Collective Molecular Activities of the Plant: Humulus Scandens
Unknown.
Italy; South Africa; France; United States; Belgium; Hungary
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
74 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
60 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
16 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99952
Ingredient ID: NPC99664
Ingredient ID: NPC96855
Ingredient ID: NPC93590
Ingredient ID: NPC78870
Ingredient ID: NPC74214
Ingredient ID: NPC71945
Ingredient ID: NPC70479
Ingredient ID: NPC52836
Ingredient ID: NPC51700
Ingredient ID: NPC50898
Ingredient ID: NPC49158
Ingredient ID: NPC48831
Ingredient ID: NPC47616
Ingredient ID: NPC42960
Ingredient ID: NPC39619
Ingredient ID: NPC38707
Ingredient ID: NPC32581
Ingredient ID: NPC310580
Ingredient ID: NPC306381
Ingredient ID: NPC304721
Ingredient ID: NPC304669
Ingredient ID: NPC30168
Ingredient ID: NPC300492
Ingredient ID: NPC299174
Ingredient ID: NPC299135
Ingredient ID: NPC290527
Ingredient ID: NPC290328
Ingredient ID: NPC28751
Ingredient ID: NPC285371
Ingredient ID: NPC272736
Ingredient ID: NPC260265
Ingredient ID: NPC255565
Ingredient ID: NPC253619
Ingredient ID: NPC253171
Ingredient ID: NPC252531
Ingredient ID: NPC251708
Ingredient ID: NPC246903
Ingredient ID: NPC245344
Ingredient ID: NPC243702
Ingredient ID: NPC230332
Ingredient ID: NPC229943
Ingredient ID: NPC228346
Ingredient ID: NPC224543
Ingredient ID: NPC222001
Ingredient ID: NPC219862
Ingredient ID: NPC210293
Ingredient ID: NPC201602
Ingredient ID: NPC19900
Ingredient ID: NPC197962
Ingredient ID: NPC196499
Ingredient ID: NPC194297
Ingredient ID: NPC191617
Ingredient ID: NPC18873
Ingredient ID: NPC18727
Ingredient ID: NPC183191
Ingredient ID: NPC1786
Ingredient ID: NPC177114
Ingredient ID: NPC176829
Ingredient ID: NPC17091
Ingredient ID: NPC167931
Ingredient ID: NPC165418
Ingredient ID: NPC15889
Ingredient ID: NPC156705
Ingredient ID: NPC15622
Ingredient ID: NPC153340
Ingredient ID: NPC14508
Ingredient ID: NPC136030
Ingredient ID: NPC135808
Ingredient ID: NPC116595
Ingredient ID: NPC116467
Ingredient ID: NPC110228
Ingredient ID: NPC107473
Ingredient ID: NPC104195
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Therapeutic Target | Oxidoreductase | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02337933 | Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome | metabolic syndrome | Ursolic Acid (NPC51700) | NP level |
| NCT03216876 | A Study Of Ursolic Acid For Primary Sclerosing Cholangitis | sclerosing cholangitis | Ursolic Acid (NPC51700) | NP level |
| NCT04403568 | Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate | prostate cancer | Ursolic Acid (NPC51700) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
RELA
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,TTR,THPO,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,CYP1B1,TTR,DPP4,XDH,RECQL,CES1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TTR
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CYP19A1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE,MAOA,ESR2
|
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
TTR
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
