Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC131624 PTGS2 3 Median: 46000
Range: 46000 to 46000
IC50 PMID: 16038536
PMID: 24631898
PMID: 25956953
NPC230301 DPP4 1 28840 IC50 DOI: 10.1039/C0MD00245C
NPC230301 POLB 1 26300 IC50 PMID: 14640519
NPC237435 CDK1 1 14360 IC50 PMID: 18639462
NPC239312 THRB 2 Median: 44668.4
Range: 44668.4 to 44668.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC239312 ABCB1 1 41000 IC50 PMID: 15481991
NPC239312 PREP 1 36000 IC50 PMID: 18650094
NPC239312 SI 2 Median: 43500
Range: 35000 to 52000
IC50 PMID: 9834167
PMID: 18255289
NPC239312 CYP3A4 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC239312 HBB 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC239312 CYP2D6 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC239312 GPR35 1 28200 IC50 PMID: 24900447
NPC239312 L3MBTL1 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC78540 CALM1;CALM2;CALM3 1 33430 IC50 PMID: 21129983
NPC78540 MAPK1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC78540 KDM4E 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC78540 PTGS2 1 25500 IC50 PMID: 24332492
NPC78540 TP53 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC237435 PREP 2 Median: 12150
Range: 12000 to 12300
IC50 PMID: 18650094
PMID: 20058865
NPC239312 CREB1 1 13500 AC50 PMID: 18722769
NPC239312 SMN1;SMN2 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC239312 ALDH1A1 2 Median: 13104.55
Range: 11220.2 to 14988.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC239312 GLO1 1 11000 IC50 PMID: 18258440
NPC239312 PTPRS 1 10300 IC50 PMID: 26602279
NPC78540 CYP2D6 1 12589.25 AC50 PubChem BioAssay data set
CHEMBL1201862