Collective Molecular Activities of the Plant: Fritillaria Hupehensis
Plant ID: NPO7844
Plant Latin Name: Fritillaria Hupehensis
Taxonomy Genus: Fritillaria
Taxonomy Family: Liliaceae
Plant External Links:
NCBI TaxonomyDB:
152089
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
103 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
69 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
37 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC90701
Ingredient ID: NPC8821
Ingredient ID: NPC87828
Ingredient ID: NPC86947
Ingredient ID: NPC85270
Ingredient ID: NPC76145
Ingredient ID: NPC75097
Ingredient ID: NPC71339
Ingredient ID: NPC68204
Ingredient ID: NPC66913
Ingredient ID: NPC63027
Ingredient ID: NPC62086
Ingredient ID: NPC61198
Ingredient ID: NPC5952
Ingredient ID: NPC54320
Ingredient ID: NPC52370
Ingredient ID: NPC49074
Ingredient ID: NPC44611
Ingredient ID: NPC43246
Ingredient ID: NPC41080
Ingredient ID: NPC39333
Ingredient ID: NPC36490
Ingredient ID: NPC36002
Ingredient ID: NPC35344
Ingredient ID: NPC312637
Ingredient ID: NPC305224
Ingredient ID: NPC299964
Ingredient ID: NPC288411
Ingredient ID: NPC278525
Ingredient ID: NPC27699
Ingredient ID: NPC264779
Ingredient ID: NPC263034
Ingredient ID: NPC262431
Ingredient ID: NPC259976
Ingredient ID: NPC248520
Ingredient ID: NPC248047
Ingredient ID: NPC243728
Ingredient ID: NPC242582
Ingredient ID: NPC242385
Ingredient ID: NPC241055
Ingredient ID: NPC238829
Ingredient ID: NPC23733
Ingredient ID: NPC232924
Ingredient ID: NPC230301
Ingredient ID: NPC226879
Ingredient ID: NPC226803
Ingredient ID: NPC22481
Ingredient ID: NPC223951
Ingredient ID: NPC221134
Ingredient ID: NPC218988
Ingredient ID: NPC216216
Ingredient ID: NPC215158
Ingredient ID: NPC214251
Ingredient ID: NPC214237
Ingredient ID: NPC212875
Ingredient ID: NPC211722
Ingredient ID: NPC211608
Ingredient ID: NPC211342
Ingredient ID: NPC209011
Ingredient ID: NPC204050
Ingredient ID: NPC198865
Ingredient ID: NPC194677
Ingredient ID: NPC190036
Ingredient ID: NPC189719
Ingredient ID: NPC189470
Ingredient ID: NPC186944
Ingredient ID: NPC185072
Ingredient ID: NPC184615
Ingredient ID: NPC179024
Ingredient ID: NPC177465
Ingredient ID: NPC176740
Ingredient ID: NPC175313
Ingredient ID: NPC168829
Ingredient ID: NPC168409
Ingredient ID: NPC168255
Ingredient ID: NPC166963
Ingredient ID: NPC166097
Ingredient ID: NPC160913
Ingredient ID: NPC157927
Ingredient ID: NPC156461
Ingredient ID: NPC154920
Ingredient ID: NPC149700
Ingredient ID: NPC142632
Ingredient ID: NPC142400
Ingredient ID: NPC141777
Ingredient ID: NPC141003
Ingredient ID: NPC138466
Ingredient ID: NPC13789
Ingredient ID: NPC128494
Ingredient ID: NPC128457
Ingredient ID: NPC122792
Ingredient ID: NPC117862
Ingredient ID: NPC117527
Ingredient ID: NPC116628
Ingredient ID: NPC115119
Ingredient ID: NPC114526
Ingredient ID: NPC114239
Ingredient ID: NPC113650
Ingredient ID: NPC11358
Ingredient ID: NPC112355
Ingredient ID: NPC109813
Ingredient ID: NPC105255
Ingredient ID: NPC105004
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Hydrolase | CDA | Cytidine deaminase | P32320 | CHEMBL4502 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1D | Alpha-1d adrenergic receptor | P25100 | CHEMBL223 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1A | Alpha-1a adrenergic receptor | P35348 | CHEMBL229 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA1 | Adenosine A1 receptor | P30542 | CHEMBL226 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA2A | Adenosine A2a receptor | P29274 | CHEMBL251 |
| Therapeutic Target | Transferase | TK1 | Thymidine kinase, cytosolic | P04183 | CHEMBL2883 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 70 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000699 | A Phase I/II Trial of Ribavirin (With Escalation) + Isoprinosine in Asymptomatic HIV-Viremic Patients | HIV infection | Inosine (NPC54320) | NP level |
| NCT00002801 | Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00003925 | Combination Chemotherapy In Treating Patients With Advanced Cancer | neoplasm | Uracil (NPC27699) | NP level |
| NCT00004860 | Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00005025 | Gene Therapy in Treating Women With Refractory or Relapsed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer | fallopian tube cancer;ovarian cancer;peritoneum cancer | Thymidine (NPC71339) | NP level |
| NCT00005608 | Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer | breast cancer | Uracil (NPC27699) | NP level |
| NCT00009815 | Combination Chemotherapy in Treating Patients With Advanced Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT00009828 | Paclitaxel Combined With Fluorouracil-Uracil and Leucovorin in Treating Patients With Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT00037089 | A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients With Metastatic Esophageal Cancer | neoplasm of esophagus | Uracil (NPC27699) | NP level |
| NCT00067327 | Treatment of Multiple Sclerosis Using Over the Counter Inosine | relapsing-remitting multiple sclerosis | Inosine (NPC54320) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
CNR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TK1
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404,NCT00271765
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CDA,ACHE,F2,TK1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADORA2A,ACHE,MMP2,TK1,CNR2,F2,ADORA3
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
