CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Lithospermum Officinale

Example Image

PLANiTS DNA barcode

Click for details-----ITS

TCGAATCCTGTATAGCAGAACCACTCGTGAACACGTTTTTTAACTCGGGCATCGGTTAATACGGGATACTCCCGACTATTGATCGGAGCCTAACGGTGCCCCGGCATCTTGCCGTGTGGTGCTTAACAACAACCCCCGGCGCGAGAAGCGCCAAGGAATACTTTGACAAGGGCTTGAACCATCCTCTCCCGCTCGCGGGGCACAGAGGCTTGGAGATGGCTTCTTTCTAAACCACAACGACTCTCGGCAACGGATATCTCGGCTCTCGCATCGATGAAGAACGTAGCGAAATGCGATACTTGGTGTGAATTGCAGAATCCCGTGAACCATCGAGTCTTTGAACGCAAGTTGCGCCTGAAGCCATTAGGCTAAAGGCACGTCTGCCTGGGCGTCACGCATCGCGTCACCCATCCCCAATTCTCGTGGATGTGGTGGATTGTGACCTCCTGTGCCTTGAGGTGCAGTTGGTCGAAATTCGAGTTCGGAGTTAAGGACTTCACGACAAGTGGTGGTTGGACGACCAACTCGCGTCATGTCGTGTGCCAAACCTTCGTGGCTCTCAAGACCCTAAGGCACGTGCTTCCCGGCTCTTGGGTCGGAAAACTCGTGCTACGACCGCGAC

Click for details-----ITS1

TTGTCGAATCCTGTATAGCAGAACCACTCGTGAACACGTTTTTTAACTCGGGCATCGGTTAATACGGGATACTCCCGACTATTGATCGGAGCCTAACGGTGCCCCGGCATCTTGCCGTGTGGTGCTTAACAACAACCCCCGGCGCGAGAAGCGCCAAGGAATACTTTGACAAGGGCTTGAACCATCCTCTCCCGCTCGCGGGGCACAGAGGCTTGGAGATGGCTTCTTTCTAAACCACAA

Click for details-----ITS2

ATCGCGTCACCCATCCCCAATTCTCGTGGATGTGGTGGATTGTGACCTCCTGTGCCTTGAGGTGCAGTTGGTCGAAATTCGAGTTCGGAGTTAAGGACTTCACGACAAGTGGTGGTTGGACGACCAACTCGCGTCATGTCGTGTGCCAAACCTTCGTGGCTCTCAAGACCCTAAGGCACGTGCTTCCCGGCTCTTGGGTCGGAAAACTCGTGCTACGACCGCGAC

Taxonomic Information

Plant ID: NPO8642
Plant Latin Name: Lithospermum Officinale
Taxonomy Genus: Lithospermum
Taxonomy Family: Boraginaceae

Plant External Links:

NCBI TaxonomyDB: 475907
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

China; India; Spain

Traditional Medicine System:

Indian Folk; TCM; Unani

Medicinal Functions:

Contraceptive; Depurative; Diuretic; Lithontripic; Oxytoxic; Sedative

Geographical Distribution

India; China; Spain

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

51 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

33 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)