Collective Molecular Activities of the Plant: Lagerstroemia Indica
Country/Region:
Indonesia; India; Vietnam; China; Laos; ThailandTraditional Medicine System:
Indian Folk; TCM; Ayurveda; SiddhaMedicinal Functions:
Astringent; Depurative; Diuretic; Febrifuge; Hydrogogue; Purgative; Stimulant; Styptic
Jamaica; Bangladesh; Myanmar; Cuba; Indonesia; India; Cambodia; South Africa; United States; Trinidad and Tobago; Vietnam; China; Laos; Thailand; Dominican Republic; Venezuela; Haiti
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
128 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
46 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
34 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99016
Ingredient ID: NPC9830
Ingredient ID: NPC98257
Ingredient ID: NPC97824
Ingredient ID: NPC86688
Ingredient ID: NPC8526
Ingredient ID: NPC84956
Ingredient ID: NPC82839
Ingredient ID: NPC82505
Ingredient ID: NPC81792
Ingredient ID: NPC80710
Ingredient ID: NPC77349
Ingredient ID: NPC75322
Ingredient ID: NPC7479
Ingredient ID: NPC72194
Ingredient ID: NPC72093
Ingredient ID: NPC71458
Ingredient ID: NPC66569
Ingredient ID: NPC6298
Ingredient ID: NPC61139
Ingredient ID: NPC56867
Ingredient ID: NPC54538
Ingredient ID: NPC53545
Ingredient ID: NPC52956
Ingredient ID: NPC52876
Ingredient ID: NPC51770
Ingredient ID: NPC51044
Ingredient ID: NPC46801
Ingredient ID: NPC46190
Ingredient ID: NPC45782
Ingredient ID: NPC45677
Ingredient ID: NPC4538
Ingredient ID: NPC44321
Ingredient ID: NPC43094
Ingredient ID: NPC4268
Ingredient ID: NPC39591
Ingredient ID: NPC37852
Ingredient ID: NPC37691
Ingredient ID: NPC37578
Ingredient ID: NPC36882
Ingredient ID: NPC33747
Ingredient ID: NPC33631
Ingredient ID: NPC32441
Ingredient ID: NPC313449
Ingredient ID: NPC313179
Ingredient ID: NPC310098
Ingredient ID: NPC309585
Ingredient ID: NPC305766
Ingredient ID: NPC305227
Ingredient ID: NPC302780
Ingredient ID: NPC294656
Ingredient ID: NPC294409
Ingredient ID: NPC293832
Ingredient ID: NPC292318
Ingredient ID: NPC292279
Ingredient ID: NPC288426
Ingredient ID: NPC287295
Ingredient ID: NPC281255
Ingredient ID: NPC280102
Ingredient ID: NPC264145
Ingredient ID: NPC263031
Ingredient ID: NPC262505
Ingredient ID: NPC25913
Ingredient ID: NPC25692
Ingredient ID: NPC256078
Ingredient ID: NPC255204
Ingredient ID: NPC254942
Ingredient ID: NPC254894
Ingredient ID: NPC254772
Ingredient ID: NPC242419
Ingredient ID: NPC239632
Ingredient ID: NPC239416
Ingredient ID: NPC237804
Ingredient ID: NPC235126
Ingredient ID: NPC234560
Ingredient ID: NPC232080
Ingredient ID: NPC230085
Ingredient ID: NPC22845
Ingredient ID: NPC227260
Ingredient ID: NPC226453
Ingredient ID: NPC225710
Ingredient ID: NPC220125
Ingredient ID: NPC21937
Ingredient ID: NPC217741
Ingredient ID: NPC209846
Ingredient ID: NPC209560
Ingredient ID: NPC204617
Ingredient ID: NPC196638
Ingredient ID: NPC19513
Ingredient ID: NPC194701
Ingredient ID: NPC194293
Ingredient ID: NPC190385
Ingredient ID: NPC186179
Ingredient ID: NPC185137
Ingredient ID: NPC184054
Ingredient ID: NPC18223
Ingredient ID: NPC180145
Ingredient ID: NPC178901
Ingredient ID: NPC17810
Ingredient ID: NPC17230
Ingredient ID: NPC170052
Ingredient ID: NPC16922
Ingredient ID: NPC166225
Ingredient ID: NPC165410
Ingredient ID: NPC16366
Ingredient ID: NPC163209
Ingredient ID: NPC161700
Ingredient ID: NPC15825
Ingredient ID: NPC158069
Ingredient ID: NPC156694
Ingredient ID: NPC151808
Ingredient ID: NPC150950
Ingredient ID: NPC142108
Ingredient ID: NPC141357
Ingredient ID: NPC139075
Ingredient ID: NPC138139
Ingredient ID: NPC132904
Ingredient ID: NPC130530
Ingredient ID: NPC129185
Ingredient ID: NPC121509
Ingredient ID: NPC120464
Ingredient ID: NPC118773
Ingredient ID: NPC116280
Ingredient ID: NPC114289
Ingredient ID: NPC110487
Ingredient ID: NPC109504
Ingredient ID: NPC104396
Ingredient ID: NPC102256
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Serine protease | DPP4 | Dipeptidyl peptidase IV | P27487 | CHEMBL284 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 79 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
| NCT00005107 | Role of Nitric Oxide in Cirrhosis: Relationship With Systemic Hemodynamics, Renal Function, Vasoactive Systems and Endotoxemia | cirrhosis of liver | Arginine (NPC226453) | NP level |
| NCT00006136 | Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia Intermedia | Beta-thalassemia | Arginine (NPC226453) | NP level |
| NCT00006202 | Lutein for Age-Related Macular Degeneration | macular degeneration | Lutein (NPC313179) | NP level |
| NCT00010686 | Dietary Phytoestrogens and Bone Metabolism | osteoporosis | Formononetin (NPC209560);Daidzein (NPC234560) | NP level |
| NCT00029289 | Effects of Lutein in Retinitis Pigmentosa | retinitis pigmentosa | Lutein (NPC313179) | NP level |
| NCT00047983 | Omega-3 Fatty Acids That Affect the Immune System in Kidney Transplant Patients | kidney disease | Arginine (NPC226453) | NP level |
| NCT00056433 | Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia | sickle cell anemia | Arginine (NPC226453) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,BLM,SLCO1B1,CYP2C9,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA7,BLM,LMNA,FUT7,CYP2C9,MAOB,DPP4
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM,CYP19A1,SLCO1B1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
