Collective Molecular Activities of the Plant: Tribulus Terrestris
Plant ID: NPO7395
Plant Latin Name: Tribulus Terrestris
Taxonomy Genus: Tribulus
Taxonomy Family: Zygophyllaceae
Plant External Links:
NCBI TaxonomyDB:
210369
Plant-of-the-World-Online:
n.a.
Country/Region:
China; India; AlgeriaTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; Kampo; TCM; HomeopathyMedicinal Functions:
Abortifacient; Alterative; Anthelmintic; Aphrodisiac; Carminative; Demulcent; Diuretic; Galactogogue; Infertility; Pectoral
India; China; Algeria
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
71 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
17 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
25 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97700
Ingredient ID: NPC95051
Ingredient ID: NPC90984
Ingredient ID: NPC84059
Ingredient ID: NPC75973
Ingredient ID: NPC7479
Ingredient ID: NPC70744
Ingredient ID: NPC6295
Ingredient ID: NPC58852
Ingredient ID: NPC5723
Ingredient ID: NPC52197
Ingredient ID: NPC4925
Ingredient ID: NPC47517
Ingredient ID: NPC46575
Ingredient ID: NPC39591
Ingredient ID: NPC32932
Ingredient ID: NPC328506
Ingredient ID: NPC326879
Ingredient ID: NPC3254
Ingredient ID: NPC322861
Ingredient ID: NPC320135
Ingredient ID: NPC318995
Ingredient ID: NPC318215
Ingredient ID: NPC316871
Ingredient ID: NPC304971
Ingredient ID: NPC301938
Ingredient ID: NPC300557
Ingredient ID: NPC294830
Ingredient ID: NPC291389
Ingredient ID: NPC282082
Ingredient ID: NPC269056
Ingredient ID: NPC241669
Ingredient ID: NPC24101
Ingredient ID: NPC232727
Ingredient ID: NPC231900
Ingredient ID: NPC230861
Ingredient ID: NPC227702
Ingredient ID: NPC227260
Ingredient ID: NPC223687
Ingredient ID: NPC218109
Ingredient ID: NPC216650
Ingredient ID: NPC216012
Ingredient ID: NPC212278
Ingredient ID: NPC21108
Ingredient ID: NPC207819
Ingredient ID: NPC205003
Ingredient ID: NPC204295
Ingredient ID: NPC204286
Ingredient ID: NPC195749
Ingredient ID: NPC195713
Ingredient ID: NPC18729
Ingredient ID: NPC186898
Ingredient ID: NPC179787
Ingredient ID: NPC178444
Ingredient ID: NPC170438
Ingredient ID: NPC164766
Ingredient ID: NPC163264
Ingredient ID: NPC161035
Ingredient ID: NPC160607
Ingredient ID: NPC160125
Ingredient ID: NPC158823
Ingredient ID: NPC15715
Ingredient ID: NPC153644
Ingredient ID: NPC14963
Ingredient ID: NPC141744
Ingredient ID: NPC137666
Ingredient ID: NPC136730
Ingredient ID: NPC132487
Ingredient ID: NPC116562
Ingredient ID: NPC115165
Ingredient ID: NPC104788
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Therapeutic Target | Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Therapeutic Target | Protein Kinase | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Q9Y463 | CHEMBL5543 |
| Therapeutic Target | Protein Kinase | DYRK3 | Dual-specificity tyrosine-phosphorylation regulated kinase 3 | O43781 | CHEMBL4575 |
| Therapeutic Target | Protein Kinase | DYRK2 | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | Q92630 | CHEMBL4376 |
| Therapeutic Target | Protein Kinase | CLK1 | Dual specificty protein kinase CLK1 | P49759 | CHEMBL4224 |
| Therapeutic Target | Protein Kinase | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Q13627 | CHEMBL2292 |
| Therapeutic Target | Protein Kinase | HASPIN | Serine/threonine-protein kinase haspin | Q8TF76 | CHEMBL1075163 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2C | Alpha-2c adrenergic receptor | P18825 | CHEMBL1916 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 Plant level | 4 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01407445 | Effects of Tribulus Terrestris on Sexual Function in Post-menopausal Women | Sexual Functions and Problems in the Adult | Tribulus Terrestris | Plant level As single plant |
| NCT01971099 | Effects of Tribulus Terrestris in Women With Hypoactive Sexual Desire Disorder | Hypoactive Sexual Desire Disfunction | Tribulus Terrestris | Plant level As single plant |
| NCT01975649 | Effects of Tribulus Terrestris in Postmenopausal Women With Hypoactive Sexual Desire Disorder | Menopause|Sexual Abstinence | Tribulus Terrestris | Plant level As single plant |
| NCT03820453 | Clinical Trial to Investigate the Effectiveness of a Dietary Supplement in Increasing Libido and Sexual Function in Postmenopausal Women. | Female Sexual Arousal Disorder | Tribulus Terrestris | Plant level As single plant |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,CDK9
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
SNCA,DYRK2,LMNA
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT,MAOA,SNCA,ADRA2C
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
DYRK1B
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
DYRK2,DYRK3
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
ADRA2C
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
