Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC161571 POLB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC161571 PMP22 1 42561.5 Potency PubChem BioAssay data set
CHEMBL1201862
NPC161571 GAA 1 39506.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC161571 CYP1A1 1 34000 IC50 PMID: 27265259
NPC161571 HSD17B10 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC161571 ALDH1A1 4 Median: 37646
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC161571 MAOB 1 29370 IC50 DOI: 10.1039/C3MD00376K
NPC161571 BCR 1 28000 IC50 PMID: 16686543
NPC161571 CYP19A1 2 Median: 25000
Range: 25000 to 25000
IC50 PMID: 22115839
PMID: 22386564
NPC161571 SIRT1 3 Median: 46200
Range: 23600 to 87200
EC50 PMID: 18046409
PMID: 23316803
PMID: 23316803
NPC161571 KDM4E 4 Median: 28370.85
Range: 22387.2 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC161571 RELA 1 20000 IC50 Patent: Patent: US20130178536 A1
NPC161571 ODC1 1 19000 IC50 PMID: 10075742
NPC292452 CYP1B1 2 Median: 34000
Range: 34000 to 34000
IC50 PMID: 11754588
PMID: 27265259
NPC292452 MMP2 1 27600 IC50 PMID: 22658537
NPC292452 CYP1A1 1 15000 IC50 PMID: 11754588
NPC303422 MAPT 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC303422 GAA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC303422 KDM4E 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC303422 MAPK1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC303422 POLB 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC40488 BCHE 1 19460 IC50 PMID: 23062825
NPC292452 TYR 1 12700 IC50 PMID: 16919455