Collective Molecular Activities of the Plant: Pulsatilla Campanella
Country/Region:
ChinaTraditional Medicine System:
TCMChina; Mongolia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
48 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
24 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
24 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC92320
Ingredient ID: NPC87545
Ingredient ID: NPC78341
Ingredient ID: NPC6930
Ingredient ID: NPC6501
Ingredient ID: NPC62290
Ingredient ID: NPC53545
Ingredient ID: NPC39426
Ingredient ID: NPC38065
Ingredient ID: NPC313163
Ingredient ID: NPC308379
Ingredient ID: NPC302981
Ingredient ID: NPC297575
Ingredient ID: NPC291129
Ingredient ID: NPC289774
Ingredient ID: NPC279121
Ingredient ID: NPC265376
Ingredient ID: NPC262573
Ingredient ID: NPC260060
Ingredient ID: NPC247832
Ingredient ID: NPC245919
Ingredient ID: NPC238041
Ingredient ID: NPC237395
Ingredient ID: NPC236657
Ingredient ID: NPC21949
Ingredient ID: NPC209970
Ingredient ID: NPC209560
Ingredient ID: NPC20791
Ingredient ID: NPC203313
Ingredient ID: NPC202656
Ingredient ID: NPC192638
Ingredient ID: NPC185750
Ingredient ID: NPC184683
Ingredient ID: NPC183950
Ingredient ID: NPC179950
Ingredient ID: NPC152107
Ingredient ID: NPC149543
Ingredient ID: NPC149184
Ingredient ID: NPC139364
Ingredient ID: NPC13879
Ingredient ID: NPC133671
Ingredient ID: NPC130057
Ingredient ID: NPC125637
Ingredient ID: NPC120116
Ingredient ID: NPC117418
Ingredient ID: NPC116775
Ingredient ID: NPC111249
Ingredient ID: NPC109594
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 52 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001696 | A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor | cancer | Genistein (NPC39426) | NP level |
| NCT00005827 | Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate Cancer | prostate cancer | Genistein (NPC39426) | NP level |
| NCT00010686 | Dietary Phytoestrogens and Bone Metabolism | osteoporosis | Formononetin (NPC209560);Genistein (NPC39426) | NP level |
| NCT00016744 | Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis) | cystic fibrosis | Genistein (NPC39426) | NP level |
| NCT00058266 | Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo Radical Prostatectomy | prostate cancer | Genistein (NPC39426) | NP level |
| NCT00118040 | Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer | urinary bladder carcinoma | Genistein (NPC39426) | NP level |
| NCT00244933 | Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer | breast cancer | Genistein (NPC39426) | NP level |
| NCT00287690 | Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease | coronary artery disease | Genistein (NPC39426) | NP level |
| NCT00290758 | Genistein in Preventing Breast Cancer in Women at High Risk for Breast Cancer | breast cancer | Genistein (NPC39426) | NP level |
| NCT00376948 | Genistein, Gemcitabine, and Erlotinib in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer | pancreatic carcinoma | Genistein (NPC39426) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB,TYR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,KDR,DPP4,AURKB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,AURKB,KDM1A,AXL,TP53,SRC,PIM1,FLT3,GSK3B
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM,AURKB,CA7,CA12,TSHR,MMP12,NPSR1,CDK1,CYP2C9,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA7,CISD1,POLB,DPP4,CA2,XDH,HSD17B2,RECQL,AURKB,CYP1B1,HIF1A,CYP2C9,BLM,MET,MAOB,ALOX15,PIM1,ABCG2,AXL,NPSR1,ALOX5,CES1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,ALOX15
NCT00546039,NCT01126879,NCT01912820,NCT01325311 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP12,AURKB,CDK1,BLM,NOX4,MET,CYP19A1,ALOX15,NPSR1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
