Similar Natural Products in NPASS
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC119368 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
range |
Tanimoto Coefficient |
0-0.1 | 23129 |
0.1-0.2 | 6611 |
0.2-0.3 | 779 |
0.3-0.4 | 278 |
0.4-0.5 | 51 |
0.5-0.6 | 19 |
0.6-0.7 | 16 |
0.7-0.8 | 5 |
0.8-0.85 | 1 |
0.85-0.9 | 0 |
0.9-0.95 | 0 |
0.95-1 | 0 |
  Similar Clinical/Approved Drugs
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC119368 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
range |
Tanimoto Coefficient |
0-0.1 | 3207 |
0.1-0.2 | 5136 |
0.2-0.3 | 507 |
0.3-0.4 | 208 |
0.4-0.5 | 71 |
0.5-0.6 | 21 |
0.6-0.7 | 6 |
0.7-0.8 | 5 |
0.8-0.85 | 0 |
0.85-0.9 | 0 |
0.9-0.95 | 0 |
0.95-1 | 0 |
Similarity Score |
Similarity Level |
Drug ID |
Developmental Stage |
0.7692 |
Intermediate Similarity |
NPD9063 |
Approved |
0.7692 |
Intermediate Similarity |
NPD9064 |
Approved |
0.7407 |
Intermediate Similarity |
NPD8544 |
Approved |
0.7407 |
Intermediate Similarity |
NPD9465 |
Approved |
0.7241 |
Intermediate Similarity |
NPD1156 |
Clinical (unspecified phase) |
0.6897 |
Remote Similarity |
NPD401 |
Approved |
0.6818 |
Remote Similarity |
NPD8816 |
Approved |
0.6667 |
Remote Similarity |
NPD8560 |
Clinical (unspecified phase) |
0.6522 |
Remote Similarity |
NPD7383 |
Phase 3 |
0.625 |
Remote Similarity |
NPD8556 |
Phase 3 |
0.6 |
Remote Similarity |
NPD2707 |
Clinical (unspecified phase) |
0.5938 |
Remote Similarity |
NPD2276 |
Clinical (unspecified phase) |
0.5714 |
Remote Similarity |
NPD9059 |
Approved |
0.5676 |
Remote Similarity |
NPD2273 |
Clinical (unspecified phase) |
0.5676
|
Remote Similarity |
NPD1463 |
Clinical (unspecified phase) |