CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Angelica Archangelica

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO6190
Plant Latin Name: Angelica Archangelica
Taxonomy Genus: Angelica
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 40949
Plant-of-the-World-Online: 837560-1

Used in Medicines

Country/Region:

India; Romania; Finland; Lithuania; China

Traditional Medicine System:

Indian Folk; TCM; Ayurveda

Medicinal Functions:

Antispasmodic; Appetizer; Carminative; Diaphoretic; Diuretic; Expectorant; Stimulant; Stomachic; Tonic

Geographical Distribution

Ukraine; Netherlands; Belarus; Lithuania; Denmark; Finland; India; Romania; France; United Kingdom; Sweden; Albania; China; Iceland; Belgium; Germany; Russia; Greenland; Bulgaria

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

20 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

18 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

13 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC96286

Ingredient ID: NPC95472

Ingredient ID: NPC70741

Ingredient ID: NPC64022

Ingredient ID: NPC35273

Ingredient ID: NPC33320

Ingredient ID: NPC324923

Ingredient ID: NPC313036

Ingredient ID: NPC295110

Ingredient ID: NPC286514

Ingredient ID: NPC278010

Ingredient ID: NPC266689

Ingredient ID: NPC250042

Ingredient ID: NPC220217

Ingredient ID: NPC194691

Ingredient ID: NPC168105

Ingredient ID: NPC159993

Ingredient ID: NPC15819

Ingredient ID: NPC154176

Ingredient ID: NPC131725

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450	Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Drug Transporter	Hydrolase	ATP12A	Potassium-transporting ATPase alpha chain 2	P54707	CHEMBL2933
Therapeutic Target	Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Therapeutic Target	Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Therapeutic Target	Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	18

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00030589	Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma	lymphoma	Methoxsalen (NPC33320)	NP level
NCT00221026	Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Crohn's Disease	Crohn's disease	Methoxsalen (NPC33320)	NP level
NCT00639717	Addition of Etanercept and Extracorporeal Photopheresis (ECP) to Standard Graft-Versus-Host Disease (GVHD) Prophylaxis in Stem Cell Transplant	graft versus host disease	Methoxsalen (NPC33320)	NP level
NCT03512756	A Randomized Phase 2/3 Multi-Center Study of SM-88 in Patients With Metastatic Pancreatic Cancer	pancreatic carcinoma	Methoxsalen (NPC33320)	NP level
NCT01686594	PUVA Maintenance Therapy in Mycosis Fungoides	mycosis fungoides	Methoxsalen (NPC33320)	NP level
NCT00221000	Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis	rheumatoid arthritis	Methoxsalen (NPC33320)	NP level
NCT00930566	Extracorporal Photopheresis Pilot Study	lymphoid neoplasm	Methoxsalen (NPC33320)	NP level
NCT00282503	Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Acute Graft Versus-Host Disease	acute graft vs. host disease	Methoxsalen (NPC33320)	NP level
NCT03778996	SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma	Ewing sarcoma	Methoxsalen (NPC33320)	NP level
NCT00054600	Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease	graft versus host disease	Methoxsalen (NPC33320)	NP level
NCT00004359	Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita	epidermolysis bullosa acquisita	Methoxsalen (NPC33320)	NP level
NCT00056056	Ultraviolet Light Therapy Using Methoxsalen With or Without Bexarotene in Treating Patients With Mycosis Fungoides	lymphoma	Methoxsalen (NPC33320)	NP level
NCT03563040	Study of Photopheresis in the Treatment of Erythrodermic MF and SS	Sezary's disease;mycosis fungoides	Methoxsalen (NPC33320)	NP level
NCT04986605	Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis	diffuse scleroderma	Methoxsalen (NPC33320)	NP level
NCT04291261	Extracorporal Photopheresis With UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease	acute graft vs. host disease	Methoxsalen (NPC33320)	NP level
NCT02524847	Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease	acute graft vs. host disease	Methoxsalen (NPC33320)	NP level
NCT00056355	Extracorporeal Photopheresis to Maintain Symptoms Remission During Steroid Withdrawal in Patients With Steroid-Dependent Crohn's Disease	Crohn's disease	Methoxsalen (NPC33320)	NP level
NCT00054613	Safety and Efficacy Study of Photopheresis Plus Standard Therapy to Treat Chronic Graft-versus-Host Disease	graft versus host disease	Methoxsalen (NPC33320)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Graft-versus-host disease Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4B24	NCT02524847,NCT04291261,NCT00054600,NCT00639717,NCT00054613,NCT00282503
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	CA12,GAA,CA9,ATP12A,CYP2A13,CYP1A2
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	CA12,ACHE,FXYD2,CA9,ATP12A
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	CA12,CA9,FXYD2,CA12,CA9
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	CA9,ATP12A,POLB,CYP2A13
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	ACHE,GAA,CA9,ATP12A
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	CA12,CYP2A13,CYP2A6,CA9
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	CA12,POLB,CA9
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	CA9 NCT00030589,NCT00056056
Mycosis fungoides Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B01	CYP2A6 NCT01686594,NCT03563040
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	ACHE,CA9,CA9
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	CA12,CA9,ATP12A
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	ACHE,CA9,POLB
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	CA12,GAA,CA9
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CA9,ATP12A,CYP1A2
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	CA12,ACHE,CA9
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	CA12,GAA,CA9
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	CA12,ACHE,ATP12A
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	CA12,CA9
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	NCT00056355,NCT00221026
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	FXYD2,CA9
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	CA12,FXYD2
Idiopathic pulmonary fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB03.4	CYP2A13,ATP12A
Other specified malignant neoplasms of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.Y	CA12,CA9
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	ACHE,FXYD2
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	CA12,ATP12A
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	CA9,ATP12A
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CA12,CYP1A2
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	GAA,FXYD2
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	CA12,CA9
Unspecific substance harmful effect Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NE6Z	ACHE
Oesophageal/gastroduodenal disorder Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD90	ACHE
Myasthenia gravis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C6Y	ACHE
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	ACHE
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	ACHE
Pediculosis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1G00	ACHE
Parasitic worm infestation Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F90	ACHE
Renal cell carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90	CA9
Mild neurocognitive disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D71	ACHE
Inborn carbohydrate metabolism error Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C51	GAA
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	ACHE
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	CYP2A6
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	ACHE
Seborrhoeic dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA81	CA12
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA12
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	ACHE
Substance abuse Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C40	ACHE
Ewing sarcoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B52	NCT03778996
Neoplasms of haematopoietic or lymphoid tissues, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B3Z	NCT00930566
Malignant neoplasm of pancreas, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.Z	NCT03512756
Epidermolysis bullosa acquisita Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EB43	NCT00004359
Sezary syndrome Disease Category: X.Extension Codes Disease ICD-11 Code: XH8HN3	NCT03563040
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	NCT00221000
NA Disease Category: NA Disease ICD-11 Code: NA	NCT04986605
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	ACHE
Zika virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D48	ACHE
Osteoarthritis, unspecified Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA0Z	CA12
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	FXYD2
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	CA9
West Nile virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D46	ACHE
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	CA9
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	ACHE
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	ACHE
Chronic rhinosinusitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA0A	CA9
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	ACHE
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	ATP12A
Ebola virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D60.01	ACHE
Gliomas of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.0	FXYD2

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Angelica Archangelica

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

20 All known Ingredients in Total

18 Ingredients with Acceptable Bioavailablity

13 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Graft-versus-host disease

Serous cystadenoma,borderline malignancy of ovary

Diffuse large B-cell lymphomas

Hepatocellular carcinoma of liver

Carcinosarcoma of uterus

Malignant neoplasms of thymus

Invasive carcinoma of breast

Solid tumour/cancer

Mature T-cell lymphoma

Mycosis fungoides

Other specified malignant neoplasms of kidney, except renal pelvis

Squamous cell carcinoma of bronchus or lung

Adenocarcinoma of pancreas

Mesothelioma of pleura

Urothelial carcinoma of bladder

Adenocarcinoma of bronchus or lung

Glioblastoma of brain

Germ cell tumour of testis

Breast cancer

Crohn disease

Malignant neoplasms of biliary tract, distal bile duct

Hepatoblastoma

Idiopathic pulmonary fibrosis

Other specified malignant neoplasms of bronchus or lung

Cytomegaloviral disease

Malignant neoplasms of thyroid gland, unspecified

Malignant neoplasms of corpus uteri, unspecified

Renal cell carcinoma, chromophobe type

Carpal tunnel syndrome

Malignant neoplasms of adrenal gland

Unspecific substance harmful effect

Oesophageal/gastroduodenal disorder

Myasthenia gravis

Pain, unspecified

Dementia

Pediculosis

Parasitic worm infestation

Renal cell carcinoma

Mild neurocognitive disorder

Inborn carbohydrate metabolism error

Alzheimer disease

Psoriasis

Parkinsonism

Seborrhoeic dermatitis

Bacterial infection

Glaucoma

Substance abuse

Ewing sarcoma

Neoplasms of haematopoietic or lymphoid tissues, unspecified

Malignant neoplasm of pancreas, unspecified

Epidermolysis bullosa acquisita

Sezary syndrome

Rheumatoid arthritis

NA

Pheochromocytoma

Zika virus disease

Osteoarthritis, unspecified

Leishmaniasis

Malignant neoplasm metastasis in lymph nodes of head, face or neck

West Nile virus infection

Other specified malignant neoplasms ofcolon