CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Annona Glabra

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO6333
Plant Latin Name: Annona Glabra
Taxonomy Genus: Annona
Taxonomy Family: Annonaceae

Plant External Links:

NCBI TaxonomyDB: 301703
Plant-of-the-World-Online: 72208-1

Used in Medicines

Country/Region:

Netherlands; China

Traditional Medicine System:

TCM

Geographical Distribution

Brazil; Guinea; Costa Rica; Bahamas; Suriname; Nigeria; Cameroon; Cote d'Ivoire; Ecuador; Cuba; El Salvador; Venezuela; Guatemala; China; Haiti; Belize; Sierra Leone; Liberia; Netherlands; Gambia; New Caledonia; United States; Trinidad and Tobago; Gabon; Guinea-Bissau; Guyana; Dominican Republic; Jamaica; Seychelles; Honduras; Mexico; Nicaragua; India; Senegal; Congo; Colombia; French Guiana; Fiji

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

97 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

73 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

64 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC99920

Ingredient ID: NPC93606

Ingredient ID: NPC91067

Ingredient ID: NPC87125

Ingredient ID: NPC82149

Ingredient ID: NPC79589

Ingredient ID: NPC76637

Ingredient ID: NPC76336

Ingredient ID: NPC66414

Ingredient ID: NPC66185

Ingredient ID: NPC50864

Ingredient ID: NPC480092

Ingredient ID: NPC480091

Ingredient ID: NPC480090

Ingredient ID: NPC480089

Ingredient ID: NPC480088

Ingredient ID: NPC480087

Ingredient ID: NPC480086

Ingredient ID: NPC478793

Ingredient ID: NPC477919

Ingredient ID: NPC476737

Ingredient ID: NPC476582

Ingredient ID: NPC476581

Ingredient ID: NPC476580

Ingredient ID: NPC476579

Ingredient ID: NPC476578

Ingredient ID: NPC476577

Ingredient ID: NPC476576

Ingredient ID: NPC476575

Ingredient ID: NPC476574

Ingredient ID: NPC476573

Ingredient ID: NPC476572

Ingredient ID: NPC476571

Ingredient ID: NPC476570

Ingredient ID: NPC476569

Ingredient ID: NPC476568

Ingredient ID: NPC476567

Ingredient ID: NPC472274

Ingredient ID: NPC472273

Ingredient ID: NPC472272

Ingredient ID: NPC428

Ingredient ID: NPC42598

Ingredient ID: NPC416

Ingredient ID: NPC4071

Ingredient ID: NPC39793

Ingredient ID: NPC35627

Ingredient ID: NPC312918

Ingredient ID: NPC311485

Ingredient ID: NPC294852

Ingredient ID: NPC286619

Ingredient ID: NPC286006

Ingredient ID: NPC280612

Ingredient ID: NPC280249

Ingredient ID: NPC278525

Ingredient ID: NPC264640

Ingredient ID: NPC253915

Ingredient ID: NPC251382

Ingredient ID: NPC250461

Ingredient ID: NPC243469

Ingredient ID: NPC24014

Ingredient ID: NPC234666

Ingredient ID: NPC230301

Ingredient ID: NPC229873

Ingredient ID: NPC229166

Ingredient ID: NPC228569

Ingredient ID: NPC226712

Ingredient ID: NPC220751

Ingredient ID: NPC220337

Ingredient ID: NPC215570

Ingredient ID: NPC210434

Ingredient ID: NPC207786

Ingredient ID: NPC204932

Ingredient ID: NPC203784

Ingredient ID: NPC202460

Ingredient ID: NPC20118

Ingredient ID: NPC190827

Ingredient ID: NPC185721

Ingredient ID: NPC182907

Ingredient ID: NPC180199

Ingredient ID: NPC176869

Ingredient ID: NPC169828

Ingredient ID: NPC16452

Ingredient ID: NPC161187

Ingredient ID: NPC149919

Ingredient ID: NPC148709

Ingredient ID: NPC147390

Ingredient ID: NPC147150

Ingredient ID: NPC147001

Ingredient ID: NPC145013

Ingredient ID: NPC142429

Ingredient ID: NPC130235

Ingredient ID: NPC128560

Ingredient ID: NPC113744

Ingredient ID: NPC110532

Ingredient ID: NPC110481

Ingredient ID: NPC107986

Ingredient ID: NPC103284

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Therapeutic Target	Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Therapeutic Target	Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Therapeutic Target	Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Therapeutic Target	Methyl-lysine/arginine binding protein	SMN1	Survival motor neuron protein	Q16637	CHEMBL1293232
Therapeutic Target	Phosphodiesterase	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 7 of 7 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
No data available in table

Showing 0 to 0 of 0 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

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Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	F2,CA9,CA12,CA7
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	F2,CA9,CA7,LMNA
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	F2
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	F2
Arteries/arterioles disorder Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD52	MTOR
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	CA4,F2
Atrial fibrillation Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BC81.3	CA7
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA4,CA12
Bladder cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	MTOR
Bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20-GA21	F2

Showing 1 to 10 of 76 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Annona Glabra

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

97 All known Ingredients in Total

73 Ingredients with Acceptable Bioavailablity

64 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Adenocarcinoma of stomach

Angina pectoris

Arteries/arterioles disorder

Asthma

Atrial fibrillation

Bacterial infection

Bladder cancer

Bleeding disorder

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities