Plant ID: NPO4386
Plant Latin Name: Strychnos Icaja
Taxonomy Genus: Strychnos
Taxonomy Family: Loganiaceae
NCBI TaxonomyDB:
1040889
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC96901
Ingredient ID: NPC66848
Ingredient ID: NPC63047
Ingredient ID: NPC478948
Ingredient ID: NPC476464
Ingredient ID: NPC475248
Ingredient ID: NPC329833
Ingredient ID: NPC286994
Ingredient ID: NPC277057
Ingredient ID: NPC262973
Ingredient ID: NPC260977
Ingredient ID: NPC260075
Ingredient ID: NPC22689
Ingredient ID: NPC215267
Ingredient ID: NPC200166
Ingredient ID: NPC162440
Ingredient ID: NPC129909
Ingredient ID: NPC110812
Ingredient ID: NPC10732
Ingredient ID: NPC102165
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Isomerase | TOP1 | DNA topoisomerase I | P11387 | CHEMBL1781 |
Therapeutic Target | Membrane receptor | SIGMAR1 | Sigma opioid receptor | Q99720 | CHEMBL287 |
Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Therapeutic Target | Phosphodiesterase | TDP2 | Tyrosyl-DNA phosphodiesterase 2 | O95551 | CHEMBL2169736 |
Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Therapeutic Target | Protein Kinase | CHEK1 | Serine/threonine-protein kinase Chk1 | O14757 | CHEMBL4630 |
Therapeutic Target | Protein Kinase | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
Therapeutic Target | Secreted protein | HBB | Hemoglobin beta chain | P68871 | CHEMBL4331 |
Therapeutic Target | Secreted protein | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2B | Serotonin 2b (5-HT2b) receptor | P41595 | CHEMBL1833 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Therapeutic Target | Transcription factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
Therapeutic Target | Unclassified protein | PMP22 | Peripheral myelin protein 22 | Q01453 | CHEMBL1293298 |
Therapeutic Target | Unclassified protein | GMNN | Geminin | O75496 | CHEMBL1293278 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 87 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT04447534 | Zinc With Chloroquine/Hydroxychloroquine in Treatment of COVID-19 | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT00224978 | Chloroquine for Treatment of Glioblastoma Multiforme | glioblastoma multiforme | Chloroquine (NPC476464) | NP level |
NCT00486694 | Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malaria | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT00082563 | Azithromycin in Combination With Chloroquine Versus Chloroquine in the Eradication of Asymptomatic Plasmodium Falciparum | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT03278808 | Chloroquine (CQ) and Azithromycin (AZ) Combination for Malaria Prophylaxis | malaria | Chloroquine (NPC476464) | NP level |
NCT02610686 | Evaluating the Efficacy of Chloroquine for the Treatment of Plasmodium Vivax Infections in Central Vietnam | malaria | Chloroquine (NPC476464) | NP level |
NCT01292408 | Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients | breast cancer | Chloroquine (NPC476464) | NP level |
NCT01500980 | Malaria Challenge in Healthy Volunteers | malaria | Chloroquine (NPC476464) | NP level |
NCT00677833 | Azithromycin Plus Chloroquine Versus Artemether-Lumefantrine For The Treatment Of Uncomplicated P. Falciparum Malaria In Children In Africa | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT04627467 | Prevention With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19) (TS-COVID) | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT00819390 | Chloroquine for Reducing Immune Activation in HIV- Infected Individuals | HIV infection | Chloroquine (NPC476464) | NP level |
NCT02071537 | Chloroquine in Combination With Carboplatin/Gemcitabine in Advanced Solid Tumors | cancer | Chloroquine (NPC476464) | NP level |
NCT02216123 | Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT01777477 | Adjuvant Effect of Chloroquine on Gemcitabine | pancreatic carcinoma | Chloroquine (NPC476464) | NP level |
NCT01575782 | Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung Cancer | small cell lung carcinoma | Chloroquine (NPC476464) | NP level |
NCT00118807 | Trial of the Effectiveness of AQ/AS, SP/AQ and SP/CQ for Uncomplicated Malaria in Gambian Children | malaria | Chloroquine (NPC476464) | NP level |
NCT00871156 | Tafenoquine/Chloroquine DDI Study | malaria | Chloroquine (NPC476464) | NP level |
NCT02348788 | Artemether-lumefantrine vs Chloroquine for Uncomplicated P. Vivax Malaria in Malaysia | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT04349371 | Saved From COVID-19 - Chloroquine (CQ) Prophylaxis for Health Care Workers at Risk for COVID | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT01074905 | Study on the Treatment of Vivax Malaria | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT01100060 | A Phase 1 Study To Estimate The Relative Bioavailability Of Co-Administered Formulations Of Azithromycin Microsphere And Chloroquine Test Formulation Compared With Co-Administered Immediate Release Individual Azithromycin And Chloroquine Tablets In Healthy Adult Subjects | malaria | Chloroquine (NPC476464) | NP level |
NCT01391403 | Artemisinin With Risperidone for First-Episode and Drug-Naive Schizophrenia | schizophrenia | Artemisinin (NPC260977) | NP level |
NCT00682578 | A Comparative Study of Artekin With Standard Malarial Treatment Regimes in Afghanistan | Plasmodium falciparum malaria;Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT02389374 | A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh | malaria | Chloroquine (NPC476464) | NP level |
NCT01438177 | Chloroquine in Combination With VELCADE and Cyclophosphamide for Relapsed and Refractory Multiple Myeloma | multiple myeloma | Chloroquine (NPC476464) | NP level |
NCT02333890 | A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer | breast cancer | Chloroquine (NPC476464) | NP level |
NCT00440999 | Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria | malaria | Chloroquine (NPC476464) | NP level |
NCT04333628 | Chloroquine for Mild Symptomatic and Asymptomatic COVID-19 | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT00442403 | Safety and Efficacy of Chloroquine Associated With Dehydroepiandrosterone Sulphate to Treat Uncomplicated Falciparum Malaria | malaria | Chloroquine (NPC476464) | NP level |
NCT01376167 | Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT02432417 | The Addition of Chloroquine to Chemoradiation for Glioblastoma, | glioblastoma multiforme | Chloroquine (NPC476464) | NP level |
NCT00082576 | Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Malaria in Africa | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT01290601 | Study to Evaluate the Efficacy and Safety of Tafenoquine for the Treatment of Plasmodium Vivax in Adults | malaria | Chloroquine (NPC476464) | NP level |
NCT04351295 | Efficacy of Faviprevir in COVID-19 Treatment | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT01103713 | Evaluate Parasitological Clearance Rates And Pharmacokinetics Of The Combination Of Azithromycin And Chloroquine In Asymptomatic Pregnant Women With Falciparum Parasitemia In Africa | pregnancy | Chloroquine (NPC476464) | NP level |
NCT01205178 | G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine) | malaria | Chloroquine (NPC476464) | NP level |
NCT01718054 | Vascular Function Intervention Trial in Sickle Cell Disease | sickle cell anemia | Chloroquine (NPC476464) | NP level |
NCT01946880 | Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE) | systemic lupus erythematosus | Chloroquine (NPC476464) | NP level |
NCT02691910 | Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infection | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT01708876 | P. Knowlesi Trial of Artesunate-mefloquine Versus Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
NCT03503058 | Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted Malaria | malaria | Chloroquine (NPC476464) | NP level |
NCT00131703 | Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women | pregnancy;malaria | Chloroquine (NPC476464) | NP level |
NCT01814423 | Pharmacokinetic Study of Multi-dose Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
NCT02698748 | Evaluating the Role of Chloroquine for Malaria Elimination | malaria | Chloroquine (NPC476464) | NP level |
NCT04801017 | A Study to Evaluate the Safety and Efficacy of OT-101+Artemisinin in Hospitalized COVID-19 Subjects | COVID-19 | Artemisinin (NPC260977) | NP level |
NCT02511054 | Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B... | malaria | Chloroquine (NPC476464) | NP level |
NCT01640574 | Comparison Between 7 and 14 Day Primaquine Combined With Dihydroartemisinin-piperaquine or 3 Day Chloroquine Radical Cure of P. Vivax (BPD) | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT00323375 | Studies of AQ-13, a Candidate Aminoquinoline Antimalarial, in Comparison With Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
NCT01546389 | Sanaria™ PfSPZ Challenge Vaccine | malaria | Chloroquine (NPC476464) | NP level |
NCT00158548 | ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan | Plasmodium falciparum malaria;Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT01443130 | Chloroquine for Malaria in Pregnancy | malaria | Chloroquine (NPC476464) | NP level |
NCT00959517 | Trial of Artesunate Combination Therapy in Pakistan | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT01941095 | A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis | rheumatoid arthritis | Chloroquine (NPC476464) | NP level |
NCT04420247 | Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19 | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT00290420 | Prevention of P. Vivax Malaria During Pregnancy in Bolivia | malaria | Chloroquine (NPC476464) | NP level |
NCT04303299 | Fight COVID-19 Trial | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT04345406 | Angiotensin Converting Enzyme Inhibitors in Treatment of Covid 19 | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT01078779 | The Chloroquine for Influenza Prevention Trial | influenza | Chloroquine (NPC476464) | NP level |
NCT04360759 | Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19 | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT01680406 | Ethiopia Antimalarial in Vivo Efficacy Study 2012 | malaria | Chloroquine (NPC476464) | NP level |
NCT00972725 | Evaluation of the Immune Response of a HIV Candidate Vaccine After Administration of One Chloroquine Dose | AIDS | Chloroquine (NPC476464) | NP level |
NCT00844207 | A Phase 1 Study To Estimate The Relative Bioavailability Of Fixed Combination Tablets Of Azithromycin And Chloroquine Compared To Co-Administered Individual Tablets Of Azithromycin And Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
NCT01378286 | Efficacy and Tolerability of Artesunate Amodiaquine Versus Chloroquine in the Treatment of Uncomplicated Plasmodium Vivax Malaria | malaria | Chloroquine (NPC476464) | NP level |
NCT02001012 | P. Knowlesi Trial of Artemether-lumefantrine vs Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
NCT00282919 | A Three Day Trial of Azithromycin Plus Chloroquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT00849602 | The Effect of Chloroquine in the Treatment of Patients With Dengue | Dengue Hemorrhagic Fever | Chloroquine (NPC476464) | NP level |
NCT00367653 | Azithromycin Plus Chloroquine Versus Mefloquine In the Treatment of Uncomplicated P. Falciparum Malaria. | malaria | Chloroquine (NPC476464) | NP level |
NCT04319900 | Clinical Trial of Favipiravir Tablets Combine With Chloroquine Phosphate in the Treatment of Novel Coronavirus Pneumonia | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT00084240 | Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine For The Treatment Of Uncomplicated, Symptomatic Falciparum Malaria In Southeast Asia | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT04397679 | Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma | gliosarcoma | Chloroquine (NPC476464) | NP level |
NCT02563496 | A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT04351724 | Austrian CoronaVirus Adaptive Clinical Trial (COVID-19) | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT01894633 | Study of Whole-brain Irradiation With Chloroquine for Brain Metastases | brain disease | Chloroquine (NPC476464) | NP level |
NCT02996695 | Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian Adults | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT01023477 | Study of the Efficacy of Chloroquine in the Treatment of Ductal Carcinoma in Situ (The PINC Trial) | breast ductal carcinoma in situ | Chloroquine (NPC476464) | NP level |
NCT01103063 | Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa | pregnancy | Chloroquine (NPC476464) | NP level |
NCT00084227 | Azithromycin Plus Chloroquine Versus Atovaquone-Proguanil For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In South America | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT00811096 | Pilot Human Study of Tinidazole Efficacy For Radical Cure Of Plasmodium Vivax | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
NCT00969306 | Chloroquine as an Anti-Autophagy Drug in Stage IV Small Cell Lung Cancer (SCLC) Patients | small cell lung carcinoma | Chloroquine (NPC476464) | NP level |
NCT02378532 | The Addition of Chloroquine to Chemoradiation for Glioblastoma | glioblastoma multiforme | Chloroquine (NPC476464) | NP level |
NCT04353336 | Efficacay of Chloroquine or Hydroxychloroquine in COVID-19 Treatment | COVID-19 | Chloroquine (NPC476464) | NP level |
NCT00074841 | Trial of Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine for the Treatment of Uncomplicated Malaria in India | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT00379821 | Chloroquine Alone or in Combination for Malaria in Children in Malawi | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT02773979 | PfSPZ Challenge in Healthy Malaria-Naïve Adults in the United States | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
NCT00521924 | Induction of Remission in RA Patients at Low Disease Activity by Additional Infliximab Therapy (Study P04644AM1) (TERMINATED) | rheumatoid arthritis | Chloroquine (NPC476464) | NP level |
NCT04387240 | Evaluating the Efficacy of Artesunate in Adults With Mild Symptoms of COVID-19 | COVID-19 | Artemisinin (NPC260977) | NP level |
NCT04368910 | Safety and Efficacy of Pyronaridine Artesunate Vs Chloroquine in Children and Adult Patients With Acute Vivax Malaria | malaria | Chloroquine (NPC476464) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CHEK1,TP53,PMP22,HIF1A,GMNN,SSTR3,LMNA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CHEK1,HTR2B,PMP22,HIF1A,TOP1,LMNA,CYP2B6
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
SMN1,TMEM97,GMNN,SSTR3,SIGMAR1,TOP1,LMNA
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CHEK1,SMN1,CYP2B6,HIF1A,GMNN,TOP1,RAB9A
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CHEK1,GMNN,SSTR3,CHEK1,GMNN,SSTR3
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CHEK1,MTOR,HIF1A,TOP1,TP53
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TMEM97,TP53,GMNN,TOP1,CYP2B6
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CHEK1,PMP22,GMNN,HBB,SSTR3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CHEK1,THPO,HTR2B,GMNN,CYP2B6
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
NCT00082576,NCT00442403,NCT01378286,NCT00074841,NCT01100060,NCT00440999,NCT04368910,NCT01708876,NCT03278808,NCT01500980,NCT02001012,NCT00844207,NCT00082563,NCT01680406,NCT00084240,NCT03503058,NCT00367653,NCT02698748,NCT00158548,NCT02389374,NCT00677833,NCT00131703,NCT00118807,NCT00871156,NCT02996695,NCT01814423,NCT01205178,NCT02511054,NCT01290601,NCT02773979,NCT01443130,NCT00959517,NCT01546389,NCT00379821,NCT00290420,NCT00084227,NCT00682578,NCT00323375,NCT00282919,NCT02610686
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
HIF1A,MTOR,CHEK1,TOP1
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
MTOR,TOP1
NCT01292408,NCT02333890 |
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CHEK1,TP53,GMNN,SIGMAR1
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CHEK1,TMEM97,THPO,CYP2B6
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CHEK1,GMNN,TMEM97,SSTR3
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
CHEK1,MTOR,TP53
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
MTOR,CHEK1,TP53
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TOP1,CHEK1,TP53
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
HIF1A,TOP1,TP53
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
HTR2B,MTOR,HIF1A
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
SIGMAR1,TMEM97
NCT01391403 |
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
CHEK1,MTOR,TOP1
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT02378532,NCT02432417,NCT00224978
|
Pregnancy/childbirth/puerperium maternal infectionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JB63 |
NCT00131703,NCT01103063,NCT01103713
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
PMP22,LMNA,RAB9A
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
GMNN,LMNA,RAB9A
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
HTR2B,THPO,HBB
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
SIGMAR1,HTR2B
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
MTOR,SIGMAR1
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
TP53,MTOR
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
TOP1,MTOR
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
TOP1,TP53
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
MTOR,TP53
|
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
SIGMAR1,HTR2B
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TP53,MTOR
|
Muscular atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B61 |
SMN1,SMN2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
TMEM97,SIGMAR1
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
MTOR,TP53
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
TOP1,TP53
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TP53,TOP1
|
Sickle-cell disorderDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A51 |
HBB
NCT01718054 |
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
MTOR
NCT01438177 |
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
TP53,TOP1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NCT01941095,NCT00521924
|
Small cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.1 |
NCT00969306,NCT01575782
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CHEK1,GMNN
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
CHEK1,CYP2B6
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CHEK1,CYP2B6
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Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CHEK1,CYP2B6
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
HIF1A,LMNA
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04801017,NCT04360759,NCT04333628,NCT04319900,NCT04349371,NCT04353336,NCT04420247,NCT04627467,NCT04387240,NCT04351724,NCT04303299,NCT04345406,NCT04447534,NCT04351295
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Malaria due to Plasmodium vivaxDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F41 |
NCT01640574,NCT00158548,NCT02691910,NCT00682578,NCT00811096,NCT02563496,NCT01074905,NCT02216123,NCT01376167,NCT02348788,NCT00486694
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Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CHEK1,SMN1,TMEM97,THPO,HTR2B,TP53,PMP22,GMNN,SSTR3,SIGMAR1,LMNA
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
SIGMAR1
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
MTOR
|
Immune system diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01-4B41 |
SIGMAR1
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
MTOR
|
Metastatic liver/bile duct neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D80 |
TP53
|
SomnolenceDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG42 |
SIGMAR1
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
TOP1
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
MTOR
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
SIGMAR1
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
TP53
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
TP53
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
TP53
|
Gastrointestinal stromal tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5B |
TOP1
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
THPO
|
ThalassaemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A50 |
HBB
|
Anal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C00 |
CHEK1
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
SSTR3
|
Bulimia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B81 |
SIGMAR1
|
LymphangioleiomyomatosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB07 |
MTOR
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
RAB9A
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
TOP1
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
SIGMAR1
|
Lip/oral cavity/pharynx neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6E |
TP53
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
HTR2B
|
Intellectual development disorderDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD90 |
SIGMAR1
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
SIGMAR1
|
Epileptic encephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A62 |
SIGMAR1
|
HydrocephalusDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D64 |
MTOR
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MTOR
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
TP53
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
SIGMAR1
|
Kidney failureDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60-GB6Z |
TP53
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SIGMAR1
|
Neurobehavioral disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00-8A0Z |
SIGMAR1
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
THPO
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
TP53
|
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
MTOR
|
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
MTOR
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
Fallopian tube cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C74 |
TP53
|
LiposarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B59 |
TP53
|
Pleural mesotheliomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26 |
MTOR
|
Hodgkin lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B30 |
CHEK1
|
Human immunodeficiency virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C60-1C62 |
TOP1
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
HTR2B
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
SIGMAR1
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
SIGMAR1
|
Malignant mesenchymal neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5D-2B5Y |
MTOR
|
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
SIGMAR1
|
Dengue with warning signsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D21 |
NCT00849602
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT02071537
|
Ductal carcinoma in situ of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65.2 |
NCT01023477
|
Congenital human immunodeficiency virus infectionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA62.6 |
NCT00972725
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
NCT01078779
|
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT01777477
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
NCT01946880
|
GliosarcomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH9RC8 |
NCT04397679
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT00819390
|
Brain diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70-8E61 |
NCT01894633
|
Non-alcoholic steatohepatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92.1 |
HBB
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
SSTR3
|
Hypertrophic cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.1 |
HBB
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
HBB
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
SSTR3
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CHEK1
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
HBB
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
SSTR3
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
THPO
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
SSTR3
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
HBB
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
TMEM97
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
GMNN
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
HBB
|