Plant ID: NPO7385
Plant Latin Name: Schisandra Sphenanthera
Taxonomy Genus: Schisandra
Taxonomy Family: Schisandraceae
NCBI TaxonomyDB:
13674
Plant-of-the-World-Online:
n.a.
Antirheumatic; Antitussive; Aphrodisiac; Astringent; Cancer; Cardiotonic; Cholagogue; Expectorant; Hepatic; Lenitive; Nervine; Pectoral; Sedative; Stimulant; Tonic
China
Ingredient ID: NPC9880
Ingredient ID: NPC96754
Ingredient ID: NPC95675
Ingredient ID: NPC91574
Ingredient ID: NPC87828
Ingredient ID: NPC86939
Ingredient ID: NPC83049
Ingredient ID: NPC79322
Ingredient ID: NPC79273
Ingredient ID: NPC77550
Ingredient ID: NPC77237
Ingredient ID: NPC76451
Ingredient ID: NPC76449
Ingredient ID: NPC74304
Ingredient ID: NPC67986
Ingredient ID: NPC65933
Ingredient ID: NPC63061
Ingredient ID: NPC61828
Ingredient ID: NPC60427
Ingredient ID: NPC57877
Ingredient ID: NPC53722
Ingredient ID: NPC53669
Ingredient ID: NPC470916
Ingredient ID: NPC46277
Ingredient ID: NPC45404
Ingredient ID: NPC42797
Ingredient ID: NPC41474
Ingredient ID: NPC37407
Ingredient ID: NPC36733
Ingredient ID: NPC3621
Ingredient ID: NPC3357
Ingredient ID: NPC33241
Ingredient ID: NPC326223
Ingredient ID: NPC325024
Ingredient ID: NPC323357
Ingredient ID: NPC32189
Ingredient ID: NPC320062
Ingredient ID: NPC319697
Ingredient ID: NPC3155
Ingredient ID: NPC306765
Ingredient ID: NPC305579
Ingredient ID: NPC297271
Ingredient ID: NPC293378
Ingredient ID: NPC292092
Ingredient ID: NPC290078
Ingredient ID: NPC289366
Ingredient ID: NPC289258
Ingredient ID: NPC286263
Ingredient ID: NPC285776
Ingredient ID: NPC285734
Ingredient ID: NPC284159
Ingredient ID: NPC283114
Ingredient ID: NPC282665
Ingredient ID: NPC27690
Ingredient ID: NPC276627
Ingredient ID: NPC274356
Ingredient ID: NPC270531
Ingredient ID: NPC269116
Ingredient ID: NPC268130
Ingredient ID: NPC268095
Ingredient ID: NPC267990
Ingredient ID: NPC262345
Ingredient ID: NPC261317
Ingredient ID: NPC256776
Ingredient ID: NPC255133
Ingredient ID: NPC253746
Ingredient ID: NPC244074
Ingredient ID: NPC237312
Ingredient ID: NPC236426
Ingredient ID: NPC235586
Ingredient ID: NPC229218
Ingredient ID: NPC22782
Ingredient ID: NPC227378
Ingredient ID: NPC227211
Ingredient ID: NPC226250
Ingredient ID: NPC22484
Ingredient ID: NPC222986
Ingredient ID: NPC220270
Ingredient ID: NPC217708
Ingredient ID: NPC217706
Ingredient ID: NPC215161
Ingredient ID: NPC211861
Ingredient ID: NPC207702
Ingredient ID: NPC206737
Ingredient ID: NPC202189
Ingredient ID: NPC201404
Ingredient ID: NPC198461
Ingredient ID: NPC195747
Ingredient ID: NPC192402
Ingredient ID: NPC191352
Ingredient ID: NPC19044
Ingredient ID: NPC186975
Ingredient ID: NPC185680
Ingredient ID: NPC18174
Ingredient ID: NPC17941
Ingredient ID: NPC179085
Ingredient ID: NPC176030
Ingredient ID: NPC174999
Ingredient ID: NPC16791
Ingredient ID: NPC165721
Ingredient ID: NPC156860
Ingredient ID: NPC153195
Ingredient ID: NPC152896
Ingredient ID: NPC150329
Ingredient ID: NPC149008
Ingredient ID: NPC148699
Ingredient ID: NPC145722
Ingredient ID: NPC143979
Ingredient ID: NPC131769
Ingredient ID: NPC126405
Ingredient ID: NPC126240
Ingredient ID: NPC118162
Ingredient ID: NPC115784
Ingredient ID: NPC114011
Ingredient ID: NPC103637
Ingredient ID: NPC102256
Ingredient ID: NPC100360
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Therapeutic Target | Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 7 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01647217 | Demodex Blepharitis Treatment Study | blepharitis | Terpin (NPC77550) | NP level |
NCT01602068 | Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Delivery Prior to Implantation of a Posterior Chamber IOL | cataract | Citric Acid (NPC293378) | NP level |
NCT00249951 | Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants | Nephrocalcinosis | Citric Acid (NPC293378) | NP level |
NCT01012349 | Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache. | Tension-type headache | Citric Acid (NPC293378) | NP level |
NCT01754779 | Treatment for Calcium Phosphate Kidney Stone Disease | nephrolithiasis | Citric Acid (NPC293378) | NP level |
NCT01962116 | Citrate Versus Heparin for the Lock of Non-tunneled Hemodialysis Catheters in Patients Hospitalised in ICU | Renal insufficiency | Citric Acid (NPC293378) | NP level |
NCT01421160 | Regulating Urine pH Levels to Alleviate Chronic Joint Pain | osteoarthritis | Citric Acid (NPC293378) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CA12,CA14,CYP3A4,CA1,CA9,CA2
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CA12,CA9,MAPT,CA12,CA9,MAPT
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA14,CA9,CA1,CA2,CA12
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CA14,CA7,TDP1,CA9,CA2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA14,CA7,CA9,RECQL,CA2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
CA7,TDP1,CA9,CA12,RECQL
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CA12,CA2,CA9,TDP1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TDP1,CA9,CA12,RECQL
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CA12,CA7,CYP3A4,CA9
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA1,CA12,CA2
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA14,CA12,CA2
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CA14,MAPT,CA2
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CA9,CA9,CA1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA12,CA7,CA9
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4,CA9,CA2
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CA14,CA2,CA1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CA7,CA9
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP3A4,CA9,MAPT
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA12,CA2,CA9
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA12,CYP3A4,CA2
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CA2,CA1
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA1,CA2
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
CA2,CA1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CA9,MAPT
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CA12,CA1
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA12,CA9
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA12,CA7
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CA2,CA9
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA12,CA9
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CA14,CA12
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
MAPT
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
CA2
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
CA9
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CA9
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Inborn metabolism deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5C59 |
CA14
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAPT
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
NCT01012349
|
Posterior blepharitisDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A02.1 |
NCT01647217
|
CholelithiasisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC11 |
NCT01754779
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
NCT01602068
|
NephrocalcinosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB57 |
NCT00249951
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT01421160
|
Kidney failure, unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB6Z |
NCT01962116
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CA12
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
CA9
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
CA1
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
CA14
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CA9
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
CA2
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CA9
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
CA1
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
CA1
|