Collective Molecular Activities of the Plant: Phaseolus Vulgaris
Country/Region:
Brazil; Turkey; Madagascar; Italy; South Africa; Lebanon; Indonesia; India; Mexico; Zimbabwe; Jordan; Swaziland; Angola; China; Russia; SpainTraditional Medicine System:
Unani; Indian Folk; TCM; Homeopathy; SiddhaMedicinal Functions:
Cancer; Diuretic; Homeopathy; Hypoglycaemic; Hypotensive; Miscellany; Narcotic
Brazil; Turkey; Madagascar; Italy; Bangladesh; Guinea; Nepal; Costa Rica; Mongolia; Ethiopia; Rwanda; Peru; Swaziland; Argentina; Bolivia; Cameroon; Nigeria; Ecuador; Turkmenistan; Belarus; Cuba; Venezuela; Zambia; Russia; Togo; Zimbabwe; China; Lebanon; Jordan; Haiti; Iraq; Kazakhstan; Tanzania; Spain; Ukraine; Uganda; Pakistan; Philippines; Indonesia; United States; Trinidad and Tobago; Australia; Thailand; Honduras; Dominican Republic; Jamaica; Angola; Myanmar; Chad; Mexico; Tajikistan; South Africa; India; Uzbekistan; Senegal; Vietnam; Colombia; Sri Lanka; Kenya; Nicaragua
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
177 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
102 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
115 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99717
Ingredient ID: NPC99088
Ingredient ID: NPC98028
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC87641
Ingredient ID: NPC86655
Ingredient ID: NPC85896
Ingredient ID: NPC85813
Ingredient ID: NPC83538
Ingredient ID: NPC81010
Ingredient ID: NPC78312
Ingredient ID: NPC73694
Ingredient ID: NPC64679
Ingredient ID: NPC64250
Ingredient ID: NPC62765
Ingredient ID: NPC62045
Ingredient ID: NPC60151
Ingredient ID: NPC59650
Ingredient ID: NPC58190
Ingredient ID: NPC55412
Ingredient ID: NPC5447
Ingredient ID: NPC5413
Ingredient ID: NPC52238
Ingredient ID: NPC49871
Ingredient ID: NPC491218
Ingredient ID: NPC490469
Ingredient ID: NPC490427
Ingredient ID: NPC490424
Ingredient ID: NPC490401
Ingredient ID: NPC490375
Ingredient ID: NPC490368
Ingredient ID: NPC490332
Ingredient ID: NPC489939
Ingredient ID: NPC489928
Ingredient ID: NPC489910
Ingredient ID: NPC489909
Ingredient ID: NPC489908
Ingredient ID: NPC489907
Ingredient ID: NPC489904
Ingredient ID: NPC489901
Ingredient ID: NPC489899
Ingredient ID: NPC489875
Ingredient ID: NPC48623
Ingredient ID: NPC48342
Ingredient ID: NPC46274
Ingredient ID: NPC424
Ingredient ID: NPC39620
Ingredient ID: NPC39426
Ingredient ID: NPC37793
Ingredient ID: NPC328788
Ingredient ID: NPC328478
Ingredient ID: NPC328447
Ingredient ID: NPC324750
Ingredient ID: NPC322254
Ingredient ID: NPC321850
Ingredient ID: NPC319667
Ingredient ID: NPC317120
Ingredient ID: NPC316926
Ingredient ID: NPC313955
Ingredient ID: NPC311987
Ingredient ID: NPC310601
Ingredient ID: NPC309330
Ingredient ID: NPC302857
Ingredient ID: NPC300933
Ingredient ID: NPC300326
Ingredient ID: NPC300059
Ingredient ID: NPC299704
Ingredient ID: NPC295644
Ingredient ID: NPC294902
Ingredient ID: NPC294548
Ingredient ID: NPC293628
Ingredient ID: NPC293203
Ingredient ID: NPC291650
Ingredient ID: NPC291473
Ingredient ID: NPC290319
Ingredient ID: NPC281686
Ingredient ID: NPC280717
Ingredient ID: NPC279865
Ingredient ID: NPC279661
Ingredient ID: NPC279121
Ingredient ID: NPC279026
Ingredient ID: NPC27836
Ingredient ID: NPC27797
Ingredient ID: NPC277867
Ingredient ID: NPC27641
Ingredient ID: NPC272614
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC2660
Ingredient ID: NPC265885
Ingredient ID: NPC265305
Ingredient ID: NPC264395
Ingredient ID: NPC263727
Ingredient ID: NPC261831
Ingredient ID: NPC260837
Ingredient ID: NPC251791
Ingredient ID: NPC246558
Ingredient ID: NPC245346
Ingredient ID: NPC242580
Ingredient ID: NPC237812
Ingredient ID: NPC236202
Ingredient ID: NPC235260
Ingredient ID: NPC234560
Ingredient ID: NPC232080
Ingredient ID: NPC229942
Ingredient ID: NPC226453
Ingredient ID: NPC226027
Ingredient ID: NPC225710
Ingredient ID: NPC225696
Ingredient ID: NPC220825
Ingredient ID: NPC220765
Ingredient ID: NPC219876
Ingredient ID: NPC219539
Ingredient ID: NPC219143
Ingredient ID: NPC213876
Ingredient ID: NPC208793
Ingredient ID: NPC20791
Ingredient ID: NPC203468
Ingredient ID: NPC201844
Ingredient ID: NPC201284
Ingredient ID: NPC199072
Ingredient ID: NPC197087
Ingredient ID: NPC196776
Ingredient ID: NPC196749
Ingredient ID: NPC193989
Ingredient ID: NPC192248
Ingredient ID: NPC190501
Ingredient ID: NPC190454
Ingredient ID: NPC189436
Ingredient ID: NPC188428
Ingredient ID: NPC187770
Ingredient ID: NPC185755
Ingredient ID: NPC181574
Ingredient ID: NPC180905
Ingredient ID: NPC17810
Ingredient ID: NPC176740
Ingredient ID: NPC174246
Ingredient ID: NPC173637
Ingredient ID: NPC173365
Ingredient ID: NPC169749
Ingredient ID: NPC168579
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC164614
Ingredient ID: NPC161700
Ingredient ID: NPC161593
Ingredient ID: NPC156980
Ingredient ID: NPC156654
Ingredient ID: NPC155263
Ingredient ID: NPC154186
Ingredient ID: NPC154139
Ingredient ID: NPC152451
Ingredient ID: NPC150950
Ingredient ID: NPC149803
Ingredient ID: NPC147983
Ingredient ID: NPC146422
Ingredient ID: NPC137958
Ingredient ID: NPC137167
Ingredient ID: NPC136014
Ingredient ID: NPC135539
Ingredient ID: NPC133671
Ingredient ID: NPC133183
Ingredient ID: NPC130683
Ingredient ID: NPC127624
Ingredient ID: NPC126681
Ingredient ID: NPC125062
Ingredient ID: NPC118429
Ingredient ID: NPC116775
Ingredient ID: NPC11433
Ingredient ID: NPC112890
Ingredient ID: NPC111888
Ingredient ID: NPC110899
Ingredient ID: NPC110557
Ingredient ID: NPC108831
Ingredient ID: NPC108811
Ingredient ID: NPC100971
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A2 | Norepinephrine transporter | P23975 | CHEMBL222 |
| Therapeutic Target | 5HT3 receptor | HTR3A | Serotonin 3a (5-HT3a) receptor | P46098 | CHEMBL1899 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 976 | |
 Plant level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Folic Acid (NPC147983);Pyridoxine (NPC269919);Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
AR,ESR1,MMP2
NCT03522922,NCT03090048 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR,MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARA,FFAR1,AURKB,HTR2A,DPP4,KDR,AKR1B1,HTR2C
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,TOP2A,TP53,AR,GSK3B,FLT3,AURKB,PIM1,SRC,AXL,NFKB1
NCT01842139,NCT00329498,NCT00184054 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888,NCT00781404
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
