CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Catha Edulis

Example Image

PLANiTS DNA barcode

Click for details-----ITS

TGCGGAAGGATCATTGTCGAAACCTGCAACGCAGAACGACCCGCGAATCGGTTTAAACTAATGCGGATGACGGTCCTCAGGGCCCGTCGCCCCAAGTCCAAGACGATGGCCGTAGGGCAAGCCCCCACGTCCGTTGTTGCGGGCGCAAACAACAACCCCGGGCGCGAATCGCGCCAAGGAACTAGAAAAAGATGTGTCGTTCCCCCCGTGCCGGAAACGGTGTGTTGGGGGCAGCGGCGTCGTCGTTATCATATTTGAAACGACTCTCGGCAACGGATATCTAGGCTCTCGCATCGATGAAGAACGTAGCGAAATGCGATACTTGGTGTGAATTGCAGAATCCCGTGAACCATCGAGTTTTTGAACGCAAGTTGCGCCCGAAGCCGTCAGGCCGAGGGCACGTCTGCCTGGGTGTCACGTAACGTCGCCAAAAATCCCCTCACCCCTTCCGACGGGGAACAACGAGGGACGGCGGATATTGGCCTCCCGTGTGCGTATGCTTGCGGTTGGCCCAAAATAAGATTCCCGGCGAGGCAGCCACGACACGCGGTGGTTTGCAGCACATGCTCCTTTAACACCGTCGTGGGCGAGCCTCGTAGACCGGGATCCAAAGACCCCGACGCAAAGCGTCTTCACA

Click for details-----ITS1

TCGAAACCTGCATAGCAGAACGACCTGTGAACATGTAACAACAATTGGGTGTTCTAAGTATCGGGCTCTTGTCCGATTCCTAGGATGCTATGTTGACGTGCGTCTTTGGCAAGCCCCTTGGGTTTCTAAGGACGTCACGTCGGCGCAACAACAAACCCCCGGCACGGCATGTGCCAAGGAAATATAAACTTAAGAAGGGCTTGTTTCGTGTTTTGCCGTTCGCGGTGATTGCATTGAAACTTGCTTCTTTATAATTCATAAA

Click for details-----ITS2

AACGTCGCCAAAAATCCCCTCACCCCTTCCGACGGGGAACAACGAGGGACGGCGGATATTGGCCTCCCGTGTGCGTATGCTTGCGGTTGGCCCAAAATAAGATTCCCGGCGAGGCAGCCACGACACGCGGTGGTTTGCAGCACATGCTCCTTTAACACCGTCGTGGGCGAGCCTCGTAGACCGGGATCCAAAGACCCCGACGCAAAGCGTCTTCACA

Taxonomic Information

Plant ID: NPO5194
Plant Latin Name: Catha Edulis
Taxonomy Genus: Catha
Taxonomy Family: Celastraceae

Plant External Links:

NCBI TaxonomyDB: 123405
Plant-of-the-World-Online: 941530-1

Used in Medicines

Country/Region:

Madagascar; Angola; South Africa; Tanzania; Zimbabwe; Rwanda; Swaziland; Kenya

Traditional Medicine System:

Geographical Distribution

Eritrea; Madagascar; Angola; Uganda; South Africa; Sudan; Tanzania; Zimbabwe; Zambia; United States; Ethiopia; Rwanda; Mozambique; Somalia; Swaziland; Kenya; Yemen; Malawi

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

49 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

39 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)