Plant ID: NPO9947
Plant Latin Name: Teucrium Scorodonia
Taxonomy Genus: Teucrium
Taxonomy Family: Lamiaceae
NCBI TaxonomyDB:
53178
Plant-of-the-World-Online:
n.a.
Alterative; Appetizer; Astringent; Carminative; Diaphoretic; Diuretic; Emmenagogue; Skin; Tonic; Vulnerary
China
Ingredient ID: NPC94045
Ingredient ID: NPC83831
Ingredient ID: NPC76145
Ingredient ID: NPC71853
Ingredient ID: NPC61
Ingredient ID: NPC52691
Ingredient ID: NPC47844
Ingredient ID: NPC4152
Ingredient ID: NPC35543
Ingredient ID: NPC33090
Ingredient ID: NPC309399
Ingredient ID: NPC283908
Ingredient ID: NPC283655
Ingredient ID: NPC279666
Ingredient ID: NPC27184
Ingredient ID: NPC270818
Ingredient ID: NPC253722
Ingredient ID: NPC253481
Ingredient ID: NPC243591
Ingredient ID: NPC235625
Ingredient ID: NPC231730
Ingredient ID: NPC229403
Ingredient ID: NPC219945
Ingredient ID: NPC203108
Ingredient ID: NPC190810
Ingredient ID: NPC177228
Ingredient ID: NPC128248
Ingredient ID: NPC109854
Ingredient ID: NPC100362
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Enzyme | KARS1 | Lysyl-tRNA synthetase | Q15046 | CHEMBL5575 |
Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 4 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
NCT01659580 | Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina | angina pectoris | Borneol (NPC283655) | NP level |
NCT02029118 | Acupoint Application in Patients With Stable Angina Pectoris (AASAP) | angina pectoris | Borneol (NPC283655) | NP level |
NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
POLB,APEX1,PKM,TP53
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
PKM,TDP1,TP53,POLB
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TDP1,TP53,PKM,APEX1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
APEX1,TDP1,TP53
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
SNCA,APEX1,TDP1
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT01659580,NCT02029118
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
PKM,TP53
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
SNCA,POLB
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
PKM,PKM
|
LiposarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B59 |
TP53
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
TP53
|
Metastatic liver/bile duct neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D80 |
TP53
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
TP53
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Fallopian tube cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C74 |
TP53
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
TP53
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
APEX1
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
PKM
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TP53
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
TP53
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
TP53
|
Ocular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D00-2D07 |
APEX1
|
Lip/oral cavity/pharynx neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6E |
TP53
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
TP53
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
TP53
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TP53
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
TP53
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TP53
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
TP53
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
TP53
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
PKM
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
TP53
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
TP53
|
Kidney failureDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60-GB6Z |
TP53
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
TP53
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
TP53
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SNCA
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53
|
Other specified non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92.Y |
NCT04853082
|
XerostomiaDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA02.1 |
NCT04392622
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
SNCA
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
PKM
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
SNCA
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
PKM
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
APEX1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
SNCA
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
SNCA
|