CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Angelica Taiwaniana

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO8471
Plant Latin Name: Angelica Taiwaniana
Taxonomy Genus: Angelica
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution

China

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

69 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

51 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

39 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC98143

Ingredient ID: NPC93843

Ingredient ID: NPC89591

Ingredient ID: NPC88445

Ingredient ID: NPC75428

Ingredient ID: NPC74539

Ingredient ID: NPC71853

Ingredient ID: NPC7180

Ingredient ID: NPC71506

Ingredient ID: NPC6323

Ingredient ID: NPC60175

Ingredient ID: NPC57788

Ingredient ID: NPC44193

Ingredient ID: NPC37733

Ingredient ID: NPC37250

Ingredient ID: NPC34770

Ingredient ID: NPC33320

Ingredient ID: NPC310175

Ingredient ID: NPC3044

Ingredient ID: NPC302939

Ingredient ID: NPC287182

Ingredient ID: NPC281835

Ingredient ID: NPC281658

Ingredient ID: NPC281131

Ingredient ID: NPC272965

Ingredient ID: NPC27184

Ingredient ID: NPC271215

Ingredient ID: NPC269800

Ingredient ID: NPC253754

Ingredient ID: NPC253526

Ingredient ID: NPC246519

Ingredient ID: NPC243509

Ingredient ID: NPC241055

Ingredient ID: NPC235076

Ingredient ID: NPC230301

Ingredient ID: NPC226827

Ingredient ID: NPC225680

Ingredient ID: NPC225434

Ingredient ID: NPC220111

Ingredient ID: NPC216630

Ingredient ID: NPC215894

Ingredient ID: NPC210460

Ingredient ID: NPC20791

Ingredient ID: NPC206596

Ingredient ID: NPC194691

Ingredient ID: NPC184014

Ingredient ID: NPC182432

Ingredient ID: NPC177684

Ingredient ID: NPC176790

Ingredient ID: NPC176740

Ingredient ID: NPC173637

Ingredient ID: NPC167539

Ingredient ID: NPC167488

Ingredient ID: NPC163343

Ingredient ID: NPC154176

Ingredient ID: NPC151327

Ingredient ID: NPC147957

Ingredient ID: NPC144288

Ingredient ID: NPC14234

Ingredient ID: NPC14213

Ingredient ID: NPC139546

Ingredient ID: NPC132669

Ingredient ID: NPC131417

Ingredient ID: NPC126029

Ingredient ID: NPC124226

Ingredient ID: NPC118284

Ingredient ID: NPC107244

Ingredient ID: NPC103123

Ingredient ID: NPC10146

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450	Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450	Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450	Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Therapeutic Target	Enzyme	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Therapeutic Target	Enzyme	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Therapeutic Target	Enzyme	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Therapeutic Target	Enzyme	POLB	DNA polymerase beta	P06746	CHEMBL2392
Therapeutic Target	Fatty acid binding protein family	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Therapeutic Target	Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220

Showing 1 to 10 of 27 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	44

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00004359	Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita	epidermolysis bullosa acquisita	Methoxsalen (NPC33320)	NP level
NCT00030589	Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma	lymphoma	Methoxsalen (NPC33320)	NP level
NCT00054600	Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease	graft versus host disease	Methoxsalen (NPC33320)	NP level
NCT00054613	Safety and Efficacy Study of Photopheresis Plus Standard Therapy to Treat Chronic Graft-versus-Host Disease	graft versus host disease	Methoxsalen (NPC33320)	NP level
NCT00056056	Ultraviolet Light Therapy Using Methoxsalen With or Without Bexarotene in Treating Patients With Mycosis Fungoides	lymphoma	Methoxsalen (NPC33320)	NP level
NCT00056355	Extracorporeal Photopheresis to Maintain Symptoms Remission During Steroid Withdrawal in Patients With Steroid-Dependent Crohn's Disease	Crohn's disease	Methoxsalen (NPC33320)	NP level
NCT00221000	Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis	rheumatoid arthritis	Methoxsalen (NPC33320)	NP level
NCT00221026	Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Crohn's Disease	Crohn's disease	Methoxsalen (NPC33320)	NP level
NCT00282503	Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Acute Graft Versus-Host Disease	acute graft vs. host disease	Methoxsalen (NPC33320)	NP level
NCT00455416	Dietary Intervention in Follicular Lymphoma	follicular lymphoma	Quercetin (NPC20791)	NP level

Showing 1 to 10 of 44 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

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Associated Disease of the Plant	Association Type & Detailed Evidence
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	AKR1B1,KDR,AURKB,CNR1
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	SRC,PIM1,AXL,TP53,AURKB,FLT3,NFKB1
Acute/subacute hepatic failure Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB91	NFKB1
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	CA12,ACHE,F2,CA9,XDH,CDK1,AURKB,NPSR1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	ACHE,PIM1,NPSR1,SNCA,ABCG2,ALOX5,OR51E2,F2,RECQL,CYP1B1,CA9,AURKB,XDH,POLB,ALOX15,MET,AXL,CNR2
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	NOX4,OR51E2,FABP5,ALOX15 NCT01912820
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	NOX4,CYP19A1,F2,ALOX15,CDK1,MET,AURKB,NPSR1
Ageing associated decline in intrinsic capacity Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG2A	NCT04946383,NCT05422885
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	FLT3,ACHE,SNCA,MET,KDR
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	EGFR,F2

Showing 1 to 10 of 235 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Angelica Taiwaniana

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

69 All known Ingredients in Total

51 Ingredients with Acceptable Bioavailablity

39 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute diabete complication

Acute myeloid leukaemia

Acute/subacute hepatic failure

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Adenocarcinoma of prostate

Adenocarcinoma of stomach

Ageing associated decline in intrinsic capacity

Alzheimer disease

Angina pectoris

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities