Collective Molecular Activities of the Plant: Stellera Chamaejasme
Plant ID: NPO7067
Plant Latin Name: Stellera Chamaejasme
Taxonomy Genus: Stellera
Taxonomy Family: Thymelaeaceae
Plant External Links:
NCBI TaxonomyDB:
142738
Plant-of-the-World-Online:
n.a.
Country/Region:
India; ChinaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Vulnerary
India; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
83 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
23 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
54 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95995
Ingredient ID: NPC81775
Ingredient ID: NPC78612
Ingredient ID: NPC73738
Ingredient ID: NPC69083
Ingredient ID: NPC56840
Ingredient ID: NPC485701
Ingredient ID: NPC485700
Ingredient ID: NPC485699
Ingredient ID: NPC485698
Ingredient ID: NPC485697
Ingredient ID: NPC485696
Ingredient ID: NPC485695
Ingredient ID: NPC485694
Ingredient ID: NPC485693
Ingredient ID: NPC485692
Ingredient ID: NPC485691
Ingredient ID: NPC485690
Ingredient ID: NPC485689
Ingredient ID: NPC485688
Ingredient ID: NPC48151
Ingredient ID: NPC478793
Ingredient ID: NPC474508
Ingredient ID: NPC471942
Ingredient ID: NPC471941
Ingredient ID: NPC471940
Ingredient ID: NPC471939
Ingredient ID: NPC471110
Ingredient ID: NPC469648
Ingredient ID: NPC37745
Ingredient ID: NPC328112
Ingredient ID: NPC309991
Ingredient ID: NPC307178
Ingredient ID: NPC304443
Ingredient ID: NPC302327
Ingredient ID: NPC287789
Ingredient ID: NPC283875
Ingredient ID: NPC276356
Ingredient ID: NPC274282
Ingredient ID: NPC273385
Ingredient ID: NPC271741
Ingredient ID: NPC267801
Ingredient ID: NPC263899
Ingredient ID: NPC26251
Ingredient ID: NPC262265
Ingredient ID: NPC258750
Ingredient ID: NPC258474
Ingredient ID: NPC247553
Ingredient ID: NPC239931
Ingredient ID: NPC239704
Ingredient ID: NPC239568
Ingredient ID: NPC237603
Ingredient ID: NPC234536
Ingredient ID: NPC233581
Ingredient ID: NPC233105
Ingredient ID: NPC22571
Ingredient ID: NPC223464
Ingredient ID: NPC22219
Ingredient ID: NPC221374
Ingredient ID: NPC217901
Ingredient ID: NPC211849
Ingredient ID: NPC20939
Ingredient ID: NPC208543
Ingredient ID: NPC201227
Ingredient ID: NPC193234
Ingredient ID: NPC189226
Ingredient ID: NPC183182
Ingredient ID: NPC182266
Ingredient ID: NPC179464
Ingredient ID: NPC179194
Ingredient ID: NPC171411
Ingredient ID: NPC169222
Ingredient ID: NPC166137
Ingredient ID: NPC161557
Ingredient ID: NPC159226
Ingredient ID: NPC149618
Ingredient ID: NPC145649
Ingredient ID: NPC138641
Ingredient ID: NPC126052
Ingredient ID: NPC114239
Ingredient ID: NPC11410
Ingredient ID: NPC113928
Ingredient ID: NPC102166
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT03059160 | Open Label Trial of Triheptanoin (UX007) in Treatment of Rett Syndrome. | Rett syndrome | Tridecanoate (NPC113928) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CA9
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA9
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA12,CA9
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CA9,PRKCQ
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
PRKCQ
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1,CA9
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
