Collective Molecular Activities of the Plant: Scrophularia Ningpoensis
Plant ID: NPO4802
Plant Latin Name: Scrophularia Ningpoensis
Taxonomy Genus: Scrophularia
Taxonomy Family: Scrophulariaceae
Plant External Links:
NCBI TaxonomyDB:
291326
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Antibacterial; Antifungal; Antiphlogistic; Antipyretic; Cardiac; Diuretic; Febrifuge; Haemolytic; Hypoglycaemic; Restorative; Sialagogue; Tonic; Vasodilator
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
96 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
55 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
32 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC92647
Ingredient ID: NPC89900
Ingredient ID: NPC89121
Ingredient ID: NPC8364
Ingredient ID: NPC82026
Ingredient ID: NPC81010
Ingredient ID: NPC77156
Ingredient ID: NPC74361
Ingredient ID: NPC71853
Ingredient ID: NPC70744
Ingredient ID: NPC70741
Ingredient ID: NPC62765
Ingredient ID: NPC62469
Ingredient ID: NPC60583
Ingredient ID: NPC47481
Ingredient ID: NPC46540
Ingredient ID: NPC424
Ingredient ID: NPC41476
Ingredient ID: NPC36061
Ingredient ID: NPC34927
Ingredient ID: NPC34908
Ingredient ID: NPC34587
Ingredient ID: NPC32977
Ingredient ID: NPC329148
Ingredient ID: NPC322423
Ingredient ID: NPC310905
Ingredient ID: NPC305449
Ingredient ID: NPC304152
Ingredient ID: NPC294548
Ingredient ID: NPC291309
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC289758
Ingredient ID: NPC284538
Ingredient ID: NPC283823
Ingredient ID: NPC278642
Ingredient ID: NPC276047
Ingredient ID: NPC271027
Ingredient ID: NPC267733
Ingredient ID: NPC263804
Ingredient ID: NPC261831
Ingredient ID: NPC258320
Ingredient ID: NPC257124
Ingredient ID: NPC256703
Ingredient ID: NPC2518
Ingredient ID: NPC2517
Ingredient ID: NPC2499
Ingredient ID: NPC245106
Ingredient ID: NPC244601
Ingredient ID: NPC236788
Ingredient ID: NPC233858
Ingredient ID: NPC230301
Ingredient ID: NPC223695
Ingredient ID: NPC223002
Ingredient ID: NPC219449
Ingredient ID: NPC214153
Ingredient ID: NPC211445
Ingredient ID: NPC208057
Ingredient ID: NPC207306
Ingredient ID: NPC206800
Ingredient ID: NPC203719
Ingredient ID: NPC200812
Ingredient ID: NPC200053
Ingredient ID: NPC199561
Ingredient ID: NPC197316
Ingredient ID: NPC194953
Ingredient ID: NPC183600
Ingredient ID: NPC180058
Ingredient ID: NPC179694
Ingredient ID: NPC176029
Ingredient ID: NPC171484
Ingredient ID: NPC171280
Ingredient ID: NPC171158
Ingredient ID: NPC169577
Ingredient ID: NPC166956
Ingredient ID: NPC162762
Ingredient ID: NPC156461
Ingredient ID: NPC153370
Ingredient ID: NPC151898
Ingredient ID: NPC1507
Ingredient ID: NPC149018
Ingredient ID: NPC142753
Ingredient ID: NPC139029
Ingredient ID: NPC136699
Ingredient ID: NPC127513
Ingredient ID: NPC12690
Ingredient ID: NPC124746
Ingredient ID: NPC120914
Ingredient ID: NPC12025
Ingredient ID: NPC115160
Ingredient ID: NPC113219
Ingredient ID: NPC110899
Ingredient ID: NPC107482
Ingredient ID: NPC10251
Ingredient ID: NPC10209
Ingredient ID: NPC101466
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Therapeutic Target | Oxidoreductase | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA1 | Adenosine A1 receptor | P30542 | CHEMBL226 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA2A | Adenosine A2a receptor | P29274 | CHEMBL251 |
| Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 105 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00062972 | Improving Memory in Patients With Multiple Sclerosis | multiple sclerosis | Glucose, Liquid (NPC289758) | NP level |
| NCT00091507 | IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium. | congestive heart failure;intermediate coronary syndrome;myocardial infarction | Glucose, Liquid (NPC289758) | NP level |
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT00213759 | Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSF | neutropenia | Glucose, Liquid (NPC289758) | NP level |
| NCT00284323 | Salvage: Postconditioning With Adenosine for STEMI | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT00298636 | Dose-Response of Adenosine for Perioperative Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00337597 | Continuous Regional Analgesia After Total Knee Arthroplasty | pain | Glucose, Liquid (NPC289758) | NP level |
| NCT00349921 | Clonidine Versus Adenosine to Treat Neuropathic Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00552786 | Antioxidation Medication for Noise-induced Hearing Loss | hearing loss | Glucose, Liquid (NPC289758) | NP level |
| NCT00565188 | Application of ATP Infusions in Palliative Home Care | cancer | Adenosine (NPC156461) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARA,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,NR1I2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADORA2A,CA2,F2,NR1I2,NAPRT,ALOX15,ADORA3,SNCA
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15,FABP5
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,ALOX15
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
