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Collective Molecular Activities of the Plant: Relhania Pumila


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO4448
Plant Latin Name: Relhania Pumila
Taxonomy Genus: Relhania
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

44 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


13 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

25 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC80302

Ingredient ID: NPC76662

Ingredient ID: NPC75384

Ingredient ID: NPC73219

Ingredient ID: NPC6913

Ingredient ID: NPC50880

Ingredient ID: NPC46335

Ingredient ID: NPC38343

Ingredient ID: NPC33338

Ingredient ID: NPC310342

Ingredient ID: NPC305307

Ingredient ID: NPC302857

Ingredient ID: NPC294558

Ingredient ID: NPC286956

Ingredient ID: NPC282812

Ingredient ID: NPC279406

Ingredient ID: NPC278906

Ingredient ID: NPC277510

Ingredient ID: NPC272552

Ingredient ID: NPC264084

Ingredient ID: NPC261324

Ingredient ID: NPC256849

Ingredient ID: NPC255246

Ingredient ID: NPC236202

Ingredient ID: NPC234222

Ingredient ID: NPC227491

Ingredient ID: NPC226315

Ingredient ID: NPC226108

Ingredient ID: NPC224161

Ingredient ID: NPC223548

Ingredient ID: NPC219876

Ingredient ID: NPC195952

Ingredient ID: NPC185392

Ingredient ID: NPC185231

Ingredient ID: NPC159451

Ingredient ID: NPC157417

Ingredient ID: NPC156654

Ingredient ID: NPC139940

Ingredient ID: NPC136014

Ingredient ID: NPC129800

Ingredient ID: NPC126029

Ingredient ID: NPC119133

Ingredient ID: NPC118284

Ingredient ID: NPC108811

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target Type Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Therapeutic Target Enzyme ALPL Alkaline phosphatase, tissue-nonspecific isozyme P05186 CHEMBL5979
Therapeutic Target Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Therapeutic Target Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Therapeutic Target Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Therapeutic Target Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Therapeutic Target Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Therapeutic Target Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Therapeutic Target Protein Kinase PTK2 Focal adhesion kinase 1 Q05397 CHEMBL2695
Therapeutic Target Protein Kinase ALK ALK tyrosine kinase receptor Q9UM73 CHEMBL4247
Therapeutic Target Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Therapeutic Target Small molecule receptor (family A GPCR) DRD3 Dopamine D3 receptor P35462 CHEMBL234
Therapeutic Target Transcription factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level87
Clinical trial details
NCT ID Title Condition Form in clinical use Associated by plant or compound
NCT01289561 Combined Effects of Alcohol and Caffeine alcohol dependence Caffeine (NPC256849) NP level
NCT01435837 Interaction of Caffeine and Hydration on Voice voice disorders Caffeine (NPC256849) NP level
NCT01755702 Paracetamol With Caffeine to Treat Episodic Tension Type Headache Tension-type headache Caffeine (NPC256849) NP level
NCT02621060 Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance abnormal glucose tolerance Chlorogenic Acid (NPC302857) NP level
NCT02772601 This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis psoriasis Caffeine (NPC256849) NP level
NCT00223691 Treatment of Orthostatic Hypotension in Autonomic Failure orthostatic hypotension Caffeine (NPC256849) NP level
NCT00443170 A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects anemia (phenotype) Caffeine (NPC256849) NP level
NCT01875159 Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm hypoxia Caffeine (NPC256849) NP level
NCT03864042 Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors metastatic melanoma Caffeine (NPC256849) NP level
NCT03236662 (-)- Epicatechin Becker Muscular Dystrophy Becker muscular dystrophy (-)-Epicatechin (NPC126029) NP level
NCT01525628 Drug Drug Interaction Study Between BI 201335 and BI 207127 in Chronic Hepatitis C Infected Patients chronic hepatitis C virus infection Caffeine (NPC256849) NP level
NCT04570085 Effect of CAFfeine on Cognition in Alzheimer's Disease Alzheimer disease Caffeine (NPC256849) NP level
NCT05445232 A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants obesity Caffeine (NPC256849) NP level
NCT01596647 Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors neoplasm Caffeine (NPC256849) NP level
NCT00564824 The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease coronary artery disease Caffeine (NPC256849) NP level
NCT02655614 A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis Caffeine (NPC256849) NP level
NCT00377975 "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat obesity Caffeine (NPC256849) NP level
NCT02647086 Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD) atopic eczema Caffeine (NPC256849) NP level
NCT01080677 Caffeine/Propranolol Intervention for Acute Migraine migraine disorder Caffeine (NPC256849) NP level
NCT00930306 AZD2066 Cocktail Study Chronic pain Caffeine (NPC256849) NP level
NCT02740712 Pharmacokinetic Drug-Drug Interaction Study of Rucaparib neoplasm Caffeine (NPC256849) NP level
NCT00692510 Drug Interaction Study Between AZD3480 and Cytochrome P450 Alzheimer disease Caffeine (NPC256849) NP level
NCT00302289 B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients obesity Caffeine (NPC256849) NP level
NCT03751592 Phase Ib/IIa Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Advanced Lung Cancer lung cancer Chlorogenic Acid (NPC302857) NP level
NCT02862977 Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment pain Caffeine (NPC256849) NP level
NCT00726726 Drug Interaction Study With a Potential Alzheimer's Disease Compound Alzheimer disease Caffeine (NPC256849) NP level
NCT01842633 Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache pain Caffeine (NPC256849) NP level
NCT02594358 Caffeine in Amblyopia Study amblyopia Caffeine (NPC256849) NP level
NCT02225093 A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer prostate cancer Caffeine (NPC256849) NP level
NCT02985671 To Evaluate the Superiority of Fixed Combination (Orfenadrine 35mg, Acetaminophen 325mg, Caffeine 65mg and Diclofenac Sodium 50mg) Compared to Voltaren® (Diclofenac Sodium 50mg) in the Treatment of Acute Postural Low Back Pain. Low back pain Caffeine (NPC256849) NP level
NCT01172405 Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache Headache Caffeine (NPC256849) NP level
NCT02863575 A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine pain Caffeine (NPC256849) NP level
NCT03333824 Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer neoplasm Caffeine (NPC256849) NP level
NCT02245204 Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers cancer Chlorogenic Acid (NPC302857) NP level
NCT04872270 Pain Management After Shoulder Arthroplasty pain Caffeine (NPC256849) NP level
NCT04425902 Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults HIV infection Caffeine (NPC256849) NP level
NCT03358706 A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis Crohn's disease;ulcerative colitis Caffeine (NPC256849) NP level
NCT01686646 Effects of Two Doses of a Common Cold Treatment on Alertness common cold Caffeine (NPC256849) NP level
NCT03187496 Drug-drug Interaction Study Between EDP-305, Midazolam, Caffeine and Rosuvastatin in Healthy Volunteers. non-alcoholic steatohepatitis Caffeine (NPC256849) NP level
NCT04643249 Drug-drug Interaction Study of KL1333 in Healthy Subjects mitochondrial disease Caffeine (NPC256849) NP level
NCT03533556 Effects of L-theanine and Caffeine on Attention and Attention-related Brain Activity of Children With Attention Deficit Hyperactivity Disorder attention deficit hyperactivity disorder Caffeine (NPC256849) NP level
NCT04504045 Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes type 2 diabetes mellitus Caffeine (NPC256849) NP level
NCT03321734 Intermittent Hypoxia and Caffeine in Infants Born Preterm hypoxia Caffeine (NPC256849) NP level
NCT01462370 Study to Assess the Safety and Efficacy of Etoricoxib Versus Ibuprofen in the Treatment of Dysmenorrhea (MK-0663-145 AM1) Dysmenorrhea Caffeine (NPC256849) NP level
NCT03768492 Study of the Safety and Efficacy of a Caffeine-based Antifibrosis Cream in Patients With Breast Cancer Undergoing Radiation Therapy breast carcinoma Caffeine (NPC256849) NP level
NCT04132336 Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed pain Caffeine (NPC256849) NP level
NCT02311088 Trial of Caffeine to Alleviate Dyspnea Related to Ticagrelor Dyspnea Caffeine (NPC256849) NP level
NCT01517399 Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects neoplasm Caffeine (NPC256849) NP level
NCT00495092 Efficacy of Caffeine, With and Without Biperiden, in the Detoxification of Cocaine Dependent Patients cocaine dependence Caffeine (NPC256849) NP level
NCT02397382 Pharmacokinetic Study to Evaluate the Effect of a Single Dose of Guselkumab (CNTO 1959) on CYP 450 Enzyme Activities After Subcutaneous Administration in Participants With Psoriasis psoriasis Caffeine (NPC256849) NP level
NCT01999829 Prevention of Atrial Fibrillation Following Valvular Replacement With Cardiopulmonary Bypass: a Prospective, Randomized Clinical Study Comparing Oral Caffeine With Placebo atrial fibrillation Caffeine (NPC256849) NP level
NCT01880866 (-)-Epicatechin and Pulmonary Arterial Hypertension pulmonary arterial hypertension (-)-Epicatechin (NPC126029) NP level
NCT00437632 Study To Investigate If Repeat Doses Of GSK598809 Are Safe And Well Tolerated And To Evaluate Blood Levels Of GSK598809 substance dependence Caffeine (NPC256849) NP level
NCT04246762 Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4 rheumatoid arthritis Caffeine (NPC256849) NP level
NCT01190735 Caffeine for Motor Manifestations of Parkinson's Disease Parkinson disease Caffeine (NPC256849) NP level
NCT03131973 Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin rheumatoid arthritis Caffeine (NPC256849) NP level
NCT02582996 Cefalium® Compared to Tylenol® in the Treatment of Migraine Attacks migraine disorder Caffeine (NPC256849) NP level
NCT01462318 An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing Remitting Multiple Sclerosis relapsing-remitting multiple sclerosis Caffeine (NPC256849) NP level
NCT02323698 Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury Spinal cord injury Caffeine (NPC256849) NP level
NCT00471952 Maxalt 10mg Plus Caffeine 75mg in the Acute Treatment of Migraine Headache migraine with aura;migraine without aura Caffeine (NPC256849) NP level
NCT03970798 A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin Parkinson disease Caffeine (NPC256849) NP level
NCT00432887 Experimental Studies of the Effects of Caffeine on Glucose Regulation type 2 diabetes mellitus Caffeine (NPC256849) NP level
NCT02183688 Acetylsalicylic Acid (ASA) + Paracetamol + Caffeine Combination Compared With ASA + Paracetamol as Well as ASA, Paracetamol, and Caffeine in Headache Patients migraine disorder Caffeine (NPC256849) NP level
NCT05170464 The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine Deprivation memory impairment Caffeine (NPC256849) NP level
NCT05485805 A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo toothache Caffeine (NPC256849) NP level
NCT01248468 Efficacy and Safety of Acetaminophen, Aspirin and Caffeine With Sumatriptan in the Acute Treatment of Migraine migraine disorder Caffeine (NPC256849) NP level
NCT03003000 Ibuprofen/Caffeine Lower Back or Neck Pain Study Back pain;Neck pain Caffeine (NPC256849) NP level
NCT03758014 Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients glioblastoma multiforme Chlorogenic Acid (NPC302857) NP level
NCT02832336 The Effect of Caffeine on the Narcoleptic Patients narcolepsy Caffeine (NPC256849) NP level
NCT01738178 Caffeine as a Therapy for Parkinson's Disease Parkinson disease Caffeine (NPC256849) NP level
NCT03556592 Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4 atopic eczema Caffeine (NPC256849) NP level
NCT00733993 Caffeine and Cocaine cocaine dependence Caffeine (NPC256849) NP level
NCT00388128 Caffeine and Intermittent Claudication intermittent vascular claudication Caffeine (NPC256849) NP level
NCT02728349 Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma glioblastoma multiforme Chlorogenic Acid (NPC302857) NP level
NCT00513110 A Possible Therapeutic Role for Adenosine During Inflammation serum lipopolysaccharide activity Caffeine (NPC256849) NP level
NCT01629329 Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine migraine disorder Caffeine (NPC256849) NP level
NCT01636557 A Study to Evaluate the Effect of a Single Dose of CNTO 136 (Sirukumab) on CYP450 Enzyme Activities After Subcutaneous Administration in Patients With Rheumatoid Arthritis rheumatoid arthritis Caffeine (NPC256849) NP level
NCT00459420 Caffeine for Excessive Daytime Somnolence in Parkinson's Disease Parkinson disease Caffeine (NPC256849) NP level
NCT01275170 A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005) infectious disease Caffeine (NPC256849) NP level
NCT01416480 Clinical Trial to Evaluate the Safety and Efficacy of "Theobromine Capsule" as an Antitussive in Acute Cougher bronchial disease Theobromine (NPC119133) NP level
NCT03022838 The Effects of Caffeine Withdrawal on Migraine migraine disorder Caffeine (NPC256849) NP level
NCT01426971 Ibuprofen Versus Ibuprofen Plus Caffeine in the Treatment of Migraine. pain Caffeine (NPC256849) NP level
NCT01856868 Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) Becker muscular dystrophy (-)-Epicatechin (NPC126029) NP level
NCT02048215 Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in Obesity obesity Caffeine (NPC256849) NP level
NCT02520752 A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors neoplasm Caffeine (NPC256849) NP level
NCT02974114 Exploratory Study to Investigate Cognition Function and Mobility in Individuals With Pain pain Caffeine (NPC256849) NP level
NCT02136342 Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer cancer Chlorogenic Acid (NPC302857) NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Pain, unspecified
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG3Z
 AKR1B1,IGF1R
 NCT04872270,NCT01426971,NCT02863575,NCT02974114,NCT02862977,NCT04132336,NCT01842633
Parkinsonism
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A00
 SNCA,SRC,DRD3
 NCT00459420,NCT03970798,NCT01738178,NCT01190735
Breast cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C60-2C6Y
 CA2,KDR,ALK,IGF1R,AXL,SRC,CA14
Diffuse large B-cell lymphomas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 SRC,AKR1B1,HSD17B10,AXL,ALK,KDR,PTK2
Alzheimer disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A20
 KDR,SNCA,DRD3
 NCT04570085,NCT00726726,NCT00692510
Rheumatoid arthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA20
 NFKB1,CA2,AKR1B1
 NCT01636557,NCT04246762,NCT03131973
Migraine disorder(TM1)
Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module I
Disease ICD-11 Code: SD10
 NCT01629329,NCT02582996,NCT02183688,NCT01080677,NCT01248468,NCT03022838
Carcinosarcoma of uterus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.43
 CA14,AKR1B1,HSD17B10,CA2,ALK,ALPL
Lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 KDR,IGF1R,ALK,AXL
 NCT03751592
Multiple myeloma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A83
 DRD3,AXL,KDR,SRC,IGF1R
Neoplasms
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 02
 NCT03333824,NCT01596647,NCT02740712,NCT02520752,NCT01517399
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 CA14,AXL,CA2,ALK,SNCA
Mesothelioma of pleura
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C26.0
 SRC,AXL,ALK,KDR,SNCA
Germ cell tumour of testis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80.2
 CA14,AKR1B1,MAPK1,KDR,SNCA
Pancreatic cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10
 SRC,PTK2,MAPK1,IGF1R
Obesity
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B80-5B81
 NCT00302289,NCT05445232,NCT00377975,NCT02048215
Pheochromocytoma
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH3854
 CA14,CA2,ALK,SNCA
Hepatoblastoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.01
 SRC,AKR1B1,IGF1R,ALK
Acute myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A60
 SRC,NFKB1,AXL
Psoriasis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA90
 NFKB1
 NCT02397382,NCT02772601
Ovarian cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73
 PTK2,SRC,KDR
Peritoneal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C51
 KDR,PTK2,SRC
Colorectal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B91
 ALK,KDR,IGF1R
Brain cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00
 DRD3,KDR,SRC
Type 2 diabetes mellitus
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A11
 NFKB1
 NCT04504045,NCT00432887
Atopic eczema
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA80
 NFKB1
 NCT03556592,NCT02647086
Serous cystadenoma,borderline malignancy of ovary
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73.4
 CA2,ALK,ALPL
Malignant neoplasms of biliary tract, distal bile duct
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C15
 IGF1R,SRC,AKR1B1
Superficial ovarian endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10.B4
 SNCA,CA2,SRC
Malignant neoplasms of corpus uteri, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.Z
 CA2,ALK,ALPL
Malignant neoplasms of thymus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C27
 NFKB1,AKR1B1,HSD17B10
Mature B-cell leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A82
 AXL,SRC
Motor neuron disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B60
 SRC,IGF1R
Stomach cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72
 DRD3,KDR
Schizophrenia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A20
 DRD3,AKR1B1
Non-small cell lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 ALK,KDR
Gastrointestinal stromal tumour
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B5B
 KDR,SRC
Mature T-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A90
 ALK,DRD3
BCR-ABL1-negative chronic myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A41
 SRC,DRD3
Pulmonary hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BB01
 PTK2
 NCT01880866
Liver cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12
 KDR,IGF1R
Cardiovascular disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA00-BE2Z
 SRC,KDR
Attention deficit hyperactivity disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A05
 DRD3
 NCT03533556
Multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40
 SRC,NFKB1
Pleomorphic sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B54
 KDR,SRC
Acute diabete complication
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A2Y
 AKR1B1,KDR
Chronic pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG30
 KDR
 NCT00930306
Malignant digestive organ neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C11
 SRC,KDR
Endometrial cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76
 SRC,DRD3
Myelodysplastic syndrome
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A37
 KDR,AXL
Melanoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 MAPK1,KDR
Bacterial infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-1C4Z
 CA14,CA2
Glaucoma
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9C61
 CA2,AKR1B1
Tension-type headache
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A81
 NCT01172405,NCT01755702
Becker muscular dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C70.0
 NCT01856868,NCT03236662
Unspecified malignant neoplasms of unspecified sites
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D4Z
 NCT02245204,NCT02136342
Asphyxia
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MD11.1
 NCT03321734,NCT01875159
Glioblastoma, primary, NOS
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH0MB1
 NCT02728349,NCT03758014
Cocaine use disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C45
 NCT00733993,NCT00495092
Crohn disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD70
 ALPL
 NCT03358706
Leishmaniasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F54
 ALPL,AKR1B1
Other specified malignant neoplasms of kidney, except renal pelvis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90.Y
 ALK,ALK
West Nile virus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D46
 NFKB1,AXL
Urothelial carcinoma of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.2
 CA2,AKR1B1
Cytomegaloviral disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D82
 CA14,CA2
Malignant neoplasms of thyroid gland, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10.Z
 ALK,ALPL
Human immunodeficiency virus disease without mention of tuberculosis or malaria
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C62
 PTK2,AXL
Glioblastoma of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.00
 KDR,CA2
Solid tumour/cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00-2F9Z
 PTK2,AXL,DRD3,NFKB1,CA2,ALK,SRC,KDR,CA14,MAPK1,IGF1R
Acute/subacute hepatic failure
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB91
 NFKB1
Leiomyosarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B58
 SRC
Diffuse large B-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 ALK
Acute upper respiratory infection
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA07
 DRD3
Postoperative inflammation
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-CA43
 SRC
Psychoactive substances use disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C4G
 DRD3
Cataract
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B10
 AKR1B1
Genetic prion disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8E02
 ALPL
Skin and skin-structure infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F28-1G0Z
 NFKB1
Indeterminate colitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD72
 NFKB1
Lupus erythematosus
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A40
 NFKB1
Irritable bowel syndrome
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD91
 NFKB1
Autonomic nervous system disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8D87
 SNCA
Digestive organ benign neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E92
 KDR
Renal cell carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90
 KDR
Synovial sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B5A
 SRC
Multiple structural anomalies syndrome
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD2F
 IGF1R
Retinopathy
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B71
 IGF1R
Essential hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA00
 CA2
Diabetes mellitus, type unspecified
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A14
 NFKB1
Head and neck cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D42
 KDR
Sexual dysfunction
Disease Category: 17.Conditions related to sexual health
Disease ICD-11 Code: HA00-HA01
 DRD3
Metastatic digestive system neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D8Y
 SRC
Depression
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A70-6A7Z
 DRD3
Bipolar disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A60
 DRD3
Seborrhoeic dermatitis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA81
 CA2
Low bone mass disorder
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FB83
 CA2
Nasopharyngeal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6B
 DRD3
Myeloproliferative neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A20
 SRC
Thyroid cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10
 KDR
Parasitic infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D0Y-1G2Z
 ALPL
Arteries/arterioles disorder
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD52
 MAPK1
Adrenal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 ALK
Malignant haematopoietic neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B33
 SRC
Inborn metabolism deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C50-5C59
 CA14
Fallopian tube cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C74
 SRC
Thrombosis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB61-GB90
 AKR1B1
Thrombocytopenia
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3B64
 KDR
Chronic kidney disease
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB61
 IGF1R
Metastatic lymph node neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60
 KDR
Metastatic tumour
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D50-2E2Z
 PTK2
Thyrotoxicosis
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A02
 IGF1R
Pituitary gland disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A60-5A61
 IGF1R
Colon cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90
 ALPL
Gastroduodenal motor/secretory disorder
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA41
 DRD3
Heart failure
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD10-BD1Z
 CA2
Metastatic malignant neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D50-2E09
 AXL
Muscular dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C70
 NFKB1
Ischemia
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B10-8B11
 SRC
Osteosarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B51
 SRC
Insomnia
Disease Category: 07.Sleep-wake disorders
Disease ICD-11 Code: 7A00-7A0Z
 CA2
Neuropathy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C0Z
 AKR1B1
Choreiform disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A01
 NFKB1
Epidermal dysplasias
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EK90
 SRC
Extraocular muscle disorder
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9C82
 IGF1R
Cervical cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C77
 SRC
Fungal infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F29-1F2F
 NFKB1
Duodenal ulcer
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA63
 CA2
Impaired glucose tolerance
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A40.1
 NCT02621060
Alcohol dependence
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C40.2
 NCT01289561
Atrial fibrillation
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC81.3
 NCT01999829
Impairment of binocular functions
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9D46
 NCT02594358
Migraine without aura
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A80.0
 NCT00471952
NA
Disease Category: NA
Disease ICD-11 Code: NA
 NCT00388128
Dysmenorrhoea
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA34.3
 NCT01462370
Relapsing-remitting multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40.0
 NCT01462318
Bacterial infection of unspecified site
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C41
 NCT00513110
Malignant neoplasm metastasis, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E2Z
 NCT03864042
Common cold disorder(TM1)
Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module I
Disease ICD-11 Code: SA60
 NCT01686646
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C62.Z
 NCT04425902
Age-associated cognitive decline
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MB21.0
 NCT05170464
Breast in situ carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E65
 NCT03768492
Prostate cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82
 NCT02225093
Low back pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: ME84.2
 NCT02985671
Substance abuse
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C40
 NCT00437632
Amyotrophic lateral sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B60.0
 NCT02655614
Voice disturbances, unspecified
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MA82.Z
 NCT01435837
coronary artery disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA8Y-BA8Z
 NCT00564824
Ulcerative colitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD71
 NCT03358706
Cervical spine pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: ME84.0
 NCT03003000
Orthostatic hypotension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA21
 NCT00223691
Spinal pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: ME84
 NCT03003000
Non-alcoholic fatty liver disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB92
 NCT03187496
Other specified diseases of the respiratory system
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB40.Y
 NCT01416480
Chronic hepatitis C
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E51.1
 NCT01525628
Migraine with aura
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A80.1
 NCT00471952
Narcolepsy
Disease Category: 07.Sleep-wake disorders
Disease ICD-11 Code: 7A20
 NCT02832336
Infection, unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1H0Z
 NCT01275170
Injury of spinal cord, level unspecified
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: ND51.2
 NCT02323698
Other specified inborn errors of energy metabolism
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C53.Y
 NCT04643249
Dyspnoea
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MD11.5
 NCT02311088
Anemia
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3A00-3A9Z
 NCT00443170
Other specified disorders of teeth and supporting structures
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA0A.Y
 NCT05485805
Myelodysplastic syndromes, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A3Z
 ALK
Inflammatory bowel diseases, unspecified
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD7Z
 ALPL
Zika virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D48
 AXL
Osteoarthritis, unspecified
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA0Z
 ALPL
Dengue fever, unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D2Z
 DRD3
Tetralogy of Fallot
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LA88.2
 CA14
Melanoma of skin
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 IGF1R
Hepatocellular carcinoma of liver
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.02
 SRC
Chikungunya virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D40
 AXL
Renal cell carcinoma, chromophobe type
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH6153
 CA2
Carpal tunnel syndrome
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C10.0
 ALK
Ebola virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D60.01
 AXL
Malignant neoplasms of adrenal gland
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 SNCA
Gliomas of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.0
 ALK

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

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Principle Investigator:
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chenyuzong@sz.tsinghua.edu.cn
Prof. Zeng Xian
zengxian@fudan.edu.cn

Developer & Maintainer:
Ph.D. Student Dongyue Hou
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Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
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