Natural Product: NPC115998

Natural Product ID:  NPC115998
Common Name:   5-Hydroxy-2-Styrylchromone
IUPAC Name:   5-hydroxy-2-[(E)-2-phenylethenyl]chromen-4-one
Synonyms:  
Molecular Formula:   C17H12O3
Standard InCHIKey:  TVYPHWROTJAZCQ-MDZDMXLPSA-N
Standard InCHI:  InChI=1S/C17H12O3/c18-14-7-4-8-16-17(14)15(19)11-13(20-16)10-9-12-5-2-1-3-6-12/h1-11,18H/b10-9+
Canonical SMILES:  Oc1cccc2c1c(=O)cc(o2)/C=C/c1ccccc1
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO23628 Imperata cylindrica Species Poaceae Eukaryota PMID[16499335]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2 Others Unspecified IC50 = 6900 nM 11520240
NPT2 Others Unspecified IC50 = 39000 nM 11520240
NPT2 Others Unspecified IC50 = 8200 nM 17432904
NPT2 Others Unspecified IC50 = 7000 nM 18232640
NPT2 Others Unspecified Ratio CC50/IC50 > 21.6 20939516
NPT2 Others Unspecified Activity = -11.3 % DrugMatrix in vitro pharmacology data
NPT113 Cell Line RAW264.7 Mus musculus CC50 > 150000 nM 19654408
NPT2 Others Unspecified Inhibition = 17 % 22742732

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC115998 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC39753
0.9919 High Similarity NPC137264
0.9919 High Similarity NPC197425
0.9683 High Similarity NPC113006
0.9606 High Similarity NPC128216
0.96 High Similarity NPC187907
0.9531 High Similarity NPC50898
0.9531 High Similarity NPC274121
0.9531 High Similarity NPC78540
0.9531 High Similarity NPC57601
0.9531 High Similarity NPC213216
0.9462 High Similarity NPC473887
0.9462 High Similarity NPC234133
0.9462 High Similarity NPC47815
0.9462 High Similarity NPC124784
0.9462 High Similarity NPC29353
0.9462 High Similarity NPC13408
0.9462 High Similarity NPC194281
0.9462 High Similarity NPC127447
0.9462 High Similarity NPC231772
0.9457 High Similarity NPC248872
0.9457 High Similarity NPC172262
0.944 High Similarity NPC41721
0.9389 High Similarity NPC266597
0.9389 High Similarity NPC228661
0.9389 High Similarity NPC250266
0.9355 High Similarity NPC193805
0.9318 High Similarity NPC201395
0.9313 High Similarity NPC281917
0.9313 High Similarity NPC116775
0.9313 High Similarity NPC187432
0.9313 High Similarity NPC256042
0.9313 High Similarity NPC216361
0.9286 High Similarity NPC22783
0.9248 High Similarity NPC78913
0.9248 High Similarity NPC55018
0.9248 High Similarity NPC152042
0.9248 High Similarity NPC18260
0.9248 High Similarity NPC301217
0.9248 High Similarity NPC220062
0.9248 High Similarity NPC303633
0.9248 High Similarity NPC96565
0.9248 High Similarity NPC143799
0.9248 High Similarity NPC241838
0.9248 High Similarity NPC216978
0.9242 High Similarity NPC299379
0.9242 High Similarity NPC275055
0.9242 High Similarity NPC290291
0.9237 High Similarity NPC9985
0.9237 High Similarity NPC239495
0.9179 High Similarity NPC475680
0.9179 High Similarity NPC59951
0.9179 High Similarity NPC269652
0.9179 High Similarity NPC281207
0.9179 High Similarity NPC241100
0.9179 High Similarity NPC103342
0.9179 High Similarity NPC184536
0.9179 High Similarity NPC103904
0.9179 High Similarity NPC230285
0.9179 High Similarity NPC159275
0.9179 High Similarity NPC172986
0.9179 High Similarity NPC261227
0.9179 High Similarity NPC270883
0.9179 High Similarity NPC305355
0.9179 High Similarity NPC146679
0.9173 High Similarity NPC99333
0.9173 High Similarity NPC118813
0.9173 High Similarity NPC280284
0.9173 High Similarity NPC188947
0.9167 High Similarity NPC240593
0.9154 High Similarity NPC10971
0.9147 High Similarity NPC5515
0.9147 High Similarity NPC270369
0.9111 High Similarity NPC136840
0.9111 High Similarity NPC147688
0.9111 High Similarity NPC156590
0.9111 High Similarity NPC64908
0.9111 High Similarity NPC282300
0.9111 High Similarity NPC118840
0.9111 High Similarity NPC90582
0.9111 High Similarity NPC14871
0.9111 High Similarity NPC205006
0.9111 High Similarity NPC262094
0.9111 High Similarity NPC110969
0.9104 High Similarity NPC310135
0.9104 High Similarity NPC274784
0.9104 High Similarity NPC53181
0.9104 High Similarity NPC222342
0.9104 High Similarity NPC20709
0.9104 High Similarity NPC265871
0.9104 High Similarity NPC261234
0.9104 High Similarity NPC217186
0.9104 High Similarity NPC329203
0.9104 High Similarity NPC150648
0.9104 High Similarity NPC225153
0.9098 High Similarity NPC287246
0.9098 High Similarity NPC476480
0.9098 High Similarity NPC13768
0.9098 High Similarity NPC188879
0.9098 High Similarity NPC107586
0.9098 High Similarity NPC295261
0.9098 High Similarity NPC296490
0.9098 High Similarity NPC32441
0.9098 High Similarity NPC84585
0.9098 High Similarity NPC12296
0.9098 High Similarity NPC243083
0.9098 High Similarity NPC79943
0.9077 High Similarity NPC31872
0.9077 High Similarity NPC186097
0.9077 High Similarity NPC475009
0.9077 High Similarity NPC308037
0.9077 High Similarity NPC475008
0.9077 High Similarity NPC64359
0.9077 High Similarity NPC473584
0.9077 High Similarity NPC278556
0.9077 High Similarity NPC284424
0.9077 High Similarity NPC475589
0.907 High Similarity NPC228184
0.9044 High Similarity NPC200694
0.9044 High Similarity NPC1534
0.9044 High Similarity NPC78803
0.9044 High Similarity NPC217083
0.9044 High Similarity NPC62840
0.9044 High Similarity NPC214236
0.9044 High Similarity NPC293852
0.9044 High Similarity NPC59739
0.9044 High Similarity NPC299080
0.9044 High Similarity NPC473042
0.9044 High Similarity NPC11561
0.9044 High Similarity NPC226636
0.9037 High Similarity NPC76445
0.9037 High Similarity NPC150522
0.9037 High Similarity NPC284550
0.9037 High Similarity NPC6407
0.9037 High Similarity NPC69769
0.9037 High Similarity NPC110228
0.9037 High Similarity NPC235239
0.9037 High Similarity NPC129853
0.9037 High Similarity NPC188243
0.903 High Similarity NPC124269
0.903 High Similarity NPC18457
0.903 High Similarity NPC329225
0.903 High Similarity NPC276905
0.903 High Similarity NPC147686
0.903 High Similarity NPC472460
0.9008 High Similarity NPC205468
0.9008 High Similarity NPC25937
0.9008 High Similarity NPC101294
0.9008 High Similarity NPC473655
0.9008 High Similarity NPC212631
0.9008 High Similarity NPC87231
0.9008 High Similarity NPC257756
0.9008 High Similarity NPC129132
0.8978 High Similarity NPC9117
0.8978 High Similarity NPC212932
0.8978 High Similarity NPC38219
0.8978 High Similarity NPC190637
0.8978 High Similarity NPC24821
0.8978 High Similarity NPC293053
0.8978 High Similarity NPC11700
0.8978 High Similarity NPC470216
0.8978 High Similarity NPC219915
0.8971 High Similarity NPC324386
0.8971 High Similarity NPC103362
0.8971 High Similarity NPC213322
0.8971 High Similarity NPC4743
0.8971 High Similarity NPC3188
0.8971 High Similarity NPC312391
0.8963 High Similarity NPC316480
0.8963 High Similarity NPC140890
0.8955 High Similarity NPC162680
0.8955 High Similarity NPC7013
0.8955 High Similarity NPC160972
0.8955 High Similarity NPC209560
0.8955 High Similarity NPC181124
0.8955 High Similarity NPC254841
0.8955 High Similarity NPC294409
0.8955 High Similarity NPC116632
0.8955 High Similarity NPC303644
0.8947 High Similarity NPC151113
0.8947 High Similarity NPC39426
0.8947 High Similarity NPC234560
0.8939 High Similarity NPC18877
0.8939 High Similarity NPC56031
0.8939 High Similarity NPC294593
0.8939 High Similarity NPC204960
0.8939 High Similarity NPC242294
0.8939 High Similarity NPC20560
0.8939 High Similarity NPC312318
0.8939 High Similarity NPC263670
0.8939 High Similarity NPC93756
0.8939 High Similarity NPC472365
0.8939 High Similarity NPC192304
0.8939 High Similarity NPC292998
0.8939 High Similarity NPC188646
0.8939 High Similarity NPC139813
0.8939 High Similarity NPC82225
0.8939 High Similarity NPC159623
0.8939 High Similarity NPC337373
0.8939 High Similarity NPC28753

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC115998 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9098 High Similarity NPD1552 Clinical (unspecified phase)
0.9098 High Similarity NPD1550 Clinical (unspecified phase)
0.903 High Similarity NPD1549 Phase 2
0.8947 High Similarity NPD1510 Phase 2
0.8931 High Similarity NPD1240 Approved
0.8913 High Similarity NPD4378 Clinical (unspecified phase)
0.8841 High Similarity NPD1511 Approved
0.8797 High Similarity NPD1607 Approved
0.8777 High Similarity NPD7410 Clinical (unspecified phase)
0.8759 High Similarity NPD3750 Approved
0.8741 High Similarity NPD1551 Phase 2
0.8741 High Similarity NPD2796 Approved
0.8714 High Similarity NPD1512 Approved
0.8682 High Similarity NPD1203 Approved
0.8521 High Similarity NPD5403 Approved
0.8511 High Similarity NPD5401 Approved
0.8425 Intermediate Similarity NPD2801 Approved
0.8394 Intermediate Similarity NPD3748 Approved
0.8372 Intermediate Similarity NPD1547 Clinical (unspecified phase)
0.8358 Intermediate Similarity NPD2313 Discontinued
0.8357 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.8356 Intermediate Similarity NPD1934 Approved
0.8346 Intermediate Similarity NPD1548 Phase 1
0.8345 Intermediate Similarity NPD4380 Phase 2
0.831 Intermediate Similarity NPD6799 Approved
0.8308 Intermediate Similarity NPD9717 Approved
0.8299 Intermediate Similarity NPD2393 Clinical (unspecified phase)
0.8288 Intermediate Similarity NPD7411 Suspended
0.8258 Intermediate Similarity NPD2797 Approved
0.8255 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.8243 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.8231 Intermediate Similarity NPD422 Phase 1
0.8214 Intermediate Similarity NPD970 Clinical (unspecified phase)
0.8195 Intermediate Similarity NPD2798 Approved
0.8182 Intermediate Similarity NPD3225 Approved
0.8133 Intermediate Similarity NPD7075 Discontinued
0.8133 Intermediate Similarity NPD3749 Approved
0.8121 Intermediate Similarity NPD5402 Approved
0.8108 Intermediate Similarity NPD6801 Discontinued
0.8088 Intermediate Similarity NPD3268 Approved
0.8088 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.8074 Intermediate Similarity NPD6832 Phase 2
0.8067 Intermediate Similarity NPD7768 Phase 2
0.8067 Intermediate Similarity NPD3882 Suspended
0.8054 Intermediate Similarity NPD7096 Clinical (unspecified phase)
0.8054 Intermediate Similarity NPD7819 Suspended
0.8028 Intermediate Similarity NPD2800 Approved
0.8028 Intermediate Similarity NPD1243 Approved
0.8014 Intermediate Similarity NPD2344 Approved
0.8 Intermediate Similarity NPD4308 Phase 3
0.8 Intermediate Similarity NPD3817 Phase 2
0.7973 Intermediate Similarity NPD6599 Discontinued
0.7955 Intermediate Similarity NPD1610 Phase 2
0.7943 Intermediate Similarity NPD6099 Approved
0.7943 Intermediate Similarity NPD6100 Approved
0.7907 Intermediate Similarity NPD9493 Approved
0.7902 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7872 Intermediate Similarity NPD2799 Discontinued
0.7862 Intermediate Similarity NPD643 Clinical (unspecified phase)
0.7852 Intermediate Similarity NPD3267 Approved
0.7852 Intermediate Similarity NPD3266 Approved
0.7834 Intermediate Similarity NPD3818 Discontinued
0.7821 Intermediate Similarity NPD6166 Phase 2
0.7821 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.7821 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.7821 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.782 Intermediate Similarity NPD1201 Approved
0.7817 Intermediate Similarity NPD2935 Discontinued
0.7793 Intermediate Similarity NPD2309 Approved
0.7786 Intermediate Similarity NPD1933 Approved
0.7785 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.7785 Intermediate Similarity NPD7054 Approved
0.7785 Intermediate Similarity NPD3226 Approved
0.7762 Intermediate Similarity NPD2346 Discontinued
0.7755 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.7746 Intermediate Similarity NPD7033 Discontinued
0.7742 Intermediate Similarity NPD6959 Discontinued
0.7736 Intermediate Similarity NPD7472 Approved
0.773 Intermediate Similarity NPD6651 Approved
0.7724 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.7714 Intermediate Similarity NPD943 Approved
0.7714 Intermediate Similarity NPD4307 Phase 2
0.7698 Intermediate Similarity NPD411 Approved
0.7698 Intermediate Similarity NPD1296 Phase 2
0.7688 Intermediate Similarity NPD6797 Phase 2
0.7681 Intermediate Similarity NPD4908 Phase 1
0.766 Intermediate Similarity NPD447 Suspended
0.766 Intermediate Similarity NPD1899 Clinical (unspecified phase)
0.7651 Intermediate Similarity NPD920 Approved
0.7647 Intermediate Similarity NPD4288 Approved
0.764 Intermediate Similarity NPD7251 Discontinued
0.763 Intermediate Similarity NPD1608 Approved
0.7626 Intermediate Similarity NPD4625 Phase 3
0.7625 Intermediate Similarity NPD7074 Phase 3
0.7597 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.7593 Intermediate Similarity NPD4419 Clinical (unspecified phase)
0.7593 Intermediate Similarity NPD4338 Clinical (unspecified phase)
0.7593 Intermediate Similarity NPD7808 Phase 3
0.7591 Intermediate Similarity NPD1470 Approved
0.7574 Intermediate Similarity NPD4749 Approved
0.7571 Intermediate Similarity NPD4907 Clinical (unspecified phase)
0.7559 Intermediate Similarity NPD9266 Approved
0.7559 Intermediate Similarity NPD74 Approved
0.7554 Intermediate Similarity NPD1529 Clinical (unspecified phase)
0.7538 Intermediate Similarity NPD1241 Discontinued
0.7536 Intermediate Similarity NPD1019 Discontinued
0.7531 Intermediate Similarity NPD6559 Discontinued
0.75 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.75 Intermediate Similarity NPD1481 Phase 2
0.7482 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.748 Intermediate Similarity NPD9263 Approved
0.748 Intermediate Similarity NPD9267 Approved
0.748 Intermediate Similarity NPD9264 Approved
0.7469 Intermediate Similarity NPD5953 Discontinued
0.7468 Intermediate Similarity NPD6232 Discontinued
0.7453 Intermediate Similarity NPD7286 Phase 2
0.7452 Intermediate Similarity NPD5494 Approved
0.7447 Intermediate Similarity NPD3764 Approved
0.7438 Intermediate Similarity NPD7473 Discontinued
0.7426 Intermediate Similarity NPD1535 Discovery
0.7415 Intermediate Similarity NPD2654 Approved
0.7407 Intermediate Similarity NPD17 Approved
0.74 Intermediate Similarity NPD2532 Approved
0.74 Intermediate Similarity NPD2534 Approved
0.74 Intermediate Similarity NPD2533 Approved
0.7391 Intermediate Similarity NPD5940 Clinical (unspecified phase)
0.7388 Intermediate Similarity NPD9545 Approved
0.7388 Intermediate Similarity NPD1894 Discontinued
0.7375 Intermediate Similarity NPD7784 Clinical (unspecified phase)
0.7368 Intermediate Similarity NPD405 Clinical (unspecified phase)
0.7365 Intermediate Similarity NPD4628 Phase 3
0.7355 Intermediate Similarity NPD1465 Phase 2
0.7343 Intermediate Similarity NPD1613 Approved
0.7343 Intermediate Similarity NPD1612 Clinical (unspecified phase)
0.7338 Intermediate Similarity NPD1164 Approved
0.7305 Intermediate Similarity NPD1008 Clinical (unspecified phase)
0.7292 Intermediate Similarity NPD5124 Phase 1
0.7292 Intermediate Similarity NPD5123 Clinical (unspecified phase)
0.729 Intermediate Similarity NPD6844 Discontinued
0.7285 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7285 Intermediate Similarity NPD4661 Approved
0.7285 Intermediate Similarity NPD4662 Approved
0.7279 Intermediate Similarity NPD2343 Clinical (unspecified phase)
0.7278 Intermediate Similarity NPD919 Approved
0.7266 Intermediate Similarity NPD968 Approved
0.7246 Intermediate Similarity NPD3972 Approved
0.7226 Intermediate Similarity NPD7615 Clinical (unspecified phase)
0.7219 Intermediate Similarity NPD7390 Discontinued
0.7208 Intermediate Similarity NPD5808 Clinical (unspecified phase)
0.7205 Intermediate Similarity NPD3926 Phase 2
0.7203 Intermediate Similarity NPD6798 Discontinued
0.7203 Intermediate Similarity NPD6410 Clinical (unspecified phase)
0.7197 Intermediate Similarity NPD2296 Approved
0.7188 Intermediate Similarity NPD9697 Approved
0.7188 Intermediate Similarity NPD1247 Approved
0.7165 Intermediate Similarity NPD9261 Approved
0.7161 Intermediate Similarity NPD6585 Discontinued
0.7152 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.7151 Intermediate Similarity NPD4360 Phase 2
0.7151 Intermediate Similarity NPD4363 Phase 3
0.7143 Intermediate Similarity NPD1876 Approved
0.7143 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.7134 Intermediate Similarity NPD5844 Phase 1
0.7118 Intermediate Similarity NPD4287 Approved
0.7115 Intermediate Similarity NPD5889 Approved
0.7115 Intermediate Similarity NPD5890 Approved
0.7113 Intermediate Similarity NPD2861 Phase 2
0.711 Intermediate Similarity NPD4362 Clinical (unspecified phase)
0.711 Intermediate Similarity NPD4361 Phase 2
0.7095 Intermediate Similarity NPD5405 Approved
0.7095 Intermediate Similarity NPD5404 Approved
0.7095 Intermediate Similarity NPD5408 Approved
0.7095 Intermediate Similarity NPD5406 Approved
0.7091 Intermediate Similarity NPD1729 Discontinued
0.709 Intermediate Similarity NPD9281 Approved
0.7086 Intermediate Similarity NPD3295 Clinical (unspecified phase)
0.7078 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.7073 Intermediate Similarity NPD3751 Discontinued
0.7069 Intermediate Similarity NPD8090 Clinical (unspecified phase)
0.7067 Intermediate Similarity NPD1652 Phase 2
0.7055 Intermediate Similarity NPD230 Phase 1
0.7047 Intermediate Similarity NPD1471 Phase 3
0.7039 Intermediate Similarity NPD7440 Discontinued
0.7037 Intermediate Similarity NPD6671 Approved
0.7034 Intermediate Similarity NPD6233 Phase 2
0.7029 Intermediate Similarity NPD1778 Approved
0.7024 Intermediate Similarity NPD8313 Approved
0.7024 Intermediate Similarity NPD8312 Approved
0.702 Intermediate Similarity NPD7003 Approved
0.7006 Intermediate Similarity NPD2366 Approved
0.7 Intermediate Similarity NPD6971 Discontinued
0.7 Intermediate Similarity NPD955 Approved
0.6993 Remote Similarity NPD7213 Phase 3
0.6993 Remote Similarity NPD7212 Phase 2
0.6974 Remote Similarity NPD2354 Approved
0.6953 Remote Similarity NPD846 Approved
0.6953 Remote Similarity NPD940 Approved
0.6948 Remote Similarity NPD7447 Phase 1
0.6947 Remote Similarity NPD290 Approved
0.6947 Remote Similarity NPD9265 Clinical (unspecified phase)

Structure

External Identifiers

PubChem CID   6477677
ChEMBL   CHEMBL228675
ZINC  

Physicochemical Properties

Molecular Weight:  264.08
ALogP:  -0.4961
MLogP:  3
XLogP:  5.364
# Rotatable Bonds:  3
Polar Surface Area:  46.53
# H-Bond Aceptor:  1
# H-Bond Donor:  1
# Rings:  3
# Heavy Atoms:  20

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs