Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC10251 L3MBTL1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC107482 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC113733 POLB 2 Median: 51840
Range: 43400 to 60280
IC50 PMID: 14640519
PMID: 18343122
NPC138113 TSHR 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC149184 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC149184 PPARD 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC149184 PPARA 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC157340 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC203719 HPGD 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC203719 ABAT 1 17100 IC50 PMID: 16290145
NPC203719 ALDH5A1 1 15600 IC50 PMID: 16290145
NPC203719 ALDH1A1 2 Median: 19622.15
Range: 14125.4 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC209970 ALOX15 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC209970 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC209970 TDP1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC209970 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216630 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC219913 ALDH5A1 1 24700 IC50 PMID: 16290145
NPC219913 ABAT 1 16500 IC50 PMID: 16290145
NPC230301 DPP4 1 28840 IC50 DOI: 10.1039/C0MD00245C
NPC230301 POLB 1 26300 IC50 PMID: 14640519
NPC255042 CYP3A4 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC257124 AR 2 Median: 19027.305
Range: 19000 to 19054.61
IC50 PMID: 20226658
PMID: 20226658
NPC261831 BLM 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC261831 CYP19A1 1 32700 IC50 PMID: 16643058
NPC261831 TOP1 1 31000 IC50 PMID: 12444712
NPC261831 MAPT 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC261831 FABP4 1 26100 IC50 PMID: 20471252
NPC261831 KMT2A 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC261831 ATM 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC261831 HSD17B10 2 Median: 17900.75
Range: 15848.9 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC26960 PTPN1 1 32600 IC50 PMID: 25497963
NPC277704 ALOX12 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC301585 PPARD 1 24000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC301585 PPARG 1 21000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC434 ALDH1A1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC434 HSD17B10 2 Median: 35716.75
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC434 CYP3A4 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC47946 ALDH1A1 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC47946 ALOX15 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC68889 ALOX15 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC71853 ALDH1A1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC71853 ALOX15 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 CYP19A1 1 48000 IC50 PMID: 16643058
NPC85813 F3 1 41000 IC50 PMID: 9834151
NPC85813 HSD17B10 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 TSHR 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC85813 CYP3A4 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC85813 ALDH1A1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC10251 TSHR 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC257124 ALDH1A1 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC257124 PTGS1 1 11000 IC50 PMID: 16038536
NPC261831 KCNH2 1 10410 EC50 PubChem BioAssay data set
CHEMBL1201862
NPC277704 TSHR 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC434 HPGD 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC71853 CYP3A4 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC71853 TSHR 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC71853 ALOX12 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 FABP4 2 Median: 15650
Range: 13600 to 17700
IC50 PMID: 20471252
PMID: 25461324
NPC85813 PTGS1 1 13000 IC50 PMID: 16038536