Collective Molecular Activities of the Plant: Tussilago Farfara
Country/Region:
Turkey; India; Romania; Albania; Italy; Lebanon; Finland; Lithuania; Sweden; China; BulgariaTraditional Medicine System:
Indian Folk; TCM; HomeopathyMedicinal Functions:
Antitussive; Astringent; Bitter; Demulcent; Diaphoretic; Emollient; Expectorant; Skin; Stimulant; Tonic
Canada; Afghanistan; Italy; Turkmenistan; Lebanon; Nepal; Lithuania; France; Netherlands; Ireland; Norway; Uzbekistan; Belarus; Iran; Algeria; Turkey; China; Belgium; Germany; Kazakhstan; Spain; Ukraine; Georgia; Libya; Denmark; Poland; Finland; United States; Morocco; Sweden; Switzerland; New Zealand; Russia; Bulgaria; Pakistan; Romania; Albania; Portugal; Egypt; Tajikistan; India; United Kingdom; Tunisia; Austria; Greece; Hungary; Cyprus
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
128 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
92 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
79 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99480
Ingredient ID: NPC98098
Ingredient ID: NPC97663
Ingredient ID: NPC95381
Ingredient ID: NPC93888
Ingredient ID: NPC93831
Ingredient ID: NPC93617
Ingredient ID: NPC90226
Ingredient ID: NPC89042
Ingredient ID: NPC86227
Ingredient ID: NPC7901
Ingredient ID: NPC7774
Ingredient ID: NPC75236
Ingredient ID: NPC73418
Ingredient ID: NPC72722
Ingredient ID: NPC7208
Ingredient ID: NPC70744
Ingredient ID: NPC68873
Ingredient ID: NPC59537
Ingredient ID: NPC53872
Ingredient ID: NPC486413
Ingredient ID: NPC486412
Ingredient ID: NPC486411
Ingredient ID: NPC486410
Ingredient ID: NPC486409
Ingredient ID: NPC486408
Ingredient ID: NPC486407
Ingredient ID: NPC486406
Ingredient ID: NPC486405
Ingredient ID: NPC486404
Ingredient ID: NPC486403
Ingredient ID: NPC474716
Ingredient ID: NPC470978
Ingredient ID: NPC43611
Ingredient ID: NPC43246
Ingredient ID: NPC3857
Ingredient ID: NPC37633
Ingredient ID: NPC3357
Ingredient ID: NPC329597
Ingredient ID: NPC327393
Ingredient ID: NPC321606
Ingredient ID: NPC321217
Ingredient ID: NPC31891
Ingredient ID: NPC317111
Ingredient ID: NPC309355
Ingredient ID: NPC302857
Ingredient ID: NPC302003
Ingredient ID: NPC300326
Ingredient ID: NPC29883
Ingredient ID: NPC29793
Ingredient ID: NPC297517
Ingredient ID: NPC294902
Ingredient ID: NPC293378
Ingredient ID: NPC291473
Ingredient ID: NPC290613
Ingredient ID: NPC290437
Ingredient ID: NPC290240
Ingredient ID: NPC29
Ingredient ID: NPC282895
Ingredient ID: NPC281131
Ingredient ID: NPC276422
Ingredient ID: NPC275463
Ingredient ID: NPC273330
Ingredient ID: NPC272614
Ingredient ID: NPC262962
Ingredient ID: NPC249505
Ingredient ID: NPC249437
Ingredient ID: NPC245390
Ingredient ID: NPC245346
Ingredient ID: NPC245027
Ingredient ID: NPC238394
Ingredient ID: NPC236709
Ingredient ID: NPC230301
Ingredient ID: NPC226250
Ingredient ID: NPC226027
Ingredient ID: NPC225710
Ingredient ID: NPC224651
Ingredient ID: NPC224389
Ingredient ID: NPC223192
Ingredient ID: NPC218109
Ingredient ID: NPC213935
Ingredient ID: NPC21290
Ingredient ID: NPC210040
Ingredient ID: NPC208793
Ingredient ID: NPC20791
Ingredient ID: NPC206095
Ingredient ID: NPC197376
Ingredient ID: NPC196676
Ingredient ID: NPC196073
Ingredient ID: NPC195448
Ingredient ID: NPC195435
Ingredient ID: NPC194498
Ingredient ID: NPC193471
Ingredient ID: NPC192402
Ingredient ID: NPC19044
Ingredient ID: NPC18335
Ingredient ID: NPC179950
Ingredient ID: NPC177213
Ingredient ID: NPC176740
Ingredient ID: NPC175352
Ingredient ID: NPC174246
Ingredient ID: NPC17248
Ingredient ID: NPC167976
Ingredient ID: NPC16728
Ingredient ID: NPC164706
Ingredient ID: NPC162620
Ingredient ID: NPC162282
Ingredient ID: NPC159900
Ingredient ID: NPC156461
Ingredient ID: NPC149018
Ingredient ID: NPC138839
Ingredient ID: NPC138261
Ingredient ID: NPC137958
Ingredient ID: NPC136014
Ingredient ID: NPC133671
Ingredient ID: NPC132307
Ingredient ID: NPC131610
Ingredient ID: NPC130683
Ingredient ID: NPC126925
Ingredient ID: NPC119090
Ingredient ID: NPC117724
Ingredient ID: NPC116775
Ingredient ID: NPC116709
Ingredient ID: NPC11433
Ingredient ID: NPC1075
Ingredient ID: NPC10720
Ingredient ID: NPC103189
Ingredient ID: NPC10251
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Therapeutic Target | Enzyme | PKM | Pyruvate kinase isozymes M1/M2 | P14618 | CHEMBL1075189 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Hydrolase | CDA | Cytidine deaminase | P32320 | CHEMBL4502 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Ionotropic glutamate receptor | GRIK1 | Glutamate receptor ionotropic kainate 1 | P39086 | CHEMBL1918 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 138 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00005674 | Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS] | amyotrophic lateral sclerosis | Creatine (NPC195448) | NP level |
| NCT00016653 | Creatine and Glutamine in Steroid-Naive Duchenne Muscular Dystrophy | Duchenne muscular dystrophy | Creatine (NPC195448) | NP level |
| NCT00018109 | A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD) | Duchenne muscular dystrophy | Creatine (NPC195448) | NP level |
| NCT00026988 | Creatine Therapy for Huntington's Disease | Huntington disease | Creatine (NPC195448) | NP level |
| NCT00063193 | National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial | Parkinson disease | Creatine (NPC195448) | NP level |
| NCT00069186 | Study of Creatine Monohydrate in Patients With Amyotrophic Lateral Sclerosis | amyotrophic lateral sclerosis | Creatine (NPC195448) | NP level |
| NCT00070993 | Creatine for the Treatment of Amyotrophic Lateral Sclerosis | amyotrophic lateral sclerosis | Creatine (NPC195448) | NP level |
| NCT00140192 | Creatine Treatment in Psychiatric Disorders | schizophrenia | Creatine (NPC195448) | NP level |
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT00210080 | A Study to Diagnose Lung Cancer by Sputum Cytology (01-312) | lung cancer | Uridine (NPC43246) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,DPP4,AKR1B1,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,AURKB,AXL,TP53,PIM1,KDM1A,FLT3,SRC
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507,NCT04588441
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
