Plant ID: NPO4443
Plant Latin Name: Digitalis Purpurea
Taxonomy Genus: Digitalis
Taxonomy Family: Plantaginaceae
NCBI TaxonomyDB:
4164
Plant-of-the-World-Online:
n.a.
Cardiac; Diuretic; Homeopathy; Stimulant; Tonic
Jordan; India; Indonesia; China
Ingredient ID: NPC98656
Ingredient ID: NPC97027
Ingredient ID: NPC886
Ingredient ID: NPC83287
Ingredient ID: NPC81515
Ingredient ID: NPC76406
Ingredient ID: NPC76372
Ingredient ID: NPC74259
Ingredient ID: NPC72260
Ingredient ID: NPC71838
Ingredient ID: NPC60450
Ingredient ID: NPC60091
Ingredient ID: NPC60056
Ingredient ID: NPC58848
Ingredient ID: NPC55777
Ingredient ID: NPC53566
Ingredient ID: NPC53288
Ingredient ID: NPC4949
Ingredient ID: NPC41586
Ingredient ID: NPC32336
Ingredient ID: NPC30912
Ingredient ID: NPC308262
Ingredient ID: NPC307150
Ingredient ID: NPC297830
Ingredient ID: NPC297075
Ingredient ID: NPC295558
Ingredient ID: NPC295110
Ingredient ID: NPC294902
Ingredient ID: NPC293039
Ingredient ID: NPC292379
Ingredient ID: NPC288816
Ingredient ID: NPC287597
Ingredient ID: NPC287440
Ingredient ID: NPC28024
Ingredient ID: NPC276739
Ingredient ID: NPC264741
Ingredient ID: NPC259347
Ingredient ID: NPC253997
Ingredient ID: NPC242031
Ingredient ID: NPC239860
Ingredient ID: NPC237567
Ingredient ID: NPC236993
Ingredient ID: NPC225439
Ingredient ID: NPC222736
Ingredient ID: NPC222635
Ingredient ID: NPC220217
Ingredient ID: NPC215135
Ingredient ID: NPC208193
Ingredient ID: NPC205195
Ingredient ID: NPC204166
Ingredient ID: NPC203375
Ingredient ID: NPC202523
Ingredient ID: NPC198909
Ingredient ID: NPC197316
Ingredient ID: NPC193893
Ingredient ID: NPC189588
Ingredient ID: NPC184748
Ingredient ID: NPC183529
Ingredient ID: NPC183075
Ingredient ID: NPC178595
Ingredient ID: NPC175372
Ingredient ID: NPC173555
Ingredient ID: NPC172644
Ingredient ID: NPC170065
Ingredient ID: NPC160359
Ingredient ID: NPC154792
Ingredient ID: NPC149410
Ingredient ID: NPC148739
Ingredient ID: NPC146414
Ingredient ID: NPC143309
Ingredient ID: NPC142411
Ingredient ID: NPC122150
Ingredient ID: NPC118715
Ingredient ID: NPC117756
Ingredient ID: NPC117445
Ingredient ID: NPC116520
Ingredient ID: NPC109571
Ingredient ID: NPC1075
Ingredient ID: NPC100998
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Drug Transporter | Hydrolase | ATP12A | Potassium-transporting ATPase alpha chain 2 | P54707 | CHEMBL2933 |
Therapeutic Target | Hydrolase | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Therapeutic Target | P-type ATPase | ATP1A1 | Sodium/potassium-transporting ATPase alpha-1 chain | P05023 | CHEMBL1807 |
Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Therapeutic Target | Protein Kinase | PRKCA | Protein kinase C alpha | P17252 | CHEMBL299 |
Drug Transporter | SLC superfamily of solute carriers | SLCO4C1 | Solute carrier organic anion transporter family member 4C1 | Q6ZQN7 | CHEMBL2073690 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Therapeutic Target | Transcription factor | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
Therapeutic Target | Transcription factor | KLF5 | Kruppel-like factor 5 | Q13887 | CHEMBL1293249 |
Therapeutic Target | Transcription factor | STAT3 | Signal transducer and activator of transcription 3 | P40763 | CHEMBL4026 |
Therapeutic Target | Transporter | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Therapeutic Target | Unclassified protein | GMNN | Geminin | O75496 | CHEMBL1293278 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 72 | |
Plant level | 1 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT02106845 | Effect of Regorafenib on Digoxin and Rosuvastatin in Patients With Advanced Solid Malignant Tumors. | neoplasm | Digoxin (NPC173555) | NP level |
NCT01266590 | A Study of LY2216684 and Digoxin in Healthy Subjects | major depressive disorder | Digoxin (NPC173555) | NP level |
NCT01699776 | Efficacy Study of Digoxin & Ivabradine to Treat Heart Failure | heart failure | Digoxin (NPC173555) | NP level |
NCT03684772 | Topical Ionic Contra-Viral Therapy in Actinic Keratosis | actinic keratosis | Digoxin (NPC173555) | NP level |
NCT02138292 | A Phase 1B Clinical Trial of Trametinib Plus Digoxin in Patients With Unresectable or Metastatic BRAF Wild-type Melanoma | melanoma | Digoxin (NPC173555) | NP level |
NCT02243098 | Investigating the Influence of Semaglutide on the Pharmacokinetics of Single Doses of Atorvastatin and Digoxin in Healthy Subjects | diabetes mellitus | Digoxin (NPC173555) | NP level |
NCT01288742 | TMC435-TiDP16-C108 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC435 and Digoxin and Between TMC435 and Rosuvastatin | hepatitis C virus infection | Digoxin (NPC173555) | NP level |
NCT00782288 | Phase II Study of Digitoxin to Treat Cystic Fibrosis | cystic fibrosis | Digitoxin (NPC72260) | NP level |
NCT02172742 | The Effect of BIA 2-093 on the Steady-state Pharmacokinetics of Digoxin | epilepsy | Digoxin (NPC173555) | NP level |
NCT01763931 | DIG-HIF-1 Pharmacodynamic Trial in Newly Diagnosed Operable Breast Cancer | breast cancer | Digoxin (NPC173555) | NP level |
NCT03433833 | Digoxin for Congenital Erythrocytosis Due to Up-Regulated Hypoxia Sensing | von Hippel-Lindau disease | Digoxin (NPC173555) | NP level |
NCT03131973 | Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin | rheumatoid arthritis | Digoxin (NPC173555) | NP level |
NCT02762123 | A Study to Assess the Effect of BMS-986142 on Pharmacokinetics (PK) of Probe Substrates | rheumatoid arthritis | Digoxin (NPC173555) | NP level |
NCT04216693 | Digoxin for Patients With Non-alcoholic Steatohepatitis (NASH) | non-alcoholic steatohepatitis | Digoxin (NPC173555) | NP level |
NCT04493931 | Drug-drug Interaction Study of Gepotidacin | infection | Digoxin (NPC173555) | NP level |
NCT01103622 | Investigate the Effect of AZD1656 on the Pharmacokinetics of Digoxin in Type 2 Diabetes Mellitus Patients | type 2 diabetes mellitus | Digoxin (NPC173555) | NP level |
NCT03113071 | Safety and Activity of Digoxin With Decitabine in Adult AML and MDS | acute myeloid leukemia;myelodysplastic syndrome | Digoxin (NPC173555) | NP level |
NCT00504413 | Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone | drug dependence | Digoxin (NPC173555) | NP level |
NCT04094519 | A Study to Evaluate the Effect of Multiple Doses of Enzalutamide on the Pharmacokinetics of Substrates of P-glycoprotein (Digoxin) and Breast Cancer Resistant Protein (Rosuvastatin) in Male Subjects With Prostate Cancer | prostate cancer | Digoxin (NPC173555) | NP level |
NCT00000476 | Digitalis Investigation Group (DIG) | Arrhythmia|Cardiovascular Diseases|Heart Diseases|Heart Failure;Congestive|Sinus Arrhythmia|Heart Failure | Digitalis Purpurea | Plant level As single plant |
NCT02489786 | A Prospective Study of Different Digoxin Treatment Regimens in Egyptian Hospital | atrial fibrillation | Digoxin (NPC173555) | NP level |
NCT02888327 | A Drug-Drug Interaction Study to Evaluate the Effect of AL-794 on the Pharmacokinetics of Oseltamivir and JNJ-63623872 | influenza | Digoxin (NPC173555) | NP level |
NCT03718273 | IvaBRAdine blocK of Funny Current for Heart Rate Control in permanEnt Atrial Fibrillation. (BRAKE-AF Study). | atrial fibrillation | Digoxin (NPC173555) | NP level |
NCT02906800 | Potentiation of Cisplatin-based Chemotherapy by Digoxin in Advanced Unresectable Head and Neck Cancer Patients | head and neck malignant neoplasia | Digoxin (NPC173555) | NP level |
NCT03783429 | Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands | heart failure | Digoxin (NPC173555) | NP level |
NCT02915666 | A Clinical Trial of Patients With Melanoma | melanoma | Digoxin (NPC173555) | NP level |
NCT00991783 | A Study to Evaluate the Effect of Fimasartan on Pharmacokinetics, and the Safety of Digoxin in Healthy Male Volunteers | essential hypertension | Digoxin (NPC173555) | NP level |
NCT02740712 | Pharmacokinetic Drug-Drug Interaction Study of Rucaparib | neoplasm | Digoxin (NPC173555) | NP level |
NCT02775240 | Study of SHP620 (Maribavir) in Healthy Adults | cytomegalovirus infection | Digoxin (NPC173555) | NP level |
NCT02391337 | Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF) | atrial fibrillation | Digoxin (NPC173555) | NP level |
NCT01147718 | A Drug Interaction Study of Albiglutide and Digoxin | type 2 diabetes mellitus | Digoxin (NPC173555) | NP level |
NCT00650910 | Study To Examine The Effects Of Lapatinib On The Pharmacokinetics Of Digoxin In Subjects w/ ErbB2 Positive Breast Cancer | breast neoplasm | Digoxin (NPC173555) | NP level |
NCT04648917 | GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC) | esophageal cancer | Caffeic Acid (NPC294902) | NP level |
NCT05287191 | MAGNAM Trial, Magnesium Versus Amiodarone in Atrial Fribrillation in Critical Care | atrial fibrillation | Digoxin (NPC173555) | NP level |
NCT01056874 | Effect Of Maraviroc On The Pharmacokinetics Of Digoxin | HIV infection | Digoxin (NPC173555) | NP level |
NCT03928210 | Digoxin Induced Dissolution of CTC Clusters | breast cancer | Digoxin (NPC173555) | NP level |
NCT01583036 | An Open-label, Single-centre Study Evaluating the Pharmacokinetics of Digoxin Alone and When Administered at Various Doses of Ezogabine/Retigabine in Healthy Adults. The Pharmacokinetics of Ezogabine/Retigabine and the N-acetyl Metabolite of Ezogabine/Retigabine (NAMR) Will Also be Assessed | epilepsy | Digoxin (NPC173555) | NP level |
NCT00281021 | Second Line Erlotinib (Tarceva) Plus Digoxin in Non-Small Cell Lung Cancer | non-small cell lung carcinoma | Digoxin (NPC173555) | NP level |
NCT01517399 | Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects | neoplasm | Digoxin (NPC173555) | NP level |
NCT01765569 | A Pharmacokinetics Study to Investigate the Effect of Vemurafenib on Digoxin in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma | melanoma | Digoxin (NPC173555) | NP level |
NCT04425902 | Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults | HIV infection | Digoxin (NPC173555) | NP level |
NCT03559868 | Inhibition of Sterile Inflammation by Digoxin | inflammation | Digoxin (NPC173555) | NP level |
NCT03197324 | Bexagliflozin Drug/Drug Interaction Study With Digoxin | diabetes mellitus | Digoxin (NPC173555) | NP level |
NCT01005602 | Digoxin Dosing in Heart Failure: A Simplified Nomogram Versus Standard Care | heart failure | Digoxin (NPC173555) | NP level |
NCT03136237 | A Drug-Drug Interaction Study to Evaluate Drug Transporter Interactions | hereditary angioedema | Digoxin (NPC173555) | NP level |
NCT02662283 | Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy | IGA glomerulonephritis | Acetoside (NPC197316) | NP level |
NCT02351622 | Caffeic Acid Tablets as a Second-line Therapy for ITP | autoimmune thrombocytopenic purpura | Caffeic Acid (NPC294902) | NP level |
NCT04778787 | Sodium-glucose Cotransporter Type 2 Inhibitors for Acute Cardiorenal Syndrome Prevention | congestive heart failure | Digoxin (NPC173555) | NP level |
NCT05273775 | A Pharmacokinetic Study to Evaluate the Drug Interaction Between HRS5091 and Probe Drugs in Healthy Volunteers | chronic hepatitis B virus infection | Digoxin (NPC173555) | NP level |
NCT02456844 | Study to Investigate the Effect of BMS-986142 on the Pharmacokinetics (PK) of Methotrexate and Probe Substrate Cocktail in Healthy Patients | rheumatoid arthritis | Digoxin (NPC173555) | NP level |
NCT00000556 | Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) | atrial fibrillation | Digoxin (NPC173555) | NP level |
NCT00390546 | Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia | Supraventricular tachycardia | Digoxin (NPC173555) | NP level |
NCT01047566 | Effect of Addition of Dronedarone to Standard Rate Control Therapy on Ventricular Rate During Persistent Atrial Fibrillation (AFRODITE) | atrial fibrillation | Digoxin (NPC173555) | NP level |
NCT01436201 | A Study of the Effect of Dulaglutide on How Body Handles Digoxin in Healthy Participants | type 2 diabetes mellitus | Digoxin (NPC173555) | NP level |
NCT02046044 | Digoxin Versus Ivabradine in Heart Failure With Reduced Ejection Fraction | heart failure | Digoxin (NPC173555) | NP level |
NCT04972396 | ALT-801 DDI Study in Healthy Volunteers | non-alcoholic steatohepatitis | Digoxin (NPC173555) | NP level |
NCT02434861 | An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects | Chemotherapy-induced nausea and vomiting | Digoxin (NPC173555) | NP level |
NCT00904176 | Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects | type 2 diabetes mellitus | Digoxin (NPC173555) | NP level |
NCT01887288 | Capecitabine With Digoxin for Metastatic Breast Cancer | breast cancer | Digoxin (NPC173555) | NP level |
NCT02544815 | Digoxin Short Term Treatment Assessment Randomized Trial in AHF | heart failure | Digoxin (NPC173555) | NP level |
NCT00712465 | An Interaction Study With Digoxin and AZD1305 | atrial fibrillation | Digoxin (NPC173555) | NP level |
NCT01704638 | Kinetics of Fluvoxamine and Digoxin in Subjects With Different MDR1 Genotypes | depressive disorder | Digoxin (NPC173555) | NP level |
NCT02626234 | A Drug-drug Interaction (DDI) Study to Assess the Effect of INC280 on the Pharmacokinetics of Digoxin and Rosuvastatin in Patients With cMET-dysregulated Advanced Solid Tumors | neoplasm | Digoxin (NPC173555) | NP level |
NCT03889795 | Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors | pancreatic carcinoma | Digoxin (NPC173555) | NP level |
NCT01355354 | Effects of Administration of Fostamatinib on Blood Concentrations of Digoxin in Healthy Subjects | rheumatoid arthritis | Digoxin (NPC173555) | NP level |
NCT02249910 | Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects | diabetes mellitus | Digoxin (NPC173555) | NP level |
NCT04834557 | Evaluating the Effect of Digoxin and Ursodeoxycholic Acid in Patients With Rheumatoid Arthritis | rheumatoid arthritis | Digoxin (NPC173555) | NP level |
NCT04887194 | PK Study to Assess Drug-drug Interaction and QTc Between Sitravatinib and a Cocktail of Substrates | neoplasm | Digoxin (NPC173555) | NP level |
NCT02212639 | Phase II Multicentric Study of Digoxin Per os in Classic or Endemic Kaposi' s Sarcoma | Kaposi's sarcoma | Digoxin (NPC173555) | NP level |
NCT02797145 | Intensive Versus Conventional Digoxin Use in Patients With Heart Failure | heart failure | Digoxin (NPC173555) | NP level |
NCT04322552 | A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Transporter Pgp Substrate Digoxin in Advanced Solid Tumor Subjects | neoplasm | Digoxin (NPC173555) | NP level |
NCT01162135 | Digoxin for Recurrent Prostate Cancer | prostate cancer | Digoxin (NPC173555) | NP level |
NCT05357911 | A Study on the Effect of AB-106 on the Pharmacokinetics of Digoxin | neoplasm | Digoxin (NPC173555) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
ATP1A1,SLCO4C1
NCT00000476 NCT02046044,NCT01005602,NCT01699776,NCT02544815,NCT02797145,NCT03783429 |
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TDP1,TSHR,GMNN,MMP9,SLCO4C1,TP53,MMP1,ATP12A,ATP1A1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
MMP1,MMP9,NFKB1
NCT03131973,NCT02762123,NCT04834557,NCT02456844,NCT01355354 |
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
RAB9A,MMP2,GMNN,SLCO4C1,ATP12A,MMP1,SMN1,ATP1A1
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT02740712,NCT04887194,NCT02626234,NCT05357911,NCT01517399,NCT04322552,NCT02106845
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT00000556,NCT02391337,NCT05287191,NCT03718273,NCT00712465,NCT01047566,NCT02489786
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
KLF5,PAX8,MMP2,NPC1,MMP1,LMNA
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
NFKB1,GMNN,MMP9,ATP12A,MAPT,HSD17B10
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MMP1,STAT3,TP53,ATP1A1,MMP2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
TP53,MMP9,STAT3,NFKB1,ATP1A1
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
MMP1,MMP2,TP53,MMP9,STAT3
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NFKB1
NCT01436201,NCT01147718,NCT00904176,NCT01103622 |
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
SLCO4C1,MMP9,MMP1,MAPT,ATP1A1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
MMP2,GMNN,MMP9,MMP1,FXYD2
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
TSHR,MMP2,MMP9,MMP1,FXYD2
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
TSHR,GMNN,MMP9,ATP12A,MMP1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
PAX8,SLCO4C1,MMP9,ATP12A,MMP1
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
PAX8,SLCO4C1,MMP9,ATP12A,MMP1
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
RAB9A,TSHR,STAT3,GMNN,LMNA
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NFKB1
NCT03197324,NCT02243098,NCT02249910 |
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,MAPT,TP53
NCT03113071 |
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
MMP9,TSHR,MMP9,MMP1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
SLCO4C1,MMP9,KDM4E,FXYD2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
GMNN,MMP9,TSHR,MMP1
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
KLF5,MMP2,ATP12A,LMNA
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
SLCO4C1,MMP2,PRKCA,FXYD2
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
MMP9
MMP9,MMP1 |
Muscular atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B61 |
SMN1,SMN2,PRKCA
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
MMP9,MMP1,MMP2
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NCT02915666,NCT01765569,NCT02138292
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
NCT01763931,NCT03928210,NCT01887288
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
MMP9
NCT04972396,NCT04216693 |
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
PRKCA,RAB9A,LMNA
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
SLCO4C1,MMP9,MMP1
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
SLCO4C1,ATP12A,MMP1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
GMNN,MMP9,MMP1
|
Congestive heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10 |
NCT00000476
NCT04778787 |
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
TP53,STAT3
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
TP53,PRKCA
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
NFKB1,MAPT
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
MMP9,MMP2
|
Cardiac arrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC9Z |
SLCO4C1,ATP1A1
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
RAB9A,NFKB1
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
STAT3,NFKB1
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
STAT3,TP53
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
MMP9,TP53
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
MMP9,STAT3
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
STAT3,TP53
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
TP53
NCT02906800 |
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TP53
NCT04648917 |
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
TP53
NCT03113071 |
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
NCT01162135,NCT04094519
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT04425902,NCT01056874
|
Epilepsy/seizureDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A61-8A6Z |
NCT01583036,NCT02172742
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
MMP9,MMP1
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
MMP9,MMP2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP9,MMP1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
MMP9,MMP1
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
MMP9,MMP1
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
MMP9,MMP1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
KLF5,MMP9
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
MMP9,MMP1
|
Malaria, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F4Z |
KLF5,MMP9
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
MMP9,FXYD2
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
KLF5,TDP1,TSHR,PAX8,GMNN,MMP9,SLCO4C1,TP53,MMP1,ATP12A,HSD17B10,ATP1A1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
KLF5,PAX8,MMP2,PRKCA,GMNN,MMP9,ATP1A1,TP53,MMP1,FXYD2,MAPT,LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TDP1,TSHR,PAX8,MMP2,GMNN,TP53,MMP1,ATP12A,FXYD2,SMN1,HSD17B10,LMNA
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
PAX8,GMNN,MMP9,MMP1,FXYD2,MAPT,GMNN,MMP9,MMP1,MAPT,ATP1A1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
KLF5,TDP1,PAX8,PRKCA,GMNN,MMP9,NPC1,MMP1,SMN1,LMNA
|
Cardiac arrhythmia, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC9Z |
NCT00000476
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
NCT00000476
|
Other specified diseases of the circulatory systemDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BE2Y |
NCT00000476
|
Other specified syndromic genetic deafnessDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2H.Y |
NCT00000476
|
Corneal diseaseDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A76-9A78 |
ATP1A1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
TP53
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
MMP9
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
TSHR
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
ATP1A1
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1
|
LiposarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B59 |
TP53
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TP53
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
TP53
|
Mycosis fungoidesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B01 |
STAT3
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1
|
HyperhidrosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EE00 |
ATP1A1
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
STAT3
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
ATP1A1
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
TP53
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1
|
Immune system diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01-4B41 |
STAT3
|
Lip/oral cavity/pharynx neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6E |
TP53
|
Dental diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA08 |
ATP1A1
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
MAPT
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
MMP2
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
TP53
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
STAT3
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAPT
|
Supraventricular tachyarrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81 |
ATP1A1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
ATP1A1
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
TSHR
|
Malignant digestive organ neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C11 |
STAT3
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NFKB1
|
Kidney failureDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60-GB6Z |
TP53
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
TP53
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT
|
Metastatic liver/bile duct neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D80 |
TP53
|
Fallopian tube cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C74 |
TP53
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
STAT3
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
STAT3
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TP53
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Nephritic syndromeDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB40 |
NCT02662283
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT00782288
|
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT03889795
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
NCT03433833
|
Hereditary angioedemaDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A00.14 |
NCT03136237
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT03684772
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
NCT00991783
|
Unknown or unspecified psychoactive substance dependence, substance and state of remission unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4G.2Z |
NCT00504413
|
Single episode depressive disorder, severe, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70.3 |
NCT01266590
|
Supraventricular tachyarrhythmia, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.Z |
NCT00390546
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
NCT02888327
|
Chronic hepatitis B, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.0Z |
NCT05273775
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT00281021
|
Congenital cytomegalovirus infectionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA62.3 |
NCT02775240
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT01704638
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT03559868
|
Immune thrombocytopenic purpuraDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64.10 |
NCT02351622
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
NCT02434861
|
Kaposi sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B57 |
NCT02212639
|
Neoplasms of unknown behaviour of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F95 |
NCT00650910
|
Chronic hepatitis CDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.1 |
NCT01288742
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT04493931
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
TSHR
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
TSHR
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
KLF5
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
ATP12A
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
MMP1
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
PRKCA
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
MMP9
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
MMP1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
NPC1
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
MMP9
|