| Target ID | Target Name | Target Organism | # Natural Product | # Activity Record |
|---|---|---|---|---|
| NPT143 | DNA topoisomerase I | Homo sapiens | 79 | 196 |
| NPT5653 | DNA topoisomerase 1 | Rattus norvegicus | 1 | 2 |
| NPT4491 | DNA topoisomerase type IB small subunit | Leishmania major | 1 | 1 |
| NPT5754 | DNA gyrase subunit B | Staphylococcus aureus subsp. aureus Mu50 | 2 | 3 |
| NPT5491 | Topoisomerase IV | Staphylococcus aureus | 2 | 3 |
| NPT5490 | DNA gyrase subunit B | Staphylococcus aureus | 1 | 1 |
| NPT4476 | DNA topoisomerase | Bos taurus | 2 | 2 |
| NPT4477 | DNA topoisomerase 1 | Chlorocebus aethiops | 2 | 2 |
| NPT5486 | DNA gyrase subunit B | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | 1 | 1 |
| NPT5487 | ParE | Streptococcus pneumoniae | 1 | 1 |
| NPT5484 | DNA gyrase | Staphylococcus aureus | 4 | 22 |
| NPT5489 | DNA gyrase subunit B | Mycobacterium smegmatis | 1 | 8 |
| NPT1567 | DNA gyrase | Escherichia coli K-12 | 21 | 63 |
| NPT6545 | DNA topoisomerase II beta | Mus musculus | 1 | 1 |
| NPT6211 | DNA gyrase subunit A | Mycobacterium tuberculosis | 1 | 1 |
| NPT4451 | DNA topoisomerase I | Mus musculus | 4 | 6 |
| NPT3703 | DNA topoisomerase 2 | Saccharomyces cerevisiae S288c | 1 | 1 |
| NPT3702 | DNA topoisomerase 1 | Saccharomyces cerevisiae S288c | 3 | 6 |
| NPT4940 | DNA gyrase subunit B | Escherichia coli K-12 | 2 | 7 |
| NPT4942 | DNA gyrase subunit A | Escherichia coli K-12 | 2 | 2 |
| NPT4943 | DNA gyrase subunit B | Escherichia coli | 2 | 2 |
| NPT5763 | Topoisomerase IV subunit A | Staphylococcus aureus | 1 | 5 |
| NPT5376 | DNA topoisomerase II | Drosophila melanogaster | 8 | 8 |
| NPT6607 | DNA topoisomerase II alpha | Mus musculus | 1 | 1 |
| NPT322 | DNA topoisomerase II beta | Homo sapiens | 20 | 52 |
| NPT320 | DNA topoisomerase II | Homo sapiens | 22 | 62 |
| NPT3976 | DNA gyrase | Staphylococcus aureus subsp. aureus Mu50 | 1 | 3 |
| NPT1044 | DNA topoisomerase II alpha | Homo sapiens | 77 | 204 |