CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Musa Paradisiaca Var. Sapientum

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO549.1
Plant Latin Name: Musa Paradisiaca Var. Sapientum
Taxonomy Genus: Musa
Taxonomy Family: Musaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

9 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

8 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

1 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC52015

Ingredient ID: NPC47226

Ingredient ID: NPC44382

Ingredient ID: NPC313955

Ingredient ID: NPC234086

Ingredient ID: NPC169207

Ingredient ID: NPC120866

Ingredient ID: NPC119806

Ingredient ID: NPC111131

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Therapeutic Target	Phosphodiesterase	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Therapeutic Target	Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Therapeutic Target	Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Therapeutic Target	Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Therapeutic Target	Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Therapeutic Target	Small molecule receptor (family A GPCR)	ADRB3	Beta-3 adrenergic receptor	P13945	CHEMBL246
Therapeutic Target	Small molecule receptor (family A GPCR)	ADRA1A	Alpha-1a adrenergic receptor	P35348	CHEMBL229
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	32

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT02019810	Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury	brain injury	Norepinephrine (NPC169207)	NP level
NCT01263366	Exploratory Study of Norepinephrine to Prevent Radiodermatitis in Breast Cancer Patients	radiodermatitis	Norepinephrine (NPC169207)	NP level
NCT04536194	Dopamine Versus Norepinephrine Under General Anesthesia	congenital heart disease	Norepinephrine (NPC169207)	NP level
NCT04067817	Norepinephrine and Phenylephrine, Which Better for Elderly?	hypotension	Norepinephrine (NPC169207)	NP level
NCT00639015	Phenylephrine in Septic Shock	septic shock	Norepinephrine (NPC169207)	NP level
NCT00604019	Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock	septic shock	Norepinephrine (NPC169207)	NP level
NCT01505231	Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery	Shock	Norepinephrine (NPC169207)	NP level
NCT01544504	Exploratory Study of Topical Norepinephrine in Breast Cancer Patients Receiving Radiotherapy	radiodermatitis	Norepinephrine (NPC169207)	NP level
NCT00134212	Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock	septic shock	Norepinephrine (NPC169207)	NP level
NCT00481572	Continuous Infusion of Terlipressin in Septic Shock	septic shock	Norepinephrine (NPC169207)	NP level
NCT03702400	Norepinephrine or Phenylephrine in Bolus for Hypotension in Cesarean Delivery	hypotension	Norepinephrine (NPC169207)	NP level
NCT03340779	Norepinephrine vs Norepinephrine and Dobutamine in Cardiogenic Shock	Shock	Norepinephrine (NPC169207)	NP level
NCT05497700	Comparative Efficacity of Ephedrine Versus Norepinephrine to Correct Anesthesia Induction Related Hypotension	hypotension	Norepinephrine (NPC169207)	NP level
NCT02428062	Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly	Cognitive impairment	Norepinephrine (NPC169207)	NP level
NCT04218773	Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study	Ischemic stroke	Norepinephrine (NPC169207)	NP level
NCT01153802	An Open Label Positron Emission Tomography Study in Healthy Male Subjects to Investigate Brain DAT and SERT Occupancy,Pharmacokinetics and Safety of Single Oral Doses of GSK1360707, Using 11C- PE2I and 11C-DASB as PET Ligands	depressive disorder	Norepinephrine (NPC169207)	NP level
NCT02473263	Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock	Sepsis	Norepinephrine (NPC169207)	NP level
NCT05179499	Early Vasopressors in Sepsis	Sepsis	Norepinephrine (NPC169207)	NP level
NCT04295993	Methylene Blue and Microcirculation in Septic Shock	septic shock	Norepinephrine (NPC169207)	NP level
NCT04436731	Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity	obesity	Norepinephrine (NPC169207)	NP level
NCT03215797	Phenylephrine or Norepinephrine for a Better Hemodynamic Stability	hypotension	Norepinephrine (NPC169207)	NP level
NCT00264186	Recombinant Human Superoxide Dismutase (rhSOD) and Vascular Reactivity	inflammation	Norepinephrine (NPC169207)	NP level
NCT01285908	Intravenous Norepinephrine for Orthostatic Hypotension	orthostatic hypotension	Norepinephrine (NPC169207)	NP level
NCT02789150	Outcomes of Renal Function in Hepatorenal Syndrome (HRS) Determined By Comparison of Target Mean Arterial Pressure (MAP) of 65 - 70 Mmhg Versus ≥ 85 Mmhg	Renal insufficiency	Norepinephrine (NPC169207)	NP level
NCT03302650	Angiotensin II for Septic Shock Treatment	septic shock	Norepinephrine (NPC169207)	NP level
NCT05219799	Sex Disparities in Hypoxic Vasodilation and Impact of Obesity	obesity	Norepinephrine (NPC169207)	NP level
NCT04501861	Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:	heart disease	Norepinephrine (NPC169207)	NP level
NCT01718613	Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients	septic shock	Norepinephrine (NPC169207)	NP level
NCT03483753	Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery	Shock	Norepinephrine (NPC169207)	NP level
NCT00314704	Dopamine and Norepinephrine in Shock Patients	Shock	Norepinephrine (NPC169207)	NP level
NCT04789005	Comparison of Phenylephrine and Norepinephrine for Spinal-induced Hypotension	hypotension	Norepinephrine (NPC169207)	NP level
NCT00624650	Hemodynamics and Extravascular Lung Water in Acute Lung Injury	acute lung injury	Norepinephrine (NPC169207)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Hypotension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA20-BA21	DRD2,ADRA2C NCT04067817,NCT03702400,NCT05497700,NCT03215797,NCT04789005
Septic shock Disease Category: X.Extension Codes Disease ICD-11 Code: XS26	NCT04295993,NCT00639015,NCT01718613,NCT00481572,NCT03302650,NCT00604019,NCT00134212
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	ADRB3,RECQL,ADRA2C,ADRA2A,APEX1,TDP1,LMNA
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	RECQL,ADRA2A,APEX1,TDP1,DRD2,LMNA
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	DRD2,ADRA2C,ADRB3,ADRA1A,DRD2
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	ADRA2B,ADRA2A,ADRA2C,ADRA1A,DRD2
Substance abuse Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C40	DRD2,ADRA2A,ADRA2B,ADRA2C
Obesity Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B80-5B81	ADRB3,ADRA2C NCT04436731,NCT05219799
Shock Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG40	NCT03340779,NCT00314704,NCT01505231,NCT03483753
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	ADRA2C,APEX1,TDP1,DRD2
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	ADRB3,DRD2,LMNA,RECQL
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	DRD2,ADRA2B,ADRA2C
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	ADRB3,ADRA2C,DRD2
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	ADRA2C,ADRA2A,LMNA
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	ADRA2B,DRD2,ADRA2C
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	ADRA2B,ADRA1A,LMNA
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	ADRA2C,APEX1,DRD2
Functional bladder disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GC50	ADRB3,ADRB3
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	DRD2,ADRB3
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	DRD2,ADRA2C
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	DRD2,ADRB3
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	APEX1,DRD2
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	DRD2,ADRB3
Depression Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A70-6A7Z	DRD2,ADRA2A
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	ADRA2A,DRD2
Chronic kidney disease Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB61	ADRA2C,DRD2
NA Disease Category: NA Disease ICD-11 Code: NA	DRD2 NCT00264186
Dermatoses due to ionizing radiation, unspecified Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EJ7Z	NCT01263366,NCT01544504
Sepsis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1G40-1G41	NCT02473263,NCT05179499
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	ADRA2A,DRD2
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	DRD2,ADRA2B
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	ADRA2A,LMNA
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	ADRA2B,DRD2
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	ADRB3,ADRA2C
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	ADRB3,ADRA2C
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	ADRA2A,ADRA2C
Inborn porphyrin/heme metabolism error Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C58	DRD2
Ischaemic/haemorrhagic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B20	ADRB3
Essential hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00	DRD2
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	ADRA2C
Endometrial cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76	DRD2
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	DRD2
Psychotic disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20-6A25	DRD2
Dystonic disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A02	ADRB3
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	DRD2
Endocrine gland neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2F37	DRD2
Schizophrenia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20	DRD2
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	ADRB3
Abnormal micturition Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MF50	ADRB3
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	DRD2
Anxiety Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB24.3	DRD2
Digestive system disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DE2Z	DRD2
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	DRD2
Prostate hyperplasia Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA90	ADRA1A
Restless legs syndrome Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A80	DRD2
Bipolar disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A60	DRD2
Pituitary gland disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A60-5A61	DRD2
Retinopathy Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9B71	APEX1
Gastroduodenal motor/secretory disorder Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA41	DRD2
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	DRD2
Acute upper respiratory infection Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA07	DRD2
Non-specific cutaneous vascular sympton Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: ME64	ADRA2C
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	DRD2
Herpes simplex infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F00	ADRA2C
Cerebral ischaemia Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B1Z	DRD2
Vasomotor/allergic rhinitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA08	ADRA2C
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	ADRB3
Gangrene Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MC85	DRD2
Opioid use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C43	ADRA2A
Multiple myeloma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A83	DRD2
Stomach cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	DRD2
Chronic pain Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG30	ADRA2C
Heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10-BD1Z	DRD2
Sexual dysfunction Disease Category: 17.Conditions related to sexual health Disease ICD-11 Code: HA00-HA01	DRD2
Carcinoid syndrome Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B10	DRD2
Hyperaemia Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A61-9B7Y	DRD2
BCR-ABL1-negative chronic myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A41	DRD2
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	DRD2
Nausea/vomiting Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD90	DRD2
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	DRD2
Schizoaffective disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A21	DRD2
Intellectual development disorder Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LD90	DRD2
Ocular cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D00-2D07	APEX1
Idiopathic interstitial pneumonitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB03	DRD2
Dissociative neurological symptom disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6B60	ADRA2C
Thyrotoxicosis Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A02	DRD2
Allergic/hypersensitivity disorder Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A80-4A8Z	DRD2
Chronic obstructive pulmonary disease Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA22	ADRB3
Breathing abnormality Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD11	DRD2
Itching Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F28-1G07	DRD2
Faecal incontinence Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: ME07	DRD2
Post-traumatic stress disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6B40	ADRA2C
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	ADRA1A
Postpartum haemorrhage Disease Category: 18.Pregnancy, childbirth or the puerperium Disease ICD-11 Code: JA43	DRD2
Migraine Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A80	DRD2
Mild neurocognitive disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D71	ADRA1A
Intracranial injury, unspecified Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NA07.Z	NCT02019810
Ischemic heart disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40-BA6Z	NCT04501861
Structural developmental anomaly of heart or great vessels, unspecified Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA8Z	NCT04536194
Symptoms and signs involving cognition, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB21.Z	NCT02428062
Orthostatic hypotension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA21	NCT01285908
Injury of lung, unspecified Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NB32.3Z	NCT00624650
Kidney failure, unspecified Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB6Z	NCT02789150
Cerebral ischaemic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B11	NCT04218773
Depressive disorders, unspecified Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A7Z	NCT01153802
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	TDP1
Myelodysplastic syndromes, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A3Z	ADRA2B
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	ADRA2C
Myotonic dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C71.0	ADRA2A
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	DRD2
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	ADRA2C
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	ADRA2A
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	LMNA
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	DRD2
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	ADRA2B

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Musa Paradisiaca Var. Sapientum

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

9 All known Ingredients in Total

8 Ingredients with Acceptable Bioavailablity

1 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Hypotension

Septic shock

Diffuse large B-cell lymphomas

Mesothelioma of pleura

Pulmonary hypertension

Pain, unspecified

Substance abuse

Obesity

Shock

Serous cystadenoma,borderline malignancy of ovary

Adenocarcinoma of pancreas

General pain disorder

Glaucoma

Malignant neoplasms of biliary tract, distal bile duct

Cytomegaloviral disease

Chikungunya virus disease

Malignant neoplasms of thymus

Functional bladder disorder

Asthma

Alzheimer disease

Parkinsonism

Solid tumour/cancer

Type 2 diabetes mellitus

Depression

Attention deficit hyperactivity disorder

Chronic kidney disease

NA

Dermatoses due to ionizing radiation, unspecified

Sepsis

Pheochromocytoma

Squamous cell carcinoma of bronchus or lung

Superficial ovarian endometriosis

Systemic lupus erythematosus

Malignant neoplasms of thyroid gland, unspecified

Germ cell tumour of testis

Malignant neoplasms of adrenal gland

Inborn porphyrin/heme metabolism error

Ischaemic/haemorrhagic stroke

Essential hypertension

Chronic arterial occlusive disease

Endometrial cancer

Mature T-cell lymphoma

Psychotic disorder

Dystonic disorder

Psoriasis

Endocrine gland neoplasm

Schizophrenia

Acute diabete complication

Abnormal micturition

Insomnia

Anxiety

Digestive system disease

Cardiovascular disease

Prostate hyperplasia

Restless legs syndrome

Bipolar disorder

Pituitary gland disorder

Retinopathy

Gastroduodenal motor/secretory disorder

Brain cancer

Acute upper respiratory infection

Non-specific cutaneous vascular sympton

Choreiform disorder

Herpes simplex infection