=	124	nM	19454369
NPT2	Others	Unspecified		Ratio Ki	=	0.6		19454369
NPT43	Individual Protein	Tyrosinase	Agaricus bisporus	Activity	=	439	/s	19386398
NPT2	Others	Unspecified		Ratio EC50	=	24.5		20038106
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	209	nM	20038106
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	8.53	nM	20038106
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	2100	nM	20155917
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	2.9	nM	20155917
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ratio Ki	=	724		20155917
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	209	nM	20146482
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	4.76	nM	20146482
NPT2	Others	Unspecified		Ratio EC50	=	43.9		20146482
NPT246	Individual Protein	Dopamine transporter	Homo sapiens	Activity	>	10000	%	19962901
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	EC50	=	20	nM	20709559
NPT2	Others	Unspecified		Ki	=	251420	nM	16799554
NPT2	Others	Unspecified		Ki	=	234900	nM	16799554
NPT2	Others	Unspecified		Kd	=	1.33	nM	20801048
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	209	nM	20605099
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	4.76	nM	20605099
NPT2	Others	Unspecified		Ratio EC50	=	43.9		20605099
NPT2	Others	Unspecified		Ki	=	3900	nM	20801048
NPT2	Others	Unspecified		EC50	=	4800	nM	20801048
NPT47	Individual Protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	1778.3	nM	PubChem BioAssay data set
NPT149	Individual Protein	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Homo sapiens	Potency	=	31622.8	nM	PubChem BioAssay data set
NPT149	Individual Protein	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Homo sapiens	Potency	=	15848.9	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	=	89125.1	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	=	7943.3	nM	PubChem BioAssay data set
NPT47	Individual Protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	14125.4	nM	PubChem BioAssay data set
NPT48	Individual Protein	Lysine-specific demethylase 4D-like	Homo sapiens	Potency	=	15848.9	nM	PubChem BioAssay data set
NPT49	Individual Protein	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	Potency	=	28183.8	nM	PubChem BioAssay data set
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Potency	=	26121.6	nM	PubChem BioAssay data set
NPT50	Individual Protein	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens	Potency	=	1258.9	nM	PubChem BioAssay data set
NPT50	Individual Protein	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens	Potency	=	446.7	nM	PubChem BioAssay data set
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	5011.9	nM	PubChem BioAssay data set
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	1584.9	nM	PubChem BioAssay data set
NPT211	Individual Protein	Hypoxia-inducible factor 1 alpha	Homo sapiens	Potency	=	10000	nM	PubChem BioAssay data set
NPT94	Individual Protein	Aldehyde dehydrogenase 1A1	Homo sapiens	Potency	=	35481.3	nM	PubChem BioAssay data set
NPT94	Individual Protein	Aldehyde dehydrogenase 1A1	Homo sapiens	Potency	=	31622.8	nM	PubChem BioAssay data set
NPT53	Individual Protein	4'-phosphopantetheinyl transferase ffp	Bacillus subtilis	Potency	=	79432.8	nM	PubChem BioAssay data set
NPT53	Individual Protein	4'-phosphopantetheinyl transferase ffp	Bacillus subtilis	Potency	=	1258.9	nM	PubChem BioAssay data set
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	Potency	=	6309.6	nM	PubChem BioAssay data set
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Potency	=	23280.9	nM	PubChem BioAssay data set
NPT55	Individual Protein	Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	=	6294.6	nM	PubChem BioAssay data set
NPT282	Individual Protein	MAP kinase ERK2	Homo sapiens	Potency	=	28183.8	nM	PubChem BioAssay data set
NPT96	Individual Protein	Thrombopoietin	Homo sapiens	Potency	=	3162.3	nM	PubChem BioAssay data set
NPT539	Individual Protein	Cellular tumor antigen p53	Homo sapiens	Potency	=	12589.3	nM	PubChem BioAssay data set
NPT149	Individual Protein	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Homo sapiens	Potency	=	501.2	nM	PubChem BioAssay data set
NPT110	Individual Protein	Cytochrome P450 2D6	Homo sapiens	Potency	=	31622.8	nM	PubChem BioAssay data set
NPT47	Individual Protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	0.0316	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Activity	=	86	%	21041094
NPT35	Others	n.a.		Inhibition	=	43	%	21041094
NPT2	Others	Unspecified		IC50	=	100000	nM	21041094
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	13	%	21041094
NPT1482	Individual Protein	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	Leishmania major	Potency		23934.1	nM	PubChem BioAssay data set
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Potency		100	nM	PubChem BioAssay data set
NPT800	Individual Protein	M-phase phosphoprotein 8	Homo sapiens	Potency		1062.1	nM	PubChem BioAssay data set
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Potency		82	nM	PubChem BioAssay data set
NPT5	Individual Protein	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Homo sapiens	Potency		8912.5	nM	PubChem BioAssay data set
NPT62	Individual Protein	6-phospho-1-fructokinase	Trypanosoma brucei	Potency		30131.3	nM	PubChem BioAssay data set
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Potency		251.2	nM	PubChem BioAssay data set
NPT803	Individual Protein	Flap endonuclease 1	Homo sapiens	Potency		843.7	nM	PubChem BioAssay data set
NPT478	Individual Protein	Ataxin-2	Homo sapiens	Potency		22387.2	nM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Potency		16944.1	nM	PubChem BioAssay data set
NPT7	Individual Protein	Thioredoxin reductase 1, cytoplasmic	Rattus norvegicus	Potency		14125.4	nM	PubChem BioAssay data set
NPT803	Individual Protein	Flap endonuclease 1	Homo sapiens	Potency		89125.1	nM	PubChem BioAssay data set
NPT8	Individual Protein	DNA polymerase iota	Homo sapiens	Potency		89125.1	nM	PubChem BioAssay data set
NPT199	Individual Protein	DNA polymerase kappa	Homo sapiens	Potency		39810.7	nM	PubChem BioAssay data set
NPT199	Individual Protein	DNA polymerase kappa	Homo sapiens	Potency		89125.1	nM	PubChem BioAssay data set
NPT199	Individual Protein	DNA polymerase kappa	Homo sapiens	Potency		8912.5	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		18356.4	nM	PubChem BioAssay data set
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Potency		31622.8	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		28070.2	nM	PubChem BioAssay data set
NPT699	Individual Protein	UDP-glucuronosyltransferase 1-10	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT903	Individual Protein	UDP-glucuronosyltransferase 1-7	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT901	Individual Protein	UDP-glucuronosyltransferase 1-1	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT902	Individual Protein	UDP-glucuronosyltransferase 1A4	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT704	Individual Protein	UDP-glucuronosyltransferase 2B15	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT697	Individual Protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT445	Individual Protein	Peripheral myelin protein 22	Rattus norvegicus	Potency		8087.5	nM	PubChem BioAssay data set
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Ki	=	12000	nM	22846798
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	2100	nM	22846798
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	15	nM	22846798
NPT2	Others	Unspecified		Ratio Ki	=	5.7		22846798
NPT2	Others	Unspecified		Ratio Ki	=	800		22846798
NPT2	Others	Unspecified		Ratio Ki	=	140		22846798
NPT434	Individual Protein	Solute carrier family 22 member 5	Mus musculus	Activity	=	70.9	%	11160873
NPT613	Individual Protein	Solute carrier family 22 member 1	Homo sapiens	Activity	=	0.487	nM	12606755
NPT1544	Individual Protein	Solute carrier family 22 member 2	Rattus norvegicus	IC50	=	2300000	nM	9830022
NPT1542	Individual Protein	Solute carrier family 22 member 3	Rattus norvegicus	IC50	=	384000	nM	9830022
NPT1542	Individual Protein	Solute carrier family 22 member 3	Rattus norvegicus	IC50	=	62000	nM	9830022
NPT1544	Individual Protein	Solute carrier family 22 member 2	Rattus norvegicus	Ki	=	347000	nM	11758759
NPT435	Individual Protein	Solute carrier family 22 member 1	Rattus norvegicus	Ki	=	603000	nM	11758759
NPT100	Individual Protein	Glutaminase kidney isoform, mitochondrial	Homo sapiens	Potency		22387.2	nM	PubChem BioAssay data set
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Potency		51.7	nM	PubChem BioAssay data set
NPT478	Individual Protein	Ataxin-2	Homo sapiens	Potency		31622.8	nM	PubChem BioAssay data set
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	227	nM	22642365
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	8.57	nM	22642365
NPT2	Others	Unspecified		Ratio EC50	=	26.5		22642365
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	6.1	nM	23134120
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	65	nM	23134120
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	20	nM	23134120
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	422	nM	23134120
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Ki	=	4470	nM	23134120
NPT2	Others	Unspecified		Ratio EC50	=	42		23275802
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	5.8	nM	23275802
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	240	nM	23275802
NPT3056	Individual Protein	Dopamine D3 receptor	Rattus norvegicus	IC50	=	111	nM	10.1007/s00044-004-0006-x
NPT3056	Individual Protein	Dopamine D3 receptor	Rattus norvegicus	IC50	=	124	nM	10.1007/s00044-004-0006-x
NPT4666	Others	Dopamine receptor D2 and D3	Rattus norvegicus	IC50	=	483	nM	10.1007/s00044-004-0006-x
NPT4666	Others	Dopamine receptor D2 and D3	Rattus norvegicus	IC50	=	582	nM	10.1007/s00044-004-0006-x
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	3260	nM	10.1007/s00044-004-0006-x
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	IC50	=	3140	nM	10.1007/s00044-004-0006-x
NPT2	Others	Unspecified		IC50	>	300000	nM	23394144
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	21	nM	23428965
NPT245	Individual Protein	Dopamine D4 receptor	Homo sapiens	Ki	=	8.9	nM	23428965
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	110	nM	23428965
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	190	nM	23428965
NPT4657	Individual Protein	Dopamine D1 receptor	Bos taurus	Ki	=	440	nM	23428965
NPT2	Others	Unspecified		Potency		29855.4	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		5173.5	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		35481.3	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		31622.8	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		18837.5	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		4109.5	nM	PubChem BioAssay data set
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	1.8	nM	23675993
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Activity	=	100.3	%	23675993
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	6.7	nM	23675993
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Activity	=	101.3	%	23675993
NPT2	Others	Unspecified		Ratio EC50	=	26.6		23623679
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	7.64	nM	23623679
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	227	nM	23623679
NPT2	Others	Unspecified		Ratio Ki	=	140		23727194
NPT2	Others	Unspecified		Ratio Ki	=	5.7		23727194
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	15	nM	23727194
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	2100	nM	23727194
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	Ki	=	12000	nM	23727194
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	8	nM	24138311
NPT2	Others	Unspecified		Ratio EC50	=	1		24296012
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	36	nM	24296012
NPT242	Individual Protein	Dopamine D1 receptor	Homo sapiens	EC50	=	39	nM	24296012
NPT2	Others	Unspecified		Ratio EC50	=	26.5		24471976
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	10.6	nM	24471976
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	218	nM	24471976
NPT2	Others	Unspecified		Potency		268.3	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		29849.3	nM	PubChem BioAssay data set
NPT152	Individual Protein	Nuclear factor erythroid 2-related factor 2	Homo sapiens	Potency		375.8	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		37578	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		33491.5	nM	PubChem BioAssay data set
NPT104	Individual Protein	Cerebroside-sulfatase	Homo sapiens	Potency		26854.5	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		16774.4	nM	PubChem BioAssay data set
NPT49	Individual Protein	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	Potency		891.3	nM	PubChem BioAssay data set
NPT49	Individual Protein	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	Potency		1584.9	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		118.8	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		6309.6	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		13333.2	nM	PubChem BioAssay data set
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	2.7	10'-6mg/kg	671451
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	2.9	ug	533879
NPT4664	Protein Family	Adenylate cyclase	Rattus norvegicus	Activity	=	150	%	650669
NPT2	Others	Unspecified		EC50	=	309.03	nM	24831693
NPT2	Others	Unspecified		EC50	=	310	nM	24831693
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	467.74	nM	24831693
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	470	nM	24831693
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	9.333	nM	24831693
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	9.3	nM	24831693
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ratio	=	8.56		24827597
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ratio	=	8.72		24827597
NPT48	Individual Protein	Lysine-specific demethylase 4D-like	Homo sapiens	IC50	=	3000	nM	10.1039/C1MD00199J
NPT712	Individual Protein	Bile salt export pump	Rattus norvegicus	IC50	>	1000000	nM	21965623
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	1000000	nM	21965623
NPT2	Others	Unspecified		AC50		39810.7	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		4466.8	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency		4216.3	nM	PubChem BioAssay data set
NPT1	Others	Radical scavenging activity		Activity	=	86	%	26515039
NPT35	Others	n.a.		Inhibition	=	43	%	26515039
NPT2	Others	Unspecified		IC50	=	100000	nM	26515039
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	13	%	26515039
NPT1858	Individual Protein	Dopamine D2 receptor	Rattus norvegicus	Ki	=	990	nM	26555041
NPT3056	Individual Protein	Dopamine D3 receptor	Rattus norvegicus	Ki	=	101	nM	26555041
NPT2	Others	Unspecified		Ratio Ki	=	9.8		26555041
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	183	nM	26555041
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	5.34	nM	26555041
NPT2	Others	Unspecified		Ratio EC50	=	34.3		26555041
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ratio	=	8.5		26555041
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ratio	=	31.3		26555041
NPT2	Others	Unspecified		Ratio Ki	=	0.87		27035329
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	7.58	nM	27035329
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	8.73	nM	27035329
NPT2	Others	Unspecified		Ratio Ki	=	0.08		27035329
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	Ki	=	293	nM	27035329
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	3690	nM	27035329
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	5	nM	27035329
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	1.8	nM	27035329
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	EC50	=	7.7	nM	27035329
NPT244	Individual Protein	Dopamine D3 receptor	Homo sapiens	EC50	=	2.7	nM	27035329
NPT226	Individual Protein	Beta-2 adrenergic receptor	Homo sapiens	Ki	=	61000	nM	27132867
NPT243	Individual Protein	Dopamine D2 receptor	Homo sapiens	Ki	=	48	nM	27132867
NPT2	Others	Unspecified		Ratio Ki	=	710		27132867

Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC146422 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	118
0.1-0.2	1073
0.2-0.3	5218
0.3-0.4	8592
0.4-0.5	4899
0.5-0.6	7581
0.6-0.7	2825
0.7-0.8	524
0.8-0.85	39
0.85-0.9	14
0.9-0.95	6
0.95-1	0

Similarity Score	Similarity Level	Natural Product ID
0.9455	High Similarity	NPC85276
0.9286	High Similarity	NPC115627
0.9286	High Similarity	NPC118522
0.9286	High Similarity	NPC169207
0.9135	High Similarity	NPC68055
0.9091	High Similarity	NPC142599
0.8966	High Similarity	NPC140359
0.8966	High Similarity	NPC13020
0.8846	High Similarity	NPC125732
0.8803	High Similarity	NPC318777
0.875	High Similarity	NPC109955
0.8739	High Similarity	NPC323775
0.8739	High Similarity	NPC236347
0.8667	High Similarity	NPC16031
0.8667	High Similarity	NPC145888
0.8667	High Similarity	NPC161593
0.8655	High Similarity	NPC318965
0.8534	High Similarity	NPC268572
0.8522	High Similarity	NPC283468
0.8505	High Similarity	NPC110764
0.8468	Intermediate Similarity	NPC145638
0.8468	Intermediate Similarity	NPC290566
0.8455	Intermediate Similarity	NPC329595
0.8455	Intermediate Similarity	NPC326599
0.8448	Intermediate Similarity	NPC122009
0.8426	Intermediate Similarity	NPC196479
0.8411	Intermediate Similarity	NPC29601
0.839	Intermediate Similarity	NPC284078
0.8387	Intermediate Similarity	NPC88667
0.8381	Intermediate Similarity	NPC107522
0.8362	Intermediate Similarity	NPC120075
0.8349	Intermediate Similarity	NPC12278
0.8349	Intermediate Similarity	NPC471511
0.8349	Intermediate Similarity	NPC120719
0.8318	Intermediate Similarity	NPC131587
0.8304	Intermediate Similarity	NPC71266
0.8279	Intermediate Similarity	NPC321561
0.8273	Intermediate Similarity	NPC239291
0.8241	Intermediate Similarity	NPC223393
0.824	Intermediate Similarity	NPC300020
0.824	Intermediate Similarity	NPC33338
0.824	Intermediate Similarity	NPC302171
0.8205	Intermediate Similarity	NPC137096
0.8198	Intermediate Similarity	NPC477814
0.8158	Intermediate Similarity	NPC280382
0.8145	Intermediate Similarity	NPC271808
0.8091	Intermediate Similarity	NPC178902
0.8073	Intermediate Similarity	NPC155847
0.8073	Intermediate Similarity	NPC289381
0.8065	Intermediate Similarity	NPC153990
0.8056	Intermediate Similarity	NPC107619
0.8053	Intermediate Similarity	NPC233835
0.8034	Intermediate Similarity	NPC10286
0.8034	Intermediate Similarity	NPC213
0.8018	Intermediate Similarity	NPC52087
0.8018	Intermediate Similarity	NPC79672
0.8	Intermediate Similarity	NPC170170
0.8	Intermediate Similarity	NPC219233
0.8	Intermediate Similarity	NPC211468
0.7982	Intermediate Similarity	NPC55617
0.7982	Intermediate Similarity	NPC62258
0.7982	Intermediate Similarity	NPC254833
0.7982	Intermediate Similarity	NPC228343
0.7966	Intermediate Similarity	NPC281686
0.7966	Intermediate Similarity	NPC106551
0.7966	Intermediate Similarity	NPC188867
0.7951	Intermediate Similarity	NPC298486
0.7939	Intermediate Similarity	NPC323123
0.7928	Intermediate Similarity	NPC477801
0.7928	Intermediate Similarity	NPC477802
0.7913	Intermediate Similarity	NPC226401
0.7913	Intermediate Similarity	NPC79793
0.7913	Intermediate Similarity	NPC174096
0.7913	Intermediate Similarity	NPC222084
0.7913	Intermediate Similarity	NPC120982
0.7913	Intermediate Similarity	NPC147634
0.7895	Intermediate Similarity	NPC153690
0.7879	Intermediate Similarity	NPC66518
0.7876	Intermediate Similarity	NPC294902
0.7876	Intermediate Similarity	NPC231705
0.7876	Intermediate Similarity	NPC19149
0.7876	Intermediate Similarity	NPC1786
0.7876	Intermediate Similarity	NPC1075
0.787	Intermediate Similarity	NPC274678
0.7863	Intermediate Similarity	NPC59387
0.7845	Intermediate Similarity	NPC179002
0.7845	Intermediate Similarity	NPC257124
0.7845	Intermediate Similarity	NPC257430
0.7845	Intermediate Similarity	NPC187583
0.7845	Intermediate Similarity	NPC297657
0.7845	Intermediate Similarity	NPC156840
0.7845	Intermediate Similarity	NPC8547
0.7845	Intermediate Similarity	NPC173746
0.7845	Intermediate Similarity	NPC268032
0.7826	Intermediate Similarity	NPC172046
0.7826	Intermediate Similarity	NPC258056
0.7812	Intermediate Similarity	NPC214869
0.7812	Intermediate Similarity	NPC130595
0.7812	Intermediate Similarity	NPC93882
0.781	Intermediate Similarity	NPC27974
0.7807	Intermediate Similarity	NPC142297
0.7807	Intermediate Similarity	NPC176527
0.7778	Intermediate Similarity	NPC251571
0.7769	Intermediate Similarity	NPC239697
0.7769	Intermediate Similarity	NPC283760
0.7759	Intermediate Similarity	NPC474149
0.7752	Intermediate Similarity	NPC6854
0.7752	Intermediate Similarity	NPC285078
0.7752	Intermediate Similarity	NPC313737
0.7739	Intermediate Similarity	NPC24101
0.7739	Intermediate Similarity	NPC105727
0.7739	Intermediate Similarity	NPC96224
0.7739	Intermediate Similarity	NPC58427
0.7739	Intermediate Similarity	NPC34864
0.7739	Intermediate Similarity	NPC114392
0.7734	Intermediate Similarity	NPC114102
0.7724	Intermediate Similarity	NPC211992
0.7717	Intermediate Similarity	NPC155838
0.7714	Intermediate Similarity	NPC23167
0.7712	Intermediate Similarity	NPC471485
0.7712	Intermediate Similarity	NPC148969
0.7712	Intermediate Similarity	NPC264558
0.7692	Intermediate Similarity	NPC175313
0.7692	Intermediate Similarity	NPC21890
0.7692	Intermediate Similarity	NPC218530
0.768	Intermediate Similarity	NPC105513
0.7672	Intermediate Similarity	NPC36108
0.7672	Intermediate Similarity	NPC7097
0.7672	Intermediate Similarity	NPC246358
0.7672	Intermediate Similarity	NPC233731
0.7664	Intermediate Similarity	NPC300017
0.7664	Intermediate Similarity	NPC192
0.7656	Intermediate Similarity	NPC35961
0.7656	Intermediate Similarity	NPC52029
0.7656	Intermediate Similarity	NPC195749
0.7647	Intermediate Similarity	NPC120280
0.7642	Intermediate Similarity	NPC25493
0.7642	Intermediate Similarity	NPC113460
0.7636	Intermediate Similarity	NPC202986
0.7634	Intermediate Similarity	NPC6913
0.7632	Intermediate Similarity	NPC42383
0.7619	Intermediate Similarity	NPC197783
0.7615	Intermediate Similarity	NPC20142
0.7615	Intermediate Similarity	NPC215351
0.7597	Intermediate Similarity	NPC308885
0.7597	Intermediate Similarity	NPC255550
0.7596	Intermediate Similarity	NPC265146
0.7593	Intermediate Similarity	NPC304541
0.7593	Intermediate Similarity	NPC45040
0.7586	Intermediate Similarity	NPC97811
0.7583	Intermediate Similarity	NPC4665
0.7574	Intermediate Similarity	NPC294249
0.757	Intermediate Similarity	NPC123273
0.757	Intermediate Similarity	NPC258219
0.757	Intermediate Similarity	NPC177420
0.757	Intermediate Similarity	NPC318325
0.757	Intermediate Similarity	NPC242240
0.757	Intermediate Similarity	NPC280347
0.7568	Intermediate Similarity	NPC32674
0.7561	Intermediate Similarity	NPC252817
0.7559	Intermediate Similarity	NPC301713
0.7542	Intermediate Similarity	NPC195873
0.7542	Intermediate Similarity	NPC226250
0.7542	Intermediate Similarity	NPC78918
0.7542	Intermediate Similarity	NPC139617
0.7541	Intermediate Similarity	NPC142638
0.7541	Intermediate Similarity	NPC317784
0.7524	Intermediate Similarity	NPC150837
0.7524	Intermediate Similarity	NPC248817
0.7523	Intermediate Similarity	NPC94139
0.7523	Intermediate Similarity	NPC55903
0.7523	Intermediate Similarity	NPC3358
0.7523	Intermediate Similarity	NPC325292
0.7523	Intermediate Similarity	NPC210497
0.7523	Intermediate Similarity	NPC162314
0.7523	Intermediate Similarity	NPC306884
0.7523	Intermediate Similarity	NPC147284
0.7523	Intermediate Similarity	NPC138117
0.7521	Intermediate Similarity	NPC299252
0.7521	Intermediate Similarity	NPC221049
0.7521	Intermediate Similarity	NPC61062
0.7521	Intermediate Similarity	NPC277394
0.75	Intermediate Similarity	NPC115803
0.75	Intermediate Similarity	NPC118202
0.75	Intermediate Similarity	NPC312304
0.75	Intermediate Similarity	NPC291847
0.75	Intermediate Similarity	NPC318357
0.75	Intermediate Similarity	NPC55561
0.7479	Intermediate Similarity	NPC51698
0.7479	Intermediate Similarity	NPC131530
0.7479	Intermediate Similarity	NPC471179
0.7477	Intermediate Similarity	NPC104216
0.7459	Intermediate Similarity	NPC150919
0.7459	Intermediate Similarity	NPC200988
0.7459	Intermediate Similarity	NPC145023
0.7459	Intermediate Similarity	NPC164386
0.7459	Intermediate Similarity	NPC293619
0.7459	Intermediate Similarity	NPC175799
0.7459	Intermediate Similarity	NPC278652
0.7459	Intermediate Similarity	NPC86947

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC146422 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	116
0.1-0.2	735
0.2-0.3	1182
0.3-0.4	2524
0.4-0.5	2429
0.5-0.6	1548
0.6-0.7	472
0.7-0.8	111
0.8-0.85	28
0.85-0.9	12
0.9-0.95	2
0.95-1	2

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD9379	Approved
1.0	High Similarity	NPD9377	Approved
0.9286	High Similarity	NPD9384	Approved
0.9286	High Similarity	NPD9381	Approved
0.8966	High Similarity	NPD9622	Approved
0.8889	High Similarity	NPD5310	Approved
0.8889	High Similarity	NPD9634	Clinical (unspecified phase)
0.8889	High Similarity	NPD5311	Approved
0.8814	High Similarity	NPD3053	Approved
0.8814	High Similarity	NPD3055	Approved
0.8739	High Similarity	NPD9620	Approved
0.8739	High Similarity	NPD9621	Approved
0.8739	High Similarity	NPD9619	Approved
0.8692	High Similarity	NPD9610	Approved
0.8692	High Similarity	NPD9608	Approved
0.8667	High Similarity	NPD9569	Approved
0.8468	Intermediate Similarity	NPD9380	Clinical (unspecified phase)
0.8455	Intermediate Similarity	NPD601	Approved
0.8455	Intermediate Similarity	NPD598	Approved
0.8455	Intermediate Similarity	NPD597	Approved
0.8455	Intermediate Similarity	NPD2028	Clinical (unspecified phase)
0.8421	Intermediate Similarity	NPD9614	Approved
0.8421	Intermediate Similarity	NPD9618	Approved
0.8387	Intermediate Similarity	NPD1130	Approved
0.8387	Intermediate Similarity	NPD1136	Approved
0.8387	Intermediate Similarity	NPD1132	Approved
0.8387	Intermediate Similarity	NPD259	Phase 1
0.8374	Intermediate Similarity	NPD9536	Phase 1
0.8374	Intermediate Similarity	NPD9537	Phase 1
0.832	Intermediate Similarity	NPD3061	Approved
0.832	Intermediate Similarity	NPD3059	Approved
0.832	Intermediate Similarity	NPD3062	Approved
0.8279	Intermediate Similarity	NPD258	Approved
0.8279	Intermediate Similarity	NPD257	Approved
0.8254	Intermediate Similarity	NPD555	Phase 2
0.8205	Intermediate Similarity	NPD9616	Approved
0.8205	Intermediate Similarity	NPD9613	Approved
0.8205	Intermediate Similarity	NPD9615	Approved
0.8189	Intermediate Similarity	NPD817	Approved
0.8189	Intermediate Similarity	NPD823	Approved
0.8189	Intermediate Similarity	NPD5314	Approved
0.8136	Intermediate Similarity	NPD316	Approved
0.8	Intermediate Similarity	NPD1632	Clinical (unspecified phase)
0.8	Intermediate Similarity	NPD9570	Approved
0.7982	Intermediate Similarity	NPD3021	Approved
0.7982	Intermediate Similarity	NPD3022	Approved
0.7966	Intermediate Similarity	NPD9568	Approved
0.7951	Intermediate Similarity	NPD2337	Clinical (unspecified phase)
0.7939	Intermediate Similarity	NPD2029	Clinical (unspecified phase)
0.7913	Intermediate Similarity	NPD9280	Clinical (unspecified phase)
0.7899	Intermediate Similarity	NPD856	Approved
0.7899	Intermediate Similarity	NPD16	Approved
0.7899	Intermediate Similarity	NPD318	Approved
0.7899	Intermediate Similarity	NPD317	Approved
0.7891	Intermediate Similarity	NPD825	Approved
0.7891	Intermediate Similarity	NPD826	Approved
0.7876	Intermediate Similarity	NPD1444	Approved
0.7876	Intermediate Similarity	NPD1445	Approved
0.7845	Intermediate Similarity	NPD228	Approved
0.7829	Intermediate Similarity	NPD274	Approved
0.7829	Intermediate Similarity	NPD275	Approved
0.7812	Intermediate Similarity	NPD2674	Phase 3
0.7712	Intermediate Similarity	NPD2229	Approved
0.7712	Intermediate Similarity	NPD2228	Approved
0.7712	Intermediate Similarity	NPD2234	Approved
0.7698	Intermediate Similarity	NPD2195	Approved
0.7698	Intermediate Similarity	NPD2194	Approved
0.7672	Intermediate Similarity	NPD1792	Phase 2
0.7647	Intermediate Similarity	NPD3845	Phase 1
0.7647	Intermediate Similarity	NPD1793	Approved
0.7647	Intermediate Similarity	NPD2422	Clinical (unspecified phase)
0.7647	Intermediate Similarity	NPD1791	Approved
0.7597	Intermediate Similarity	NPD3144	Approved
0.7597	Intermediate Similarity	NPD3145	Approved
0.7583	Intermediate Similarity	NPD256	Approved
0.7583	Intermediate Similarity	NPD255	Approved
0.7574	Intermediate Similarity	NPD302	Approved
0.7556	Intermediate Similarity	NPD3060	Approved
0.7536	Intermediate Similarity	NPD4160	Clinical (unspecified phase)
0.752	Intermediate Similarity	NPD2561	Approved
0.752	Intermediate Similarity	NPD2562	Approved
0.748	Intermediate Similarity	NPD4093	Discontinued
0.7455	Intermediate Similarity	NPD2934	Approved
0.7455	Intermediate Similarity	NPD2933	Approved
0.7455	Intermediate Similarity	NPD1432	Clinical (unspecified phase)
0.7429	Intermediate Similarity	NPD111	Approved
0.7422	Intermediate Similarity	NPD599	Approved
0.7422	Intermediate Similarity	NPD858	Approved
0.7422	Intermediate Similarity	NPD602	Approved
0.7422	Intermediate Similarity	NPD859	Approved
0.7411	Intermediate Similarity	NPD9611	Approved
0.7411	Intermediate Similarity	NPD9612	Approved
0.7411	Intermediate Similarity	NPD9609	Approved
0.7405	Intermediate Similarity	NPD554	Clinical (unspecified phase)
0.7387	Intermediate Similarity	NPD2859	Approved
0.7387	Intermediate Similarity	NPD2860	Approved
0.7387	Intermediate Similarity	NPD844	Approved
0.7381	Intermediate Similarity	NPD2231	Phase 2
0.7381	Intermediate Similarity	NPD2235	Phase 2
0.7376	Intermediate Similarity	NPD1972	Approved
0.7376	Intermediate Similarity	NPD1973	Approved
0.7376	Intermediate Similarity	NPD1969	Clinical (unspecified phase)
0.7368	Intermediate Similarity	NPD2568	Approved
0.736	Intermediate Similarity	NPD2688	Clinical (unspecified phase)
0.7353	Intermediate Similarity	NPD7153	Discontinued
0.7345	Intermediate Similarity	NPD3020	Approved
0.7344	Intermediate Similarity	NPD1134	Approved
0.7344	Intermediate Similarity	NPD1131	Approved
0.7344	Intermediate Similarity	NPD1135	Approved
0.7344	Intermediate Similarity	NPD1129	Approved
0.7344	Intermediate Similarity	NPD1133	Approved
0.7324	Intermediate Similarity	NPD3455	Phase 2
0.7321	Intermediate Similarity	NPD288	Approved
0.7308	Intermediate Similarity	NPD596	Approved
0.7308	Intermediate Similarity	NPD600	Approved
0.7299	Intermediate Similarity	NPD4162	Approved
0.7287	Intermediate Similarity	NPD558	Phase 2
0.7287	Intermediate Similarity	NPD7451	Discontinued
0.7286	Intermediate Similarity	NPD3645	Discontinued
0.7281	Intermediate Similarity	NPD1242	Phase 1
0.7281	Intermediate Similarity	NPD289	Clinical (unspecified phase)
0.728	Intermediate Similarity	NPD1751	Approved
0.7258	Intermediate Similarity	NPD2226	Clinical (unspecified phase)
0.7257	Intermediate Similarity	NPD9273	Approved
0.7239	Intermediate Similarity	NPD2653	Approved
0.7218	Intermediate Similarity	NPD1558	Phase 1
0.7143	Intermediate Similarity	NPD6405	Approved
0.7143	Intermediate Similarity	NPD6407	Approved
0.7132	Intermediate Similarity	NPD196	Phase 1
0.7123	Intermediate Similarity	NPD2977	Approved
0.7123	Intermediate Similarity	NPD2978	Approved
0.7121	Intermediate Similarity	NPD3136	Phase 2
0.712	Intermediate Similarity	NPD5304	Approved
0.712	Intermediate Similarity	NPD5303	Approved
0.7094	Intermediate Similarity	NPD311	Approved
0.7094	Intermediate Similarity	NPD314	Approved
0.7094	Intermediate Similarity	NPD310	Approved
0.7094	Intermediate Similarity	NPD309	Approved
0.7094	Intermediate Similarity	NPD315	Approved
0.7094	Intermediate Similarity	NPD10	Approved
0.7092	Intermediate Similarity	NPD2421	Approved
0.7092	Intermediate Similarity	NPD2420	Approved
0.7069	Intermediate Similarity	NPD846	Approved
0.7069	Intermediate Similarity	NPD940	Approved
0.7045	Intermediate Similarity	NPD5752	Clinical (unspecified phase)
0.7031	Intermediate Similarity	NPD5351	Clinical (unspecified phase)
0.7031	Intermediate Similarity	NPD5350	Clinical (unspecified phase)
0.7015	Intermediate Similarity	NPD829	Discontinued
0.7015	Intermediate Similarity	NPD840	Approved
0.7015	Intermediate Similarity	NPD839	Approved
0.7014	Intermediate Similarity	NPD3686	Approved
0.7014	Intermediate Similarity	NPD3687	Approved
0.7008	Intermediate Similarity	NPD2667	Approved
0.7008	Intermediate Similarity	NPD2668	Approved
0.7008	Intermediate Similarity	NPD5238	Clinical (unspecified phase)
0.697	Remote Similarity	NPD3637	Approved
0.697	Remote Similarity	NPD3636	Approved
0.697	Remote Similarity	NPD3635	Approved
0.6957	Remote Similarity	NPD2161	Phase 2
0.6953	Remote Similarity	NPD1981	Approved
0.6953	Remote Similarity	NPD1983	Approved
0.6953	Remote Similarity	NPD1980	Approved
0.694	Remote Similarity	NPD5718	Phase 2
0.6935	Remote Similarity	NPD593	Approved
0.6935	Remote Similarity	NPD595	Approved
0.693	Remote Similarity	NPD1809	Phase 2
0.6929	Remote Similarity	NPD3638	Discontinued
0.6923	Remote Similarity	NPD4659	Approved
0.6923	Remote Similarity	NPD1669	Approved
0.6923	Remote Similarity	NPD1771	Clinical (unspecified phase)
0.6923	Remote Similarity	NPD1755	Approved
0.6917	Remote Similarity	NPD2605	Approved
0.6917	Remote Similarity	NPD3594	Approved
0.6917	Remote Similarity	NPD2614	Approved
0.6917	Remote Similarity	NPD2606	Approved
0.6917	Remote Similarity	NPD3595	Approved
0.6903	Remote Similarity	NPD845	Approved
0.6875	Remote Similarity	NPD7527	Clinical (unspecified phase)
0.6875	Remote Similarity	NPD52	Approved
0.6875	Remote Similarity	NPD2286	Discontinued
0.6875	Remote Similarity	NPD7526	Approved
0.6866	Remote Similarity	NPD5156	Approved
0.6866	Remote Similarity	NPD2669	Clinical (unspecified phase)
0.6866	Remote Similarity	NPD9718	Approved
0.6866	Remote Similarity	NPD5155	Approved
0.6861	Remote Similarity	NPD3052	Approved
0.6861	Remote Similarity	NPD3054	Approved
0.6857	Remote Similarity	NPD4256	Phase 2
0.6857	Remote Similarity	NPD4257	Approved
0.685	Remote Similarity	NPD1759	Phase 1
0.6846	Remote Similarity	NPD2233	Approved
0.6846	Remote Similarity	NPD2232	Approved
0.6846	Remote Similarity	NPD2230	Approved
0.6831	Remote Similarity	NPD5241	Discontinued
0.6818	Remote Similarity	NPD1817	Approved
0.6818	Remote Similarity	NPD4104	Clinical (unspecified phase)
0.6818	Remote Similarity	NPD4103	Phase 2
0.6818	Remote Similarity	NPD1818	Approved
0.6818	Remote Similarity	NPD1820	Approved
0.6818	Remote Similarity	NPD1819	Approved

Structure

External Identifiers

PubChem CID	681
ChEMBL	CHEMBL59
ZINC

Physicochemical Properties

Molecular Weight:	153.08
ALogP:	-1.4033
MLogP:	2.01
XLogP:	0.57
# Rotatable Bonds:	5
Polar Surface Area:	66.48
# H-Bond Aceptor:	1
# H-Bond Donor:	3
# Rings:	1
# Heavy Atoms:	11

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Similar NPs/Drugs