CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Othonna Dentata

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO5383
Plant Latin Name: Othonna Dentata
Taxonomy Genus: Othonna
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

69 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

21 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

14 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC93845

Ingredient ID: NPC92117

Ingredient ID: NPC75573

Ingredient ID: NPC74881

Ingredient ID: NPC66221

Ingredient ID: NPC64156

Ingredient ID: NPC62496

Ingredient ID: NPC59870

Ingredient ID: NPC51443

Ingredient ID: NPC45136

Ingredient ID: NPC40943

Ingredient ID: NPC35554

Ingredient ID: NPC313116

Ingredient ID: NPC299923

Ingredient ID: NPC299144

Ingredient ID: NPC295146

Ingredient ID: NPC287020

Ingredient ID: NPC286818

Ingredient ID: NPC282661

Ingredient ID: NPC276115

Ingredient ID: NPC271870

Ingredient ID: NPC268342

Ingredient ID: NPC266613

Ingredient ID: NPC264972

Ingredient ID: NPC263398

Ingredient ID: NPC260895

Ingredient ID: NPC256572

Ingredient ID: NPC252155

Ingredient ID: NPC246162

Ingredient ID: NPC246044

Ingredient ID: NPC244793

Ingredient ID: NPC242529

Ingredient ID: NPC229745

Ingredient ID: NPC22691

Ingredient ID: NPC222193

Ingredient ID: NPC219876

Ingredient ID: NPC215291

Ingredient ID: NPC211985

Ingredient ID: NPC210843

Ingredient ID: NPC209544

Ingredient ID: NPC199927

Ingredient ID: NPC194109

Ingredient ID: NPC1940

Ingredient ID: NPC188762

Ingredient ID: NPC18270

Ingredient ID: NPC181953

Ingredient ID: NPC17928

Ingredient ID: NPC177986

Ingredient ID: NPC177573

Ingredient ID: NPC177061

Ingredient ID: NPC17129

Ingredient ID: NPC167520

Ingredient ID: NPC166264

Ingredient ID: NPC16496

Ingredient ID: NPC1612

Ingredient ID: NPC158587

Ingredient ID: NPC154771

Ingredient ID: NPC148834

Ingredient ID: NPC139608

Ingredient ID: NPC138469

Ingredient ID: NPC138287

Ingredient ID: NPC132193

Ingredient ID: NPC130683

Ingredient ID: NPC126029

Ingredient ID: NPC123052

Ingredient ID: NPC114308

Ingredient ID: NPC110899

Ingredient ID: NPC110838

Ingredient ID: NPC10941

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Therapeutic Target	Enzyme	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Therapeutic Target	Enzyme	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Therapeutic Target	Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Therapeutic Target	Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Therapeutic Target	Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Therapeutic Target	Phosphodiesterase	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Therapeutic Target	Protein Kinase	CDK6	Cyclin-dependent kinase 6	Q00534	CHEMBL2508
Therapeutic Target	Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Therapeutic Target	Transcription factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Showing 1 to 10 of 10 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	30

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00218946	Nasogastric Tube in Premature Babies - Pain and Treatment	premature birth	Sucrose (NPC130683)	NP level
NCT00482560	Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening	pain	Sucrose (NPC130683)	NP level
NCT00519207	Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture	pain	Sucrose (NPC130683)	NP level
NCT00787059	AC6 Gene Transfer for CHF	congestive heart failure	Sucrose (NPC130683)	NP level
NCT00949104	Role of Oral Sucrose in Reducing the Pain to Orogastric Tube Insertion in Preterm Neonates	pain	Sucrose (NPC130683)	NP level
NCT01190995	Role of Repeated Painful Procedures in Preterm Neonates on Short Term Neurobehavioural Outcome	pain	Sucrose (NPC130683)	NP level
NCT01201954	Pain Relief of Newborn Preterm Infants During Endotracheal Suctioning	pain	Sucrose (NPC130683)	NP level
NCT01238471	Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study	retinopathy of prematurity	Sucrose (NPC130683)	NP level
NCT01503060	Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain	pain	Sucrose (NPC130683)	NP level
NCT01561547	Trial of Repeated Analgesia With Kangaroo Care	pain	Sucrose (NPC130683)	NP level

Showing 1 to 10 of 30 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

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Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	GSK3B,NFKB1
Acute respiratory distress syndrome Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB00	NCT03718507
Acute/subacute hepatic failure Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB91	NFKB1
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	ACHE,CA12,CA7,CCNB2,CDK5R1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CA7,SNCA,CDK5R1,ACHE
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	CCNB2,CDK6
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	SNCA,ACHE
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	NFKB1
Atrial fibrillation Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BC81.3	CA7
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	NCT02086864

Showing 1 to 10 of 97 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Othonna Dentata

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

69 All known Ingredients in Total

21 Ingredients with Acceptable Bioavailablity

14 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute myeloid leukaemia

Acute respiratory distress syndrome

Acute/subacute hepatic failure

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Adenocarcinoma of stomach

Alzheimer disease

Atopic eczema

Atrial fibrillation

Attention deficit hyperactivity disorder

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities