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Plant Name: Hypericum perforatum


Taxonomic Information:

Plant ID: NPO4391
Plant Latin Name: Hypericum perforatum
Taxonomy Genus: Hypericum
Taxonomy Family: Hypericaceae

Plant External Links:

NCBI TaxonomyDB: 65561
Plant-of-the-World-Online: n.a.


Used in Medicines:

Country/Region:
Turkey; Australia; Italy; Turkmenistan; South Africa; India; Lithuania; United States; Albania; Germany; Chile; Greece; Lebanon; Argentina; China; New Zealand; Spain

Traditional Medicine System:
TCM; Homeopathy; Siddha


Medicinal Functions:

Analgesic; Antidepressant; Antiseptic; Antispasmodic; Aromatic; Astringent; Cholagogue; Digestive; Diuretic; Expectorant; Homeopathy; Nervine; Resolvent; Sedative; Stimulant; Vermifuge; Vulnerary


Geographical Distribution:

Turkey; Australia; Italy; Turkmenistan; South Africa; Lebanon; India; United States; Albania; Germany; Spain; Chile; Greece; China; Argentina; New Zealand; Lithuania

Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available



Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Peptide receptor (family A GPCR)
TSHR; OPRD1; NPSR1;
Peptide receptor (family B GPCR)
CRHR1;
Small molecule receptor (family A GPCR)
DRD3;
Enzyme_unclassified
RECQL; ALPL; ALOX12; CBR1; HSD17B2; HSD17B10; NOX4; APEX1; POLB;
Hydrolase
ACHE;
Protein Kinase
MET; AXL; CDK6; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase
CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 1 group H
NR1H4;
Nuclear hormone receptor subfamily 1 group I
NR1I2;
Oxidoreductase
TYR; MAOA; XDH;
Metallo protease
MMP9; MMP1; MMP2;
Transcription Factor
AHR; TP53; NFKB1;
SLC superfamily of solute carriers
SLCO1B1;
Unclassified
LMNA;
Methyl-lysine/arginine binding protein
SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP2C19; CYP19A1; CYP1A2; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified ALPL Alkaline phosphatase, tissue-nonspecific isozyme P05186 CHEMBL5979
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified CBR1 Carbonyl reductase [NADPH] 1 P16152 CHEMBL5586
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified APEX1 DNA-(apurinic or apyrimidinic site) lyase P27695 CHEMBL5619
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Metallo protease MMP1 Matrix metalloproteinase-1 P03956 CHEMBL332
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Methyl-lysine/arginine binding protein SMN1;SMN2 Survival motor neuron protein Q16637 CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H NR1H4 Bile acid receptor FXR Q96RI1 CHEMBL2047
Nuclear hormone receptor subfamily 1 group I NR1I2 Pregnane X receptor O75469 CHEMBL3401
Oxidoreductase TYR Tyrosinase P14679 CHEMBL1973
Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Oxidoreductase XDH Xanthine dehydrogenase P47989 CHEMBL1929
Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Peptide receptor (family A GPCR) OPRD1 Delta opioid receptor P41143 CHEMBL236
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Peptide receptor (family B GPCR) CRHR1 Corticotropin releasing factor receptor 1 P34998 CHEMBL1800
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase CDK6 Cyclin-dependent kinase 6 Q00534 CHEMBL2508
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
SLC superfamily of solute carriers SLCO1B1 Solute carrier organic anion transporter family member 1B1 Q9Y6L6 CHEMBL1697668
Small molecule receptor (family A GPCR) DRD3 Dopamine D3 receptor P35462 CHEMBL234
Transcription Factor AHR Aryl hydrocarbon receptor P35869 CHEMBL3201
Transcription Factor TP53 Cellular tumor antigen p53 P04637 CHEMBL4096
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
MF GO:0005488; binding GO:0019825; oxygen binding 2.117E-11 7.682E-08 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NOX4
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 2.786E-10 6.067E-07 CA12, CA14, CA2, CA4, CA7
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 3.074E-09 4.183E-06 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF GO:0005488; binding GO:0005506; iron ion binding 7.429E-09 7.033E-06 ALOX12, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, XDH
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 8.246E-09 7.481E-06 CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 1.936E-08 1.446E-05 CYP1A2, CYP2C19, CYP3A4, NR1I2
MF GO:0005488; binding GO:0020037; heme binding 3.749E-08 2.474E-05 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NOX4
BP GO:0051179; localization GO:0015701; bicarbonate transport 9.524E-08 5.458E-05 CA12, CA14, CA2, CA4, CA7
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 2.301E-07 1.044E-04 CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 3.246E-07 1.334E-04 CYP1A2, CYP2C19, CYP3A4
BP GO:0009987; cellular process GO:0043066; negative regulation of apoptotic process 1.377E-06 4.053E-04 ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, MMP9, NFKB1, NR1H4, PIM1, TP53
BP GO:0032502; developmental process GO:0007568; aging 2.060E-06 5.608E-04 APEX1, AURKB, CDK1, CYP1A1, NOX4, POLB, TP53
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 2.201E-06 5.779E-04 CA12, CA2, CA4, CA7
BP GO:0009987; cellular process GO:0006286; base-excision repair, base-free sugar-phosphate removal 6.567E-06 1.571E-03 APEX1, POLB
BP GO:0008283; cell proliferation GO:0008284; positive regulation of cell proliferation 1.297E-05 2.742E-03 ALOX12, CDK1, CDK6, DRD3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, TSHR
BP GO:0050896; response to stimulus GO:1901653; cellular response to peptide 1.553E-05 3.252E-03 APEX1, CRHR1, IGF1R, NFKB1, TP53, TSHR
BP GO:0009987; cellular process GO:0070301; cellular response to hydrogen peroxide 1.859E-05 3.784E-03 APEX1, AXL, CDK1, CYP1B1
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.967E-05 3.893E-03 CA2, CA7
MF GO:0003824; catalytic activity GO:0070576; vitamin D 24-hydroxylase activity 1.967E-05 3.893E-03 CYP1A1, CYP3A4
BP GO:0050896; response to stimulus GO:0055093; response to hyperoxia 2.100E-05 4.120E-03 CYP1A1, POLB, TP53
BP GO:0008152; metabolic process GO:0009404; toxin metabolic process 2.787E-05 5.186E-03 CYP1A1, CYP1A2, CYP1B1
BP GO:0009987; cellular process GO:0071407; cellular response to organic cyclic compound 3.144E-05 5.674E-03 ALPL, APEX1, CYP1A1, CYP1B1, FLT3, NFKB1, NOX4
MF GO:0060089; molecular transducer activity GO:0038023; signaling receptor activity 3.411E-05 5.990E-03 AHR, AXL, CRHR1, DRD3, FLT3, IGF1R, KDR, MET, NPSR1, NR1H4, NR1I2, OPRD1, TSHR
MF GO:0005488; binding GO:0008270; zinc ion binding 3.671E-05 6.343E-03 CA12, CA2, CA4, CA7, MMP1, MMP2, MMP9, NR1H4, NR1I2, TP53
BP GO:0032502; developmental process GO:0048513; animal organ development 3.859E-05 6.528E-03 ACHE, AXL, CA2, CDK1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, TYR
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 3.927E-05 6.528E-03 CYP1A1, CYP1A2
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 3.927E-05 6.528E-03 CYP1A2, CYP3A4
BP GO:0008152; metabolic process GO:0006706; steroid catabolic process 4.069E-05 6.612E-03 CYP19A1, CYP1A2, CYP3A4
BP GO:0050896; response to stimulus GO:0001666; response to hypoxia 5.316E-05 8.388E-03 CYP1A1, LMNA, MMP2, NOX4, OPRD1, TP53
BP GO:0050896; response to stimulus GO:0033273; response to vitamin 5.988E-05 9.380E-03 ALPL, CYP1A1, TP53, TYR
MF GO:0003824; catalytic activity GO:0101020; estrogen 16-alpha-hydroxylase activity 6.534E-05 9.950E-03 CYP1A1, CYP3A4
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)


Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways
Pathway Category Top Level Pathway Category Second Level Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
09100 Metabolism 09103 Lipid metabolism hsa00140 Steroid hormone biosynthesis 6.564E-09 4.562E-07 CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism 09102 Energy metabolism hsa00910 Nitrogen metabolism 4.809E-10 6.685E-08 CA12, CA2, CA4, CA7, CA14
09150 Organismal Systems 09152 Endocrine system hsa04913 Ovarian steroidogenesis 1.548E-07 5.379E-06 HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09160 Human Diseases 09161 Cancers hsa05200 Pathways in cancer 5.333E-07 1.483E-05 CDK6, FLT3, MMP1, MMP2, MET, TP53, MMP9, NFKB1, IGF1R
09160 Human Diseases 09161 Cancers hsa05204 Chemical carcinogenesis 5.427E-08 2.515E-06 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19
09100 Metabolism 09111 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 1.051E-06 2.435E-05 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism 09105 Amino acid metabolism hsa00380 Tryptophan metabolism 2.956E-06 5.680E-05 MAOA, CYP1A2, CYP1A1, CYP1B1
Unclassified Unclassified hsa01100 Metabolic pathways 7.649E-06 1.063E-04 CBR1, MAOA, ALOX12, CYP2C19, CYP3A4, TYR, CYP19A1, HSD17B10, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH
09160 Human Diseases 09161 Cancers hsa05205 Proteoglycans in cancer 1.112E-05 1.289E-04 MMP2, KDR, TP53, MMP9, MET, IGF1R
09160 Human Diseases 09161 Cancers hsa05219 Bladder cancer 3.269E-06 5.680E-05 MMP1, MMP2, MMP9, TP53
09160 Human Diseases 09161 Cancers hsa05206 MicroRNAs in cancer 8.578E-06 1.084E-04 CDK6, PIM1, CYP1B1, TP53, MMP9, MET, NFKB1
09160 Human Diseases 09161 Cancers hsa05202 Transcriptional misregulation in cancer 5.593E-06 8.638E-05 FLT3, TP53, MMP9, MET, NFKB1, IGF1R
09160 Human Diseases 09161 Cancers hsa05218 Melanoma 2.968E-05 2.750E-04 CDK6, TP53, MET, IGF1R
09100 Metabolism 09111 Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450 2.651E-05 2.750E-04 MAOA, CYP1A2, CYP3A4, CYP2C19
09150 Organismal Systems 09154 Digestive system hsa04976 Bile secretion 2.968E-05 2.750E-04 SLCO1B1, CA2, NR1H4, CYP3A4
09130 Environmental Information Processing 09132 Signal transduction hsa04151 PI3K-Akt signaling pathway 1.985E-04 1.452E-03 CDK6, KDR, TP53, MET, NFKB1, IGF1R
09160 Human Diseases 09161 Cancers hsa05203 Viral carcinogenesis 1.569E-04 1.212E-03 POLB, CDK6, CDK1, TP53, NFKB1
09160 Human Diseases 09167 Infectious diseases hsa05161 Hepatitis B 4.835E-04 3.167E-03 CDK6, TP53, MMP9, NFKB1
09160 Human Diseases 09161 Cancers hsa05221 Acute myeloid leukemia 3.912E-04 2.719E-03 FLT3, PIM1, NFKB1
09160 Human Diseases 09161 Cancers hsa05214 Glioma 5.758E-04 3.335E-03 CDK6, TP53, IGF1R
09100 Metabolism 09103 Lipid metabolism hsa00590 Arachidonic acid metabolism 5.012E-04 3.167E-03 CBR1, ALOX12, CYP2C19
09160 Human Diseases 09161 Cancers hsa05212 Pancreatic cancer 6.022E-04 3.348E-03 CDK6, TP53, NFKB1
09160 Human Diseases 09161 Cancers hsa05230 Central carbon metabolism in cancer 6.293E-04 3.364E-03 FLT3, TP53, MET
09160 Human Diseases 09161 Cancers hsa05220 Chronic myeloid leukemia 8.085E-04 4.013E-03 CDK6, TP53, NFKB1
09100 Metabolism 09108 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism 5.758E-04 3.335E-03 CYP1A2, CYP1A1, CYP3A4
09100 Metabolism 09103 Lipid metabolism hsa00591 Linoleic acid metabolism 5.132E-05 4.458E-04 CYP1A2, CYP3A4, CYP2C19
09160 Human Diseases 09161 Cancers hsa05215 Prostate cancer 1.435E-03 6.650E-03 TP53, NFKB1, IGF1R
09160 Human Diseases 09166 Endocrine and metabolic diseases hsa04933 AGE-RAGE signaling pathway in diabetic complications 2.062E-03 8.687E-03 MMP2, PIM1, NFKB1
09160 Human Diseases 09161 Cancers hsa05222 Small cell lung cancer 1.300E-03 6.232E-03 CDK6, TP53, NFKB1
09150 Organismal Systems 09149 Aging hsa04211 Longevity regulating pathway - mammal 1.679E-03 7.295E-03 TP53, NFKB1, IGF1R
09140 Cellular Processes 09143 Cell growth and death hsa04115 p53 signaling pathway 6.858E-04 3.531E-03 CDK6, CDK1, TP53
09150 Organismal Systems 09155 Excretory system hsa04964 Proximal tubule bicarbonate reclamation 1.499E-03 6.719E-03 CA2, CA4
09100 Metabolism 09110 Biosynthesis of other secondary metabolites hsa00232 Caffeine metabolism 6.096E-05 4.984E-04 CYP1A2, XDH
Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Associated Disease Targets
(Association Ref: TTD database)
C00-D49: Neoplasms Ovarian cancer C56 KDR; MMP2;
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 KDR;
N00-N99: Diseases of the genitourinary system Prostate disease N42.9 CYP19A1;
C00-D49: Neoplasms Prostate cancer C61 FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cough R05 OPRD1;
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3;
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53;
C00-D49: Neoplasms Bladder cancer C67 CYP19A1;
C00-D49: Neoplasms Biliary cancer C22, C24 KDR;
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2;
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychotic disorders F20-F29 DRD3;
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic nephropathy E11.21 MMP1;
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 ACHE;
NA: NA GIST NA FLT3;
C00-D49: Neoplasms Gliosarcoma NA FLT3;
C00-D49: Neoplasms Glioblastoma NA FLT3;
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE;
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 ACHE; MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cocaine addiction F14.2 DRD3;
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR;
K00-K95: Diseases of the digestive system Diarrhea-predominant IBS K58.0 OPRD1;
G00-G99: Diseases of the nervous system G00-G99 Acute migraine G43 OPRD1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities Genetic disease Q00-Q99 ALPL;
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 KDR;
C00-D49: Neoplasms Overactive bladder disorder C67, N32.81 OPRD1;
I00-I99: Diseases of the circulatory system Ischemic heart diseases I20-I25 OPRD1;
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR;
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 KDR; TP53;
C00-D49: Neoplasms Breast cancer C50 CDK1; IGF1R; KDR; FLT3; CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 MMP2;
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53;
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET;
NA: NA Chronic diarrhea associated with inflammatory bowel disease NA OPRD1;
C00-D49: Neoplasms Advanced breast cancer C50 CYP19A1;
I00-I99: Diseases of the circulatory system Heart failure I50 XDH;
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET;
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53;
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 MMP2;
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 MAOA; CRHR1;
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R;
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 CA4; ACHE; CA2;
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 CA4;
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR;
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR;
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 ACHE; MAOA;
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 XDH;
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ACHE;
G00-G99: Diseases of the nervous system G00-G99 Epilepsy G40 MAOA;
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Male sexual disorders F52 DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 MAOA; OPRD1; CRHR1;
C00-D49: Neoplasms Non-small-cell lung cancer NA KDR;
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; IGF1R; KDR; AXL;
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 ACHE;
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR;
C00-D49: Neoplasms Melanoma C43 KDR; TYR;
L00-L99: Diseases of the skin and subcutaneous tissue Melasma L81.1 TYR;
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 NPSR1;
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 MAOA;
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 ACHE;
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3;
C00-D49: Neoplasms Acute myeloid leukemia C92.0 AURKB; FLT3; TP53;
NA: NA Acute nonspecific diarrhea NA OPRD1;
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE;
NA: NA Early satiation associated with functional dyspepsia NA ACHE;
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA2;
C00-D49: Neoplasms Metastatic breast cancer C50 KDR;
C00-D49: Neoplasms Metastasis C00-C97 AXL;
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 KDR;
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R;
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3;
N00-N99: Diseases of the genitourinary system Endometriosis N80 CYP19A1;
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2;
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Emesis R11 DRD3;
I00-I99: Diseases of the circulatory system Atherosclerosis I70 NR1I2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE;
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 KDR;
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET;
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE;
C00-D49: Neoplasms Myeloid leukemia C92 FLT3;
C00-D49: Neoplasms Myelodysplastic syndrome D46 KDR;
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 CYP3A4; ACHE; MAOA; OPRD1; CRHR1;
A00-B99: Certain infectious and parasitic diseases Anthelmintic B89 ALPL;
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR;
N00-N99: Diseases of the genitourinary system Urinary incontinence N39.3, N39.4, R32 OPRD1;
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE;
NA: NA Upper abdominal bloating NA ACHE;
K00-K95: Diseases of the digestive system Ulcerative colitis K51 MMP9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 MAOA;
N00-N99: Diseases of the genitourinary system Bladder disease N30-N32 OPRD1;
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET;
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 NFKB1;
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53;
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH;
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH;
A00-B99: Certain infectious and parasitic diseases Irritable bowel syndrome A09, K58, K59.1 CRHR1;
C00-D49: Neoplasms AML NA KDR; FLT3;
C00-D49: Neoplasms Ocular cancer C69 APEX1;
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR;
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 MAOA; TYR;
NA: NA Edema NA CA2;
C00-D49: Neoplasms Liver cancer C22 IGF1R; KDR;
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A TP53;
C00-D49: Neoplasms Leukemia C90-C95 FLT3;
C00-D49: Neoplasms Gastric cancer C16 KDR;
K00-K95: Diseases of the digestive system Gastric motility disorder K22.4 DRD3;
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Female sexual dysfunction F52 DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 MAOA; OPRD1; CRHR1;
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET;
C00-D49: Neoplasms Lung cancer C33-C34 MMP2;
C00-D49: Neoplasms Glioma C71 KDR;
A00-B99: Certain infectious and parasitic diseases Staphylococcus aureus infection B95.6 CRHR1;
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9;
J00-J99: Diseases of the respiratory system Asthma J45 CBR1;
C00-D49: Neoplasms Colorectal cancer C18-C21 IGF1R; KDR; FLT3; MMP9; TP53;
C00-D49: Neoplasms Colon cancer C50 FLT3; ALPL;
NA: NA Anxiety disorders NA CRHR1;
C00-D49: Neoplasms Thyroid cancer C73 KDR; TSHR;
C00-D49: Neoplasms Pancreatic cancer C25 KDR; FLT3; MMP2;
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 CDK1; IGF1R; ACHE; OPRD1;
C00-D49: Neoplasms CLL NA FLT3;
NA: NA Severe mood disorder NA CRHR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Premature ejaculation F52.4 OPRD1;
C00-D49: Neoplasms Solid tumours C00-D48 MET; AURKB; IGF1R; KDR; FLT3; MMP9; TP53; MMP2;
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE;
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Moderate-to-severe pain R52, G89 OPRD1;
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 OPRD1; MMP1; TYR;
G00-G99: Diseases of the nervous system G00-G99 Spinal muscular atrophy G00-G99 SMN1;SMN2;
C00-D49: Neoplasms Multiple myeloma C90 IGF1R; AHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Drug abuse F10-F19 DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Schizophrenia F20 DRD3;
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 IGF1R;
C00-D49: Neoplasms Hormonally-responsive breast cancer C50 CYP19A1;
NA: NA HIV infections NA AHR;
C00-D49: Neoplasms Cancer C00-C96 PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; MMP9; TP53; MMP2;
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE;
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; KDR;
C00-D49: Neoplasms Hematological malignancies C81-C86 AURKB; TP53;
NA: NA Hematopoietic stem cell transplantation NA FLT3;
C00-D49: Neoplasms Renal cancer C64 KDR;
C00-D49: Neoplasms Renal cell carcinoma NA KDR; MMP2;
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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