Collective Molecular Activities of the Plant: Lilium Lancifolium
Example Image
PLANiTS DNA barcode
Taxonomic Information
Used in Medicines
Country/Region:
South Korea; IndiaTraditional Medicine System:
KampoMedicinal Functions:
Antiinflammatory; Cardiac; Carminative; Diuretic; Emmenagogue; Emollient; Expectorant; Ophthalmic; Women's complaints
Geographical Distribution
Canada; South Africa; India; United States; Austria; China; Japan; South Korea; Russia
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
47 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
18 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
28 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC86373
Ingredient ID: NPC84882
Ingredient ID: NPC84810
Ingredient ID: NPC81186
Ingredient ID: NPC81010
Ingredient ID: NPC73411
Ingredient ID: NPC53069
Ingredient ID: NPC52097
Ingredient ID: NPC32977
Ingredient ID: NPC311722
Ingredient ID: NPC302857
Ingredient ID: NPC296686
Ingredient ID: NPC294902
Ingredient ID: NPC294423
Ingredient ID: NPC283217
Ingredient ID: NPC282143
Ingredient ID: NPC268319
Ingredient ID: NPC261619
Ingredient ID: NPC250587
Ingredient ID: NPC243728
Ingredient ID: NPC23991
Ingredient ID: NPC225710
Ingredient ID: NPC22140
Ingredient ID: NPC219876
Ingredient ID: NPC216509
Ingredient ID: NPC215711
Ingredient ID: NPC209360
Ingredient ID: NPC20791
Ingredient ID: NPC190664
Ingredient ID: NPC180261
Ingredient ID: NPC180170
Ingredient ID: NPC17879
Ingredient ID: NPC176740
Ingredient ID: NPC176521
Ingredient ID: NPC169749
Ingredient ID: NPC167976
Ingredient ID: NPC161423
Ingredient ID: NPC156654
Ingredient ID: NPC15658
Ingredient ID: NPC146591
Ingredient ID: NPC139397
Ingredient ID: NPC138142
Ingredient ID: NPC12720
Ingredient ID: NPC12640
Ingredient ID: NPC126029
Ingredient ID: NPC116775
Ingredient ID: NPC1075
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Therapeutic Target | Oxidoreductase | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Therapeutic Target | Oxidoreductase | HSD17B3 | Estradiol 17-beta-dehydrogenase 3 | P37058 | CHEMBL4234 |
| Therapeutic Target | Oxidoreductase | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Therapeutic Target | Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Protein Kinase | YES1 | Tyrosine-protein kinase YES | P07947 | CHEMBL2073 |
| Therapeutic Target | Protein Kinase | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Q02750 | CHEMBL3587 |
| Therapeutic Target | Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Therapeutic Target | Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Therapeutic Target | Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Therapeutic Target | Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Therapeutic Target | Protein Kinase | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | O14733 | CHEMBL3530 |
| Therapeutic Target | Protein Kinase | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | O43318 | CHEMBL5776 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Therapeutic Target | Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Therapeutic Target | Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Therapeutic Target | Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Therapeutic Target | Secreted protein | SHBG | Testis-specific androgen-binding protein | P04278 | CHEMBL3305 |
| Therapeutic Target | Secreted protein | SERPINA6 | Corticosteroid binding globulin | P08185 | CHEMBL2421 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transcription factor | AHR | Aryl hydrocarbon receptor | P35869 | CHEMBL3201 |
| Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Therapeutic Target | Transcription factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
| Therapeutic Target | Transferase | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Q11130 | CHEMBL3596077 |
| Therapeutic Target | Unclassified protein | PLAA | Phospholipase A-2-activating protein | Q9Y263 | CHEMBL6114 |
| Drug Transporter | Voltage-gated calcium channel | CACNA1C | Voltage-gated L-type calcium channel alpha-1C subunit | Q13936 | CHEMBL1940 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 182 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT03378713 | Clinical Trial to Assess the Effect of Testosterone in Patients With Poor Ovarian Response (TESTOPRIM) | infertility | Testosterone (NPC161423) | NP level |
| NCT00425009 | Therapeutic Effects of Berberine in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT04946383 | Safety and Effectivness of Quercetin & Dasatinib on Epigenetic Aging | aging | Quercetin (NPC20791) | NP level |
| NCT04558567 | Testopel ® vs. Generic Testosterone Pellets. | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00372008 | Pharmacokinetics of Testosterone Lotion in the Treatment of Hypogonadal Males | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00405353 | Testosterone Treatment for Multiple Sclerosis | multiple sclerosis | Testosterone (NPC161423) | NP level |
| NCT01699178 | Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02861261 | A Study on the Efficacy and Gut Microbiota of Berberine and Probiotics in Patients With Newly Diagnosed Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT00479609 | Testosterone Therapy in Men With Low Testosterone Levels and Metabolic Syndrome or Early Stages of Type 2 Diabetes | metabolic syndrome | Testosterone (NPC161423) | NP level |
| NCT02082756 | Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment | prediabetes syndrome | Berberine (NPC53069) | NP level |
| NCT03345576 | Testosterone and Long Pulse Stimulation After SCI | Spinal cord injury | Testosterone (NPC161423) | NP level |
| NCT03345797 | Evaluation of Testosterone Nasal Gel in Hypogonadal Boys | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01419236 | A Study of Ejaculatory Dysfunction in Men With Low Testosterone Levels | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT04976595 | Vogelxo(R) ABPM Study in Hypogandal Men | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02728349 | Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma | glioblastoma multiforme | Chlorogenic Acid (NPC302857) | NP level |
| NCT01743235 | Lybridos in Pre- and Postmenopausal Women With Hypoactive Sexual Desire Disorder Due to Maladaptive Activation of Sexual Inhibitory Systems | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT00705796 | Influence of Administration Route of Testosterone on Male Fertility | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02873559 | Effect of PROGRESSive Training and Teststerone in Older Frail Men | muscular disease | Testosterone (NPC161423) | NP level |
| NCT02147964 | ITT-5 Mechanisms of Spermatogenesis in Man | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00075855 | Low-Dose Testosterone in Improving Libido in Postmenopausal Female Cancer Survivors | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT01160328 | Influence of Male Hormones on Regional Fat Metabolism | obesity | Testosterone (NPC161423) | NP level |
| NCT03281096 | A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT05062486 | A Study to Evaluate the Safety and Efficacy of RQC for AMD | age-related macular degeneration | Quercetin (NPC20791) | NP level |
| NCT03333265 | Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT00345969 | Exercise and Testosterone Therapy in Elderly Men With Physical Frailty | hip fracture;hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01880866 | (-)-Epicatechin and Pulmonary Arterial Hypertension | pulmonary arterial hypertension | (-)-Epicatechin (NPC126029) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01697345 | Breast Cancer, Aromatase Inhibitor Therapy, and Sexual Functioning: The Effects of Vaginal Testosterone Therapy | Dyspareunia | Testosterone (NPC161423) | NP level |
| NCT02433730 | Testosterone Therapy in Hypogonadal Men Treated With Opioids | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00304213 | Does Testosterone Improve Function in Hypogonadal Older Men | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02256865 | Hormonal Mechanisms of Sleep Restriction | insulin resistance | Testosterone (NPC161423) | NP level |
| NCT00467259 | Endometrial Safety Study of Transdermal Testosterone (300 Mcg/Day) in Naturally Postmenopausal Women | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT00202163 | ANDRO 2002: Dehydroepiandrosterone (DHEA) or Testosterone Versus Placebo in Men With Sexual Dysfunction | erectile dysfunction | Testosterone (NPC161423) | NP level |
| NCT00612742 | Safety and Efficacy of LibiGel® for Treatment of Hypoactive Sexual Desire Disorder in Postmenopausal Women | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT00338312 | Study of Transdermal Testosterone Patches in Naturally Menopausal Women With Low Libido | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT02110368 | Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditions | hypogonadotropic hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01469988 | The VO2 Increase With Testosterone Addition - Heart Failure (VITA-HF) Trial | heart failure | Testosterone (NPC161423) | NP level |
| NCT04265053 | Human Cerebral Blood Flow Regulation | cerebral arterial disease | Testosterone (NPC161423) | NP level |
| NCT03751592 | Phase Ib/IIa Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Advanced Lung Cancer | lung cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT02084004 | Effects of Berberine Hydrochloride and Bifidobacterium in Diabetes Mellitus Prevention and Treatment | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT00006158 | AIDS Wasting in Women: Anabolic Effects of Testosterone | AIDS | Testosterone (NPC161423) | NP level |
| NCT03236662 | (-)- Epicatechin Becker Muscular Dystrophy | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT00244023 | Co-Administering Testosterone With PDE5 Inhibitors in ED Patients Non Responders to PDE5 Inhibitors Alone | erectile dysfunction;hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00400335 | Study On Bioavailability And Pharmacokinetics Of Various Doses Of Testosterone Administered With And Without Dutasteride | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00413244 | The Cardiac Benefit of Testosterone Replacement in Men With Low Testosterone Levels With Coronary Artery Disease After Successful Intervention of the Blockage or Narrowed Heart Artery | coronary artery disease | Testosterone (NPC161423) | NP level |
| NCT01993225 | A Randomized, Double Blind, Placebo-Controlled, Multi-Center Phase III Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Testosterone and Sperm Concentration Following Treatment With 12.5 mg or 25 mg Androxal or AndroGel 1.62% | hypogonadotropic hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01652040 | Resistance Training and Testosterone After Spinal Cord Injury | Spinal cord injury | Testosterone (NPC161423) | NP level |
| NCT01690676 | Effect of an Apple Polyphenol Extract on Brachial Artery Flow-mediated Vasodilatory Function | hypertension | (+)-Epicatechin (NPC261619) | NP level |
| NCT02445716 | Transdermal Testosterone Nanoemulsion in Women Libido | menopause | Testosterone (NPC161423) | NP level |
| NCT01270841 | Normalization of Morning Testosterone Levels in Men With Secondary Hypogonadism | hypogonadotropic hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00857961 | A Study of the Pharmacokinetics of Testosterone Metered Dose (MD)-Lotion Formulations | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02081300 | Safety and Efficacy of Oral LPCN 1021 in Men With Low Testosterone or Hypogonadism | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00006044 | Testosterone in Treating Patients With Progressive Prostate Cancer That No Longer Responds to Hormone Therapy | prostate cancer | Testosterone (NPC161423) | NP level |
| NCT02203656 | Feasibility Study of Post-hospitalization Interventions to Improve Physical Function in Older Adults | aging | Testosterone (NPC161423) | NP level |
| NCT00702650 | A Titration Trial to Determine the Effectiveness of Testosterone MD-Lotion (Cutaneous Solution) Formulations | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00089843 | Bone Loss in Women With Anorexia Nervosa | anorexia nervosa | Testosterone (NPC161423) | NP level |
| NCT02712944 | Testosterone Replacement in Renal Failure | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01370369 | Efficacy, Pharmacokinetics and Safety of Testosterone | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00613002 | Safety and Efficacy of LibiGel® for the Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT00757185 | Compromised Microcirculation in Women With Polycystic Ovary Syndrome | polycystic ovary syndrome | Testosterone (NPC161423) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT02111473 | The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02679274 | Cycled Testosterone Therapy to Improve Physical Function in Frail Nursing Home Residents | aging | Testosterone (NPC161423) | NP level |
| NCT00857168 | To Determine the Effects of Deodorant, Antiperspirant and Washing on the Pharmacokinetics of 2% Testosterone MD Lotion | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00080756 | Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This Disease | Hereditary breast and ovarian cancer syndrome | Testosterone (NPC161423) | NP level |
| NCT00161486 | The Effects of Testosterone on Prostate Tissue (ACYP-1) | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00586898 | Rapid Hormonal Cycling as Treatment for Patients With Prostate Cancer: The Men's Cycle | prostate carcinoma | Testosterone (NPC161423) | NP level |
| NCT02245204 | Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers | cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT00398580 | 28-Day Study of Testosterone Co-administered With Dutasteride in Hypogonadal Men | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT03198728 | Efficacy and Safety of Oral Testosterone Undecanoate in Hypogonadal Men | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT04523480 | Vitality | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT03758014 | Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients | glioblastoma multiforme | Chlorogenic Acid (NPC302857) | NP level |
| NCT00633282 | Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease | non-alcoholic fatty liver disease | Berberine (NPC53069) | NP level |
| NCT02660112 | (+) Epicatechin to Treat Friedreich's Ataxia | Friedreich ataxia | (+)-Epicatechin (NPC261619) | NP level |
| NCT00657501 | Safety and Efficacy of LibiGel® for Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT01096329 | A Pharmacokinetic (PK) Study to Compare the Absorption of Two Formulations of Transdermal Testosterone Spray and Intrinsa® | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT02418065 | Multimodal Therapeutic Approach in Undernourished Maintenance Hemodialysis Patients (AMERICANO) | chronic kidney disease | Testosterone (NPC161423) | NP level |
| NCT04439799 | A Comparison of Side Effects in Hypogonadal Men Treated With Natesto Versus Testosterone Injections | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02226185 | Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT00957034 | Assessing the Safety/Efficacy of Transdermal Testosterone in Female Patients With Symptomatic Heart Failure | heart failure | Testosterone (NPC161423) | NP level |
| NCT01386606 | The Effect on Androxal Versus Androgel on Morning Testosterone in Men With Secondary Hypogonadism (Low Testosterone) | hypogonadotropic hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01578473 | Testosterone Pellets Plus Vitamin D and E Versus Vitamin D and E Alone for the Treatment of Peyronie's Disease | Abnormality of connective tissue | Testosterone (NPC161423) | NP level |
| NCT01893281 | The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT00161421 | Oral Androgens in Man-3 (ORAL T-3) Pharmacokinetics of Oral Testosterone | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00663793 | ORAL T-6: Oral Androgens in Man-6 | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01993212 | A Randomized, Double Blind, Placebo-Controlled, Multi-Center Phase III Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Testosterone and Sperm Concentration Following Treatment With 12.5 mg or 25 mg Androxal or AndroGel 1.62% | hypogonadotropic hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01839344 | Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. | type 2 diabetes mellitus | Quercetin (NPC20791) | NP level |
| NCT02111434 | Visceral Adiposity Index and Triglyceride/High-density Lipoprotein Cholesterol Ratio in the Congenital Hypogonadotropic Hypogonadism and Effect of Testosteron Treatment | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02848131 | Senescence in Chronic Kidney Disease | chronic kidney disease | Quercetin (NPC20791) | NP level |
| NCT03339635 | Short-term Testosterone Replacement in Testicular Cancer Survivors | testicular carcinoma | Testosterone (NPC161423) | NP level |
| NCT01228071 | Time to Eugonadal Range, Time to Steady State and Drying Time | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT05456022 | Therapeutic Efficacy of Quercetin Versus Its Encapsulated Nanoparticle on Tongue Squamous Cell Carcinoma Cell Line | mouth neoplasm | Quercetin (NPC20791) | NP level |
| NCT03281187 | Efficacy and Safety of Testosterone Nasal Gel for Treating Hypogonadism in Men. | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01432665 | Lybrido for Female Sexual Dysfunction | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT02317263 | A Trial to Investigate the Effectiveness of Testosterone Treatment in Men With Multiple Sclerosis | multiple sclerosis | Testosterone (NPC161423) | NP level |
| NCT04907253 | Quercetin in Coronary Artery By-pass Surgery | coronary artery disease | Quercetin (NPC20791) | NP level |
| NCT00254553 | A Study to Test a Measure of Symptoms of Older Men With Low Testosterone On and Off Testosterone Replacement Treatment (P05815) | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00577980 | Testosterone in Castration-Resistant Prostate Cancer | prostate cancer | Testosterone (NPC161423) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
| NCT00857454 | A Trial to Evaluate the Ongoing Skin Safety of Testosterone MD-Lotion Formulations | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02317640 | TRT in Combination With Electrical Stimulation and Standing: Effect on Muscle and Bone in Spinal Cord Injured Males | Spinal cord injury | Testosterone (NPC161423) | NP level |
| NCT00965341 | Testosterone Replacement for Fatigue in Male Hypogonadic Advanced Cancer Patients | cancer | Testosterone (NPC161423) | NP level |
| NCT01665599 | A Clinical Trial to Evaluate the Efficacy and Safety of Testosterone Gel | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT04831099 | Testosterone Treatment in a Patient With 17β-hydroxysteroid Dehydrogenase Type 3 Deficiency: an N-of-1 Study | Genetic disorder of sex development | Testosterone (NPC161423) | NP level |
| NCT00384046 | Testosterone Therapy in Naturally Menopausal Women With Low Sexual Desire Receiving Transdermal Estrogen | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT00433199 | Testosterone Treatment for Hypogonadal Men | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02226484 | Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? | gastroesophageal reflux disease | Quercetin (NPC20791) | NP level |
| NCT04274894 | A Study of the Effect of Topical Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00962637 | Study to Evaluate the Safety and Efficacy of Androxal™ Treatment in Men With Secondary Hypogonadism | hypogonadotropic hypogonadism | Testosterone (NPC161423) | NP level |
| NCT04386304 | Safety and Biomarker Response to (+)-Epicatechin in Becker Muscular Dystrophy | Becker muscular dystrophy | (+)-Epicatechin (NPC261619) | NP level |
| NCT01386567 | A One Year Open Label Study for the Treatment of Hypogonadism (Low Testosterone) in Men Who Have Completed ZA-203 | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02136342 | Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer | cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT03203681 | Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01323140 | Pharmacokinetics, Metabolism, Efficacy, and Safety Study of Two Testosterone Matrix Transdermal Systems | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT04492553 | Gonadal Dysfunction in Male Long-term Survivors of Malignant Lymphoma | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00382057 | Testosterone Effects on Men With the Metabolic Syndrome | metabolic syndrome | Testosterone (NPC161423) | NP level |
| NCT02722278 | A Study of Oral Testosterone Undecanoate (TU) in Hypogonadal Men | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT03734653 | Testosterone Therapy in Castration Resistant Prostate Cancer | prostate cancer | Testosterone (NPC161423) | NP level |
| NCT03989271 | Biological Effects of Quercetin in COPD | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT00140153 | Testosterone in Female Hypoactive Sexual Desire Disorder | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT03118479 | Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH) | Kallmann syndrome | Testosterone (NPC161423) | NP level |
| NCT01703741 | A Multicenter Extension Trial to Evaluate the Safety of Testosterone Gel | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01446042 | Safety and Efficacy of Intranasal TBS-1 Treatment of Male Hypogonadism | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01816295 | A Study in Men With Low Testosterone to Measure the Effects of Testosterone Solution on Testosterone Levels, Sex Drive and Energy | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01252745 | Efficacy of an Intranasal Testosterone Product | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01616732 | Testosterone and Weight Loss | obesity | Testosterone (NPC161423) | NP level |
| NCT00998933 | Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT04733534 | An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer | childhood cancer | Quercetin (NPC20791) | NP level |
| NCT02964377 | Plus Epicatechin Duchenne Muscular Dystrophy in Non-ambulatory Adolescents | Duchenne muscular dystrophy | (+)-Epicatechin (NPC261619) | NP level |
| NCT01133548 | Pharmacokinetic and Comparative Bioavailability Study of Testosterone Absorption After Administration of Testosterone Gel 1.62% to the Upper Arms/Shoulders Using an Application Site Rotation or a Combination of Application Sites in Hypogonadal Males | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00309855 | Testosterone-Driven Growth-Hormone (GH) Secretion in Aging Men | aging | Testosterone (NPC161423) | NP level |
| NCT01092858 | NEBIDO in Symptomatic Late Onset Hypogonadism (SLOH) | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02990533 | Muscle Anabolic Interventions to Accelerate Recovery From Hospitalization in Geriatric Patients | aging | Testosterone (NPC161423) | NP level |
| NCT02149264 | A Clinical Trial to Evaluate the Efficacy and Safety of Testosterone Gel in Adult Hypogonadal Males | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01786473 | Testogel® (Testosterone Gel 50mg/5g) in the Treatment of Male Hypogonadism | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00698035 | Vaginal Testosterone Cream vs ESTRING for Vaginal Dryness or Decreased Libido in Early Stage Breast Cancer Patients | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT02548832 | Bezafibrate Plus Berberine in Mixed Dyslipidemia | Combined hyperlipidemia | Berberine (NPC53069) | NP level |
| NCT05276895 | Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis | osteoarthritis | Quercetin (NPC20791) | NP level |
| NCT00183040 | HORMA: Hormonal Regulators of Muscle and Metabolism in Aging | sarcopenia | Testosterone (NPC161423) | NP level |
| NCT03943459 | Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease | coronary artery disease | Quercetin (NPC20791) | NP level |
| NCT03000127 | Testosterone for Fatigue in Men With MS | multiple sclerosis | Testosterone (NPC161423) | NP level |
| NCT01856868 | Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT00647868 | NASOBOL in Hypogonadal Men in Comparison to Testosterone Levels in Normal Healthy Male Volunteers | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00706719 | To Evaluate Sperm Parameters in Men With Secondary Hypogonadism Previously Treated With Topical Testosterone | hypogonadotropic hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00587431 | Docetaxel With Rapid Hormonal Cycling as a Treatment for Patients With Prostate Cancer | prostate cancer | Testosterone (NPC161423) | NP level |
| NCT02351622 | Caffeic Acid Tablets as a Second-line Therapy for ITP | autoimmune thrombocytopenic purpura | Caffeic Acid (NPC294902) | NP level |
| NCT01887418 | Pharmacokinetic Study of Testosterone Enanthate | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT04648917 | GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC) | esophageal cancer | Caffeic Acid (NPC294902) | NP level |
| NCT03091348 | Subcutaneous vs. Intramuscular Testosterone | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT05422885 | Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease | aging | Quercetin (NPC20791) | NP level |
| NCT02656212 | Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin (Part 2) | prediabetes syndrome | (+)-Epicatechin (NPC261619) | NP level |
| NCT00522431 | A Study of Fortigel Testosterone Gel 2% in Males With Low Testosterone | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT02419105 | Effects of Transdermal Testosterone and/or Monthly Vitamin D on Fall Risk in Pre--frail Hypogonadal Seniors | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT04851821 | The Effectiveness of Phytotherapy in SARS-COV2(COVID-19) | COVID-19 | Quercetin (NPC20791) | NP level |
| NCT01403116 | Safety and Efficacy Trial of Oral Testosterone Undecanoate (TU) in Hypogonadal Men | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00438321 | Effect of Increasing Testosterone on Insulin Sensitivity in Men With the Metabolic Syndrome | metabolic syndrome | Testosterone (NPC161423) | NP level |
| NCT02330276 | Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin | prediabetes syndrome | (+)-Epicatechin (NPC261619) | NP level |
| NCT02621060 | Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance | abnormal glucose tolerance | Chlorogenic Acid (NPC302857) | NP level |
| NCT05011383 | High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers | metastatic prostate cancer | Testosterone (NPC161423) | NP level |
| NCT00957528 | Cycled Testosterone Replacement Study | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01797718 | Constitutional Delay of Growth and Puberty: Towards Evidence-based Treatment | Growth delay | Testosterone (NPC161423) | NP level |
| NCT01127659 | Testosterone Replacement in Men With Diabetes and Obesity | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT03238092 | Comparison Between Testosterone and Estradiol Over the Homogenization of Follicular Cohort | infertility | Testosterone (NPC161423) | NP level |
| NCT00204269 | Three-Year Trial on a New Testosterone Gel | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT01364623 | PK Study of Testosterone Nasal Gel (TBS-2) in Healthy Premenopausal Women | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT01235754 | Extension Study to Assess Persistence of Benefit of LibiGel for the Treatment of Hypoactive Sexual Desire Disorder (HSDD) | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT02847806 | Effects of Replacement Therapy With Sexual Steroid Hormones on the Insulin Sensitivity of Hypogonadal Man | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00331123 | Study of Transdermal Testosterone Patches in Surgically Menopausal Women With Low Libido | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT00431197 | Steady-State Feedback Actions of Testosterone on Luteinizing Hormone Secretion in Young and Older Men | hypogonadism | Testosterone (NPC161423) | NP level |
| NCT00349791 | Study to Assess the Efficacy/Safety of Transdermal Testosterone Patches in Naturally Menopausal Women With Low Libido | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Quercetin (NPC20791) | NP level |
| NCT03486496 | Gefitinib and Berberine in the First-line Treatment of Lung Adenocarcinoma With EGFR Mutation | lung adenocarcinoma | Berberine (NPC53069) | NP level |
| NCT00515112 | Testosterone Replacement in Men With Non-Metastatic Castrate Resistant Prostate Cancer | prostate cancer | Testosterone (NPC161423) | NP level |
| NCT00331214 | Study of Transdermal Testosterone Patches in Surgically Menopausal Women With Low Libido | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT02101203 | Lybridos in Pre-and Postmenopausal Women With Hypoactive Sexual Desire Disorder | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT04853199 | Quercetin In The Treatment Of SARS-COV 2 | COVID-19 | Quercetin (NPC20791) | NP level |
| NCT00131495 | Study of Transdermal Testosterone Patches in Menopausal Women With Low Libido | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT02937740 | Open-Label Study, Evaluating Patient Satisfaction and Symptom Improvement When Treating Male Hypogonadism With Natesto™ | hypogonadism | Testosterone (NPC161423) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
MMP9,TOP2A,SRC,KDR,MMP2,EGFR,MET,TP53,MMP1
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
AURKB,ACHE,TOP2A,NOX4,NPSR1,CDK1,ALOX15,MMP9,MMP1
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
ELAVL3,AURKB,TOP2A,CA12,FUT7,SERPINA6,CDK1,MMP9,MMP1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ABCG2,NFKB1,MMP1,ALOX5,CA2,RELA,AKR1B1,MMP9
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MMP1,MAPK1,TOP2A,MMP2,SRC,TP53,IGF1R,EGFR
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
AURKB,AR
NCT00515112,NCT00587431,NCT01705652,NCT03734653,NCT00006044,NCT00577980 |
Gonadotropin deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A61.2 |
NCT03203681,NCT01887418,NCT00857961,NCT00998933,NCT00204269,NCT03118479,NCT00304213,NCT00433199,NCT02847806,NCT00372008,NCT02722278,NCT00957528,NCT00161486,NCT01993225,NCT00702650,NCT01270841,NCT02081300,NCT01893281,NCT01699178,NCT02433730,NCT03345797,NCT01703741,NCT00705796,NCT00431197,NCT02712944,NCT01993212,NCT04439799,NCT00647868,NCT00345969,NCT04523480,NCT03198728,NCT00244023,NCT01665599,NCT02147964,NCT00254553,NCT01446042,NCT04492553,NCT00663793,NCT01133548,NCT01419236,NCT01370369,NCT00161421,NCT04274894,NCT01323140,NCT02937740,NCT00400335,NCT02419105,NCT01092858,NCT03281187,NCT02110368,NCT00962637,NCT02111434,NCT00857454,NCT01228071,NCT03091348,NCT01816295,NCT00522431,NCT00857168,NCT02149264,NCT01386606,NCT01386567,NCT00398580,NCT04558567,NCT02111473,NCT00706719,NCT01403116,NCT04976595,NCT01127659,NCT01786473,NCT01252745
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
SRC,TOP2A,NFKB1,RELA
NCT02317263,NCT00405353,NCT03000127 |
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ALOX5,AHR,NFKB1,FLT3,TOP2A,DPP4,RELA
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
SRC,DPP4,AURKB,TP53,FLT3,CDK1,TOP2A
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
DPP4,RELA,NFKB1
NCT02084004,NCT00425009,NCT02861261,NCT01839344 |
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE,MET,FLT3,TOP2A,KDR,SNCA,CACNA1C
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
TOP2A,CA12,CDK1,MMP9,ALPL,HSD17B2,MMP2
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
AURKB,TOP2A,CA12,CDK1,MMP9,XDH,MMP1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
TOP2A,AURKB,CA12,CYP1A2,MET,CYP1A1,CA2
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
EGFR,TOP2A,MET,KDR,MMP9,TP53
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
EGFR,KDR,MAPK1,TYR,MET,MAP2K1
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
MET,KDR,IGF1R,TOP2A,CSNK2A1,EGFR
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TP53,TOP2A,SRC,FLT3,KDR,MET
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
KDR,FLT3,SRC,IGF1R,AXL,AHR
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT02990533,NCT02203656,NCT05422885,NCT00309855,NCT02679274,NCT04946383
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
HSD17B3,AURKB,NOX4,NPSR1,MMP9,MMP1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ACHE,NFKB1,AXL,MET,DPP4,CYP19A1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
TYR,NOX4,MET,NPSR1,CYP1A1,MMP1
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NOX4,FUT7,IGF1R,SHBG,ALDH1A1,ABCG2
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ACHE,SNCA,SRC,DPP4,CA2,LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
EGFR,AXL,MMP2,CYP19A1,XDH,LMNA
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA14,TOP2A,CA12,CYP2C9,CA2
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
KDR,TP53,AXL,AHR,EGFR
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
AR,XDH,CA2
NCT01469988,NCT00957034 |
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
IGF1R,XDH,AR
NCT02418065,NCT02848131 |
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
MET,MMP9,MMP2,KDR,EGFR
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1,NOX4,FUT7,DPP4,MMP2
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
KDR,TP53,MET,EGFR
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
AKR1B1,CA2,ACHE,MET
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
AR,KDR,MET,SRC
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,AURKB,KDR,AKR1B1
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
EGFR,SRC,AXL,TP53
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
SRC,KDR,TP53,FLT3
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
MAP2K1,KDR,TSHR,MET
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
IGF1R,ACHE,AKR1B1,ALOX5
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1,AHR,RELA,ALOX5
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
DPP4
NCT00479609,NCT00382057,NCT00438321 |
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
MMP9
MMP9,ALPL,MMP1 |
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT02136342,NCT02245204,NCT00965341,NCT04733534
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,SERPINA6,ALOX15
NCT01912820 |
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
MMP9,NOX4,ALPL,MMP1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ACHE,YES1,CYP1A1,MMP9
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
AXL,HSD17B2,MET,ACHE
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ACHE,TOP2A,CISD1,CACNA1C,SRC,AR,TP53,RECQL,AHR,EGFR,AURKB,SMN1,CSNK2A2,HSD17B10,CDK1,MMP1,APEX1,CASP6,NOX4,MET,MMP2,PLAA,CA12,AXL,TDP1,GLO1,KDR,ALDH1A1,TSHR,LMNA,AKR1B1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TOP2A,CA7,SRC,DPP4,XDH,HSD17B2,RECQL,AHR,EGFR,AURKB,SMN1,CSNK2A2,CDK1,MMP9,MMP1,APEX1,CASP6,SNCA,MET,FLT3,ALOX15,PIM1,TYR,CA12,AXL,FUT7,ALOX5,TDP1,KDR,LMNA
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NFKB1,DPP4,RELA
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
CDK1,FLT3,TOP2A
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
EGFR,KDR,MET
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
SERPINA6,APEX1,IGF1R
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ACHE,SNCA,SRC
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
EGFR,ALOX5,CDK1
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
GLO1,XDH,ALOX5
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
TOP2A,SERPINA6,ALOX5
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
AR
NCT01708278,NCT03989271 |
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
AR,TOP2A,AKR1B1
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1,RELA,ABCG2
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
SRC,SERPINA6,ALOX5
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
KDR,AHR,ALOX5
|
NADisease Category: NADisease ICD-11 Code: NA |
MET,NOX4
NCT01797718 |
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
MET,KDR,EGFR
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ALOX5,AR,IGF1R
|
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
KDR,MET,SRC
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
EGFR,KDR,FLT3
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1,ALOX5,RELA
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1,AR,RELA
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
TP53,DPP4,MET
|
Intermediate hyperglycaemia, unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.Z |
NCT02082756,NCT02656212,NCT02330276
|
Injury of spinal cord, level unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND51.2 |
NCT03345576,NCT02317640,NCT01652040
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT04907253,NCT03943459,NCT00413244
|
Becker muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.0 |
NCT01856868,NCT04386304,NCT03236662
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
TSHR,CYP1A1,CDK1
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
TSHR,PIM1,CYP2C9
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1,MMP9,MMP1
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
AXL,FLT3,MET
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
NOX4,MMP9,AHR
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ACHE,ALOX12,DPP4,XDH,HSD17B2,AHR,SMN1,SERPINA6,CDK1,CYP2C9,MMP1,CASP6,MAPK1,SNCA,NOX4,MAP3K7,MET,ABCG2,PLAA,CA12,FUT7,NPSR1,ALOX5,GLO1,CA14,MAP2K1,KDR,MMP2,AKR1B1
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TOP2A,CA7,CISD1,POLB,CA2,TP53,DPP4,XDH,HSD17B2,ELAVL3,AURKB,HSD17B10,SERPINA6,MMP9,MMP1,CASP6,MET,YES1,CYP19A1,ALOX15,ALPL,FUT7,NPSR1,TDP1,GLO1,CA14,TSHR,AKR1B1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
RELA,CDK1,CA14,XDH,KDR,IGF1R,YES1,MAP2K1,NFKB1,SRC,FLT3,AURKB,TP53,ALOX5,POLB,MMP9,AXL,CA12,AHR,MAPK1,CA2,CSNK2A1,MET,PIM1,EGFR,APEX1,TOP2A
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,CA7,CISD1,CACNA1C,POLB,DPP4,CA2,XDH,HSD17B2,RECQL,AURKB,CYP1B1,CYP2C9,MMP1,SNCA,MET,ALOX15,MMP2,PIM1,ABCG2,AXL,FUT7,NPSR1,ALOX5,CA14,LMNA
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CISD1,ALOX12,TP53,CA2,XDH,HSD17B2,AHR,ELAVL3,MMP9,MMP1,APEX1,CASP6,NOX4,MET,YES1,ALOX15,ALPL,CSNK2A3,CA12,CYP1A2,FUT7,ALOX5,TDP1,GLO1,TSHR
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1,RELA
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
EGFR,ALPL
|
Muscular atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B61 |
SMN2,SMN1
|
Respiratory system diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB40-CB7Z |
SERPINA6,TOP2A
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA12,CA2
|
Fallopian tube cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C74 |
TP53,SRC
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
AKR1B1,CYP19A1
|
IschemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B10-8B11 |
SRC,EGFR
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
FLT3,SRC
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
TP53,SRC
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TP53
NCT04648917 |
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA,NFKB1
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
SRC,FLT3
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TOP2A,TP53
|
Malignant digestive organ neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C11 |
KDR,SRC
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1,RELA
|
Motor neuron diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60 |
IGF1R,SRC
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
RELA,NFKB1
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
AR,CA2
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
FLT3,ALOX5
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ALDH1A1,ACHE
|
Testicular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80 |
EGFR
NCT03339635 |
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
TOP2A,EGFR
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
TP53,SRC
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
FLT3,TOP2A
|
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
EGFR,MET
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
AR,MMP2
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
RELA,NFKB1
|
Gastrointestinal stromal tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5B |
SRC,KDR
|
Follicular lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A80 |
TOP2A
NCT00455416 |
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT02728349,NCT03758014
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04853199,NCT04851821
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT01880866,NCT01690676
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT01616732,NCT01160328
|
Male erectile dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA01.1 |
NCT00202163,NCT00244023
|
Male infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB04 |
NCT03378713,NCT03238092
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
FUT7
NCT00757185 |
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
MMP9
NCT00633282 |
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
AXL,ACHE
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
ABCG2,AURKB
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1,TOP2A
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
CA14,ABCG2
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
MMP9,DPP4
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
NOX4,MMP1
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1,ABCG2
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
MMP9,MET
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
NCT00349791,NCT00384046,NCT01432665,NCT01364623,NCT00140153,NCT00657501,NCT01743235,NCT00613002,NCT00612742,NCT00331123,NCT00467259,NCT00698035,NCT00338312,NCT01096329,NCT00331214,NCT01235754,NCT02101203,NCT00075855,NCT00131495
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
TOP2A,ALOX12,CACNA1C,SRC,TP53,ELAVL3,AURKB,CDK1,L3MBTL1,MMP9,MMP1,NOX4,MMP2,CSNK2A3,ALOX5,IGF1R,LMNA,AKR1B1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
TYR,ACHE,TOP2A,AURKB,MET,ALOX5,CYP2C9,CYP19A1,MMP9,XDH,HSD17B3,AURKB,TOP2A,FUT7,ALOX5,MMP9,TSHR,MMP1
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
AURKB,TOP2A,CA12,NOX4,CDK1,L3MBTL1,MMP9,CYP19A1,MMP1,AURKB,TOP2A,CA12,SRC,CDK1,CYP19A1,MMP9,MMP1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
TOP2A,CA7,DPP4,AR,HSD17B2,AURKB,CDK1,MMP9,MMP1,SNCA,NOX4,MET,CYP19A1,CA12,FUT7,GLO1,HSD17B3
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
MMP1,CDK1,MMP9,MAP2K1,ALOX5,FLT3,EGFR,TOP2A,MET,MMP2,IGF1R,KDR,AXL
NCT03751592 |
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
TOP2A,CACNA1C,SRC,AURKB,CDK1,L3MBTL1,MMP9,MMP1,NOX4,CYP19A1,CA12,IGF1R,MMP2,AKR1B1
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ACHE,CISD1,NFKB1,DPP4,HSD17B2,CYP1B1,HSD17B10,CYP2C9,MMP9,APEX1,FLT3,ALOX15,FUT7,AKR1B1
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CYP19A1,TOP2A,SRC,CA12,CA2,AXL,EGFR,KDR,CDK1,IGF1R,MET,AR,CA14
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
TOP2A,CA7,ALOX12,XDH,AURKB,CDK1,CYP2C9,MMP9,MMP1,CA12,NPSR1,HSD17B3,TSHR
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
TOP2A,CYP1A1,CA2,XDH,HSD17B2,AURKB,CDK1,CYP2C9,MMP9,MMP1,ALOX15,ALPL,NPSR1
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ELAVL3,ACHE,SNCA,NOX4,CACNA1C,MET,FUT7,CA14,CA2,MMP9,XDH,MMP1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,TOP2A,CA7,AURKB,CA12,TSHR,NPSR1,CDK1,CYP2C9,MMP9,XDH,MMP1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
TOP2A,AURKB,SERPINA6,CDK1,MMP9,MMP1,NOX4,MET,CYP19A1,ALOX15,NPSR1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
HSD17B3,AURKB,TOP2A,CYP1A2,SERPINA6,CA2,CDK1,CYP2C9,MMP9,MMP1,AKR1B1
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
DPP4,AR,CA2,CYP1B1,MET,CYP19A1,CSNK2A3,CA12,KDR,TSHR,LMNA
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
TOP2A,TP53,FLT3,IGF1R,KDR,EGFR,MET
NCT03281096,NCT02226185,NCT03333265 |
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PIM1,FLT3,RELA,AXL,SRC,AR,TP53,TOP2A,NFKB1,AURKB
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
DPP4,MMP9,MMP1,NOX4,FLT3,ALPL,FUT7,TSHR,MMP2,AKR1B1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
HSD17B3,ELAVL3,ACHE,CYP1A1,CA2,CYP2C9,CA14,ALOX15,MMP9,KDM4E
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA7,CYP1B1,NOX4,CA12,MET,ALOX5,DPP4,XDH,ALPL,MMP1
|
ThyrotoxicosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A02 |
IGF1R
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
ALOX5
|
MastocytosisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A21 |
FLT3
|
Hypo-osmolality/hyponatraemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C72 |
AR
|
Metastatic malignant neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D50-2E09 |
AXL
|
Epidermal dysplasiasDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK90 |
SRC
|
Urinary tract infectionDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC08 |
TOP2A
|
Metastatic digestive system neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D8Y |
SRC
|
Metastatic liver/bile duct neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D80 |
TP53
|
OesophagitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA24 |
CYP19A1
|
Hypopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6D |
EGFR
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
AR
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
TP53
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
Inflammatory arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA2Z |
FLT3
|
Alcoholic liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB94 |
AR
|
Genetic prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E02 |
ALPL
|
AlopeciaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED70 |
AR
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
EGFR
|
EncephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E47 |
XDH
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
TSHR
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
AR
|
Digestive organ benign neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E92 |
KDR
|
HIV-infected patients with tuberculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B10-1B14 |
TOP2A
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ACHE
|
SyphilisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A61-1A6Z |
TOP2A
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
TP53
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
CYP19A1
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
MMP2
|
Mineral deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B5K |
XDH
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
MMP9
|
Urethral cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C93 |
EGFR
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
AKR1B1
|
Gonococcal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A70-1A7Z |
TOP2A
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
XDH
|
Coronavirus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D92 |
CSNK2A1
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
FLT3
|
Intracerebral haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B00 |
EGFR
|
Phakomatoses/hamartoneoplastic syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2D |
FLT3
|
Multiple structural anomalies syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2F |
IGF1R
|
Extraocular muscle disorderDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C82 |
IGF1R
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Skin postprocedural disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EL8Y |
EGFR
|
Otitis mediaDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AA80-AB0Z |
TOP2A
|
Liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB90-DB9Z |
MET
|
Ocular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D00-2D07 |
APEX1
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
Synovial sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5A |
SRC
|
Anogenital wartsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A95 |
TOP2A
|
Kaposi sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B57 |
TOP2A
|
Spinal cord/cranial nerve neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A02 |
EGFR
|
Parasitic infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D0Y-1G2Z |
ALPL
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
Human immunodeficiency virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C60-1C62 |
FLT3
|
Ureteral cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C92 |
AHR
|
LiposarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B59 |
TP53
|
Kidney failureDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60-GB6Z |
TP53
|
Lip/oral cavity/pharynx neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6E |
TP53
|
FilariasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F66 |
ALOX5
|
Bone/articular cartilage neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7B |
FLT3
|
Inborn purine/pyrimidine/nucleotide metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C55 |
XDH
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
EGFR
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
AKR1B1
|
Transplanted organ/tissueDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QB63 |
FLT3
|
Common wartsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E80 |
TOP2A
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Biliary tract cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C17 |
MET
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
DPP4
|
Muscle disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB32-FB3Z |
AR
|
Testicular dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A81 |
AR
|
Otitis externaDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AA00-AA13 |
TOP2A
|
ChemoprotectionDisease Category: NADisease ICD-11 Code: N.A. |
TOP2A
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
EGFR
|
Inborn metabolism deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5C59 |
CA14
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
CYP19A1
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
FLT3
|
LeiomyosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B58 |
SRC
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Metastatic biliary tract neoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C14-2C17 |
EGFR
|
OsteosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B51 |
SRC
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
MMP9
|
Malignant mesenchymal neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5D-2B5Y |
EGFR
|
Ischemic heart diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40-BA6Z |
MET
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Mammary tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Z |
AR
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
DPP4
|
Malignant neoplasms of other or unspecified parts of mouthDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B66 |
NCT05456022
|
Other specified disorders of musclesDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB32.Y |
NCT00183040
|
Sex development malformative disorderDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2A |
NCT04831099
|
Insulin-resistance syndromesDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A44 |
NCT02256865
|
Anorexia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B80 |
NCT00089843
|
MenopauseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30.0 |
NCT02445716
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT05062486
|
Congenital human immunodeficiency virus infectionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA62.6 |
NCT00006158
|
Hereditary breast and ovarian cancer syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C65 |
NCT00080756
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT05276895
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT01348204
|
Malignant neoplasms of prostate, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.Z |
NCT00586898
|
Mixed hyperlipidaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.2 |
NCT02548832
|
Immune thrombocytopenic purpuraDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64.10 |
NCT02351622
|
Duchenne muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.1 |
NCT02964377
|
Fracture of neck of femur, unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NC72.2Z |
NCT00345969
|
Asymptomatic stenosis of intracranial or extracranial arteryDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD55 |
NCT04265053
|
Gastro-oesophageal reflux diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA22 |
NCT02226484
|
Malignant neoplasm metastasis in male genital organsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E06 |
NCT05011383
|
Disorders of muscles, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB3Z |
NCT02873559
|
Impaired glucose toleranceDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.1 |
NCT02621060
|
Friedreich ataxiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A03.10 |
NCT02660112
|
Penile fibromatosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB06.2 |
NCT01578473
|
DyspareuniaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA12 |
NCT01697345
|
Chronic hepatitis CDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.1 |
NCT01438320
|
Congenital aplastic anaemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A70.0 |
NCT01720147
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT03486496
|
Lichen planusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA91 |
NCT01375101
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Parkinson diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00.0 |
ALDH1A1
|
Dilated cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.0 |
ABCG2
|
Malaria, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F4Z |
MMP9
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
