Collective Molecular Activities of the Plant: Peritassa Compta
Plant ID: NPO5155
Plant Latin Name: Peritassa Compta
Taxonomy Genus: Peritassa
Taxonomy Family: Celastraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
186 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
36 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
71 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99971
Ingredient ID: NPC95347
Ingredient ID: NPC88278
Ingredient ID: NPC88126
Ingredient ID: NPC87172
Ingredient ID: NPC869
Ingredient ID: NPC83975
Ingredient ID: NPC79482
Ingredient ID: NPC79223
Ingredient ID: NPC78540
Ingredient ID: NPC7777
Ingredient ID: NPC75355
Ingredient ID: NPC71852
Ingredient ID: NPC68889
Ingredient ID: NPC66655
Ingredient ID: NPC66356
Ingredient ID: NPC66001
Ingredient ID: NPC65003
Ingredient ID: NPC64548
Ingredient ID: NPC63159
Ingredient ID: NPC61201
Ingredient ID: NPC59804
Ingredient ID: NPC59033
Ingredient ID: NPC58068
Ingredient ID: NPC57853
Ingredient ID: NPC5685
Ingredient ID: NPC54045
Ingredient ID: NPC52908
Ingredient ID: NPC5208
Ingredient ID: NPC50997
Ingredient ID: NPC49074
Ingredient ID: NPC4856
Ingredient ID: NPC45338
Ingredient ID: NPC44840
Ingredient ID: NPC4452
Ingredient ID: NPC43462
Ingredient ID: NPC41681
Ingredient ID: NPC37250
Ingredient ID: NPC37111
Ingredient ID: NPC36130
Ingredient ID: NPC35185
Ingredient ID: NPC34355
Ingredient ID: NPC32451
Ingredient ID: NPC312137
Ingredient ID: NPC312132
Ingredient ID: NPC311423
Ingredient ID: NPC311082
Ingredient ID: NPC31027
Ingredient ID: NPC30973
Ingredient ID: NPC308002
Ingredient ID: NPC307699
Ingredient ID: NPC306443
Ingredient ID: NPC305162
Ingredient ID: NPC303044
Ingredient ID: NPC302989
Ingredient ID: NPC302857
Ingredient ID: NPC300498
Ingredient ID: NPC300412
Ingredient ID: NPC295371
Ingredient ID: NPC294902
Ingredient ID: NPC294185
Ingredient ID: NPC29314
Ingredient ID: NPC289415
Ingredient ID: NPC287539
Ingredient ID: NPC287144
Ingredient ID: NPC285620
Ingredient ID: NPC283178
Ingredient ID: NPC282243
Ingredient ID: NPC28198
Ingredient ID: NPC281131
Ingredient ID: NPC279121
Ingredient ID: NPC276121
Ingredient ID: NPC274885
Ingredient ID: NPC27184
Ingredient ID: NPC271218
Ingredient ID: NPC270768
Ingredient ID: NPC267296
Ingredient ID: NPC26474
Ingredient ID: NPC261022
Ingredient ID: NPC259147
Ingredient ID: NPC258978
Ingredient ID: NPC255042
Ingredient ID: NPC254861
Ingredient ID: NPC25442
Ingredient ID: NPC243728
Ingredient ID: NPC243299
Ingredient ID: NPC241784
Ingredient ID: NPC240971
Ingredient ID: NPC236579
Ingredient ID: NPC236219
Ingredient ID: NPC234030
Ingredient ID: NPC233646
Ingredient ID: NPC232954
Ingredient ID: NPC232574
Ingredient ID: NPC231710
Ingredient ID: NPC230035
Ingredient ID: NPC228329
Ingredient ID: NPC225879
Ingredient ID: NPC224389
Ingredient ID: NPC222959
Ingredient ID: NPC220011
Ingredient ID: NPC21932
Ingredient ID: NPC219313
Ingredient ID: NPC21855
Ingredient ID: NPC218445
Ingredient ID: NPC218426
Ingredient ID: NPC218284
Ingredient ID: NPC217465
Ingredient ID: NPC213908
Ingredient ID: NPC211669
Ingredient ID: NPC210685
Ingredient ID: NPC208470
Ingredient ID: NPC206095
Ingredient ID: NPC20593
Ingredient ID: NPC199819
Ingredient ID: NPC199
Ingredient ID: NPC198827
Ingredient ID: NPC197633
Ingredient ID: NPC197259
Ingredient ID: NPC195863
Ingredient ID: NPC195368
Ingredient ID: NPC193734
Ingredient ID: NPC189142
Ingredient ID: NPC187805
Ingredient ID: NPC185290
Ingredient ID: NPC183950
Ingredient ID: NPC183491
Ingredient ID: NPC183
Ingredient ID: NPC182814
Ingredient ID: NPC179950
Ingredient ID: NPC179695
Ingredient ID: NPC1786
Ingredient ID: NPC178306
Ingredient ID: NPC17810
Ingredient ID: NPC177013
Ingredient ID: NPC176740
Ingredient ID: NPC17567
Ingredient ID: NPC17514
Ingredient ID: NPC174679
Ingredient ID: NPC1713
Ingredient ID: NPC170035
Ingredient ID: NPC169906
Ingredient ID: NPC169038
Ingredient ID: NPC16797
Ingredient ID: NPC165
Ingredient ID: NPC162840
Ingredient ID: NPC160127
Ingredient ID: NPC15942
Ingredient ID: NPC157378
Ingredient ID: NPC156654
Ingredient ID: NPC156461
Ingredient ID: NPC156044
Ingredient ID: NPC145693
Ingredient ID: NPC145356
Ingredient ID: NPC145252
Ingredient ID: NPC143394
Ingredient ID: NPC138453
Ingredient ID: NPC137987
Ingredient ID: NPC137894
Ingredient ID: NPC130593
Ingredient ID: NPC130308
Ingredient ID: NPC12944
Ingredient ID: NPC129088
Ingredient ID: NPC127647
Ingredient ID: NPC127056
Ingredient ID: NPC125036
Ingredient ID: NPC123754
Ingredient ID: NPC121151
Ingredient ID: NPC11978
Ingredient ID: NPC118343
Ingredient ID: NPC115802
Ingredient ID: NPC115674
Ingredient ID: NPC114361
Ingredient ID: NPC112954
Ingredient ID: NPC111732
Ingredient ID: NPC111032
Ingredient ID: NPC108526
Ingredient ID: NPC108218
Ingredient ID: NPC107702
Ingredient ID: NPC107149
Ingredient ID: NPC106477
Ingredient ID: NPC103225
Ingredient ID: NPC103213
Ingredient ID: NPC102981
Ingredient ID: NPC10147
Ingredient ID: NPC100521
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 57 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
| NCT00061997 | Inositol in Preventing Lung Cancer in Patients With Bronchial Epithelial Dysplasia Who Are Current or Former Smokers | lung cancer | Inositol (NPC88278) | NP level |
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT00275418 | Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease | Crohn's disease | Beta Carotene (NPC17810) | NP level |
| NCT00284323 | Salvage: Postconditioning With Adenosine for STEMI | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT00298636 | Dose-Response of Adenosine for Perioperative Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00349921 | Clonidine Versus Adenosine to Treat Neuropathic Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00452829 | Prevention of Neural Tube Defects by Inositol in Conjunction With Folic Acid (PONTI Study) | neural tube defect | Inositol (NPC88278) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
KDM1A,NFKB1,GSK3B,FLT3
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
NCT04588441 |
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,AKR1B10,MMP9,MMP12,SLCO1B1,ACHE,XDH,TSHR,MMP1,SLCO1B3,CA7,CBR1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
DPP4,AKR1B10,CA14,APP,ADORA2A,CA2,ACHE,XDH,MMP2,MMP1,SLCO1B3,CYP1B1,CA7,CYP2C19,ADORA3,HIF1A,CBR1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B3,NOX4,SLCO1B1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
