Collective Molecular Activities of the Plant: Glehnia Littoralis
Plant ID: NPO8874
Plant Latin Name: Glehnia Littoralis
Taxonomy Genus: Glehnia
Taxonomy Family: Apiaceae
Plant External Links:
NCBI TaxonomyDB:
48119
Plant-of-the-World-Online:
n.a.
Country/Region:
South Korea; ChinaTraditional Medicine System:
TCM; KampoMedicinal Functions:
Analgesic; Antibacterial; Antipyretic; Diaphoretic; Expectorant
South Korea; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
282 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
214 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
141 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99480
Ingredient ID: NPC99419
Ingredient ID: NPC9880
Ingredient ID: NPC98179
Ingredient ID: NPC97790
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Ingredient ID: NPC88789
Ingredient ID: NPC88566
Ingredient ID: NPC88461
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Ingredient ID: NPC88118
Ingredient ID: NPC87828
Ingredient ID: NPC85813
Ingredient ID: NPC85488
Ingredient ID: NPC81775
Ingredient ID: NPC81483
Ingredient ID: NPC79273
Ingredient ID: NPC78551
Ingredient ID: NPC76817
Ingredient ID: NPC76336
Ingredient ID: NPC76145
Ingredient ID: NPC75816
Ingredient ID: NPC7551
Ingredient ID: NPC7491
Ingredient ID: NPC74539
Ingredient ID: NPC73311
Ingredient ID: NPC71703
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Ingredient ID: NPC70744
Ingredient ID: NPC70741
Ingredient ID: NPC7057
Ingredient ID: NPC68889
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Ingredient ID: NPC6697
Ingredient ID: NPC66835
Ingredient ID: NPC63355
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Ingredient ID: NPC198816
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Ingredient ID: NPC163556
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Ingredient ID: NPC144023
Ingredient ID: NPC143639
Ingredient ID: NPC142703
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Ingredient ID: NPC141080
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Ingredient ID: NPC138347
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Ingredient ID: NPC135088
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Ingredient ID: NPC117493
Ingredient ID: NPC114239
Ingredient ID: NPC114011
Ingredient ID: NPC113776
Ingredient ID: NPC111888
Ingredient ID: NPC110500
Ingredient ID: NPC109813
Ingredient ID: NPC1075
Ingredient ID: NPC107325
Ingredient ID: NPC106250
Ingredient ID: NPC103409
Ingredient ID: NPC101285
Ingredient ID: NPC100879
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A13 | Cytochrome P450 2A13 | Q16696 | CHEMBL3542436 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 164 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00001986 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00003610 | Capsaicin Lozenges in Treating Patients With Mucositis Caused by Radiation Therapy | head and neck malignant neoplasia | Capsaicin (NPC255550) | NP level |
| NCT00004359 | Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita | epidermolysis bullosa acquisita | Methoxsalen (NPC33320) | NP level |
| NCT00005092 | Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer | leukemia;multiple myeloma;myelodysplastic syndrome | Psoralen (NPC51146) | NP level |
| NCT00008476 | Capsaicin to Control Pain Following Third Molar Extraction | facial pain | Capsaicin (NPC255550) | NP level |
| NCT00016679 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00030589 | Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma | lymphoma | Methoxsalen (NPC33320) | NP level |
| NCT00054600 | Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,FFAR1,AKR1B1,PPARA,AURKB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,TP53,KDM1A,SRC,AURKB,AXL,PIM1,FLT3
NCT02472626 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT00284323,NCT01747174
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,MMP9,ACHE,CA12,CA7,NR1I2,AURKB,CA9,CYP2D6,CDK1,XDH,MMP1,AKR1C3,F2,CYP2C9,TSHR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NPSR1,ADORA2A,CYP2C19,ACHE,ADORA3,CA7,NR1I2,POLB,CNR2,AURKB,PIM1,MMP2,CA9,LMNA,AXL,XDH,OR51E2,MMP1,FFAR4,FABP3,AKR1C3,ALOX5,CA2,ABCG2,CYP1B1,F2,MET,SNCA,CYP2C9,ALOX15,RECQL
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,NOX4,FABP5,ALOX15
NCT01912820 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
