CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Elaphoglossum Lindbergii

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO5247
Plant Latin Name: Elaphoglossum Lindbergii
Taxonomy Genus: Elaphoglossum
Taxonomy Family: Dryopteridaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

52 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

23 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

21 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC8768

Ingredient ID: NPC8115

Ingredient ID: NPC73347

Ingredient ID: NPC67917

Ingredient ID: NPC57149

Ingredient ID: NPC56202

Ingredient ID: NPC481989

Ingredient ID: NPC481988

Ingredient ID: NPC481987

Ingredient ID: NPC481986

Ingredient ID: NPC481985

Ingredient ID: NPC39633

Ingredient ID: NPC35986

Ingredient ID: NPC34154

Ingredient ID: NPC296478

Ingredient ID: NPC291289

Ingredient ID: NPC286130

Ingredient ID: NPC276484

Ingredient ID: NPC274532

Ingredient ID: NPC274180

Ingredient ID: NPC270463

Ingredient ID: NPC261831

Ingredient ID: NPC260491

Ingredient ID: NPC250218

Ingredient ID: NPC243728

Ingredient ID: NPC230301

Ingredient ID: NPC230012

Ingredient ID: NPC225703

Ingredient ID: NPC219876

Ingredient ID: NPC216810

Ingredient ID: NPC200243

Ingredient ID: NPC198472

Ingredient ID: NPC195024

Ingredient ID: NPC192638

Ingredient ID: NPC191184

Ingredient ID: NPC190310

Ingredient ID: NPC189883

Ingredient ID: NPC188031

Ingredient ID: NPC185474

Ingredient ID: NPC180231

Ingredient ID: NPC178004

Ingredient ID: NPC165501

Ingredient ID: NPC152358

Ingredient ID: NPC15000

Ingredient ID: NPC149203

Ingredient ID: NPC137190

Ingredient ID: NPC136056

Ingredient ID: NPC127285

Ingredient ID: NPC122455

Ingredient ID: NPC109813

Ingredient ID: NPC106843

Ingredient ID: NPC105246

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Therapeutic Target	Fatty acid binding protein family	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Therapeutic Target	Nuclear hormone receptor subfamily 1	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Therapeutic Target	Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	72

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00371995	Short Course of Miltefosine and Liposomal Amphotericin B for Kala-azar	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00002316	The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis	cryptococcal meningitis	Amphotericin B (NPC67917)	NP level
NCT00263315	Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT00986713	Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT03196921	Efficacy and Safety of Oral Encochleated Amphotericin B for the Treatment of Cryptococcal Infection	infection	Amphotericin B (NPC67917)	NP level
NCT00163111	A Clinical Study Intended To Compare Treatment With Voriconazole To Treatment With Amphotericin Followed By Fluconazole In Patients With Candidemia, A Serious Fungus Infection Of The Blood.	candidiasis	Amphotericin B (NPC67917)	NP level
NCT00815516	Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis	candidiasis	Amphotericin B (NPC67917)	NP level
NCT00638196	Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS	multiple sclerosis	Oleic Acid (NPC261831)	NP level
NCT03327727	VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT00467883	Pilot Study of High Dose Liposomal Amphotericin B Efficacy in Initial Zygomycosis Treatment	mucormycosis	Amphotericin B (NPC67917)	NP level
NCT04799236	Treatment of Mucosal Bolivian Leishmaniasis	mucocutaneous Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00002159	A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis	blastomycosis;histoplasmosis	Amphotericin B (NPC67917)	NP level
NCT00003031	Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT00002742	Antifungal Therapy for Fever and Neutropenia in Patients Receiving Treatment for Hematologic Cancer	chronic myeloproliferative disorder;leukemia;multiple myeloma;myelodysplastic syndrome;infection	Amphotericin B (NPC67917)	NP level
NCT00497601	A Phase II Study To Assess Safety and Efficacy Of Short-Course Regimens Of Amphotericin B Emulsion In Kala-Azar	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00418951	Liposomal Amphotericin B (Ambisome) Versus Oral Voriconazole for the Prevention of Invasive Fungal Infections	acute myeloid leukemia;myelodysplastic syndrome	Amphotericin B (NPC67917)	NP level
NCT00002277	A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections	fungal infectious disease	Amphotericin B (NPC67917)	NP level
NCT00158730	Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT00003315	Liposomal Amphotericin B With or Without Sargramostim in Treating Patients With Invasive Fungal Infection	infection	Amphotericin B (NPC67917)	NP level
NCT02025491	Liposomal Amphotericin in Disseminated Leishmaniasis	Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT01122771	Phase III, Study of Three Short Course Combo (Ambisome®, Miltefosine, Paromomycin) Compared With AmBisome for the Treatment of VL in Bangladesh	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT01566552	Single Dose Liposomal Amphotericin B for Visceral Leishmaniasis	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT02686853	Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis	cryptococcal meningitis	Amphotericin B (NPC67917)	NP level
NCT01437020	SCH708980 With and Without AmBisome for Visceral Leishmaniasis	Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00936910	Antifungal Locks to Treat Fungal-related Central Line Infections	fungal infectious disease	Amphotericin B (NPC67917)	NP level
NCT00696969	Safety and Efficacy Study to Evaluate Different Combination Treatment Regimens for Visceral Leishmaniasis	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00419770	The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study	mucormycosis	Amphotericin B (NPC67917)	NP level
NCT00001017	Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS	cryptococcal meningitis	Amphotericin B (NPC67917)	NP level
NCT01945281	Safety, Tolerability, and Efficacy of Caspofungin Versus Amphotericin B Deoxycholate in the Treatment of Invasive Candidiasis in Neonates and Infants (MK-0991-064)	Candidiasis, Invasive	Amphotericin B (NPC67917)	NP level
NCT00847678	Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS	cryptococcal meningitis	Amphotericin B (NPC67917)	NP level
NCT00624143	Antifungal Prophylaxis in Pediatric Acute Leukemia	leukemia	Amphotericin B (NPC67917)	NP level
NCT00451711	Intermittent Liposomal Amphotericin B Primary Prophylaxis	acute myeloid leukemia	Amphotericin B (NPC67917)	NP level
NCT00003938	Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients	cancer	Amphotericin B (NPC67917)	NP level
NCT00001646	Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT00177710	Pharmacokinetic Profile of Inhaled Liposomal Amphotericin B in Lung Transplant Recipients - Ambisome Study	fungal infectious disease	Amphotericin B (NPC67917)	NP level
NCT01857479	A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis	allergic bronchopulmonary aspergillosis	Amphotericin B (NPC67917)	NP level
NCT03187691	Safety and PK of Oral Encochleated Amphotericin B (CAMB/MAT2203) for Antifungal Prophylaxis in Patients Undergoing Induction Chemotherapy for Acute Myelogenous and Lymphoblastic Leukaemia	acute lymphoblastic leukemia;acute myeloid leukemia	Amphotericin B (NPC67917)	NP level
NCT00001107	Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants	candidiasis	Amphotericin B (NPC67917)	NP level
NCT00832208	Open-Label, Sequential Step, Safety and Efficacy Study to Determine the Optimal Single Dose of Ambisome for Patients With VL	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00106288	Micafungin Versus AmBisome in Invasive Candidiasis and Candidemia	candidiasis	Amphotericin B (NPC67917)	NP level
NCT04018417	Evaluation of Amphotericin B in Optisol-GS for Prevention of Post-Keratoplasty Fungal Infections.	Fuchs endothelial corneal dystrophy	Amphotericin B (NPC67917)	NP level
NCT01067443	Clinical Trial to Assess the Safety and Efficacy of Sodium Stibogluconate (SSG) and AmBisome® Combination, Miltefosine and AmBisome® and Miltefosine Alone for the Treatment Visceral Leishmaniasis in Eastern Africa	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT01058174	Liver Transplant European Study Into the Prevention of Fungal Infection	fungal infectious disease	Amphotericin B (NPC67917)	NP level
NCT01032187	Amphotericin B to Treat Visceral Leishmaniasis in Brazilian Children	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00177684	Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®)	fungal infectious disease	Amphotericin B (NPC67917)	NP level
NCT03636659	Steady State Global Bioequivalence Study of Amphotericin B Liposome for Injection 50 mg/ Vial in Fed Condition	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00216346	Safety and Efficacy Study of Paromomycin to Treat Visceral Leishmaniasis	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT01661764	Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention	colorectal adenoma	Oleic Acid (NPC261831)	NP level
NCT01792310	A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours	glioma	Oleic Acid (NPC261831)	NP level
NCT00334412	COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT00047827	Trial of Micafungin (FK463) in Combination With Liposomal Amphotericin B (AmBisome) for Aspergillosis	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT04031833	Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial (EnACT)	cryptococcal meningitis	Amphotericin B (NPC67917)	NP level
NCT00876824	To Study the Effect Of Single Infusions Of Amphotericin B Lipid Preparations in Treatment of Patients Of Kala Azar	Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT01310738	Efficacy and Safety Study of Drugs for Treatment of Visceral Leishmaniasis in Brazil	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT04267497	Nebulised Liposomal Amphotericin for Invasive Pulmonary Aspergillosis (NAIFI01 Study)	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT00145249	Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis	cryptococcal meningitis	Amphotericin B (NPC67917)	NP level
NCT03945448	Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia	cryptococcal meningitis	Amphotericin B (NPC67917)	NP level
NCT02629419	CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis	Chronic mucocutaneous candidosis	Amphotericin B (NPC67917)	NP level
NCT00523965	Combination Therapy in Indian Visceral Leishmaniasis	Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00012467	Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis	cryptococcal meningitis	Amphotericin B (NPC67917)	NP level
NCT00000776	Dexamethasone in Cryptococcal Meningitis	intracranial hypertension;cryptococcal meningitis	Amphotericin B (NPC67917)	NP level
NCT05468372	Amphotericin Versus Posaconazole for Pulmonary Mucormycosis	mucormycosis	Amphotericin B (NPC67917)	NP level
NCT00076869	MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037)	aspergillosis	Amphotericin B (NPC67917)	NP level
NCT01845727	Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia	cutaneous Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT01293643	A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)	bacterial vaginosis;vulvovaginal candidiasis	Amphotericin B (NPC67917)	NP level
NCT00628719	Single Infusion of Liposomal Amphotericin B in Indian Visceral Leishmaniasis	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00008359	Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment	cancer	Amphotericin B (NPC67917)	NP level
NCT00370825	Combination Chemotherapy for the Treatment of Indian Kala-Azar	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT00235651	Abelcet Radiotagging Protocol: Inhaled Lipid Complex Abelcet® in Lung Transplant Recipients	lung disease	Amphotericin B (NPC67917)	NP level
NCT02656797	Topical Liposomal Amphotericin B Gel Treatment for Cutaneous Leishmaniasis	Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT02011958	Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients.	visceral Leishmaniasis	Amphotericin B (NPC67917)	NP level
NCT04502381	Combined Inhalational With Intravenous Amphotericin B Versus Intravenous Amphotericin B Alone for Pulmonary Mucormycosis	mucormycosis	Amphotericin B (NPC67917)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Meningitis due to Cryptococcus neoformans Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D01.10	NCT00002316,NCT02686853,NCT04031833,NCT00000776,NCT00012467,NCT00001017,NCT00145249,NCT03945448,NCT00847678
Candidosis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F23	NCT01945281,NCT00001107,NCT00815516,NCT00106288,NCT00163111
Skin fungal infection disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA60	NCT00936910,NCT01058174,NCT00177684,NCT00002277,NCT00177710
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	PPARA,CNR2,FABP4,FABP5,LMNA
Mucormycosis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F2C	NCT00419770,NCT04502381,NCT00467883,NCT05468372
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	F2,CNR2,LMNA,CES1
Herpes simplex infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F00	NCT03196921,NCT00002742,NCT00003315
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	NCT00451711,NCT00418951,NCT03187691
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	FABP5,F2,FABP5
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	F2,FABP5,CNR2
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	CNR2 NCT00876824,NCT01437020,NCT02656797,NCT00371995,NCT02011958,NCT01032187,NCT00216346,NCT01566552,NCT01122771,NCT00696969,NCT03636659,NCT04799236,NCT00832208,NCT00497601,NCT00370825,NCT00628719,NCT00523965,NCT01845727,NCT01067443,NCT01310738,NCT02025491
Inborn lipid metabolism error Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52	PPARA,CNR2
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	PPARA,F2
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	F2 NCT00638196
Hyper-lipoproteinaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	CES1,PPARA
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	PPARA,F2
Non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92	PPARA FABP4
Leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60-2B33	NCT00624143,NCT00002742
Myelodysplastic syndrome Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A37	NCT00418951,NCT00002742
Vaginal discharge Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MF3A	NCT01293643,NCT01293643
Unspecified malignant neoplasms of unspecified sites Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D4Z	NCT00008359,NCT00003938
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	FABP5,LMNA
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	FABP5,FABP4
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	F2,FABP4
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	LMNA,CNR2
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	FABP5,FABP4
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	FABP5,CNR2
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	FABP5,LMNA
Aspergillosis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F20	NCT00001646,NCT03327727,NCT00076869,NCT00158730,NCT00334412,NCT00003031,NCT04267497,NCT00263315,NCT00986713,NCT00047827
Gout Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA25	PPARA
Myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41-BA43	F2
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	PPARA
Coronary thrombosis Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA43	F2
Peroxisomal disease Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C57	CES1
Cerebral ischaemic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B11	F2
Dyslipidemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80-5C81	PPARA
Diabetes mellitus, type unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A14	PPARA
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	PPARA
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CNR2
Coagulation defect Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B10	F2
Ischaemic/haemorrhagic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B20	F2
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	CES1
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	F2
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	CNR2
Nutritional deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B50-5B71	F2
Bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20-GA21	F2
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	F2
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	CNR2
Thrombocytopenia Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B64	F2
Synthesis disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52-5C59	CES1
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	CNR2
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	CNR2
Hyperlipidemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	PPARA
Thrombosis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB61-GB90	F2
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	CNR2
Glioma, malignant Disease Category: X.Extension Codes Disease ICD-11 Code: XH4RQ3	NCT01792310
Myeloproliferative neoplasm, NOS Disease Category: X.Extension Codes Disease ICD-11 Code: XH5HH7	NCT00002742
NA Disease Category: NA Disease ICD-11 Code: NA	NCT00235651
Aspergillus-induced allergic or hypersensitivity conditions Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA82.4	NCT01857479
Multiple myeloma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A83	NCT00002742
Blastomycosis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F22	NCT00002159
Chronic mucocutaneous candidosis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F23.14	NCT02629419
Endothelial corneal dystrophy Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A70.0	NCT04018417
Precursor cell lymphoblastic leukaemia, NOS Disease Category: X.Extension Codes Disease ICD-11 Code: XH5J37	NCT03187691
Histoplasmosis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F2A	NCT00002159
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	NCT01661764
Other specified increased intracranial pressure Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8D60.Y	NCT00000776
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	FABP5
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	FABP5
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	FABP5
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	FABP5
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	F2
Malignant neoplasms of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	FABP4
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	F2
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	F2
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	F2
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	LMNA
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CNR2
Systemic sclerosis Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A42	FABP4
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	FABP5
Malignant neoplasms of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	FABP4
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	F2
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	F2
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	LMNA
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	CNR2
Human immunodeficiency virus disease without mention of tuberculosis or malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1C62	CNR2
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	FABP5
Malignant neoplasm of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	FABP4

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Elaphoglossum Lindbergii

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

52 All known Ingredients in Total

23 Ingredients with Acceptable Bioavailablity

21 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Meningitis due to Cryptococcus neoformans

Candidosis

Skin fungal infection disorder

Diffuse large B-cell lymphomas

Mucormycosis

Adenocarcinoma of pancreas

Herpes simplex infection

Acute myeloid leukaemia

Other specified malignant neoplasms of kidney, except renal pelvis

Germ cell tumour of testis

Leishmaniasis

Inborn lipid metabolism error

Type 2 diabetes mellitus

Multiple sclerosis

Hyper-lipoproteinaemia

Cardiovascular disease

Non-alcoholic fatty liver disease

Leukaemia

Myelodysplastic syndrome

Vaginal discharge

Unspecified malignant neoplasms of unspecified sites

Malignant neoplasms of biliary tract, distal bile duct

Hepatoblastoma

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Mesothelioma of pleura

Hepatocellular carcinoma of liver

Malignant neoplasms of thymus

Glioblastoma of brain

Aspergillosis

Gout

Myocardial infarction

Solid tumour/cancer

Coronary thrombosis

Peroxisomal disease

Cerebral ischaemic stroke

Dyslipidemia

Diabetes mellitus, type unspecified

Acute diabete complication

Atopic eczema

Coagulation defect

Ischaemic/haemorrhagic stroke

Chronic arterial occlusive disease

Angina pectoris

Insomnia

Nutritional deficiency

Bleeding disorder

Asthma

Pain, unspecified

Thrombocytopenia

Synthesis disorder

General pain disorder

Attention deficit hyperactivity disorder

Hyperlipidemia

Thrombosis

Crohn disease

Glioma, malignant

Myeloproliferative neoplasm, NOS

NA

Aspergillus-induced allergic or hypersensitivity conditions

Multiple myeloma

Blastomycosis

Chronic mucocutaneous candidosis

Endothelial corneal dystrophy

Precursor cell lymphoblastic leukaemia, NOS