Collective Molecular Activities of the Plant: Epipactis Palustris
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PLANiTS DNA barcode
Taxonomic Information
Used in Medicines
Unknown.
Geographical Distribution
Turkey; Italy; Turkmenistan; Mongolia; France; Ireland; Norway; Uzbekistan; Belarus; Iran; China; Belgium; Germany; Kazakhstan; Spain; Ukraine; Netherlands; Denmark; Poland; Finland; Sweden; Switzerland; Russia; Bulgaria; Romania; Albania; Portugal; United Kingdom; Austria; Greece; Hungary; Tajikistan
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
23 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
7 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
16 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95159
Ingredient ID: NPC83546
Ingredient ID: NPC49173
Ingredient ID: NPC4747
Ingredient ID: NPC293197
Ingredient ID: NPC281131
Ingredient ID: NPC26551
Ingredient ID: NPC257124
Ingredient ID: NPC255675
Ingredient ID: NPC252928
Ingredient ID: NPC225710
Ingredient ID: NPC223049
Ingredient ID: NPC20791
Ingredient ID: NPC203020
Ingredient ID: NPC19721
Ingredient ID: NPC184125
Ingredient ID: NPC175107
Ingredient ID: NPC172920
Ingredient ID: NPC169749
Ingredient ID: NPC156624
Ingredient ID: NPC113836
Ingredient ID: NPC106138
Ingredient ID: NPC104275
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
| Therapeutic Target | Lyase | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Therapeutic Target | Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Therapeutic Target | Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Therapeutic Target | Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Therapeutic Target | Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Therapeutic Target | Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Therapeutic Target | Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Therapeutic Target | Protein Kinase | YES1 | Tyrosine-protein kinase YES | P07947 | CHEMBL2073 |
| Therapeutic Target | Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Therapeutic Target | Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transferase | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Q11130 | CHEMBL3596077 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 22 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT05276895 | Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis | osteoarthritis | Quercetin (NPC20791) | NP level |
| NCT03989271 | Biological Effects of Quercetin in COPD | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Quercetin (NPC20791) | NP level |
| NCT03606694 | Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-Trihydroxyphenyl)-2,3-Dihydrochromen-4-One (NPC19721) | NP level |
| NCT02848131 | Senescence in Chronic Kidney Disease | chronic kidney disease | Quercetin (NPC20791) | NP level |
| NCT04946383 | Safety and Effectivness of Quercetin & Dasatinib on Epigenetic Aging | aging | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT04853199 | Quercetin In The Treatment Of SARS-COV 2 | COVID-19 | Quercetin (NPC20791) | NP level |
| NCT04907253 | Quercetin in Coronary Artery By-pass Surgery | coronary artery disease | Quercetin (NPC20791) | NP level |
| NCT05456022 | Therapeutic Efficacy of Quercetin Versus Its Encapsulated Nanoparticle on Tongue Squamous Cell Carcinoma Cell Line | mouth neoplasm | Quercetin (NPC20791) | NP level |
| NCT01839344 | Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. | type 2 diabetes mellitus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT03943459 | Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease | coronary artery disease | Quercetin (NPC20791) | NP level |
| NCT05422885 | Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease | aging | Quercetin (NPC20791) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
| NCT02226484 | Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? | gastroesophageal reflux disease | Quercetin (NPC20791) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT05062486 | A Study to Evaluate the Safety and Efficacy of RQC for AMD | age-related macular degeneration | Quercetin (NPC20791) | NP level |
| NCT04851821 | The Effectiveness of Phytotherapy in SARS-COV2(COVID-19) | COVID-19 | Quercetin (NPC20791) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT04733534 | An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer | childhood cancer | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CYP19A1,EGFR,KDR,MET,IGF1R,CDK1,SRC,AXL,TOP2A
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
CDK1,KDR,TOP2A,EGFR,FLT3,IGF1R,MET,ALOX5,AXL
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
L3MBTL1,IGF1R,TRIM24,SRC,AURKB,NOX4,CYP19A1,TOP2A,CDK1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FUT7,SNCA,AURKB,NOX4,CYP19A1,TOP2A,GLO1,MET,CDK1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
NPSR1,AURKB,NOX4,CYP19A1,TOP2A,MET,CDK1,ALOX15
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
HSD17B10,FUT7,TRIM24,CYP1B1,FLT3,APEX1,ACHE,ALOX15
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
KDR,TOP2A,EGFR,MET,FLT3,IGF1R,TP53
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AXL,SRC,TOP2A,AURKB,FLT3,PIM1,TP53
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
FUT7,SNCA,NOX4,ELAVL3,MET,ACHE,XDH
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
NPSR1,AURKB,NOX4,TOP2A,ACHE,CDK1,ALOX15
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP1A1,NPSR1,AURKB,TOP2A,CDK1,XDH,ALOX15
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
MET,EGFR,KDR,CSNK2A1,IGF1R,TOP2A
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
TP53,AURKB,FLT3,TOP2A,SRC,CDK1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
FLT3,SNCA,MET,KDR,ACHE,TOP2A
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TOP2A,SRC,FLT3,MET,KDR,TP53
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
TP53,KDR,EGFR,MET,SRC,TOP2A
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
NPSR1,AURKB,TOP2A,ALOX12,CDK1,XDH
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,AURKB,TOP2A,ACHE,CDK1,XDH
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CSNK2A3,CYP1B1,CYP19A1,MET,KDR,LMNA
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
SRC,IGF1R,FLT3,AXL,KDR
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
TP53,TOP2A,MET,EGFR,KDR
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
EGFR,SRC,TOP2A,TP53,IGF1R
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP1A1,KDM4E,ELAVL3,ACHE,ALOX15
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ALOX5,CYP1B1,NOX4,MET,XDH
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
AXL,CYP19A1,EGFR,XDH,LMNA
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
FUT7,AURKB,TOP2A,ELAVL3,CDK1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP1A1,AURKB,TOP2A,MET,CYP1A2
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
FLT3,SRC,TP53,KDR
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
EGFR,KDR,TP53,MET
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
TP53,SRC,EGFR,AXL
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
KDR,EGFR,TP53,AXL
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ACHE,MET,CYP19A1,AXL
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CYP1A1,NPSR1,NOX4,MET
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
IGF1R,FUT7,ABCG2,NOX4
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
AURKB,TOP2A,CDK1,XDH
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ACHE,SRC,SNCA,LMNA
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CDK1,TOP2A,CYP1A2,AURKB
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
XDH,GLO1,ALOX5
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
KDR,EGFR,MET
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ALOX5,TOP2A,FLT3
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ACHE,IGF1R,ALOX5
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
MET,KDR,EGFR
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
SRC,KDR,MET
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
FLT3,KDR,EGFR
|
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
SRC,KDR,MET
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
KDR,MET,EGFR
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
ALOX5,EGFR,CDK1
|
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
MET,KDR,EGFR
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
CDK1,FLT3,TOP2A
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SRC,SNCA,ACHE
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
XDH,IGF1R
NCT02848131 |
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,ALOX15
NCT01912820 |
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
FUT7,NOX4,FLT3
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
NPSR1,AURKB,NOX4
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CYP1A1,YES1,ACHE
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
MET,FLT3,AXL
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
FUT7,CYP1B1,NOX4
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
MET,ACHE,AXL
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
KDR,FUT7,ALOX5,CSNK2A2,FLT3,ALOX15,SNCA,PIM1,RECQL,APEX1,EGFR,SRC,TDP1,LMNA,AXL,AURKB,TOP2A,MET,CDK1,XDH,CASP6
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
HSD17B10,CSNK2A2,NOX4,RECQL,GLO1,APEX1,EGFR,CDK1,TRIM24,SRC,TDP1,LMNA,AXL,AURKB,TOP2A,MET,ACHE,TP53,KDR,CASP6
|
Malignant digestive organ neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C11 |
KDR,SRC
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
ALOX5,TOP2A
|
IschemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B10-8B11 |
EGFR,SRC
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
MET,TP53
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
SRC,TOP2A
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ACHE,MET
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TP53,TOP2A
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
MET,KDR
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
ALOX5,KDR
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
SRC,TP53
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
IGF1R,APEX1
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
EGFR,TOP2A
|
Gastrointestinal stromal tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5B |
KDR,SRC
|
Fallopian tube cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C74 |
TP53,SRC
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
FLT3,SRC
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ALOX5,ABCG2
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
ALOX5,SRC
|
Motor neuron diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60 |
IGF1R,SRC
|
NADisease Category: NADisease ICD-11 Code: NA |
NOX4,MET
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
TP53,SRC
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,KDR
|
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
EGFR,MET
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
SRC,FLT3
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ALOX5,IGF1R
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TOP2A,FLT3
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
FLT3,ALOX5
|
Follicular lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A80 |
TOP2A
NCT00455416 |
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04851821,NCT04853199
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
NCT01708278,NCT03989271
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT03943459,NCT04907253
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT05422885,NCT04946383
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NCT01839344,NCT03606694
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CYP1A1,CDK1
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE,AXL
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CDK1,TOP2A
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
AURKB,ABCG2
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1,TOP2A
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1,ABCG2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
TOP2A,EGFR,CSNK2A1,XDH,YES1,CDK1,POLB,KDR,AXL,AURKB,APEX1,IGF1R,SRC,MET,TP53,PIM1,ALOX5,FLT3
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HSD17B10,FUT7,NPSR1,ALOX15,XDH,YES1,GLO1,POLB,TDP1,AURKB,CYP19A1,TOP2A,ELAVL3,MET,TP53,CASP6
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
FUT7,CSNK2A3,ALOX5,NOX4,CYP1A2,ALOX15,ALOX12,YES1,GLO1,APEX1,TDP1,ELAVL3,MET,TP53,XDH,CASP6
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
POLB,FUT7,ABCG2,ALOX5,CYP1B1,SNCA,NPSR1,PIM1,RECQL,AXL,AURKB,MET,ACHE,XDH,LMNA,ALOX15
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
KDR,FUT7,ABCG2,ALOX5,SNCA,NPSR1,NOX4,ALOX12,GLO1,MET,ACHE,CDK1,XDH,CASP6
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
L3MBTL1,IGF1R,CDK1,CSNK2A3,ALOX5,SRC,AURKB,NOX4,TOP2A,ALOX12,ELAVL3,TP53,LMNA
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
L3MBTL1,CYP19A1,AURKB,NOX4,TOP2A,CDK1,TRIM24,SRC,CYP19A1,AURKB,TOP2A,CDK1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ALOX5,AURKB,CYP19A1,TOP2A,MET,ACHE,XDH,FUT7,ALOX5,AURKB,TOP2A
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
TP53
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
EGFR
|
Kaposi sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B57 |
TOP2A
|
SyphilisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A61-1A6Z |
TOP2A
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
CYP19A1
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
XDH
|
Otitis mediaDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AA80-AB0Z |
TOP2A
|
Mineral deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B5K |
XDH
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
EGFR
|
Transplanted organ/tissueDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QB63 |
FLT3
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
EGFR
|
Inflammatory arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA2Z |
FLT3
|
Gonococcal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A70-1A7Z |
TOP2A
|
Anogenital wartsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A95 |
TOP2A
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
CYP19A1
|
OesophagitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA24 |
CYP19A1
|
Liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB90-DB9Z |
MET
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
ALOX5
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
EncephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E47 |
XDH
|
Spinal cord/cranial nerve neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A02 |
EGFR
|
Biliary tract cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C17 |
MET
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
ABCG2
|
Testicular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80 |
EGFR
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
ALOX5
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
ALOX5
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
EGFR
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
FLT3
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
|
Metastatic liver/bile duct neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D80 |
TP53
|
Multiple structural anomalies syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2F |
IGF1R
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TP53
|
Phakomatoses/hamartoneoplastic syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2D |
FLT3
|
Ischemic heart diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40-BA6Z |
MET
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
CYP19A1
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ACHE
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
ThyrotoxicosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A02 |
IGF1R
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
Ocular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D00-2D07 |
APEX1
|
Otitis externaDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AA00-AA13 |
TOP2A
|
Metastatic malignant neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D50-2E09 |
AXL
|
Inborn purine/pyrimidine/nucleotide metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C55 |
XDH
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
ChemoprotectionDisease Category: NADisease ICD-11 Code: N.A. |
TOP2A
|
Skin postprocedural disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EL8Y |
EGFR
|
Respiratory system diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB40-CB7Z |
TOP2A
|
Intracerebral haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B00 |
EGFR
|
FilariasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F66 |
ALOX5
|
Digestive organ benign neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E92 |
KDR
|
Common wartsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E80 |
TOP2A
|
Urinary tract infectionDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC08 |
TOP2A
|
Epidermal dysplasiasDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK90 |
SRC
|
Kidney failureDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60-GB6Z |
TP53
|
LeiomyosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B58 |
SRC
|
Synovial sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5A |
SRC
|
Metastatic biliary tract neoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C14-2C17 |
EGFR
|
Extraocular muscle disorderDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C82 |
IGF1R
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
TOP2A
|
MastocytosisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A21 |
FLT3
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
TOP2A
|
Metastatic digestive system neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D8Y |
SRC
|
Lip/oral cavity/pharynx neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6E |
TP53
|
Human immunodeficiency virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C60-1C62 |
FLT3
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
XDH
|
OsteosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B51 |
SRC
|
Malignant mesenchymal neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5D-2B5Y |
EGFR
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Coronavirus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D92 |
CSNK2A1
|
HIV-infected patients with tuberculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B10-1B14 |
TOP2A
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
TP53
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
AURKB
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
FLT3
|
Bone/articular cartilage neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7B |
FLT3
|
Hypopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6D |
EGFR
|
Urethral cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C93 |
EGFR
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
LiposarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B59 |
TP53
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT05062486
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT04733534
|
Congenital aplastic anaemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A70.0 |
NCT01720147
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT01348204
|
Gastro-oesophageal reflux diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA22 |
NCT02226484
|
Lichen planusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA91 |
NCT01375101
|
Chronic hepatitis CDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.1 |
NCT01438320
|
Malignant neoplasms of other or unspecified parts of mouthDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B66 |
NCT05456022
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT05276895
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
PIM1
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
NOX4
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
ABCG2
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
NOX4
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
FUT7
|
Dilated cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.0 |
ABCG2
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
MET
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
NOX4
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
