Collective Molecular Activities of the Plant: Sinapis Alba
Plant ID: NPO784
Plant Latin Name: Sinapis Alba
Taxonomy Genus: Sinapis
Taxonomy Family: Brassicaceae
Plant External Links:
NCBI TaxonomyDB:
3728
Plant-of-the-World-Online:
n.a.
Country/Region:
Jordan; China; Lebanon; IndiaTraditional Medicine System:
Unani; TCM; Homeopathy; Ayurveda; SiddhaMedicinal Functions:
Antibacterial; Antifungal; Antirheumatic; Appetizer; Carminative; Cathartic; Diaphoretic; Digestive; Diuretic; Emetic; Expectorant; Rubefacient; Stimulant; Vesicant
Lebanon; India; Jordan; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
238 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
176 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
134 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99734
Ingredient ID: NPC98386
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC93617
Ingredient ID: NPC89778
Ingredient ID: NPC89042
Ingredient ID: NPC86371
Ingredient ID: NPC85813
Ingredient ID: NPC84585
Ingredient ID: NPC80989
Ingredient ID: NPC80841
Ingredient ID: NPC80710
Ingredient ID: NPC78540
Ingredient ID: NPC75611
Ingredient ID: NPC73584
Ingredient ID: NPC7208
Ingredient ID: NPC71726
Ingredient ID: NPC71375
Ingredient ID: NPC6717
Ingredient ID: NPC6516
Ingredient ID: NPC64663
Ingredient ID: NPC62045
Ingredient ID: NPC61477
Ingredient ID: NPC60151
Ingredient ID: NPC59650
Ingredient ID: NPC59581
Ingredient ID: NPC55412
Ingredient ID: NPC50898
Ingredient ID: NPC490427
Ingredient ID: NPC490424
Ingredient ID: NPC489910
Ingredient ID: NPC489908
Ingredient ID: NPC489907
Ingredient ID: NPC489904
Ingredient ID: NPC489899
Ingredient ID: NPC48623
Ingredient ID: NPC4812
Ingredient ID: NPC46715
Ingredient ID: NPC45780
Ingredient ID: NPC43143
Ingredient ID: NPC42716
Ingredient ID: NPC41240
Ingredient ID: NPC35544
Ingredient ID: NPC35446
Ingredient ID: NPC34981
Ingredient ID: NPC34908
Ingredient ID: NPC328447
Ingredient ID: NPC32641
Ingredient ID: NPC317120
Ingredient ID: NPC31643
Ingredient ID: NPC315296
Ingredient ID: NPC313955
Ingredient ID: NPC313182
Ingredient ID: NPC313032
Ingredient ID: NPC308472
Ingredient ID: NPC30720
Ingredient ID: NPC305858
Ingredient ID: NPC302003
Ingredient ID: NPC297186
Ingredient ID: NPC297026
Ingredient ID: NPC29601
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Ingredient ID: NPC294902
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Ingredient ID: NPC29391
Ingredient ID: NPC293628
Ingredient ID: NPC291796
Ingredient ID: NPC291473
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Ingredient ID: NPC290319
Ingredient ID: NPC29
Ingredient ID: NPC289536
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Ingredient ID: NPC285322
Ingredient ID: NPC284386
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Ingredient ID: NPC281972
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Ingredient ID: NPC258867
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Ingredient ID: NPC254482
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Ingredient ID: NPC253336
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Ingredient ID: NPC210886
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Ingredient ID: NPC188867
Ingredient ID: NPC187770
Ingredient ID: NPC185755
Ingredient ID: NPC185249
Ingredient ID: NPC184151
Ingredient ID: NPC181124
Ingredient ID: NPC180279
Ingredient ID: NPC179860
Ingredient ID: NPC17810
Ingredient ID: NPC176348
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Ingredient ID: NPC175429
Ingredient ID: NPC174246
Ingredient ID: NPC17322
Ingredient ID: NPC173003
Ingredient ID: NPC17151
Ingredient ID: NPC170739
Ingredient ID: NPC169749
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC164487
Ingredient ID: NPC162620
Ingredient ID: NPC162282
Ingredient ID: NPC160179
Ingredient ID: NPC158404
Ingredient ID: NPC15698
Ingredient ID: NPC15658
Ingredient ID: NPC156457
Ingredient ID: NPC156139
Ingredient ID: NPC155481
Ingredient ID: NPC155263
Ingredient ID: NPC154186
Ingredient ID: NPC152452
Ingredient ID: NPC152451
Ingredient ID: NPC150950
Ingredient ID: NPC150648
Ingredient ID: NPC149803
Ingredient ID: NPC149494
Ingredient ID: NPC149155
Ingredient ID: NPC147983
Ingredient ID: NPC147686
Ingredient ID: NPC144939
Ingredient ID: NPC143427
Ingredient ID: NPC142142
Ingredient ID: NPC139364
Ingredient ID: NPC138994
Ingredient ID: NPC138990
Ingredient ID: NPC137958
Ingredient ID: NPC13771
Ingredient ID: NPC136281
Ingredient ID: NPC136014
Ingredient ID: NPC133836
Ingredient ID: NPC132307
Ingredient ID: NPC130683
Ingredient ID: NPC130341
Ingredient ID: NPC129682
Ingredient ID: NPC128678
Ingredient ID: NPC126925
Ingredient ID: NPC126759
Ingredient ID: NPC126681
Ingredient ID: NPC126250
Ingredient ID: NPC125062
Ingredient ID: NPC124436
Ingredient ID: NPC123304
Ingredient ID: NPC122493
Ingredient ID: NPC122470
Ingredient ID: NPC121703
Ingredient ID: NPC120649
Ingredient ID: NPC12013
Ingredient ID: NPC116775
Ingredient ID: NPC116709
Ingredient ID: NPC116593
Ingredient ID: NPC11433
Ingredient ID: NPC112890
Ingredient ID: NPC112889
Ingredient ID: NPC110533
Ingredient ID: NPC108897
Ingredient ID: NPC108358
Ingredient ID: NPC10781
Ingredient ID: NPC1075
Ingredient ID: NPC107373
Ingredient ID: NPC107161
Ingredient ID: NPC106551
Ingredient ID: NPC106439
Ingredient ID: NPC106197
Ingredient ID: NPC102832
Ingredient ID: NPC100284
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2B6 | Cytochrome P450 2B6 | P20813 | CHEMBL4729 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 587 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2,ESR1
NCT03522922,NCT03090048 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR,MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,DPP4,FFAR1,PPARA,NR3C1,KDR,AKR1B1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AXL,NFKB1,SRC,PIM1,AURKB,TP53,TOP2A,GSK3B,FLT3
NCT01842139,NCT00329498,NCT00184054 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG31 |
SLC6A2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
