Collective Molecular Activities of the Plant: Rauvolfia Serpentina
Plant ID: NPO7282
Plant Latin Name: Rauvolfia Serpentina
Taxonomy Genus: Rauvolfia
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
4060
Plant-of-the-World-Online:
n.a.
Country/Region:
Thailand; Indonesia; India; VietnamTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; HomeopathyThailand; Indonesia; India; Vietnam
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
35 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
29 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
16 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97278
Ingredient ID: NPC88923
Ingredient ID: NPC7453
Ingredient ID: NPC66363
Ingredient ID: NPC63310
Ingredient ID: NPC49196
Ingredient ID: NPC315634
Ingredient ID: NPC313985
Ingredient ID: NPC296771
Ingredient ID: NPC294909
Ingredient ID: NPC289227
Ingredient ID: NPC284685
Ingredient ID: NPC275316
Ingredient ID: NPC265786
Ingredient ID: NPC265579
Ingredient ID: NPC260940
Ingredient ID: NPC249040
Ingredient ID: NPC234086
Ingredient ID: NPC234078
Ingredient ID: NPC226759
Ingredient ID: NPC221100
Ingredient ID: NPC220630
Ingredient ID: NPC197316
Ingredient ID: NPC195296
Ingredient ID: NPC195268
Ingredient ID: NPC17406
Ingredient ID: NPC173634
Ingredient ID: NPC166577
Ingredient ID: NPC152384
Ingredient ID: NPC142301
Ingredient ID: NPC141461
Ingredient ID: NPC133230
Ingredient ID: NPC110879
Ingredient ID: NPC10585
Ingredient ID: NPC100734
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Therapeutic Target | Phosphodiesterase 10 | PDE10A | Phosphodiesterase 10A | Q9Y233 | CHEMBL4409 |
| Therapeutic Target | Phosphodiesterase 3 | PDE3A | Phosphodiesterase 3A | Q14432 | CHEMBL241 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2B | Serotonin 2b (5-HT2b) receptor | P41595 | CHEMBL1833 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2B | Alpha-2b adrenergic receptor | P18089 | CHEMBL1942 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2A | Alpha-2a adrenergic receptor | P08913 | CHEMBL1867 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2C | Alpha-2c adrenergic receptor | P18825 | CHEMBL1916 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1B | Alpha-1b adrenergic receptor | P35368 | CHEMBL232 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 23 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000499 | Systolic Hypertension in the Elderly Program (SHEP) (Pilot Study) | heart disease;hypertension | Reserpine (NPC88923) | NP level |
| NCT00000514 | Systolic Hypertension in the Elderly Program (SHEP) | cerebrovascular disorder;heart disease;hypertension | Reserpine (NPC88923) | NP level |
| NCT00000620 | Action to Control Cardiovascular Risk in Diabetes (ACCORD) | atherosclerosis;coronary artery disease;Hypercholesterolemia;type 2 diabetes mellitus;hypertension | Reserpine (NPC88923) | NP level |
| NCT00033033 | Reserpine for the Treatment of Cocaine Dependence - 1 | cocaine dependence | Reserpine (NPC88923) | NP level |
| NCT00080808 | Nerve-Sparing Radical Prostatectomy With or Without Nerve Grafting Followed by Standard Therapy for Erectile Dysfunction in Treating Patients With Localized Prostate Cancer | prostate cancer | Papaverine (NPC195268) | NP level |
| NCT00223691 | Treatment of Orthostatic Hypotension in Autonomic Failure | orthostatic hypotension | Yohimbine (NPC49196) | NP level |
| NCT00267657 | A Phase 1 Parallel-Group, Double-Blind, Placebo-Controlled Cardiovascular and Behavioral Study Assessing Interactions Between Single Doses of Oral Reserpine and Intravenous Methamphetamine - 1 | methamphetamine dependence | Reserpine (NPC88923) | NP level |
| NCT00535002 | The Effect of Yohimbine on Cocaine Cue Reactivity | cocaine dependence | Yohimbine (NPC49196) | NP level |
| NCT00605904 | Modulation of Pharmacologically Induced Alcohol Craving in Recently Detoxified Alcoholics | alcohol dependence | Yohimbine (NPC49196) | NP level |
| NCT00748059 | The Pathophysiology of Orthostatic Hypotension | orthostatic hypotension;orthostatic intolerance | Yohimbine (NPC49196) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
CREBBP
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CYP2D6,ADRA2A,HTR2B
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADRA1B,PDE10A,HTR2B,CYP2C19,LMNA,DRD2,ABCB1
|
Alcohol dependenceDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40.2 |
NCT00605904
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
DRD2,ADRA2C,SLC18A2,HTR6
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
DRD2,HTR6
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
DRD2,PDE3A
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
ADRA1B,ADRA2A,HTR2B,DRD2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
