Collective Molecular Activities of the Plant: Rhododendron Latoucheae
Plant ID: NPO9925
Plant Latin Name: Rhododendron Latoucheae
Taxonomy Genus: Rhododendron
Taxonomy Family: Ericaceae
Plant External Links:
NCBI TaxonomyDB:
184576
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
43 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
36 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
25 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99707
Ingredient ID: NPC95468
Ingredient ID: NPC94245
Ingredient ID: NPC93850
Ingredient ID: NPC90185
Ingredient ID: NPC74914
Ingredient ID: NPC64332
Ingredient ID: NPC51681
Ingredient ID: NPC479529
Ingredient ID: NPC479528
Ingredient ID: NPC479527
Ingredient ID: NPC479526
Ingredient ID: NPC479525
Ingredient ID: NPC479524
Ingredient ID: NPC479523
Ingredient ID: NPC479522
Ingredient ID: NPC469895
Ingredient ID: NPC35410
Ingredient ID: NPC32411
Ingredient ID: NPC295998
Ingredient ID: NPC280399
Ingredient ID: NPC26960
Ingredient ID: NPC267077
Ingredient ID: NPC26544
Ingredient ID: NPC257790
Ingredient ID: NPC253714
Ingredient ID: NPC24238
Ingredient ID: NPC233529
Ingredient ID: NPC233224
Ingredient ID: NPC226762
Ingredient ID: NPC204120
Ingredient ID: NPC203468
Ingredient ID: NPC198330
Ingredient ID: NPC195986
Ingredient ID: NPC183987
Ingredient ID: NPC174191
Ingredient ID: NPC164023
Ingredient ID: NPC162994
Ingredient ID: NPC157944
Ingredient ID: NPC15743
Ingredient ID: NPC139209
Ingredient ID: NPC126935
Ingredient ID: NPC116711
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 48 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00453999 | Evaluation of Efficacy and Safety of Peramivir in Adults With Acute Serious or Potentially Life-threatening Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT00867139 | TCAD vs. Monotherapy for Influenza A in Immunocompromised Patients | influenza | Oseltamivir (NPC469895) | NP level |
| NCT02888327 | A Drug-Drug Interaction Study to Evaluate the Effect of AL-794 on the Pharmacokinetics of Oseltamivir and JNJ-63623872 | influenza | Oseltamivir (NPC469895) | NP level |
| NCT00545532 | A Study of Oseltamivir (Tamiflu) for Treatment of Influenza in Immunocompromised Participants. | influenza | Oseltamivir (NPC469895) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT02293863 | A Study of MHAA4549A in Combination With Oseltamivir Versus Oseltamivir in Participants With Severe Influenza A Infection | influenza | Oseltamivir (NPC469895) | NP level |
| NCT02067975 | Tryptophan MRI in People With Schizophrenia and Healthy Controls | schizophrenia | Tryptophan (NPC203468) | NP level |
| NCT02954354 | A Study of S-033188 (Baloxavir Marboxil) Compared With Placebo or Oseltamivir in Otherwise Healthy Patients With Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT01258530 | A Study to Evaluate the Bioequivalence of Over-encapsulated Oseltamivir Capsules to Marketed Oseltamivir Capsules in Healthy Volunteers | influenza | Oseltamivir (NPC469895) | NP level |
| NCT01050257 | A Study of Intravenously Administered Tamiflu (Oseltamivir) in Patients Over 13 Years of Age With Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT03629184 | Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms | influenza | Oseltamivir (NPC469895) | NP level |
| NCT01179919 | Pharmacokinetics of Oseltamivir Carboxylate In Morbidly Obese Subjects | obesity | Oseltamivir (NPC469895) | NP level |
| NCT00298233 | High-Dose Versus Standard-Dose Oseltamivir to Treat Severe Influenza and Avian Influenza | avian influenza | Oseltamivir (NPC469895) | NP level |
| NCT02612259 | A Phase II, Randomized, Double-blind, Placebo-controlled, in Parallel Groups Clinical Trial to Assess the Safety and Efficacy of Dietary Supplementation With Tryptophan to Achieve Weight Loss, and Its Neuropsychological Effects in Adolescents With Obesity | obesity | Tryptophan (NPC203468) | NP level |
| NCT01546935 | Oseltamivir for Influenza Lower Respiratory Tract Infection in Children Under One | influenza | Oseltamivir (NPC469895) | NP level |
| NCT04261270 | A Randomized,Open,Controlled Clinical Study to Evaluate the Efficacy of ASC09F and Ritonavir for 2019-nCoV Pneumonia | COVID-19 | Oseltamivir (NPC469895) | NP level |
| NCT03903718 | Evaluation of the Safety and Efficacy of a Monoclonal Antibody to Treat Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT02108366 | Treatment of Severe Influenza A Infection | influenza | Oseltamivir (NPC469895) | NP level |
| NCT01227967 | Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications | influenza | Oseltamivir (NPC469895) | NP level |
| NCT01033734 | A Study of Intravenous Tamiflu (Oseltamivir) in Children With Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT00567931 | 1-Methyl-D-Tryptophan in Treating Patients With Metastatic or Refractory Solid Tumors That Cannot Be Removed By Surgery | neoplasm | Tryptophan (NPC203468) | NP level |
| NCT04371601 | Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019 | COVID-19 | Oseltamivir (NPC469895) | NP level |
| NCT00921726 | Pharmacokinetic Study of Oseltamivir and Intravenous Zanamivir in Healthy Adults | influenza | Oseltamivir (NPC469895) | NP level |
| NCT00439530 | Pharmacologic Study of Oseltamivir in Healthy Volunteers | avian influenza | Oseltamivir (NPC469895) | NP level |
| NCT00949533 | A Study on Emergence of Resistance With Oseltamivir (Tamiflu) in Participants With Seasonal Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT01037634 | Safety and Efficacy of Oseltamivir in Children Younger Than One Year of Age | influenza | Oseltamivir (NPC469895) | NP level |
| NCT03520049 | Proof-of-Concept: A Pilot, Randomized, Double-Blind Study of Oseltamivir Versus Placebo for Immune Thrombocytopenia | autoimmune thrombocytopenic purpura | Oseltamivir (NPC469895) | NP level |
| NCT01965626 | A Multicenter Randomized Open-label Study of Oseltamivir Combined With HD-DEX Versus HD-DEX in the Management of ITP | Thrombocytopenia | Oseltamivir (NPC469895) | NP level |
| NCT04558463 | The Effectivity and Safety of Favipiravir Compared to Oseltamivir as Adjuvant Therapy for COVID-19 | COVID-19 | Oseltamivir (NPC469895) | NP level |
| NCT01715909 | A Pharmacokinetic/Pharmacodynamic Study of Oseltamivir in Immunocompromised Children With Confirmed Influenza Infection | influenza | Oseltamivir (NPC469895) | NP level |
| NCT02617784 | A Multiple-Dose Study of Oral Oseltamivir in Participants on Hemodialysis (HD) and Continuous Ambulatory Peritoneal Dialysis (CAPD) | chronic kidney disease | Oseltamivir (NPC469895) | NP level |
| NCT04338698 | Hydroxychloroquine, Oseltamivir and Azithromycin for the Treatment of COVID-19 Infection: An RCT | COVID-19 | Oseltamivir (NPC469895) | NP level |
| NCT01191216 | 1-Methyl-D-Tryptophan and Docetaxel in Treating Patients With Metastatic Solid Tumors | neoplasm | Tryptophan (NPC203468) | NP level |
| NCT01231620 | A Study of Intravenous Zanamivir Versus Oral Oseltamivir in Adults and Adolescents Hospitalized With Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT02949011 | Study of S-033188 (Baloxavir Marboxil) Compared With Placebo or Oseltamivir in Patients With Influenza at High Risk of Influenza Complications | influenza | Oseltamivir (NPC469895) | NP level |
| NCT02735707 | Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia | COVID-19;influenza;pneumonia | Oseltamivir (NPC469895) | NP level |
| NCT02618824 | Role of Terminal Warm Blood Cardioplegia as Myocardial Protection in the Use of Histidine-Tryptophan-Ketoglutarate Cardioplegia in Complex Congenital Heart Surgery | congenital heart disease | Tryptophan (NPC203468) | NP level |
| NCT01042535 | Vaccine Therapy and 1-MT in Treating Patients With Metastatic Breast Cancer | male breast carcinoma | Tryptophan (NPC203468) | NP level |
| NCT04516915 | IMU-838 and Oseltamivir in the Treatment of COVID-19 | COVID-19 | Oseltamivir (NPC469895) | NP level |
| NCT05170009 | Baloxavir in Combination With Oseltamivir in Allogenic Bone Marrow Transplant Recipients With Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT03212716 | Efficiency of Antagonist Drugs of the Cellular Transcriptomic Signature of Influenza A Virus Infection. | influenza | Oseltamivir (NPC469895) | NP level |
| NCT02927431 | Study to Evaluate the Efficacy and Safety of Danirixin Co-administered With Oseltamivir in the Treatment of Adults Hospitalized With Influenza | viral disease | Oseltamivir (NPC469895) | NP level |
| NCT04303299 | Fight COVID-19 Trial | COVID-19 | Oseltamivir (NPC469895) | NP level |
| NCT02603952 | A Phase 2a to Evaluate the Safety of MEDI8852 in Adults With Uncomplicated Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT00830323 | Efficacy and Safety of Combination Therapies With Oseltamivir & Zanamivir or Oseltamivir & Amantadine Versus Oseltamivir Monotherapy in the Treatment of Seasonal Influenza A Infection | infection | Oseltamivir (NPC469895) | NP level |
| NCT02369159 | Safety, PK and Effectiveness of IV Peramivir Versus Oseltamivir in Pediatric Subjects With Uncomplicated Influenza | influenza | Oseltamivir (NPC469895) | NP level |
| NCT00334529 | Alternative Oseltamivir Dosing Strategies | influenza | Oseltamivir (NPC469895) | NP level |
| NCT01610245 | Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza | influenza | Oseltamivir (NPC469895) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04516915,NCT04371601,NCT04338698,NCT04558463,NCT04261270,NCT02735707,NCT04303299
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
NCT00921726,NCT02954354,NCT02735707,NCT02369159,NCT00867139,NCT02293863,NCT00545532,NCT02603952,NCT05170009,NCT02888327,NCT03212716,NCT00334529,NCT02108366,NCT02949011,NCT00453999,NCT01033734,NCT03629184,NCT00949533,NCT03903718,NCT01715909,NCT01231620,NCT01227967,NCT01258530,NCT01546935,NCT01037634,NCT01050257,NCT01610245
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT02612259,NCT01179919
|
Influenza due to identified zoonotic or pandemic influenza virusDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E31 |
NCT00439530,NCT00298233
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT01191216,NCT00567931
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
NCT01965626
|
Immune thrombocytopenic purpuraDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64.10 |
NCT03520049
|
Carcinoma of male breastDisease Category: X.Extension CodesDisease ICD-11 Code: XH5KW8 |
NCT01042535
|
Structural developmental anomaly of heart or great vessels, unspecifiedDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA8Z |
NCT02618824
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
NCT02927431
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT00830323
|
PneumoniaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40 |
NCT02735707
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NCT02617784
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT00000324
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
NCT02067975
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
