CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Ziziphus Jujuba Var. Spinosa

Example Image

PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO5986.2
Plant Latin Name: Ziziphus Jujuba Var. Spinosa
Taxonomy Genus: Ziziphus
Taxonomy Family: Rhamnaceae

Plant External Links:

NCBI TaxonomyDB: 326968
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

62 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

32 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

13 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC99614

Ingredient ID: NPC96354

Ingredient ID: NPC95615

Ingredient ID: NPC83692

Ingredient ID: NPC82694

Ingredient ID: NPC7987

Ingredient ID: NPC70741

Ingredient ID: NPC70437

Ingredient ID: NPC61168

Ingredient ID: NPC41326

Ingredient ID: NPC3780

Ingredient ID: NPC34995

Ingredient ID: NPC301585

Ingredient ID: NPC293580

Ingredient ID: NPC286598

Ingredient ID: NPC286072

Ingredient ID: NPC283682

Ingredient ID: NPC282491

Ingredient ID: NPC279026

Ingredient ID: NPC277400

Ingredient ID: NPC268129

Ingredient ID: NPC264711

Ingredient ID: NPC26316

Ingredient ID: NPC256153

Ingredient ID: NPC246398

Ingredient ID: NPC242641

Ingredient ID: NPC240528

Ingredient ID: NPC239480

Ingredient ID: NPC236592

Ingredient ID: NPC236579

Ingredient ID: NPC220089

Ingredient ID: NPC216630

Ingredient ID: NPC210434

Ingredient ID: NPC203381

Ingredient ID: NPC203171

Ingredient ID: NPC201182

Ingredient ID: NPC199362

Ingredient ID: NPC199123

Ingredient ID: NPC195749

Ingredient ID: NPC195075

Ingredient ID: NPC194561

Ingredient ID: NPC191460

Ingredient ID: NPC185762

Ingredient ID: NPC172990

Ingredient ID: NPC170819

Ingredient ID: NPC167072

Ingredient ID: NPC166088

Ingredient ID: NPC161881

Ingredient ID: NPC159177

Ingredient ID: NPC155828

Ingredient ID: NPC14337

Ingredient ID: NPC142753

Ingredient ID: NPC138886

Ingredient ID: NPC125327

Ingredient ID: NPC124344

Ingredient ID: NPC122362

Ingredient ID: NPC121595

Ingredient ID: NPC111523

Ingredient ID: NPC107755

Ingredient ID: NPC107482

Ingredient ID: NPC104195

Ingredient ID: NPC10269

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Fatty acid binding protein family	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESR2	Estrogen receptor beta	Q92731	CHEMBL242

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	3

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT01871142	Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance	hypoxia	5-Hydroxymethyl-Furfural (NPC107482)	NP level
NCT01987908	Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease	sickle cell anemia	5-Hydroxymethyl-Furfural (NPC107482)	NP level
NCT01597401	A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Disease	sickle cell anemia	5-Hydroxymethyl-Furfural (NPC107482)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	CSNK2A3,ESR2,OR51E2,FABP5
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	FABP5,FABP4,ESR2,OR51E2
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	CSNK2A3,ESR1,FABP5
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	FABP5,FABP4,OR51E2
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	FABP5,FABP5,OR51E2
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	FABP5,OR51E2,FABP4
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	ESR2,ESR1
Hyper-lipoproteinaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	ESR2,ESR1
Menopausal disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA30	ESR2,ESR1
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	ESR2,ESR1
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	CSNK2A1,ESR1
Sickle-cell disorder Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3A51	NCT01987908,NCT01597401
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	FABP5,OR51E2
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	FABP5,OR51E2
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	FABP5,CSNK2A3
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	OR51E2,ESR1
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	FABP5,OR51E2
Skeletal anomaly Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LD24	ESR1
Indeterminate colitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD72	ESR2
Endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10	ESR1
Diabetes mellitus, type unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A14	ESR1
Menstrual cycle bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20	ESR1
Low bone mass disorder Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FB83	ESR1
Female infertility Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA31	ESR1
Vasomotor/allergic rhinitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA08	ESR2
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	ESR1
Metastatic tumour Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D50-2E2Z	ESR1
Male infertility Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB04	ESR1
Prostate hyperplasia Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA90	ESR2
Coronavirus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D92	CSNK2A1
Female pelvic pain Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA34	ESR1
Acne vulgaris Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED80	ESR1
Breast in situ carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2E65	ESR1
Vaginitis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA02	ESR1
Hepatitis virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1E50-1E51	ESR2
Pituitary gland disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A60-5A61	ESR1
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	ESR2
Liver cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12	CSNK2A1
Sepsis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1G40-1G41	ESR2
Dyspareunia Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA12	ESR1
Female genital tract noninflammatory disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA1Y	ESR1
Unspecified viral infection of unspecified site Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D9Z	ESR1
Cushing syndrome Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A70	ESR2
Adrenal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	ESR1
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	ESR1
Acquired prion disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E01	ESR1
Asphyxia Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD11.1	NCT01871142
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	FABP5
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	FABP5
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	FABP4
Non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92	FABP4
Malignant neoplasms of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	FABP4
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	OR51E2
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	OR51E2
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	OR51E2
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	ESR2
Systemic sclerosis Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A42	FABP4
Malignant neoplasms of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	FABP4
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	FABP5
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	ESR1
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	FABP5
Malignant neoplasm of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	FABP4

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Ziziphus Jujuba Var. Spinosa

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

62 All known Ingredients in Total

32 Ingredients with Acceptable Bioavailablity

13 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Malignant neoplasms of biliary tract, distal bile duct

Diffuse large B-cell lymphomas

Serous cystadenoma,borderline malignancy of ovary

Hepatoblastoma

Other specified malignant neoplasms of kidney, except renal pelvis

Hepatocellular carcinoma of liver

Prostate cancer

Hyper-lipoproteinaemia

Menopausal disorder

Breast cancer

Solid tumour/cancer

Sickle-cell disorder

Pheochromocytoma

Adenocarcinoma of prostate

Glioblastoma of brain

Carpal tunnel syndrome

Malignant neoplasms of adrenal gland

Skeletal anomaly

Indeterminate colitis

Endometriosis

Diabetes mellitus, type unspecified

Menstrual cycle bleeding disorder

Low bone mass disorder

Female infertility

Vasomotor/allergic rhinitis

Brain cancer

Metastatic tumour

Male infertility

Prostate hyperplasia

Coronavirus infection

Female pelvic pain

Acne vulgaris

Breast in situ carcinoma

Vaginitis

Hepatitis virus infection

Pituitary gland disorder

Alzheimer disease

Liver cancer

Sepsis

Dyspareunia

Female genital tract noninflammatory disorder

Unspecified viral infection of unspecified site

Cushing syndrome

Adrenal cancer

Multiple sclerosis

Acquired prion disease

Asphyxia

Carcinosarcoma of uterus

Psoriasis

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Non-alcoholic fatty liver disease

Malignant neoplasms of bladder

Squamous cell carcinoma of bronchus or lung

Adenocarcinoma of pancreas

Mesothelioma of pleura

Cytomegaloviral disease

Systemic sclerosis

Malignant neoplasms of stomach

Malignant neoplasms of thymus

Invasive carcinoma of breast

Germ cell tumour of testis

Malignant neoplasm of pancreas

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities