Collective Molecular Activities of the Plant: Fritillaria Hupehensis
Plant ID: NPO7844
Plant Latin Name: Fritillaria Hupehensis
Taxonomy Genus: Fritillaria
Taxonomy Family: Liliaceae
Plant External Links:
NCBI TaxonomyDB:
152089
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
103 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
69 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
37 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC90701
Ingredient ID: NPC8821
Ingredient ID: NPC87828
Ingredient ID: NPC86947
Ingredient ID: NPC85270
Ingredient ID: NPC76145
Ingredient ID: NPC75097
Ingredient ID: NPC71339
Ingredient ID: NPC68204
Ingredient ID: NPC66913
Ingredient ID: NPC63027
Ingredient ID: NPC62086
Ingredient ID: NPC61198
Ingredient ID: NPC5952
Ingredient ID: NPC54320
Ingredient ID: NPC52370
Ingredient ID: NPC49074
Ingredient ID: NPC44611
Ingredient ID: NPC43246
Ingredient ID: NPC41080
Ingredient ID: NPC39333
Ingredient ID: NPC36490
Ingredient ID: NPC36002
Ingredient ID: NPC35344
Ingredient ID: NPC312637
Ingredient ID: NPC305224
Ingredient ID: NPC299964
Ingredient ID: NPC288411
Ingredient ID: NPC278525
Ingredient ID: NPC27699
Ingredient ID: NPC264779
Ingredient ID: NPC263034
Ingredient ID: NPC262431
Ingredient ID: NPC259976
Ingredient ID: NPC248520
Ingredient ID: NPC248047
Ingredient ID: NPC243728
Ingredient ID: NPC242582
Ingredient ID: NPC242385
Ingredient ID: NPC241055
Ingredient ID: NPC238829
Ingredient ID: NPC23733
Ingredient ID: NPC232924
Ingredient ID: NPC230301
Ingredient ID: NPC226879
Ingredient ID: NPC226803
Ingredient ID: NPC22481
Ingredient ID: NPC223951
Ingredient ID: NPC221134
Ingredient ID: NPC218988
Ingredient ID: NPC216216
Ingredient ID: NPC215158
Ingredient ID: NPC214251
Ingredient ID: NPC214237
Ingredient ID: NPC212875
Ingredient ID: NPC211722
Ingredient ID: NPC211608
Ingredient ID: NPC211342
Ingredient ID: NPC209011
Ingredient ID: NPC204050
Ingredient ID: NPC198865
Ingredient ID: NPC194677
Ingredient ID: NPC190036
Ingredient ID: NPC189719
Ingredient ID: NPC189470
Ingredient ID: NPC186944
Ingredient ID: NPC185072
Ingredient ID: NPC184615
Ingredient ID: NPC179024
Ingredient ID: NPC177465
Ingredient ID: NPC176740
Ingredient ID: NPC175313
Ingredient ID: NPC168829
Ingredient ID: NPC168409
Ingredient ID: NPC168255
Ingredient ID: NPC166963
Ingredient ID: NPC166097
Ingredient ID: NPC160913
Ingredient ID: NPC157927
Ingredient ID: NPC156461
Ingredient ID: NPC154920
Ingredient ID: NPC149700
Ingredient ID: NPC142632
Ingredient ID: NPC142400
Ingredient ID: NPC141777
Ingredient ID: NPC141003
Ingredient ID: NPC138466
Ingredient ID: NPC13789
Ingredient ID: NPC128494
Ingredient ID: NPC128457
Ingredient ID: NPC122792
Ingredient ID: NPC117862
Ingredient ID: NPC117527
Ingredient ID: NPC116628
Ingredient ID: NPC115119
Ingredient ID: NPC114526
Ingredient ID: NPC114239
Ingredient ID: NPC113650
Ingredient ID: NPC11358
Ingredient ID: NPC112355
Ingredient ID: NPC109813
Ingredient ID: NPC105255
Ingredient ID: NPC105004
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Hydrolase | CDA | Cytidine deaminase | P32320 | CHEMBL4502 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1A | Alpha-1a adrenergic receptor | P35348 | CHEMBL229 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA1 | Adenosine A1 receptor | P30542 | CHEMBL226 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA2A | Adenosine A2a receptor | P29274 | CHEMBL251 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1D | Alpha-1d adrenergic receptor | P25100 | CHEMBL223 |
| Therapeutic Target | Transferase | TK1 | Thymidine kinase, cytosolic | P04183 | CHEMBL2883 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 70 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
| NCT00009828 | Paclitaxel Combined With Fluorouracil-Uracil and Leucovorin in Treating Patients With Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT03121313 | Maintenance Tegafur-uracil in Resected Oral Cavity Cancer With ECS+ | oral squamous cell carcinoma | Uracil (NPC27699) | NP level |
| NCT04666454 | BROKEN-SWEDEHEART-Optimized Pharmacological Treatment for Broken Heart (Takotsubo) Syndrome | Takotsubo cardiomyopathy | Adenosine (NPC156461) | NP level |
| NCT01539018 | Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for Patients With Advanced Stage HCC, Unresectable & Not Eligible for Local Ablation and/or TACE | hepatocellular carcinoma | Uracil (NPC27699) | NP level |
| NCT00590070 | THE REOPEN-AMI STUDY - Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction | myocardial infarction | Adenosine (NPC156461) | NP level |
| NCT00002801 | Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT05014061 | Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction | Myocardial Ischemia | Adenosine (NPC156461) | NP level |
| NCT00009815 | Combination Chemotherapy in Treating Patients With Advanced Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT03418935 | Remaxol® in Mechanical Jaundice of Non-malignant Origin | obstructive jaundice | Inosine (NPC54320) | NP level |
| NCT04392362 | A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT) | ventricular tachycardia | Adenosine (NPC156461) | NP level |
| NCT00005608 | Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer | breast cancer | Uracil (NPC27699) | NP level |
| NCT00385970 | A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00751491 | Clopidogrel Versus Adenosin in Non Urgent Percutaneous Coronary Intervention (PCI) | angina pectoris | Adenosine (NPC156461) | NP level |
| NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
| NCT01932112 | Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial) | atrial fibrillation | Adenosine (NPC156461) | NP level |
| NCT00271765 | A Study of INO-1001, an Intravenous PARP (Poly [ADP Ribose] Polymerase) Inhibitor in Acute Heart Attack Patients Undergoing Primary Percutaneous Coronary Intervention | acute myocardial infarction | Inosine (NPC54320) | NP level |
| NCT00037089 | A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients With Metastatic Esophageal Cancer | neoplasm of esophagus | Uracil (NPC27699) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT00565188 | Application of ATP Infusions in Palliative Home Care | cancer | Adenosine (NPC156461) | NP level |
| NCT01123525 | Adenosine Cardioplegia | angina pectoris | Adenosine (NPC156461) | NP level |
| NCT04649203 | Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy | diabetic neuropathy | Inosine (NPC54320) | NP level |
| NCT03403309 | Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-center, Randomized Controlled, Double Blind, Parallel Assigned Clinical Trial | multiple system atrophy | Inosine (NPC54320) | NP level |
| NCT03032965 | Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation | atrial fibrillation | Adenosine (NPC156461) | NP level |
| NCT00833690 | Safety of Urate Elevation in Parkinson's Disease | Parkinson disease | Inosine (NPC54320) | NP level |
| NCT00152243 | A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-GC) | gastric cancer | Uracil (NPC27699) | NP level |
| NCT00322764 | Phase II Study to Assess RG2417 in the Treatment of Bipolar I Depression | bipolar disorder | Uridine (NPC43246) | NP level |
| NCT00841269 | Oral Uridine for Treatment of Bipolar Depression in Adolescents | bipolar disorder | Uridine (NPC43246) | NP level |
| NCT02288091 | A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS) | amyotrophic lateral sclerosis | Inosine (NPC54320) | NP level |
| NCT02681913 | Adenosine as an Adjunct to Blood Cardioplegia | cardiomyopathy | Adenosine (NPC156461) | NP level |
| NCT00152230 | A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-CC) | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00519688 | UFUR Plus Thalidomide for Advanced Hepatocellular Carcinoma | hepatocellular carcinoma | Uracil (NPC27699) | NP level |
| NCT02867878 | Adenosin to Rapidly Reverse Left Ventricle Impairment in Takotsubo Syndrome | Takotsubo cardiomyopathy | Adenosine (NPC156461) | NP level |
| NCT00781404 | Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI | acute myocardial infarction | Adenosine (NPC156461) | NP level |
| NCT00067327 | Treatment of Multiple Sclerosis Using Over the Counter Inosine | relapsing-remitting multiple sclerosis | Inosine (NPC54320) | NP level |
| NCT00298636 | Dose-Response of Adenosine for Perioperative Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00905047 | Xeloda or UFT (Tegafur-uracil) With Folinic Acid in Advanced or Metastatic Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT03168711 | Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS) | amyotrophic lateral sclerosis | Inosine (NPC54320) | NP level |
| NCT04588441 | The ARCTIC Trial: Aerosolized Inhaled Adenosine Treatment in Patients With Acute Respiratory Distress Syndrome (ARDS) Caused by COVID-19 | acute respiratory distress syndrome | Adenosine (NPC156461) | NP level |
| NCT01262274 | Randomized Phase II Trial of Anastrozole Plus Metronomic Tegafur-uracil as Neo-adjuvant Therapy in Postmenopausal Breast Cancer | breast neoplasm | Uracil (NPC27699) | NP level |
| NCT01593644 | Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-Echodoppler | coronary artery disease | Adenosine (NPC156461) | NP level |
| NCT00005025 | Gene Therapy in Treating Women With Refractory or Relapsed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer | fallopian tube cancer;ovarian cancer;peritoneum cancer | Thymidine (NPC71339) | NP level |
| NCT00845689 | Prevention of Liver Damage During Liver Surgery | neoplasm | Adenosine (NPC156461) | NP level |
| NCT02642393 | Study of Urate Elevation in Parkinson's Disease, Phase 3 | Parkinson disease | Inosine (NPC54320) | NP level |
| NCT00152178 | The Comparative Trial of UFT + TAM With CMF + TAM in Adjuvant Therapy for Breast Cancer (CUBC) | breast cancer | Uracil (NPC27699) | NP level |
| NCT00284323 | Salvage: Postconditioning With Adenosine for STEMI | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT00272415 | A Study of Intravenous INO-1001 Plus Oral Temozolomide to Evaluate Tolerability, Safety, and Pharmacokinetics in Patients With Melanoma | melanoma | Inosine (NPC54320) | NP level |
| NCT00349921 | Clonidine Versus Adenosine to Treat Neuropathic Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00152191 | A Randomized Controlled Study of Postoperative Adjuvant Therapy of Uracil-tegafur (UFT) Compared With Cyclophosphamide/Methotrexate/5-fluorouracil (CMF) in Breast Cancer (NSAS-BC) | breast cancer | Uracil (NPC27699) | NP level |
| NCT00384800 | A Phase II Study of Tegafur/Uracil (UFUR®)Plus Thalidomide for the Treatment of Advanced or Metastatic Hepatocellular Carcinoma (HCC) | hepatocellular carcinoma | Uracil (NPC27699) | NP level |
| NCT01082510 | Study of the Efficacy of Maintenance Therapy Using Uracil-tegafur (UFT) or Bacille Calmette-Guerin (BCG) for the Prevention of Recurrences of Superficial Bladder Cancer (EMBARK Study) | urinary bladder cancer | Uracil (NPC27699) | NP level |
| NCT03236311 | A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI | coronary artery disease | Adenosine (NPC156461) | NP level |
| NCT00207831 | Trial Testing Ftorafur (UFT) Associated With Neoadjuvant Radiotherapy Versus Radiotherapy Alone in Rectal Adenocarcinoma | rectum cancer | Uracil (NPC27699) | NP level |
| NCT00855881 | Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma | head and neck malignant neoplasia | Uracil (NPC27699) | NP level |
| NCT00705874 | Study of CGC-11047 When Used in Individual Combinations With 1) Gemcitabine or 2) Docetaxel or 3) Bevacizumab or 4) Erlotinib or 5) Cisplatin or 6) 5-Flurouracil or 7) Sunitinib in Patients With Advanced Solid Tumors or Lymphoma | cancer | Uracil (NPC27699) | NP level |
| NCT00004860 | Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00660894 | Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00210080 | A Study to Diagnose Lung Cancer by Sputum Cytology (01-312) | lung cancer | Uridine (NPC43246) | NP level |
| NCT00612521 | Prophylactic Intra-coronary Adenosine to Prevent Post Coronary Artery Stenting Myonecrosis | coronary stenosis | Adenosine (NPC156461) | NP level |
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT00336947 | S-1 or Tegafur-Uracil in Treating Patients With Previously Treated Stage III or Stage IV Head and Neck Cancer | head and neck malignant neoplasia | Uracil (NPC27699) | NP level |
| NCT00000699 | A Phase I/II Trial of Ribavirin (With Escalation) + Isoprinosine in Asymptomatic HIV-Viremic Patients | HIV infection | Inosine (NPC54320) | NP level |
| NCT02447679 | Oral Thalidomide and Tegafur-uracil to Decrease Hepatocellular Carcinoma Recurrence | hepatocellular carcinoma | Uracil (NPC27699) | NP level |
| NCT01747174 | REperfusion Facilitated by LOcal Adjunctive Therapy in ST-elevation Myocardial Infarction | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT01690884 | Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake | coronary artery disease | Adenosine (NPC156461) | NP level |
| NCT00003925 | Combination Chemotherapy In Treating Patients With Advanced Cancer | neoplasm | Uracil (NPC27699) | NP level |
| NCT00580905 | Role of Adenosine in the Release of VEGF and Cytokines | inflammation | Adenosine (NPC156461) | NP level |
| NCT00714103 | 8-Chloro-Adenosine in Chronic Lymphocytic Leukemia | chronic lymphocytic leukemia | Adenosine (NPC156461) | NP level |
| NCT01037998 | UFUR (Tegafur/Uracil) Plus Iressa in Non-small-cell Lung Cancer | non-small cell lung carcinoma | Uracil (NPC27699) | NP level |
| NCT00378716 | Combination Chemotherapy in Treating Patients With Resected Colon Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
CNR1,ADORA2A
NCT00004860,NCT00660894,NCT00378716,NCT00905047,NCT00152230,NCT00385970,NCT00002801 |
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
CNR2,CNR1,ACHE,ADRA1A,ADRA1D
NCT00298636,NCT00349921 |
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADORA2A,ACHE,MMP2,TK1,CNR2,F2,ADORA3
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ADORA1,ACHE,MMP2,TK1,CNR2,CNR1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ACHE,ADORA3,CNR1,CNR1,ADORA3,F2
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
ADORA1,TK1,ADRA1D,CNR1,ADORA1,TK1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CDA,ADORA2A,ACHE,MMP2,CNR2,F2
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ADORA1,ACHE,ADORA2A
NCT00833690,NCT02642393 |
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
ADRA1D,ADORA2A,TK1,ADORA3,CDA
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ADORA2A,ACHE,CNR2,ADRA1D,CNR1
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ADORA1,ACHE,ADORA2A,ADRA1D
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
ADRA1A,TK1,ADORA2A
NCT01705652 |
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
ADORA3,ADRA1D,ADORA1,ADORA2A
|
Hepatocellular carcinoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4W48 |
NCT00519688,NCT01539018,NCT00384800,NCT02447679
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00009828,NCT00845689,NCT00003925,NCT00009815
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ACHE,CDA,TK1
NCT00037089 |
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ADORA1,ACHE,CDA,ADORA2A
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ADORA1,TK1,MMP2,CNR1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
MMP2,TK1,ADRA1D,CNR1
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
ADORA2A,MMP2,CNR2,ADORA3
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TK1,CNR2,CNR1,ADORA3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CDA,ACHE,F2,TK1
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ADORA2A,ACHE,CNR2,ADORA3
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ADORA2A,MMP2
NCT00210080 |
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ADRA1A,ADORA1,ACHE
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
ADRA1D,ADRA1A,ADORA2A
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
NCT01123525,NCT00751491 |
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT01593644,NCT01690884,NCT03236311
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
NCT00005608,NCT00152191,NCT00152178
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CDA,ADORA1,ADORA3
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
MMP2,ADORA2A,ADRA1A
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CNR2,TK1,ADORA2A
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
ADORA3,CNR1,CNR2
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MMP2,TK1
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
CNR1,F2
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CNR2,CNR1
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
ADORA2A,TK1
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2,TK1
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
ADRA1A,ADRA1D
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
CNR2,CNR1
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
ADORA2A,ADORA1
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
ADORA2A,ADORA1
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
F2
NCT00590070 |
Stress-induced cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.5 |
NCT02867878,NCT04666454
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
NCT00855881,NCT00336947
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404,NCT00271765
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT00841269,NCT00322764
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT03032965,NCT01932112
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT02288091,NCT03168711
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT00565188,NCT00705874
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
CNR1
NCT00152243 |
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE,ADORA2A
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
F2,TK1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
F2,TK1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ADORA2A,ACHE
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
ADORA3,ADORA2A
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ADORA1,CDA
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
F2,TK1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CDA,CNR1
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
ADORA3,MMP2
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ADORA1,TK1
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
ADORA3,TK1
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
CNR1
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
F2
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
TK1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Supraventricular tachyarrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81 |
ADORA1
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
ADORA2A
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
CNR1
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
ADORA3
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
F2
|
Radionuclide imagingDisease Category: NADisease ICD-11 Code: N.A. |
ADORA2A
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
ADRA1D
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ADORA3
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
CNR1
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
F2
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
Urinary tract infectionDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC08 |
CNR1
|
ZosterDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E91 |
TK1
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
F2
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
ADORA2A
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
CNR1
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
MMP2
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
ADORA2A
|
Unspecific substance use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4Z |
ADORA2A
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
MMP2
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
CNR2
|
Cardiac arrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC9Z |
ADORA1
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
|
Human immunodeficiency virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C60-1C62 |
TK1
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
MMP2
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
CNR2
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
CNR2
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2
|
Cannabis use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C41 |
CNR1
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
ADORA3
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
ADORA2A
|
Anorexia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B80 |
CNR1
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
F2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
CNR1
|
Coronary atherosclerosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA80 |
ADORA2A
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
ADORA3
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ADORA3
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
CNR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TK1
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
ADORA2A
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT00580905
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
NCT00005025
|
Malignant neoplasms of bladder, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.Z |
NCT01082510
|
Malignant neoplasms of retroperitoneumDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C50 |
NCT00005025
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT00000699
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441
|
Relapsing-remitting multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40.0 |
NCT00067327
|
Neoplasms of unknown behaviour of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F95 |
NCT01262274
|
Diabetic polyneuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C03.0 |
NCT04649203
|
Rectum cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B92 |
NCT00207831
|
Chronic lymphocytic leukaemia or small lymphocytic lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82.0 |
NCT00714103
|
Diseases of coronary artery, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Z |
NCT00612521
|
Multiple system atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87.0 |
NCT03403309
|
Fallopian tube cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C74 |
NCT00005025
|
IschemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B10-8B11 |
NCT00179010
|
Ischaemic heart diseases, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA6Z |
NCT05014061
|
Other specified non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92.Y |
NCT04853082
|
XerostomiaDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA02.1 |
NCT04392622
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NCT00272415
|
Obstruction of bile ductDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC10.02 |
NCT03418935
|
Squamous cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B60-2D01 |
NCT03121313
|
CardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43 |
NCT02681913
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT01037998
|
Ventricular tachycardiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC71.0 |
NCT04392362
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
ADORA1
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
MMP2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Intrauterine growth restrictionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA20.1 |
ADORA2A
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
ADORA2A
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F2
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
F2
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
TK1
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ACHE
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
TK1
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
ADORA3
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ACHE
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
ADORA3
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
