CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Carpesium Longifolium

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO6544
Plant Latin Name: Carpesium Longifolium
Taxonomy Genus: Carpesium
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

81 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

41 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

37 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC99298

Ingredient ID: NPC99078

Ingredient ID: NPC99006

Ingredient ID: NPC94280

Ingredient ID: NPC92489

Ingredient ID: NPC90174

Ingredient ID: NPC84718

Ingredient ID: NPC81249

Ingredient ID: NPC80999

Ingredient ID: NPC76268

Ingredient ID: NPC73883

Ingredient ID: NPC7359

Ingredient ID: NPC71105

Ingredient ID: NPC6407

Ingredient ID: NPC55307

Ingredient ID: NPC53773

Ingredient ID: NPC51352

Ingredient ID: NPC48143

Ingredient ID: NPC41331

Ingredient ID: NPC3910

Ingredient ID: NPC38566

Ingredient ID: NPC308240

Ingredient ID: NPC306420

Ingredient ID: NPC305799

Ingredient ID: NPC305602

Ingredient ID: NPC303672

Ingredient ID: NPC302531

Ingredient ID: NPC302519

Ingredient ID: NPC295895

Ingredient ID: NPC291449

Ingredient ID: NPC285596

Ingredient ID: NPC277042

Ingredient ID: NPC273416

Ingredient ID: NPC273023

Ingredient ID: NPC268041

Ingredient ID: NPC267442

Ingredient ID: NPC261158

Ingredient ID: NPC256452

Ingredient ID: NPC255817

Ingredient ID: NPC252107

Ingredient ID: NPC251466

Ingredient ID: NPC24216

Ingredient ID: NPC23376

Ingredient ID: NPC230698

Ingredient ID: NPC23035

Ingredient ID: NPC225745

Ingredient ID: NPC220923

Ingredient ID: NPC214036

Ingredient ID: NPC207541

Ingredient ID: NPC207188

Ingredient ID: NPC199209

Ingredient ID: NPC19839

Ingredient ID: NPC196609

Ingredient ID: NPC195986

Ingredient ID: NPC194266

Ingredient ID: NPC190904

Ingredient ID: NPC171928

Ingredient ID: NPC171872

Ingredient ID: NPC170583

Ingredient ID: NPC167096

Ingredient ID: NPC166725

Ingredient ID: NPC166577

Ingredient ID: NPC16634

Ingredient ID: NPC159362

Ingredient ID: NPC157740

Ingredient ID: NPC156944

Ingredient ID: NPC155753

Ingredient ID: NPC152186

Ingredient ID: NPC150195

Ingredient ID: NPC145154

Ingredient ID: NPC140857

Ingredient ID: NPC136330

Ingredient ID: NPC135155

Ingredient ID: NPC124863

Ingredient ID: NPC120066

Ingredient ID: NPC118885

Ingredient ID: NPC115688

Ingredient ID: NPC110740

Ingredient ID: NPC105821

Ingredient ID: NPC105550

Ingredient ID: NPC100163

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Therapeutic Target	Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Therapeutic Target	Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Therapeutic Target	Transient receptor potential channel	TRPV1	Vanilloid receptor	Q8NER1	CHEMBL4794

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	3

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT01383694	Effect Of Piperine In Patients With Oropharyngeal Dysphagia	Dysphagia	Piperine (NPC136330)	NP level
NCT05430087	Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients	systemic lupus erythematosus	Piperine (NPC136330)	NP level
NCT01893424	Bioequivalence Assessment of Oral Administration Vs. Oral Spray of a Cannabinoids (Tetrahydrocannabinol and Cannabidiol)	pain	Piperine (NPC136330)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CYP3A4,TRPV1,CNR2
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	TRPV1,CNR2,MAOB
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	CNR2,TRPV1 NCT01893424
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	LMNA,CNR2,MAOB
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	LMNA,CNR2,MAOB
Migraine Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A80	MAOB,TRPV1
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	LMNA,CNR2
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	CNR2,CYP3A4
Malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F40-1F45	MAOB
Depression Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A70-6A7Z	MAOB
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	CNR2
Inborn lipid metabolism error Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52	CNR2
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	TRPV1
Muscular dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70	MAOB
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	MAOB
Anxiety Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB24.3	CYP3A4
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	MAOB
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	MAOB
Functional bladder disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GC50	TRPV1
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	CNR2
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	MAOB
Skin cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30-2C37	MAOB
Lower limb mononeuropathy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C11	TRPV1
Skin tag/polyp Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EK71	MAOB
Nausea/vomiting Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD90	MAOB
Primary psychotic disorder manifestation Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A25	MAOB
Knee osteoarthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA01	TRPV1
Visual system disease Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9E1Z	TRPV1
Acquired hypomelanotic disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED63	MAOB
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	CYP3A4
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	CNR2
Osteoarthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA00-FA05	TRPV1
Chronic pain Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG30	TRPV1
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	TRPV1
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	MAOB
Dysphagia Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD93	NCT01383694
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	NCT05430087
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	LMNA
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	CNR2
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	LMNA
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CYP3A4
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CNR2
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	LMNA
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	CNR2
Human immunodeficiency virus disease without mention of tuberculosis or malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1C62	CNR2
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	LMNA
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CYP3A4
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	CNR2
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	CYP3A4

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Carpesium Longifolium

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

81 All known Ingredients in Total

41 Ingredients with Acceptable Bioavailablity

37 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Atopic eczema

General pain disorder

Pain, unspecified

Diffuse large B-cell lymphomas

Adenocarcinoma of pancreas

Migraine

Mesothelioma of pleura

Malignant neoplasms of thymus

Malaria

Depression

Crohn disease

Inborn lipid metabolism error

Asthma

Muscular dystrophy

Alzheimer disease

Anxiety

Prostate cancer

Pulmonary hypertension

Functional bladder disorder

Attention deficit hyperactivity disorder

Dementia

Skin cancer

Lower limb mononeuropathy

Skin tag/polyp

Nausea/vomiting

Primary psychotic disorder manifestation

Knee osteoarthritis

Visual system disease

Acquired hypomelanotic disorder

Solid tumour/cancer

Insomnia

Osteoarthritis

Chronic pain

Rheumatoid arthritis

Parkinsonism

Dysphagia

Systemic lupus erythematosus

Malignant neoplasms of biliary tract, distal bile duct

Leishmaniasis

Superficial ovarian endometriosis

Urothelial carcinoma of bladder

Cytomegaloviral disease

Chikungunya virus disease

Invasive carcinoma of breast

Human immunodeficiency virus disease without mention of tuberculosis or malaria

Glioblastoma of brain

Renal cell carcinoma, chromophobe type

Germ cell tumour of testis

Malignant neoplasms of adrenal gland

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities