Collective Molecular Activities of the Plant: Ormosia Hosiei
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
127 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
98 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
68 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC91115
Ingredient ID: NPC89630
Ingredient ID: NPC89299
Ingredient ID: NPC87125
Ingredient ID: NPC84694
Ingredient ID: NPC81292
Ingredient ID: NPC81010
Ingredient ID: NPC78540
Ingredient ID: NPC78107
Ingredient ID: NPC76849
Ingredient ID: NPC76286
Ingredient ID: NPC75455
Ingredient ID: NPC71303
Ingredient ID: NPC70744
Ingredient ID: NPC69101
Ingredient ID: NPC65628
Ingredient ID: NPC62107
Ingredient ID: NPC60103
Ingredient ID: NPC55412
Ingredient ID: NPC50898
Ingredient ID: NPC44079
Ingredient ID: NPC43521
Ingredient ID: NPC43143
Ingredient ID: NPC36002
Ingredient ID: NPC33940
Ingredient ID: NPC328967
Ingredient ID: NPC32203
Ingredient ID: NPC31618
Ingredient ID: NPC312501
Ingredient ID: NPC30781
Ingredient ID: NPC304079
Ingredient ID: NPC303141
Ingredient ID: NPC302857
Ingredient ID: NPC296682
Ingredient ID: NPC294941
Ingredient ID: NPC294902
Ingredient ID: NPC292996
Ingredient ID: NPC289459
Ingredient ID: NPC289116
Ingredient ID: NPC28862
Ingredient ID: NPC284424
Ingredient ID: NPC279989
Ingredient ID: NPC278068
Ingredient ID: NPC277460
Ingredient ID: NPC274692
Ingredient ID: NPC273700
Ingredient ID: NPC272149
Ingredient ID: NPC270165
Ingredient ID: NPC268846
Ingredient ID: NPC268381
Ingredient ID: NPC263386
Ingredient ID: NPC260952
Ingredient ID: NPC259903
Ingredient ID: NPC255906
Ingredient ID: NPC255392
Ingredient ID: NPC255042
Ingredient ID: NPC253671
Ingredient ID: NPC25325
Ingredient ID: NPC250527
Ingredient ID: NPC245561
Ingredient ID: NPC244231
Ingredient ID: NPC243677
Ingredient ID: NPC243289
Ingredient ID: NPC243083
Ingredient ID: NPC242580
Ingredient ID: NPC241838
Ingredient ID: NPC234133
Ingredient ID: NPC23265
Ingredient ID: NPC231772
Ingredient ID: NPC23077
Ingredient ID: NPC230301
Ingredient ID: NPC229415
Ingredient ID: NPC224389
Ingredient ID: NPC22105
Ingredient ID: NPC212938
Ingredient ID: NPC211466
Ingredient ID: NPC209945
Ingredient ID: NPC209719
Ingredient ID: NPC208183
Ingredient ID: NPC206341
Ingredient ID: NPC206095
Ingredient ID: NPC205081
Ingredient ID: NPC203719
Ingredient ID: NPC199931
Ingredient ID: NPC192744
Ingredient ID: NPC189444
Ingredient ID: NPC187770
Ingredient ID: NPC187432
Ingredient ID: NPC184536
Ingredient ID: NPC183154
Ingredient ID: NPC182840
Ingredient ID: NPC179984
Ingredient ID: NPC179309
Ingredient ID: NPC174586
Ingredient ID: NPC172563
Ingredient ID: NPC172231
Ingredient ID: NPC17192
Ingredient ID: NPC170546
Ingredient ID: NPC16651
Ingredient ID: NPC165967
Ingredient ID: NPC158675
Ingredient ID: NPC156654
Ingredient ID: NPC154831
Ingredient ID: NPC153724
Ingredient ID: NPC152042
Ingredient ID: NPC150648
Ingredient ID: NPC145977
Ingredient ID: NPC145879
Ingredient ID: NPC143765
Ingredient ID: NPC143182
Ingredient ID: NPC13818
Ingredient ID: NPC136840
Ingredient ID: NPC135452
Ingredient ID: NPC134847
Ingredient ID: NPC134525
Ingredient ID: NPC130396
Ingredient ID: NPC127447
Ingredient ID: NPC127332
Ingredient ID: NPC122828
Ingredient ID: NPC121619
Ingredient ID: NPC119631
Ingredient ID: NPC110693
Ingredient ID: NPC106770
Ingredient ID: NPC10476
Ingredient ID: NPC103213
Ingredient ID: NPC10283
Ingredient ID: NPC10052
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 171 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Ascorbate (NPC187770) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
| NCT00000555 | Women's Angiographic Vitamin and Estrogen Trial (WAVE) | menopause;Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
| NCT00000600 | Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-Up | carotid artery disease;cerebral atherosclerosis;heart disease | Ascorbate (NPC187770) | NP level |
| NCT00006021 | Arsenic Trioxide Plus Vitamin C in Treating Patients With Recurrent or Refractory Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT00065455 | Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00067899 | Oxidative Stress and Vitamin E Requirements | nicotine dependence | Ascorbate (NPC187770) | NP level |
| NCT00085345 | Melphalan, Arsenic Trioxide, and Ascorbic Acid in Treating Patients With Relapsed or Refractory Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
NCT03090048,NCT03522922 |
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA,MAOB
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
CDK8,NFKB1
NCT00329498,NCT00184054 |
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04404387
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA6,MMP9,MMP1,CA5A,CA7,TTR,F2,THPO,AKR1C3,CA9,XDH,ACHE,AKR1B10,CA12,CBR1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA14,MMP1,LMNA,DPP4,MMP2,ALOX5,CYP1B1,APP,SNCA,ALOX15,CA7,TTR,F2,AKR1C3,CA9,CA2,XDH,PTGS1,GSTP1,MAOB,ACHE,AKR1B10,HIF1A,CYP2C19,CBR1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15,TTR
NCT01080352 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
