CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Salvia Oxyodon

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PLANiTS DNA barcode

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Taxonomic Information

Plant ID: NPO5253
Plant Latin Name: Salvia Oxyodon
Taxonomy Genus: Salvia
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

13 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

10 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

5 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC82979

Ingredient ID: NPC80083

Ingredient ID: NPC74539

Ingredient ID: NPC51146

Ingredient ID: NPC45263

Ingredient ID: NPC326

Ingredient ID: NPC295618

Ingredient ID: NPC273886

Ingredient ID: NPC247553

Ingredient ID: NPC21333

Ingredient ID: NPC167625

Ingredient ID: NPC120118

Ingredient ID: NPC113733

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450	Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450	Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Therapeutic Target	Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Therapeutic Target	Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	20

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00218946	Nasogastric Tube in Premature Babies - Pain and Treatment	premature birth	Sucrose (NPC130683)	NP level
NCT00519207	Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture	pain	Sucrose (NPC130683)	NP level
NCT00949104	Role of Oral Sucrose in Reducing the Pain to Orogastric Tube Insertion in Preterm Neonates	pain	Sucrose (NPC130683)	NP level
NCT03272594	The Influence of Breastfeeding on Cortical Activity During Procedures	pain	Sucrose (NPC130683)	NP level
NCT00482560	Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening	pain	Sucrose (NPC130683)	NP level
NCT01503060	Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain	pain	Sucrose (NPC130683)	NP level
NCT04855266	Iron Sucrose in Patients With Iron Deficiency and POTS	orthostatic hypotension	Sucrose (NPC130683)	NP level
NCT01190995	Role of Repeated Painful Procedures in Preterm Neonates on Short Term Neurobehavioural Outcome	pain	Sucrose (NPC130683)	NP level
NCT00005092	Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer	leukemia;multiple myeloma;myelodysplastic syndrome	Psoralen (NPC51146)	NP level
NCT02990364	Combination Analgesia for Neonatal Circumcision	pain	Sucrose (NPC130683)	NP level
NCT02174705	Rotavirus vs. Sucrose for Vaccine Injection Pain	pain	Sucrose (NPC130683)	NP level
NCT02086864	A Placebo Controlled Study of Homeopathic Treatment of Children and Youth With ADHD	attention deficit hyperactivity disorder	Sucrose (NPC130683)	NP level
NCT00787059	AC6 Gene Transfer for CHF	congestive heart failure	Sucrose (NPC130683)	NP level
NCT01238471	Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study	retinopathy of prematurity	Sucrose (NPC130683)	NP level
NCT00533195	Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis	atopic eczema	Bergapten (NPC74539)	NP level
NCT03745963	The Influence of Skin-to-skin Contact on Cortical Activity During Painful Procedures on Preterm Infants in the NICU	pain	Sucrose (NPC130683)	NP level
NCT01201954	Pain Relief of Newborn Preterm Infants During Endotracheal Suctioning	pain	Sucrose (NPC130683)	NP level
NCT03718507	Study on the Effects of Different Premedication for LISA on Stress and Cerebral Tissue Oxygenation in Preterm Infants	acute respiratory distress syndrome	Sucrose (NPC130683)	NP level
NCT03082001	Sucrose to Reduce Pain During Initiation of Venipuncture in Extremely Low Birth Weight Babies	pain	Sucrose (NPC130683)	NP level
NCT01561547	Trial of Repeated Analgesia With Kangaroo Care	pain	Sucrose (NPC130683)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	CA12,CA9,CA12,CA9
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	CYP1A2,CA12,CA9
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	CA12,CYP2A6,CA9
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CYP1A2,CA12,CYP1A1
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	CA12,CA9
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	CA12,CA9
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	CA12,CA9
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	CA9,CA9
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	CA12,CA9
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	CA12,CA9
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	CA9,CYP1A1
Other specified malignant neoplasms of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.Y	CA12,CA9
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CYP1A2,CA9
Chronic rhinosinusitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA0A	CA9,CYP1A1
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	CA12,CA9
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	CA9,CYP1A1
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	CA12,CA9
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	CA12,CA9
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	NCT01201954,NCT02990364,NCT03745963,NCT01561547,NCT00482560,NCT00519207,NCT03082001,NCT01190995,NCT03272594,NCT02174705,NCT00949104,NCT01503060
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA12
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	CA9
Renal cell carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90	CA9
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	CYP2A6
Seborrhoeic dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA81	CA12
Mycosis fungoides Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B01	CYP2A6
Congestive heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10	NCT00787059
Myelodysplastic syndrome Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A37	NCT00005092
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	NCT00533195
Multiple myeloma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A83	NCT00005092
Retinopathy of prematurity Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9B71.3	NCT01238471
Preterm newborn, unspecified Disease Category: 19.Certain conditions originating in the perinatal period Disease ICD-11 Code: KA21.4Z	NCT00218946
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	NCT02086864
Acute respiratory distress syndrome Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB00	NCT03718507
Orthostatic hypotension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA21	NCT04855266
Leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60-2B33	NCT00005092
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	CA9
Coeliac disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA95	CYP1A1
Osteoarthritis, unspecified Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA0Z	CA12
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	CA9
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	CA12
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	CA9
Myotonic dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C71.0	CYP1A1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CA9
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CYP1A1
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	CYP1A1
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	CA12
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	CA9
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	CA12

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Salvia Oxyodon

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

13 All known Ingredients in Total

10 Ingredients with Acceptable Bioavailablity

5 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Hepatocellular carcinoma of liver

Serous cystadenoma,borderline malignancy of ovary

Invasive carcinoma of breast

Renal cell carcinoma, chromophobe type

Breast cancer

Solid tumour/cancer

Diffuse large B-cell lymphomas

Other specified malignant neoplasms of kidney, except renal pelvis

Squamous cell carcinoma of bronchus or lung

Mesothelioma of pleura

Other specified malignant neoplasms ofcolon

Other specified malignant neoplasms of bronchus or lung

Urothelial carcinoma of bladder

Chronic rhinosinusitis

Adenocarcinoma of bronchus or lung

Malignant neoplasms of corpus uteri, unspecified

Glioblastoma of brain

Malignant neoplasms of adrenal gland

Pain, unspecified

Bacterial infection

Mature T-cell lymphoma

Renal cell carcinoma

Psoriasis

Seborrhoeic dermatitis

Mycosis fungoides

Congestive heart failure

Myelodysplastic syndrome

Atopic eczema

Multiple myeloma

Retinopathy of prematurity

Preterm newborn, unspecified

Attention deficit hyperactivity disorder

Acute respiratory distress syndrome

Orthostatic hypotension

Leukaemia

Carcinosarcoma of uterus

Coeliac disease

Osteoarthritis, unspecified

Malignant neoplasms of biliary tract, distal bile duct

Hepatoblastoma

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Myotonic dystrophy

Adenocarcinoma of pancreas

Cytomegaloviral disease

Systemic lupus erythematosus

Malignant neoplasms of thyroid gland, unspecified

Malignant neoplasms of thymus

Germ cell tumour of testis

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities