CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Tylophora Ovata

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO7170
Plant Latin Name: Tylophora Ovata
Taxonomy Genus: Tylophora
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: 228704
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antitussive; Carminative; Emetic; Expectorant

Geographical Distribution

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

18 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

11 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

10 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC6984

Ingredient ID: NPC68742

Ingredient ID: NPC68430

Ingredient ID: NPC5989

Ingredient ID: NPC42057

Ingredient ID: NPC316413

Ingredient ID: NPC26253

Ingredient ID: NPC236579

Ingredient ID: NPC233650

Ingredient ID: NPC216630

Ingredient ID: NPC21142

Ingredient ID: NPC196776

Ingredient ID: NPC179694

Ingredient ID: NPC172053

Ingredient ID: NPC161617

Ingredient ID: NPC138925

Ingredient ID: NPC118511

Ingredient ID: NPC116990

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Fatty acid binding protein family	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Therapeutic Target	Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Therapeutic Target	Protein Kinase	PRKCE	Protein kinase C epsilon	Q02156	CHEMBL3582
Therapeutic Target	Protein Kinase	PRKCB	Protein kinase C beta	P05771	CHEMBL3045
Therapeutic Target	Protein Kinase	PRKCG	Protein kinase C gamma	P05129	CHEMBL2938
Therapeutic Target	Transcription factor	JUN	Proto-oncogene c-JUN	P05412	CHEMBL4977

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	10

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT01122381	Comparison of a Drug and Placebo in the Prevention of Migraine Headaches	migraine disorder	Ethosuximide (NPC21142)	NP level
NCT02205931	Ketogenic Diet in Infants With Epilepsy (KIWE)	epilepsy	Ethosuximide (NPC21142)	NP level
NCT04431778	Evaluation of the Efficacy and Tolerance of Low Doses of Ethosuximide in the Treatment of Peripheral Neuropathic Pain	neuropathic pain	Ethosuximide (NPC21142)	NP level
NCT03887624	Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression.	depressive disorder	Ethosuximide (NPC21142)	NP level
NCT04217733	Ethosuximide and Pentoxifylline in the Treatment of Abdominal Pain Related to Irritable Bowel Syndrome	irritable bowel syndrome	Ethosuximide (NPC21142)	NP level
NCT02973542	Ethosuximide to Treat IBS	irritable bowel syndrome	Ethosuximide (NPC21142)	NP level
NCT01795924	Safety and Efficacy Study of PD-616 Plus Cytarabine to Treat Acute Myelogenous Leukemia or Myelodysplastic Syndrome	acute myeloid leukemia;myelodysplastic syndrome	Phorbol Myristate Acetate (NPC5989)	NP level
NCT01009931	Phase II Study of TPA Plus Dexamethasone & CMT in Hematologic Malignancies	leukemia	Phorbol Myristate Acetate (NPC5989)	NP level
NCT00689585	Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS)	complex regional pain syndrome	Ethosuximide (NPC21142)	NP level
NCT00088452	Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study	childhood absence epilepsy;Seizure	Ethosuximide (NPC21142)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	PRKCQ,PRKCD,PRKCB,FABP5,PRKCG,PRKCE
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	PRKCQ,PRKCB,OR51E2,JUN,PRKCA,PRKCG
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	PRKCB,OR51E2,FABP5,PRKCG,PRKCE
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	PRKCD,OR51E2,PRKCG,FABP5,PRKCA
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	PRKCQ,PRKCB,OR51E2,PRKCA,PRKCG
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	PRKCQ,FABP5,OR51E2,FABP4
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	PRKCQ,PRKCG,PRKCB,RASGRP3
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	PRKCG,FABP5,OR51E2,FABP5
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	PRKCG,PRKCB,PRKCD,OR51E2
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	PRKCQ,PRKCB,OR51E2,FABP5
Transplant rejection Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NE84	PRKCA,PRKCB,PRKCQ
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	PRKCQ,PRKCG,FABP5
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	OR51E2,FABP4,FABP5
Melanoma of skin Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	PRKCQ,RASGRP3,PRKCA
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	FABP5,OR51E2,FABP4
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	PRKCQ,PRKCG,PRKCB
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	PRKCB,FABP5,PRKCG
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	PRKCG NCT01795924
Epilepsy/seizure Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A61-8A6Z	NCT02205931,NCT00088452
Irritable bowel syndrome Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD91	NCT04217733,NCT02973542
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	PRKCG,FABP4
Non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92	PRKCE,FABP4
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	OR51E2,PRKCG
West Nile virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D46	PRKCQ,PRKCE
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	OR51E2,FABP5
Malignant neoplasms of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	PRKCG,FABP4
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	FABP5,RASGRP3
Mastocytosis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A21	PRKCG
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	PRKCB
Diffuse large B-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	PRKCB
Liver vascular disorder Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB98	PRKCE
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	PRKCB
Myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41-BA43	PRKCD
Malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F40-1F45	PRKCE
Central nervous system disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A04-8D87	PRKCB
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	PRKCB
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	PRKCG
Anxiety Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB24.3	PRKCE
Chronic myelomonocytic leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A40	PRKCG
Muscular atrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B61	PRKCA
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	PRKCE
Malignant haematopoietic neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B33	PRKCB
Mature B-cell leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A82	PRKCB
Migraine disorder(TM1) Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module I Disease ICD-11 Code: SD10	NCT01122381
Complex regional pain syndrome Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG30.04	NCT00689585
Childhood absence epilepsy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A61.21	NCT00088452
Leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60-2B33	NCT01009931
Myelodysplastic syndrome Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A37	NCT01795924
Depressive disorders, unspecified Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A7Z	NCT03887624
Neuropathic pain Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43.0	NCT04431778
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	FABP5
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	PRKCG
Malignant neoplasms of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	FABP4
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	PRKCG
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	PRKCA
Systemic sclerosis Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A42	FABP4
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	PRKCG
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	JUN
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	FABP5
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	PRKCD
Malignant neoplasm of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	FABP4

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Tylophora Ovata

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

18 All known Ingredients in Total

11 Ingredients with Acceptable Bioavailablity

10 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Serous cystadenoma,borderline malignancy of ovary

Carpal tunnel syndrome

Pheochromocytoma

Malignant neoplasms of biliary tract, distal bile duct

Mesothelioma of pleura

Hepatoblastoma

Leishmaniasis

Other specified malignant neoplasms of kidney, except renal pelvis

Adenocarcinoma of pancreas

Malignant neoplasms of adrenal gland

Transplant rejection

Carcinosarcoma of uterus

Diffuse large B-cell lymphomas

Melanoma of skin

Hepatocellular carcinoma of liver

Cytomegaloviral disease

Malignant neoplasms of thymus

Acute myeloid leukaemia

Epilepsy/seizure

Irritable bowel syndrome

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Non-alcoholic fatty liver disease

Squamous cell carcinoma of bronchus or lung

West Nile virus infection

Adenocarcinoma of prostate

Malignant neoplasms of stomach

Germ cell tumour of testis

Mastocytosis

Solid tumour/cancer

Diffuse large B-cell lymphoma

Liver vascular disorder

Mature T-cell lymphoma

Myocardial infarction

Malaria

Central nervous system disease

Brain cancer

Colorectal cancer

Anxiety

Chronic myelomonocytic leukaemia

Muscular atrophy

Alzheimer disease

Malignant haematopoietic neoplasm

Mature B-cell leukaemia

Migraine disorder(TM1)

Complex regional pain syndrome

Childhood absence epilepsy

Leukaemia

Myelodysplastic syndrome

Depressive disorders, unspecified

Neuropathic pain

Psoriasis

Adenocarcinoma of stomach

Malignant neoplasms of bladder

Other specified malignant neoplasms ofcolon

Superficial ovarian endometriosis

Systemic sclerosis

Adenocarcinoma of bronchus or lung

Chikungunya virus disease

Glioblastoma of brain

Renal cell carcinoma, chromophobe type

Malignant neoplasm of pancreas