CMAUP Plant Collective Molecular Activities

Plant Name: Hypericum perforatum

Taxonomic Information:

Plant ID: NPO4391
Plant Latin Name: Hypericum perforatum
Taxonomy Genus: Hypericum
Taxonomy Family: Hypericaceae

Plant External Links:

NCBI TaxonomyDB: 65561
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; Australia; Italy; Turkmenistan; South Africa; India; Lithuania; United States; Albania; Germany; Chile; Greece; Lebanon; Argentina; China; New Zealand; Spain

Traditional Medicine System:

TCM; Homeopathy; Siddha

Medicinal Functions:

Analgesic; Antidepressant; Antiseptic; Antispasmodic; Aromatic; Astringent; Cholagogue; Digestive; Diuretic; Expectorant; Homeopathy; Nervine; Resolvent; Sedative; Stimulant; Vermifuge; Vulnerary

Geographical Distribution:

Turkey; Australia; Italy; Turkmenistan; South Africa; Lebanon; India; United States; Albania; Germany; Spain; Chile; Greece; China; Argentina; New Zealand; Lithuania

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; OPRD1; NPSR1;
Peptide receptor (family B GPCR)	CRHR1;
Small molecule receptor (family A GPCR)	DRD3;
Enzyme_unclassified	RECQL; ALPL; ALOX12; CBR1; HSD17B2; HSD17B10; NOX4; APEX1; POLB;
Hydrolase	ACHE;
Protein Kinase	MET; AXL; CDK6; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 1 group I	NR1I2;
Oxidoreductase	TYR; MAOA; XDH;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	AHR; TP53; NFKB1;
SLC superfamily of solute carriers	SLCO1B1;
Unclassified	LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP19A1; CYP1A2; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 1 group I	NR1I2	Pregnane X receptor	O75469	CHEMBL3401
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Peptide receptor (family B GPCR)	CRHR1	Corticotropin releasing factor receptor 1	P34998	CHEMBL1800
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	CDK6	Cyclin-dependent kinase 6	Q00534	CHEMBL2508
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.117E-11	7.682E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NOX4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.786E-10	6.067E-07	CA12, CA14, CA2, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.074E-09	4.183E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	7.429E-09	7.033E-06	ALOX12, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, XDH
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.246E-09	7.481E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.936E-08	1.446E-05	CYP1A2, CYP2C19, CYP3A4, NR1I2
MF	GO:0005488; binding	GO:0020037; heme binding	3.749E-08	2.474E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NOX4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.524E-08	5.458E-05	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.301E-07	1.044E-04	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.246E-07	1.334E-04	CYP1A2, CYP2C19, CYP3A4
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.377E-06	4.053E-04	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, MMP9, NFKB1, NR1H4, PIM1, TP53
BP	GO:0032502; developmental process	GO:0007568; aging	2.060E-06	5.608E-04	APEX1, AURKB, CDK1, CYP1A1, NOX4, POLB, TP53
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.201E-06	5.779E-04	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	6.567E-06	1.571E-03	APEX1, POLB
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	1.297E-05	2.742E-03	ALOX12, CDK1, CDK6, DRD3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, TSHR
BP	GO:0050896; response to stimulus	GO:1901653; cellular response to peptide	1.553E-05	3.252E-03	APEX1, CRHR1, IGF1R, NFKB1, TP53, TSHR
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	1.859E-05	3.784E-03	APEX1, AXL, CDK1, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.967E-05	3.893E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	1.967E-05	3.893E-03	CYP1A1, CYP3A4
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	2.100E-05	4.120E-03	CYP1A1, POLB, TP53
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.787E-05	5.186E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	3.144E-05	5.674E-03	ALPL, APEX1, CYP1A1, CYP1B1, FLT3, NFKB1, NOX4
MF	GO:0060089; molecular transducer activity	GO:0038023; signaling receptor activity	3.411E-05	5.990E-03	AHR, AXL, CRHR1, DRD3, FLT3, IGF1R, KDR, MET, NPSR1, NR1H4, NR1I2, OPRD1, TSHR
MF	GO:0005488; binding	GO:0008270; zinc ion binding	3.671E-05	6.343E-03	CA12, CA2, CA4, CA7, MMP1, MMP2, MMP9, NR1H4, NR1I2, TP53
BP	GO:0032502; developmental process	GO:0048513; animal organ development	3.859E-05	6.528E-03	ACHE, AXL, CA2, CDK1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, TYR
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.927E-05	6.528E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.927E-05	6.528E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	4.069E-05	6.612E-03	CYP19A1, CYP1A2, CYP3A4
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	5.316E-05	8.388E-03	CYP1A1, LMNA, MMP2, NOX4, OPRD1, TP53
BP	GO:0050896; response to stimulus	GO:0033273; response to vitamin	5.988E-05	9.380E-03	ALPL, CYP1A1, TP53, TYR
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	6.534E-05	9.950E-03	CYP1A1, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6.564E-09	4.562E-07	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.809E-10	6.685E-08	CA12, CA2, CA4, CA7, CA14
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.548E-07	5.379E-06	HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.333E-07	1.483E-05	CDK6, FLT3, MMP1, MMP2, MET, TP53, MMP9, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.427E-08	2.515E-06	CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.051E-06	2.435E-05	CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.956E-06	5.680E-05	MAOA, CYP1A2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	7.649E-06	1.063E-04	CBR1, MAOA, ALOX12, CYP2C19, CYP3A4, TYR, CYP19A1, HSD17B10, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.112E-05	1.289E-04	MMP2, KDR, TP53, MMP9, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	3.269E-06	5.680E-05	MMP1, MMP2, MMP9, TP53
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	8.578E-06	1.084E-04	CDK6, PIM1, CYP1B1, TP53, MMP9, MET, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	5.593E-06	8.638E-05	FLT3, TP53, MMP9, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	2.968E-05	2.750E-04	CDK6, TP53, MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.651E-05	2.750E-04	MAOA, CYP1A2, CYP3A4, CYP2C19
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.968E-05	2.750E-04	SLCO1B1, CA2, NR1H4, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.985E-04	1.452E-03	CDK6, KDR, TP53, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.569E-04	1.212E-03	POLB, CDK6, CDK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	4.835E-04	3.167E-03	CDK6, TP53, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.912E-04	2.719E-03	FLT3, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	5.758E-04	3.335E-03	CDK6, TP53, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.012E-04	3.167E-03	CBR1, ALOX12, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	6.022E-04	3.348E-03	CDK6, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	6.293E-04	3.364E-03	FLT3, TP53, MET
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	8.085E-04	4.013E-03	CDK6, TP53, NFKB1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.758E-04	3.335E-03	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.132E-05	4.458E-04	CYP1A2, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.435E-03	6.650E-03	TP53, NFKB1, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.062E-03	8.687E-03	MMP2, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.300E-03	6.232E-03	CDK6, TP53, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.679E-03	7.295E-03	TP53, NFKB1, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	6.858E-04	3.531E-03	CDK6, CDK1, TP53
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.499E-03	6.719E-03	CA2, CA4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	6.096E-05	4.984E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; TP53;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA; CRHR1;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; MAOA;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	XDH;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA; OPRD1; CRHR1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
NA: NA	Acute nonspecific diarrhea	NA	OPRD1;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	NR1I2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE; MAOA; OPRD1; CRHR1;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CRHR1;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA; TYR;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA; OPRD1; CRHR1;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Glioma	C71	KDR;
A00-B99: Certain infectious and parasitic diseases	Staphylococcus aureus infection	B95.6	CRHR1;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
J00-J99: Diseases of the respiratory system	Asthma	J45	CBR1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9; TP53;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; ALPL;
NA: NA	Anxiety disorders	NA	CRHR1;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE; OPRD1;
C00-D49: Neoplasms	CLL	NA	FLT3;
NA: NA	Severe mood disorder	NA	CRHR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; MMP9; TP53; MMP2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1; MMP1; TYR;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
NA: NA	HIV infections	NA	AHR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; MMP9; TP53; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases